{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T01:08:47Z","timestamp":1759972127080,"version":"build-2065373602"},"reference-count":25,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T00:00:00Z","timestamp":1718236800000},"content-version":"am","delay-in-days":317,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Auris Nasus Larynx"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.anl.2022.12.014","type":"journal-article","created":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T23:11:07Z","timestamp":1672701067000},"page":"601-606","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Elevation of C-reactive protein during concurrent chemoradiotherapy is a poor predictive factor for head and neck cancer"],"prefix":"10.1016","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6489-446X","authenticated-orcid":false,"given":"Masahiro","family":"Adachi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9285-7877","authenticated-orcid":false,"given":"Masahiro","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihide","family":"Shima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isao","family":"Uemaetomari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomonori","family":"Yoshimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6497-5099","authenticated-orcid":false,"given":"Kayoko","family":"Onishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masamitsu","family":"Senarita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0942-8655","authenticated-orcid":false,"given":"Keiji","family":"Tabuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.anl.2022.12.014_bib0001","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/s41572-020-00224-3","article-title":"Head and neck squamous cell carcinoma","volume":"6","author":"Johnson","year":"2020","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.anl.2022.12.014_bib0002","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1200\/JCO.2003.01.008","article-title":"An intergroup phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer","volume":"21","author":"Adelstein","year":"2003","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.anl.2022.12.014_bib0003","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0143080","article-title":"C-reactive protein is an important biomarker for prognosis tumor recurrence and treatment response in adult solid tumors: a systematic review","volume":"10","author":"Shrotriya","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.anl.2022.12.014_bib0004","doi-asserted-by":"crossref","first-page":"9541","DOI":"10.1002\/cam4.3520","article-title":"The prognostic role of C-reactive protein in patients with head and neck squamous cell carcinoma: a meta-analysis","volume":"9","author":"Chen","year":"2020","journal-title":"Cancer Med"},{"key":"10.1016\/j.anl.2022.12.014_bib0005","series-title":"AJCC cancer staging manual","first-page":"58","author":"Amin","year":"2017"},{"key":"10.1016\/j.anl.2022.12.014_bib0006","doi-asserted-by":"crossref","first-page":"17805","DOI":"10.1038\/s41598-017-18233-w","article-title":"The impact of elevated C-reactive protein level on the prognosis for oro-hypopharynx cancer patients treated with radiotherapy","volume":"7","author":"Katano","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.anl.2022.12.014_bib0007","doi-asserted-by":"crossref","first-page":"37008","DOI":"10.18632\/oncotarget.26438","article-title":"The high-sensitivity modified Glasgow prognostic score is superior to the modified Glasgow prognostic score as a prognostic predictor for head and neck cancer","volume":"9","author":"Hanai","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.anl.2022.12.014_bib0008","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/bmt.2012.244","article-title":"Investigation of the freely available easy-to-use software \u201cEZR\u201d for medical statistics","volume":"48","author":"Kanda","year":"2013","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.anl.2022.12.014_bib0009","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1002\/hed.23823","article-title":"Clinical utility of the modified Glasgow prognostic score in patients with advanced head and neck cancer","volume":"37","author":"Nakayama","year":"2015","journal-title":"Head Neck"},{"key":"10.1016\/j.anl.2022.12.014_bib0010","doi-asserted-by":"crossref","first-page":"11553","DOI":"10.1007\/s13277-016-5098-7","article-title":"Role of interleukin-6 in cancer progression and therapeutic resistance","volume":"37","author":"Kumari","year":"2016","journal-title":"Tumour Biol"},{"key":"10.1016\/j.anl.2022.12.014_bib0011","doi-asserted-by":"crossref","first-page":"100339","DOI":"10.18632\/oncotarget.22225","article-title":"Endothelial-derived interleukin-6 induces cancer stem cell motility by generating a chemotactic gradient towards blood vessels","volume":"8","author":"Kim","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.anl.2022.12.014_bib0012","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1007\/s00259-021-05602-x","article-title":"Interleukin-6 as surrogate marker for imaging-based hypoxia dynamics in patients with head-and-neck cancers undergoing definitive chemoradiation-results from a prospective pilot