{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:06:36Z","timestamp":1790647596992,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Diagnostic Pathology"],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1016\/j.anndiagpath.2008.10.002","type":"journal-article","created":{"date-parts":[[2008,12,14]],"date-time":"2008-12-14T09:41:09Z","timestamp":1229247669000},"page":"1-8","source":"Crossref","is-referenced-by-count":16,"title":["Renal cell carcinoma: assessment of key pathologic prognostic parameters and patient characteristics in 47\u2005909 cases using the National Cancer Data Base"],"prefix":"10.1016","volume":"13","author":[{"given":"Nalan","family":"Nese","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gladell P.","family":"Paner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Mallin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Ritchey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahul B.","family":"Amin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.anndiagpath.2008.10.002_bib1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0022-5347(05)65382-7","article-title":"Increasing incidence of all stages of kidney cancer in the last 2 decades in the United States: an analysis of surveillance, epidemiology and end results program data","volume":"167","author":"Hock","year":"2002","journal-title":"J Urol"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib2","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1093\/jnci\/djj362","article-title":"Rising incidence of small renal masses: a need to reassess treatment effect","volume":"98","author":"Hollingsworth","year":"2006","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib3","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1016\/j.juro.2006.07.144","article-title":"The evolving presentation of renal carcinoma in the United States: trends from the surveillance, epidemiology, and end results program","volume":"176","author":"Nguyen","year":"2006","journal-title":"J Urol"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib4","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1001\/jama.281.17.1628","article-title":"Rising incidence of renal cell cancer in the United States","volume":"281","author":"Chow","year":"1999","journal-title":"JAMA"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib5","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3322\/CA.2007.0010","article-title":"Cancer statistics, 2008","volume":"58","author":"Jemal","year":"2008","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib6","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1002\/(SICI)1097-0142(19971201)80:11<2167::AID-CNCR18>3.0.CO;2-X","article-title":"The National Cancer Data Base: report on kidney cancers. The American College of Surgeons Commission on Cancer and the American Cancer Society","volume":"80","author":"Marshall","year":"1997","journal-title":"Cancer"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib7","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/00000478-200203000-00001","article-title":"Prognostic impact of histologic subtyping of adult renal epithelial neoplasms: an experience of 405 cases","volume":"26","author":"Amin","year":"2002","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib8","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1097\/00000478-200305000-00005","article-title":"Comparisons of outcome and prognostic features among histologic subtypes of renal cell carcinoma","volume":"27","author":"Cheville","year":"2003","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib9","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1002\/cncr.11806","article-title":"Reassessment of the 1997 TNM classification system for renal cell carcinoma","volume":"98","author":"Elmore","year":"2003","journal-title":"Cancer"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib10","first-page":"1889","article-title":"Independent validation of the 2002 American Joint Committee on cancer primary tumor classification for renal cell carcinoma using a large, single institution cohort","volume":"173","author":"Frank","year":"2005","journal-title":"J\u00a0Urol"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib11","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/S0022-5347(05)68264-X","article-title":"Prognostic significance of the 1997 TNM classification of renal cell carcinoma","volume":"162","author":"Javidan","year":"1999","journal-title":"J Urol"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib12","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0022-5347(05)66077-6","article-title":"A postoperative prognostic nomogram for renal cell carcinoma","volume":"166","author":"Kattan","year":"2001","journal-title":"J Urol"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib13","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1097\/01.ju.0000154693.68717.12","article-title":"pT1 substaging in renal cell carcinoma: validation of the 2002 TNM staging modification of malignant renal epithelial tumors","volume":"173","author":"Salama","year":"2005","journal-title":"J Urol"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib14","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/j.juro.2006.06.005","article-title":"Pathological features of renal neoplasms classified by size and symptomatology","volume":"176","author":"Schlomer","year":"2006","journal-title":"J Urol"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib15","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S0022-5347(05)66075-2","article-title":"Reevaluation of the 1997 TNM classification for renal cell carcinoma: T1 and T2 cutoff point at 4.5 rather than 7 cm. better correlates with clinical outcome","volume":"166","author":"Zisman","year":"2001","journal-title":"J Urol"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib16","series-title":"World Health Organization classification of tumours. Pathology and genetics. Tumours of the urinary system and male genital