{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T16:50:49Z","timestamp":1747155049071,"version":"3.40.5"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"am","delay-in-days":333,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Auris Nasus Larynx"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.anl.2023.07.008","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T19:20:50Z","timestamp":1690831250000},"page":"221-229","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Application of phosphorylcholine derivative as mucosal adjuvant enhancing mucosal immune responses in the upper respiratory tract"],"prefix":"10.1016","volume":"51","author":[{"given":"Tomohiro","family":"Jimura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9549-6237","authenticated-orcid":false,"given":"Yuichi","family":"Kurono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Hirano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Kawabata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9861-1517","authenticated-orcid":false,"given":"Masaru","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.anl.2023.07.008_bib0001","series-title":"Mucosal vaccines","first-page":"3","article-title":"Mucosal immunoprophylaxis: an introductory overview","author":"Ogra","year":"1996"},{"key":"10.1016\/j.anl.2023.07.008_bib0002","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0264-410X(92)90021-B","article-title":"The mucosal immune system: from fundamental concepts to vaccine development","volume":"10","author":"McGhee","year":"1992","journal-title":"Vaccine"},{"key":"10.1016\/j.anl.2023.07.008_bib0003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.anl.2021.07.003","article-title":"The mucosal immune system of the upper respiratory tract and recent progress in mucosal vaccines","volume":"49","author":"Kurono","year":"2022","journal-title":"Auris Nasus Larynx"},{"key":"10.1016\/j.anl.2023.07.008_bib0004","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1056\/NEJM199805143382002","article-title":"The efficacy of live attenuated, cold-adapted, trivalent, intranasal influenzavirus vaccine in children","volume":"338","author":"Belshe","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.anl.2023.07.008_bib0005","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1128\/IAI.68.2.796-800.2000","article-title":"Intranasal immunization of mice with a mixture of the pneumococcal proteins PsaA and PspA is highly protective against nasopharyngeal carriage of Streptococcus pneumoniae","volume":"68","author":"Briles","year":"2000","journal-title":"Infect Immun"},{"key":"10.1016\/j.anl.2023.07.008_bib0006","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1128\/IAI.68.4.2294-2300.2000","article-title":"Induction of specific immunoglobulin A and Th2 immune responses to P6 outer membrane protein of nontypeable Haemophilus influenzae in middle ear mucosa by intranasal immunization","volume":"68","author":"Kodama","year":"2000","journal-title":"Infect Immun"},{"key":"10.1016\/j.anl.2023.07.008_bib0007","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/nri1439","article-title":"NALT- versus Peyer's-patch-mediated mucosal immunity","volume":"4","author":"Kiyono","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.anl.2023.07.008_bib0008","doi-asserted-by":"crossref","first-page":"4849","DOI":"10.1016\/j.vaccine.2008.06.091","article-title":"A combination of Flt3 ligand cDNA and CpG ODN as nasal adjuvant elicits NALT dendritic cells for prolonged mucosal immunity","volume":"26","author":"Fukuiwa","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.anl.2023.07.008_bib0009","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1080\/21645515.2018.1461298","article-title":"Cationic pullulan nanogel as a safe and effective nasal vaccine delivery system for respiratory infectious diseases","volume":"14","author":"Nakahashi-Ouchida","year":"2018","journal-title":"Hum Vaccin Immunother"},{"key":"10.1016\/j.anl.2023.07.008_bib0010","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1111\/j.1365-2249.2008.03855.x","article-title":"CpG-oligodeoxynucleotides stimulate immunoglobulin A secretion in intestinal mucosal B cells","volume":"155","author":"Blaas","year":"2009","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.anl.2023.07.008_bib0011","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1186\/s12879-022-07275-9","article-title":"Incidence of acute otitis media in children in the United States before and after the introduction of 7- and 13-valent Pneumococcal Conjugate Vaccines during 1998\u20132018","volume":"22","author":"Hu","year":"2022","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.anl.2023.07.008_bib0012","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1097\/01.inf.0000129685.04847.94","article-title":"Postlicensure surveillance for pneumococcal invasive disease after use of heptavalent pneumococcal conjugate vaccine in Northern California Kaiser Permanente","volume":"23","author":"Black","year":"2004","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.anl.2023.07.008_bib0013","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1093\/infdis\/jiu576","article-title":"Efficacy of 13-valent Pneumococcal Conjugate Vaccine (PCV13) versus that of 7-valent PCV (PCV7) against nasopharyngeal colonization of antibiotic-nonsusceptible Streptococcus pneumoniae","volume":"211","author":"Dagan","year":"2015","journal-title":"J Infect Dis"},{"key":"10.1016\/j.anl.2023.07.008_bib0014","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.1016\/j.vaccine.2006.10.014","article-title":"Intranasal immunization with phosphorylcholine induces antigen specific mucosal and systemic immune responses in mice","volume":"25","author":"Tanaka","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.anl.2023.07.008_bib0015","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.anl.2017.04.009","article-title":"Mucosal and systemic immune response to sublingual or intranasal immunization with phosphorylcholine","volume":"45","author":"Maseda","year":"2018","journal-title":"Auris Nasus Larynx"},{"key":"10.1016\/j.anl.2023.07.008_bib0016","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.anl.2016.08.006","article-title":"Transcutaneous immunization in auricle skin induces antigen-specific mucosal and systemic immune responses