trial","volume":"49","author":"R\u00fchle","year":"2022","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.anl.2022.12.014_bib0013","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.3389\/fonc.2019.01177","article-title":"Systemic inflammatory reaction in patients with head and neck cancer-an explorative study","volume":"9","author":"Astradsson","year":"2019","journal-title":"Front Oncol"},{"key":"10.1016\/j.anl.2022.12.014_bib0014","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.bbi.2018.02.013","article-title":"Rethinking IL-6 and CRP: why they are more than inflammatory biomarkers, and why it matters","volume":"70","author":"Del Giudice","year":"2018","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.anl.2022.12.014_bib0015","doi-asserted-by":"crossref","first-page":"41","DOI":"10.21037\/tcr.2017.12.23","article-title":"Radiotherapy and radiochemotherapy increase serum levels of pro-inflammatory interleukin-6 and C-reactive protein in patients with head and neck cancers","volume":"7","author":"Kiprian","year":"2018","journal-title":"Transl Cancer Res"},{"key":"10.1016\/j.anl.2022.12.014_bib0016","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1165\/ajrcmb.19.4.3058","article-title":"Hypoxia-induced interleukin-6 and interleukin-8 production is mediated by platelet-activating factor and platelet-derived growth factor in primary human lung cells","volume":"19","author":"Tamm","year":"1998","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.anl.2022.12.014_bib0017","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1084\/jem.20131916","article-title":"PD-L1 is a novel direct target of HIF-1alpha, and its blockade under hypoxia enhanced MDSC-mediated T cell activation","volume":"211","author":"Noman","year":"2014","journal-title":"J Exp Med"},{"key":"10.1016\/j.anl.2022.12.014_bib0018","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1002\/mc.23162","article-title":"Tumor immune microenvironment in head and neck cancers","volume":"59","author":"Chen","year":"2020","journal-title":"Mol Carcinog"},{"key":"10.1016\/j.anl.2022.12.014_bib0019","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1093\/jnci\/djy060","article-title":"Tobacco smoking-associated alterations in the immune microenvironment of squamous cell carcinomas","volume":"110","author":"Desrichard","year":"2018","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.anl.2022.12.014_bib0020","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1158\/1541-7786.MCR-18-1191","article-title":"Cigarette smoke induces metabolic reprogramming of the tumor stroma in head and neck squamous cell carcinoma","volume":"17","author":"Domingo-Vidal","year":"2019","journal-title":"Mol Cancer Res"},{"key":"10.1016\/j.anl.2022.12.014_bib0021","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1200\/JCO.21.01293","article-title":"Weekly cisplatin plus radiation for postoperative head and neck cancer (JCOG1008): a multicenter, noninferiority, phase II\/III randomized controlled trial","volume":"40","author":"Kiyota","year":"2022","journal-title":"J Clin Oncol"},{"issue":"Suppl 1","key":"10.1016\/j.anl.2022.12.014_bib0022","first-page":"E2151","article-title":"Cumulative cisplatin dose in concurrent chemoradiotherapy for head and neck cancer: a systematic review","volume":"38","author":"Strojan","year":"2016","journal-title":"Head Neck"},{"key":"10.1016\/j.anl.2022.12.014_bib0023","doi-asserted-by":"crossref","first-page":"4657","DOI":"10.1200\/JCO.2004.07.962","article-title":"Concurrent radiation chemotherapy for locally advanced head and neck carcinoma: are we addressing burning subjects?","volume":"22","author":"Ang","year":"2004","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.anl.2022.12.014_bib0024","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1002\/hed.21848","article-title":"Acute-phase response reactants as objective biomarkers of radiation-induced mucositis in head and neck cancer","volume":"34","author":"Mohammed","year":"2012","journal-title":"Head Neck"},{"key":"10.1016\/j.anl.2022.12.014_bib0025","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.ijrobp.2008.11.012","article-title":"C-reactive protein levels and radiation-induced mucositis in patients with head-and-neck cancer","volume":"75","author":"Ki","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["Auris Nasus Larynx"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0385814622002413?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0385814622002413?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T19:41:03Z","timestamp":1759952463000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0385814622002413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["S0385814622002413"],"URL":"https:\/\/doi.org\/10.1016\/j.anl.2022.12.014","relation":{},"ISSN":["0385-8146"],"issn-type":[{"type":"print","value":"0385-8146"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Elevation of C-reactive protein during concurrent chemoradiotherapy is a poor predictive factor for head and neck cancer","name":"articletitle","label":"Article Title"},{"value":"Auris Nasus Larynx","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anl.2022.12.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Japanese Society of Otorhinolaryngology-Head and Neck Surgery, Inc. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}