organs","author":"Eble","year":"2004"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib17","series-title":"AJCC cancer staging manual","author":"Greene","year":"2002"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib18","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1097\/00000478-198210000-00007","article-title":"Prognostic significance of morphologic parameters in renal cell carcinoma","volume":"6","author":"Fuhrman","year":"1982","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib19","first-page":"154A","article-title":"A novel nuclear grading scheme for chromophobe renal cell carcinoma: prognostic utility and comparison with Fuhrman nuclear grade","volume":"19","author":"Paner","year":"2006","journal-title":"Mod Pathol"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib20","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1097\/01.pas.0000209833.69972.2b","article-title":"Nucleolar grade but not Fuhrman grade is applicable to papillary renal cell carcinoma","volume":"30","author":"Sika-Paotonu","year":"2006","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib21","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1097\/00000478-199812000-00001","article-title":"The World Health Organization\/International Society of Urological Pathology consensus classification of urothelial (transitional cell) neoplasms of the urinary bladder. Bladder Consensus Conference Committee","volume":"22","author":"Epstein","year":"1998","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib22","series-title":"International Classification of Diseases for Oncology","author":"Percy","year":"1990"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib23","series-title":"American Joint Committee on Cancer. Manual for staging of cancer","first-page":"201","year":"1992"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib24","doi-asserted-by":"crossref","first-page":"487","DOI":"10.5858\/2005-129-487-RNIYAA","article-title":"Renal neoplasms in younger adults: analysis of 112 tumors from a single institution according to the new 2004 World Health Organization classification and 2002 American Joint Committee on Cancer Staging System","volume":"129","author":"Cao","year":"2005","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib25","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/S0090-4295(02)01884-8","article-title":"Sporadic renal cell carcinoma in young adults: presentation, treatment, and outcome","volume":"60","author":"Abou El Fettouh","year":"2002","journal-title":"Urology"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib26","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1097\/01.ju.0000099028.95679.52","article-title":"Renal tumors in young adults","volume":"171","author":"Eggener","year":"2004","journal-title":"J Urol"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib27","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1097\/01.ju.0000125487.96469.2e","article-title":"Young age is an independent prognostic factor for survival of sporadic renal cell carcinoma","volume":"171","author":"S\u00e1nchez-Ortiz","year":"2004","journal-title":"J Urol"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib28","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1097\/01.ju.0000158157.57981.80","article-title":"Comparison of presentation and outcome for patients 18 to 40 and 60 to 70 years old with solid renal masses","volume":"173","author":"Gillett","year":"2005","journal-title":"J Urol"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib29","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/S0022-5347(05)00696-8","article-title":"Outcome of renal tumors in young adults","volume":"175","author":"Siemer","year":"2006","journal-title":"J Urol"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib30","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.urology.2005.06.104","article-title":"Renal cell carcinoma: Children's Hospital Boston experience","volume":"66","author":"Estrada","year":"2005","journal-title":"Urology"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib31","series-title":"American Joint Committee on Cancer (AJCC) AJCC cancer staging manual","first-page":"231","year":"1997"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib32","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/jso.2930590310","article-title":"Renal cell carcinoma: comparison of the TNM and Robson stage groupings","volume":"59","author":"Guinan","year":"1995","journal-title":"J Surg Oncol"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib33","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0022-5347(17)39420-X","article-title":"Evaluation of the new tumor, nodes and metastases classification of renal cell carcinoma","volume":"144","author":"Hermanek","year":"1990","journal-title":"J Urol"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib34","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1002\/1097-0142(19951215)76:12<2543::AID-CNCR2820761221>3.0.CO;2-S","article-title":"Prognostic value of nuclear grade of renal cell carcinoma","volume":"76","author":"Bretheau","year":"1995","journal-title":"Cancer"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib35","doi-asserted-by":"crossref","first-page":"23","DOI":"10.5858\/1999-123-0023-PFTEOS","article-title":"Protocol for the examination of specimens from patients with carcinomas of renal tubular origin, exclusive of Wilms tumor and tumors of urothelial origin: a basis for checklists. Cancer Committee, College of American Pathologists","volume":"123","author":"Farrow","year":"1999","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib36","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1002\/cncr.10510","article-title":"Prognostic value of nuclear grading in patients with intracapsular (pT1-pT2) renal cell carcinoma. Long-term analysis in 213 patients","volume":"94","author":"Minervini","year":"2002","journal-title":"Cancer"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib37","doi-asserted-by":"crossref","first-page":"593","DOI":"10.5858\/2003-127-0593-IAIVUT","article-title":"Interobserver