{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T11:32:23Z","timestamp":1792409543980,"version":"4.4.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Auris Nasus Larynx"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.anl.2025.07.004","type":"journal-article","created":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T11:14:17Z","timestamp":1752923657000},"page":"516-521","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of Mupirocin ointment and basic fibroblast growth factor gel in the treatment of pediatric recurrent anterior epistaxis: Randomized, controlled, single blind study"],"prefix":"10.1016","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1085-9033","authenticated-orcid":false,"given":"Zhengcai","family":"Lou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7774-441X","authenticated-orcid":false,"given":"Zhengnong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.anl.2025.07.004_bib0001","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1136\/emermed-2015-205528","article-title":"Emergency Department care of childhood epistaxis","volume":"34","author":"B\u00e9quignon","year":"2017","journal-title":"Emerg Med J"},{"key":"10.1016\/j.anl.2025.07.004_bib0002","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1177\/0194599815589583","article-title":"A comparison of bipolar electrocautery and chemical cautery for control of pediatric recurrent anterior epistaxis","volume":"153","author":"Johnson","year":"2015","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.anl.2025.07.004_bib0003","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1007\/s00431-022-04701-7","article-title":"Outcome of childhood epistaxis with treatment of allergic rhinitis: a randomized controlled study","volume":"182","author":"Teo","year":"2023","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.anl.2025.07.004_bib0004","unstructured":"Subspecialty Group of Rhinology, Editorial board of Chinese journal of otorhinolaryngology head and neck surgery; subspecialty groups of rhinology and pediatrics, society of otorhinolaryngology head and neck surgery, Chinese medical association. [Guideline for diagnosis and treatment of pediatric allergic rhinitis (2022, revision)]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2022;57:392\u2013404. Chinese."},{"key":"10.1016\/j.anl.2025.07.004_bib0005","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.bjorl.2019.07.002","article-title":"Comparison of topical treatment methods used in recurrent anterior epistaxis: a randomized clinical trial","volume":"87","author":"Ko\u00e7ak","year":"2021","journal-title":"Braz J Otorhinolaryngol"},{"issue":"1_suppl","key":"10.1016\/j.anl.2025.07.004_bib0006","doi-asserted-by":"crossref","first-page":"30S","DOI":"10.1177\/0145561320912885","article-title":"Oxymetazoline, mupirocin, clotrimazole-safe, effective, off-label agents for tympanostomy tube care","volume":"99","author":"Isaacson","year":"2020","journal-title":"Ear Nose Throat J"},{"key":"10.1016\/j.anl.2025.07.004_bib0007","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1179\/joc.1999.11.5.331","article-title":"Emergence of resistance during mupirocin treatment: is it a problem in clinical practice?","volume":"11","author":"Henkel","year":"1999","journal-title":"J Chemother"},{"key":"10.1016\/j.anl.2025.07.004_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.amjoto.2021.103366","article-title":"The therapeutic effects of basic fibroblast growth factor in nasal vestibulitis","volume":"43","author":"Liu","year":"2022","journal-title":"Am J Otolaryngol"},{"key":"10.1016\/j.anl.2025.07.004_bib0009","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/coa.13955","article-title":"Therapeutic potential of recombinant human basic fibroblast growth factor on postoperative patients with chronic rhinosinusitis with nasal polyps","volume":"48","author":"Wu","year":"2023","journal-title":"Clin Otolaryngol"},{"key":"10.1016\/j.anl.2025.07.004_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.amjoto.2023.103895","article-title":"Effect of recombinant human acidic fibroblast growth factor on nasal mucosal healing after endoscopic sinus surgery","volume":"44","author":"Xu","year":"2023","journal-title":"Am J Otolaryngol"},{"key":"10.1016\/j.anl.2025.07.004_bib0011","first-page":"547","article-title":"The bFGF can improve angiogenesis in oral mucosa and accelerate wound healing","volume":"11","author":"Zare","year":"2023","journal-title":"Rep Biochem Mol Biol"},{"key":"10.1016\/j.anl.2025.07.004_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.111164","article-title":"Biomimetic nanoparticles of platelet membranes carrying bFGF and VEGFA genes promote deep burn wound healing","volume":"125","author":"Wang","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.anl.2025.07.004_bib0013","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/5583046","article-title":"Topical