{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T18:17:02Z","timestamp":1790446622896,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Diagnostic Pathology"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.anndiagpath.2021.151759","type":"journal-article","created":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T11:41:55Z","timestamp":1620474115000},"page":"151759","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Primary high-grade myoepithelial carcinoma of the lung: A study of three cases illustrating frequent SMARCB1-deficiency and review of the literature"],"prefix":"10.1016","volume":"53","author":[{"given":"Abbas","family":"Agaimy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inna","family":"Naroditsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofer","family":"Ben-Izhak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.anndiagpath.2021.151759_bb0005","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s12105-015-0618-0","article-title":"Myoepithelial neoplasms of soft tissue: an updated review of the clinicopathologic, immunophenotypic, and genetic features","volume":"9","author":"Jo","year":"2015","journal-title":"Head Neck Pathol"},{"key":"10.1016\/j.anndiagpath.2021.151759_bb0010","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s12105-019-01109-y","article-title":"Soft tissue special issue: myoepithelial neoplasms of soft tissue: an updated review with emphasis on diagnostic considerations in the head and neck","volume":"14","author":"Jo","year":"2020","journal-title":"Head Neck Pathol"},{"key":"10.1016\/j.anndiagpath.2021.151759_bb0015","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.path.2015.05.005","article-title":"Myoepithelial tumors: an update","volume":"8","author":"Jo","year":"2015","journal-title":"Surg Pathol Clin"},{"key":"10.1016\/j.anndiagpath.2021.151759_bb0020","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1097\/PAS.0000000000000452","article-title":"Prognostic factors in myoepithelial carcinoma of salivary glands: a clinicopathologic study of 48 cases","volume":"39","author":"Kong","year":"2015","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.anndiagpath.2021.151759_bb0025","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1097\/00000478-200309000-00001","article-title":"Myoepithelial tumors of soft tissue: a clinicopathologic and immunohistochemical study of 101 cases with evaluation of prognostic parameters","volume":"27","author":"Hornick","year":"2003","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.anndiagpath.2021.151759_bb0030","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1097\/PAS.0b013e31805f6775","article-title":"Myoepithelial carcinoma of soft tissue in children: an aggressive neoplasm analyzed in a series of 29 cases","volume":"31","author":"Gleason","year":"2007","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.anndiagpath.2021.151759_bb0035","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1136\/jclinpath-2012-201078","article-title":"Myoepithelial and epithelial-myoepithelial, mesenchymal and fibroepithelial breast lesions: updates from the WHO classification of Tumours of the breast 2012","volume":"66","author":"Tan","year":"2013","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.anndiagpath.2021.151759_bb0040","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/apm.12506","article-title":"Clinicopathological features of five unusual cases of intraosseous myoepithelial carcinomas, mimicking conventional primary bone tumours, including EWSR1 rearrangement in one case","volume":"124","author":"Rekhi","year":"2016","journal-title":"APMIS."},{"key":"10.1016\/j.anndiagpath.2021.151759_bb0045","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0169-5002(98)00006-3","article-title":"Myoepithelioma of the lung: report of two cases and review of the literature","volume":"20","author":"Higashiyama","year":"1998","journal-title":"Lung Cancer"},{"key":"10.1016\/j.anndiagpath.2021.151759_bb0050","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1097\/00000478-200009000-00016","article-title":"Myoepithelial carcinoma of the lung arising from bronchial submucosa","volume":"24","author":"Miura","year":"2000","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.anndiagpath.2021.151759_bb0055","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.ejcts.2005.08.003","article-title":"Myoepithelial carcinoma of the