and intraobserver variability using the Fuhrman grading system for renal cell carcinoma","volume":"127","author":"Al-Aynati","year":"2003","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib38","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/cncr.20749","article-title":"Original and reviewed nuclear grading according to the Fuhrman system: a multivariate analysis of 388 patients with conventional renal cell carcinoma","volume":"103","author":"Ficarra","year":"2005","journal-title":"Cancer"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib39","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1002\/cncr.20812","article-title":"Multicenter determination of optimal interobserver agreement using the Fuhrman grading system for renal cell carcinoma: assessment of 241 patients with >15-year follow-up","volume":"103","author":"Lang","year":"2005","journal-title":"Cancer"},{"issue":"6","key":"10.1016\/j.anndiagpath.2008.10.002_bib40","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1097\/01.pas.0000249446.28713.53","article-title":"Fuhrman grading is not appropriate for chromophobe renal cell carcinoma","volume":"31","author":"Delahunt","year":"2007","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib41","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1097\/00000478-199706000-00001","article-title":"Papillary (chromophil) renal cell carcinoma: histomorphologic characteristics and evaluation of conventional pathologic prognostic parameters in 62 cases","volume":"21","author":"Amin","year":"1997","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib42","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1097\/01.ju.0000148261.19532.2c","article-title":"A postoperative prognostic nomogram predicting recurrence for patients with conventional clear cell renal cell carcinoma","volume":"173","author":"Sorbellini","year":"2005","journal-title":"J Urol"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib43","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1200\/JCO.2001.19.6.1649","article-title":"Improved prognostication of renal cell carcinoma using an integrated system","volume":"19","author":"Zisman","year":"2001","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib44","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1016\/S0022-5347(05)64153-5","article-title":"An outcome prediction model for patients with clear cell renal cell carcinoma treated with radical nephrectomy based on tumor stage, size, grade and necrosis: the SSIGN score","volume":"168","author":"Frank","year":"2002","journal-title":"J Urol"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib45","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/S0022-5347(05)67699-9","article-title":"Prognostic indicators for renal cell carcinoma: a multivariate analysis of 643 patients using the revised 1997 TNM staging criteria","volume":"163","author":"Tsui","year":"2000","journal-title":"J Urol"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib46","article-title":"The \u201cstage, size, grade and necrosis\u201d score is more accurate than the University of California Los Angeles Integrated Staging System for predicting cancer-specific survival in patients with clear cell renal cell carcinoma","author":"Ficarra","year":"2008","journal-title":"BJU Int"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib47","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF02524349","article-title":"Effect of papillary and chromophobe cell type on disease-free survival after nephrectomy for renal cell carcinoma","volume":"11","author":"Beck","year":"2004","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib48","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.eururo.2005.04.016","article-title":"Histological subtyping and nuclear grading of renal cell carcinoma and their implications for survival: a retrospective nation-wide study of 629 patients","volume":"48","author":"Gudbjartsson","year":"2005","journal-title":"Eur Urol"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib49","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/1097-0142(20000801)89:3<604::AID-CNCR16>3.0.CO;2-Q","article-title":"Prognostic utility of the recently recommended histologic classification and revised TNM staging system of renal cell carcinoma. A Swiss experience with 588 tumors","volume":"89","author":"Moch","year":"2000","journal-title":"Cancer"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib50","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.1200\/JCO.2005.07.055","article-title":"Prognostic value of histologic subtypes in renal cell carcinoma: a multicenter experience","volume":"23","author":"Patard","year":"2005","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.anndiagpath.2008.10.002_bib51","doi-asserted-by":"crossref","DOI":"10.1097\/PAS.0b013e3181831e68","article-title":"Chromophobe renal cell carcinoma: histomorphologic characteristics and evaluation of conventional pathologic prognostic parameters in 145 cases","author":"Amin","year":"2008","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"10.1016\/j.anndiagpath.2008.10.002_bib52","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/cncr.23518","article-title":"Renal cell cancer stage migration: analysis of the National Cancer Data Base","volume":"113","author":"Kane","year":"2008","journal-title":"Cancer"}],"container-title":["Annals of Diagnostic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1092913408000981?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1092913408000981?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T20:02:55Z","timestamp":1632772975000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1092913408000981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["S1092913408000981"],"URL":"https:\/\/doi.org\/10.1016\/j.anndiagpath.2008.10.002","relation":{},"ISSN":["1092-9134"],"issn-type":[{"value":"1092-9134","type":"print"}],"subject":[],"published":{"date-parts":[[2009,2]]}}}