application of bFGF alone for the regeneration of chronic tympanic membrane perforations: a preliminary case series","volume":"2021","author":"Lou","year":"2021","journal-title":"Stem Cells Int"},{"key":"10.1016\/j.anl.2025.07.004_bib0014","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1002\/lary.20818","article-title":"An epistaxis severity score for hereditary hemorrhagic telangiectasia","volume":"120","author":"Hoag","year":"2010","journal-title":"Laryngoscope"},{"key":"10.1016\/j.anl.2025.07.004_bib0015","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1177\/0145561320920425","article-title":"Evaluation of nasal mucociliary clearance, nasal obstruction symptom evaluation, and epistaxis severity score in isotretinoin treatment","volume":"100","author":"\u0130\u015flek","year":"2021","journal-title":"Ear Nose Throat J"},{"key":"10.1016\/j.anl.2025.07.004_bib0016","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1001\/jamaoto.2013.92","article-title":"Treatment of neural anosmia by topical application of basic fibroblast growth factor-gelatin hydrogel in the nasal cavity: an experimental study in mice","volume":"139","author":"Nota","year":"2013","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.anl.2025.07.004_bib0017","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1007\/s10103-017-2285-8","article-title":"Randomized controlled trial comparing Nd:YAG laser photocoagulation and bipolar electrocautery in the management of epistaxis","volume":"32","author":"Zhang","year":"2017","journal-title":"Lasers Med Sci"},{"key":"10.1016\/j.anl.2025.07.004_bib0018","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1159\/000530842","article-title":"Analysis of multimorbidity of moderate to severe allergic rhinitis in children: a real-world study","volume":"184","author":"Gu","year":"2023","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.anl.2025.07.004_bib0019","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0022-4804(91)90008-A","article-title":"Effect of bFGF on the inhibition of contraction caused by bacteria","volume":"50","author":"Stenberg","year":"1991","journal-title":"J Surg Res"},{"key":"10.1016\/j.anl.2025.07.004_bib0020","doi-asserted-by":"crossref","first-page":"835","DOI":"10.2353\/ajpath.2006.050479","article-title":"Basic fibroblast growth factor (bFGF, FGF-2) potentiates leukocyte recruitment to inflammation by enhancing endothelial adhesion molecule expression","volume":"168","author":"Zittermann","year":"2006","journal-title":"Am J Pathol"},{"key":"10.1016\/j.anl.2025.07.004_bib0021","first-page":"375","article-title":"Effect of recombinant human basic fibroblast growth factor on acute inflammation in mice and rats","volume":"22","author":"Hu","year":"2001","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.anl.2025.07.004_bib0022","doi-asserted-by":"crossref","first-page":"8907","DOI":"10.3390\/ijms21238907","article-title":"The airway epithelium-A Central player in asthma pathogenesis","volume":"21","author":"Calv\u00e9n","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.anl.2025.07.004_bib0023","doi-asserted-by":"crossref","first-page":"316","DOI":"10.4103\/ijp.IJP_237_17","article-title":"Randomized controlled trial of topical mupirocin versus mupirocin with sucralfate combination in chronic skin ulcers","volume":"51","author":"Chatterjee","year":"2019","journal-title":"Indian J Pharmacol"},{"key":"10.1016\/j.anl.2025.07.004_bib0024","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1097\/CORR.0000000000002136","article-title":"Piuzzi NS; Cleveland Clinic orthopaedic minimal dataset episode of care (OME) arthroplasty group. Preoperative colonization with Staphylococcus Aureus in THA is associated with increased length of stay","volume":"480","author":"Santana","year":"2022","journal-title":"Clin Orthop Relat Res"}],"container-title":["Auris Nasus Larynx"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0385814625001063?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0385814625001063?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:54:26Z","timestamp":1777571666000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0385814625001063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S0385814625001063"],"URL":"https:\/\/doi.org\/10.1016\/j.anl.2025.07.004","relation":{},"ISSN":["0385-8146"],"issn-type":[{"value":"0385-8146","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of Mupirocin ointment and basic fibroblast growth factor gel in the treatment of pediatric recurrent anterior epistaxis: Randomized, controlled, single blind study","name":"articletitle","label":"Article Title"},{"value":"Auris Nasus Larynx","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anl.2025.07.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Japanese Society of Otorhinolaryngology-Head and Neck Surgery, Inc. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}