lung","volume":"28","author":"Masuya","year":"2005","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.anndiagpath.2021.151759_bb0060","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1002\/gcc.20819","article-title":"EWSR1-POU5F1 fusion in soft tissue myoepithelial tumors. A molecular analysis of sixty-six cases, including soft tissue, bone, and visceral lesions, showing common involvement of the EWSR1 gene","volume":"49","author":"Antonescu","year":"2010","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.anndiagpath.2021.151759_bb0065","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1600-0463.2010.02606.x","article-title":"Pulmonary myoepithelial carcinoma resembling matrix-producing carcinoma of the breast: case report and review of the literature","volume":"118","author":"Tanahashi","year":"2010","journal-title":"APMIS."},{"key":"10.1016\/j.anndiagpath.2021.151759_bb0070","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1510\/icvts.2011.270934","article-title":"Primary pulmonary myoepithelial carcinoma","volume":"13","author":"Hysi","year":"2011","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"10.1016\/j.anndiagpath.2021.151759_bb0075","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1749-8090-6-27","article-title":"Primary myoepithelial carcinoma of the lung: a rare entity treated with parenchymal sparing resection","volume":"6","author":"Sarkaria","year":"2011","journal-title":"J Cardiothorac Surg"},{"key":"10.1016\/j.anndiagpath.2021.151759_bb0080","first-page":"2111","article-title":"Primary myoepithelial carcinoma of the lung: a case report and review of literature","volume":"8","author":"Wei","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"10.1016\/j.anndiagpath.2021.151759_bb0085","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1097\/PAI.0000000000000113","article-title":"Myoepithelial carcinoma of the lung: a review","volume":"23","author":"Rosen","year":"2015","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"10.1016\/j.anndiagpath.2021.151759_bb0090","doi-asserted-by":"crossref","first-page":"e0049","DOI":"10.1097\/MD.0000000000010049","article-title":"Primary pulmonary myoepithelial carcinoma in a young woman: a case report and review of literature","volume":"97","author":"Zhou","year":"2018","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.anndiagpath.2021.151759_bb0095","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1097\/PAS.0000000000000560","article-title":"Thoracic myoepithelial tumors: a pathologic and molecular study of 8 cases with review of the literature","volume":"40","author":"Leduc","year":"2016","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.anndiagpath.2021.151759_bb0100","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1002\/gcc.22376","article-title":"Secondary EWSR1 gene abnormalities in SMARCB1-deficient tumors with 22q11-12 regional deletions: potential pitfalls in interpreting EWSR1 FISH results","volume":"55","author":"Huang","year":"2016","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.anndiagpath.2021.151759_bb0105","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1097\/PAS.0000000000001543","article-title":"Uterine tumor resembling ovarian sex cord stromal tumor (UTROSCT): a series of 3 cases with extensive Rhabdoid differentiation, malignant behavior, and ESR1-NCOA2 fusions","volume":"44","author":"Bennett","year":"2020","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.anndiagpath.2021.151759_bb0110","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1159\/000011891","article-title":"Rare pulmonary tumors - a review of 32 cases","volume":"55","author":"Sekine","year":"1998","journal-title":"Oncology."},{"key":"10.1016\/j.anndiagpath.2021.151759_bb0115","doi-asserted-by":"crossref","first-page":"497","DOI":"10.4103\/0970-2113.164168","article-title":"Primary pulmonary myoepithelial carcinoma in a child: an ambiguous entity","volume":"32","author":"Kridis","year":"2015","journal-title":"Lung India"},{"key":"10.1016\/j.anndiagpath.2021.151759_bb0120","doi-asserted-by":"crossref","first-page":"e52","DOI":"10.1055\/s-0040-1713766","article-title":"The first reported pediatric case of primary myoepithelial carcinoma involving the whole lung: surgical radical treatment and prosthesis implant","volume":"8","author":"Filisetti","year":"2020","journal-title":"Eur J Pediatr Surg Rep"},{"key":"10.1016\/j.anndiagpath.2021.151759_bb0125","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13000-020-00986-0","article-title":"A first case report of clinical response to targeted therapy in a patient with primary