in BALB\/c mice","volume":"44","author":"Nagano","year":"2017","journal-title":"Auris Nasus Larynx"},{"key":"10.1016\/j.anl.2023.07.008_bib0017","article-title":"Mice plasmacytoid dendritic cells were activated by lipopolysaccharides through toll-like receptor 4\/myeloid differentiation Factor 2","volume":"12","author":"Zhang","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.anl.2023.07.008_bib0018","doi-asserted-by":"crossref","first-page":"E234","DOI":"10.1002\/lary.27030","article-title":"Intranasal immunization with phosphorylcholine suppresses allergic rhinitis in mice","volume":"128","author":"Miyashita","year":"2018","journal-title":"Laryngoscope"},{"key":"10.1016\/j.anl.2023.07.008_bib0019","doi-asserted-by":"crossref","first-page":"284","DOI":"10.4049\/jimmunol.174.1.284","article-title":"Immunomodulation via novel use of TLR4 by the filarial nematode phosphorylcholine-containing secreted product, ES-62","volume":"174","author":"Goodridge","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.anl.2023.07.008_bib0020","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1365-3024.2006.00926.x","article-title":"Phosphorylcholine mimics the effects of ES-62 on macrophages and dendritic cells","volume":"29","author":"Goodridge","year":"2007","journal-title":"Parasite Immunol"},{"key":"10.1016\/j.anl.2023.07.008_bib0021","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1177\/0022034511402996","article-title":"MPC-polymer reduces adherence and biofilm formation by oral bacteria","volume":"90","author":"Hirota","year":"2011","journal-title":"J Dent Res"},{"key":"10.1016\/j.anl.2023.07.008_bib0022","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/jbm.a.35201","article-title":"Anti-inflammatory and protective effects of 2-methacryloyloxyethyl phosphorylcholine polymer on oral epithelial cells","volume":"103","author":"Yumoto","year":"2015","journal-title":"J Biomed Mater Res A"},{"key":"10.1016\/j.anl.2023.07.008_bib0023","doi-asserted-by":"crossref","DOI":"10.1080\/20002297.2020.1808425","article-title":"Inhibitory effects of 2-methacryloyloxyethyl phosphorylcholine polymer on the adherence of bacteria causing upper respiratory tract infection","volume":"12","author":"Iuchi","year":"2020","journal-title":"J Oral Microbiol"},{"key":"10.1016\/j.anl.2023.07.008_bib0024","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1086\/314827","article-title":"Nasal immunization induces Haemophilus influenzae-specific Th1 and Th2 responses with mucosal IgA and systemic IgG antibodies for protective immunity","volume":"180","author":"Kurono","year":"1999","journal-title":"J Infect Dis"},{"key":"10.1016\/j.anl.2023.07.008_bib0025","doi-asserted-by":"crossref","first-page":"7851","DOI":"10.4049\/jimmunol.0803740","article-title":"Sublingual immunization with nonreplicating antigens induces antibody-forming cells and cytotoxic T cells in the female genital tract mucosa and protects against genital papillomavirus infection","volume":"183","author":"\u04aauburu","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.anl.2023.07.008_bib0026","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1586\/erv.10.174","article-title":"CpG DNA as a vaccine adjuvant","volume":"10","author":"Bode","year":"2011","journal-title":"Expert Rev Vaccines"},{"key":"10.1016\/j.anl.2023.07.008_bib0027","doi-asserted-by":"crossref","first-page":"66","DOI":"10.4049\/jimmunol.167.1.66","article-title":"Novel roles of CpG oligodeoxynucleotides as a leader for the sampling and presentation of CpG-tagged antigen by dendritic cells","volume":"167","author":"Shirota","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.anl.2023.07.008_bib0028","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1002\/1521-4141(200208)32:8<2356::AID-IMMU2356>3.0.CO;2-Z","article-title":"CpG-DNA aided cross-presentation of soluble antigens by dendritic cells","volume":"32","author":"Maurer","year":"2002","journal-title":"Eur J Immunol"},{"issue":"Supplement 1","key":"10.1016\/j.anl.2023.07.008_bib0029","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1007\/s10875-014-0025-4","article-title":"Natural IgM: beneficial autoantibodies for the control of inflammatory and autoimmune disease","volume":"34","author":"Gr\u00f6nwall","year":"2014","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.anl.2023.07.008_bib0030","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.anl.2018.11.003","article-title":"Role of phosphorylcholine in Streptococcus pneumoniae and nontypeable Haemophilus influenzae adherence to epithelial cells","volume":"46","author":"Iuchi","year":"2019","journal-title":"Auris Nasus Larynx"},{"key":"10.1016\/j.anl.2023.07.008_bib0031","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/gene.2014.45","article-title":"Regulatory T cells and immune regulation of allergic diseases: roles of IL-10 and TGF-\u03b2","volume":"15","author":"Palomares","year":"2014","journal-title":"Genes Immun"},{"key":"10.1016\/j.anl.2023.07.008_bib0032","doi-asserted-by":"crossref","first-page":"8154","DOI":"10.1016\/j.vaccine.2007.09.034","article-title":"Inhibition of allergic airways disease by immunomodulatory therapy with whole killed Streptococcus pneumoniae","volume":"25","author":"Preston","year":"2007","journal-title":"Vaccine"}],"container-title":["Auris Nasus Larynx"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0385814623001451?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0385814623001451?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T16:38:13Z","timestamp":1741279093000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0385814623001451"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["S0385814623001451"],"URL":"https:\/\/doi.org\/10.1016\/j.anl.2023.07.008","relation":{},"ISSN":["0385-8146"],"issn-type":[{"type":"print","value":"0385-8146"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Application of phosphorylcholine derivative as mucosal adjuvant enhancing mucosal immune responses in the upper respiratory tract","name":"articletitle","label":"Article Title"},{"value":"Auris Nasus Larynx","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anl.2023.07.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Japanese Society of Otorhinolaryngology-Head and Neck Surgery, Inc. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}