{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T21:02:08Z","timestamp":1776891728722,"version":"3.51.2"},"reference-count":13,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,18]],"date-time":"2026-12-18T00:00:00Z","timestamp":1797552000000},"content-version":"am","delay-in-days":320,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Auris Nasus Larynx"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.anl.2025.12.010","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T08:28:42Z","timestamp":1766046522000},"page":"70-75","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["VEXAS syndrome with cochleovestibular involvement"],"prefix":"10.1016","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4770-3227","authenticated-orcid":false,"given":"Keishi","family":"Fujiwara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Morita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8582-7936","authenticated-orcid":false,"given":"Kimiko","family":"Hoshino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kento","family":"Komatsuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaoru","family":"Kahata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9045-4617","authenticated-orcid":false,"given":"Yuji","family":"Nakamaru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1488-0646","authenticated-orcid":false,"given":"Akihiro","family":"Homma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.anl.2025.12.010_bib0001","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1056\/NEJMoa2026834","article-title":"Somatic mutations in UBA1 and severe adult-onset autoinflammatory disease","volume":"383","author":"Beck","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.anl.2025.12.010_bib0002","doi-asserted-by":"crossref","first-page":"3682","DOI":"10.1182\/blood.2020010177","article-title":"Therapeutic options in VEXAS syndrome: insights from a retrospective series","volume":"137","author":"Bourbon","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.anl.2025.12.010_bib0003","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1182\/blood.2022016985","article-title":"Translation of cytoplasmic UBA1 contributes to VEXAS syndrome pathogenesis","volume":"140","author":"Ferrada","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.anl.2025.12.010_bib0004","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1001\/jama.2022.24836","article-title":"Estimated prevalence and clinical manifestations of UBA1 variants associated With VEXAS syndrome in a clinical population","volume":"329","author":"Beck","year":"2023","journal-title":"JAMA"},{"key":"10.1016\/j.anl.2025.12.010_bib0005","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1080\/1744666X.2023.2157262","article-title":"An update on VEXAS syndrome","volume":"19","author":"Al-Hakim","year":"2023","journal-title":"Expert Rev Clin Immunol"},{"key":"10.1016\/j.anl.2025.12.010_bib0006","doi-asserted-by":"crossref","first-page":"3203","DOI":"10.1182\/bloodadvances.2021004976","article-title":"Benign and malignant hematologic manifestations in patients with VEXAS syndrome due to somatic mutations in UBA1","volume":"5","author":"Obiorah","year":"2021","journal-title":"Blood Adv"},{"key":"10.1016\/j.anl.2025.12.010_bib0007","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.otorri.2024.09.001","article-title":"Otorhinolaryngological manifestations of autoinflammatory diseases. Systematic review","volume":"76","author":"Mallo-Miranda","year":"2025","journal-title":"Acta Otorrinolaringol Esp (Engl Ed)"},{"key":"10.1016\/j.anl.2025.12.010_bib0008","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1001\/jamaoto.2021.4092","article-title":"Ear, nose, throat, and bronchial involvements in VEXAS syndrome: specifying the spectrum of clinical features","volume":"148","author":"Beaumesnil","year":"2022","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.anl.2025.12.010_bib0009","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1002\/art.41743","article-title":"Somatic mutations in UBA1 define a distinct subset of relapsing polychondritis patients with VEXAS","volume":"73","author":"Ferrada","year":"2021","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.anl.2025.12.010_bib0010","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/00005792-197605000-00001","article-title":"Relapsing polychondritis: prospective study of 23 patients and a review of the literature","volume":"55","author":"McAdam","year":"1976","journal-title":"Medicine"},{"key":"10.1016\/j.anl.2025.12.010_bib0011","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1288\/00005537-197906000-00009","article-title":"Relapsing polychondritis\u2013report of ten cases","volume":"89","author":"Damiani","year":"1979","journal-title":"Laryngoscope"},{"key":"10.1016\/j.anl.2025.12.010_bib0012","doi-asserted-by":"crossref","first-page":"149","DOI":"10.2492\/inflammregen.34.149","article-title":"A large-scale survey of patients with relapsing polychondritis in Japan","volume":"34","author":"Oka","year":"2014","journal-title":"Inflamm Regen"},{"key":"10.1016\/j.anl.2025.12.010_bib0013","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1080\/00016480500437369","article-title":"Endolymphatic hydrops as a cause of audio-vestibular manifestations in relapsing polychondritis","volume":"126","author":"Murata","year":"2006","journal-title":"Acta Otolaryngol"}],"container-title":["Auris Nasus Larynx"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S038581462500183X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S038581462500183X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T20:26:58Z","timestamp":1776889618000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S038581462500183X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S038581462500183X"],"URL":"https:\/\/doi.org\/10.1016\/j.anl.2025.12.010","relation":{},"ISSN":["0385-8146"],"issn-type":[{"value":"0385-8146","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"VEXAS syndrome with cochleovestibular involvement","name":"articletitle","label":"Article Title"},{"value":"Auris Nasus Larynx","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anl.2025.12.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Japanese Society of Otorhinolaryngology-Head and Neck Surgery, Inc. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}