myoepithelial carcinoma of the lung harboring EGFR exon 19 deletion","volume":"15","author":"Xie","year":"2020","journal-title":"Diagn Pathol"},{"key":"10.1016\/j.anndiagpath.2021.151759_bb0130","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1097\/00000478-200006000-00001","article-title":"Myoepithelial carcinoma of the salivary glands: a clinicopathologic study of 25 patients","volume":"24","author":"Savera","year":"2000","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.anndiagpath.2021.151759_bb0135","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/PAP.0000000000000099","article-title":"Primary pulmonary salivary gland-type tumors: a review and update","volume":"23","author":"Falk","year":"2016","journal-title":"Adv Anat Pathol"},{"key":"10.1016\/j.anndiagpath.2021.151759_bb0140","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1002\/1097-0142(19940301)73:5<1390::AID-CNCR2820730513>3.0.CO;2-#","article-title":"Primary adenoid cystic carcinoma of the lung. A clinicopathologic and immunohistochemical study of 16 cases","volume":"73","author":"Moran","year":"1994","journal-title":"Cancer."},{"key":"10.1016\/j.anndiagpath.2021.151759_bb0145","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.humpath.2008.08.009","article-title":"Pulmonary epithelial-myoepithelial carcinoma: a clinicopathologic and immunohistochemical study of 5 cases","volume":"40","author":"Nguyen","year":"2009","journal-title":"Hum Pathol"},{"key":"10.1016\/j.anndiagpath.2021.151759_bb0150","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1309\/AJCP50FBZWSACKIP","article-title":"Pulmonary salivary gland-type tumors with features of malignant mixed tumor (carcinoma ex pleomorphic adenoma): a clinicopathologic study of five cases","volume":"136","author":"Weissferdt","year":"2011","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.anndiagpath.2021.151759_bb0155","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1097\/JTO.0b013e3182a7d272","article-title":"Primary salivary gland-type lung cancer: clinicopathological analysis of 88 cases from China","volume":"8","author":"Zhu","year":"2013","journal-title":"J Thorac Oncol"},{"issue":"1","key":"10.1016\/j.anndiagpath.2021.151759_bb0160","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1038\/s41467-017-01178-z","article-title":"Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions","volume":"8","author":"Dalin","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.anndiagpath.2021.151759_bb0165","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1097\/PAS.0000000000000364","article-title":"Clear cell myoepithelial carcinoma of salivary glands showing EWSR1 rearrangement: molecular analysis of 94 salivary gland carcinomas with prominent clear cell component","volume":"39","author":"Sk\u00e1lov\u00e1","year":"2015","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.anndiagpath.2021.151759_bb0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/PAS.0000000000001591","article-title":"Molecular profiling of clear cell myoepithelial carcinoma of salivary glands with EWSR1 rearrangement identifies frequent PLAG1 gene fusions but no EWSR1 fusion transcripts","volume":"45","author":"Sk\u00e1lov\u00e1","year":"2021","journal-title":"Am J Surg Pathol"},{"issue":"2","key":"10.1016\/j.anndiagpath.2021.151759_bb0175","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s12105-014-0556-2","article-title":"Rhabdoid variant of myoepithelial carcinoma, with EWSR1 rearrangement: expanding the Spectrum of EWSR1-rearranged Myoepithelial tumors","volume":"9","author":"Thway","year":"2015","journal-title":"Head Neck Pathol"},{"key":"10.1016\/j.anndiagpath.2021.151759_bb0180","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/dc.23259","article-title":"Soft tissue myoepithelial carcinoma with rhabdoid-like features and EWSR1 rearrangement: fine needle aspiration cytology with histologic correlation","volume":"43","author":"Machado","year":"2015","journal-title":"Diagn Cytopathol"},{"key":"10.1016\/j.anndiagpath.2021.151759_bb0185","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1097\/PAS.0b013e31822b325b","article-title":"INI1-deficient tumors: diagnostic features and molecular genetics","volume":"35","author":"Hollmann","year":"2011","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.anndiagpath.2021.151759_bb0190","doi-asserted-by":"crossref","first-page":"261","DOI":"10.5114\/pjp.2017.71535","article-title":"EWSR1-fusion-negative, SMARCB1-deficient primary pulmonary myxoid sarcoma","volume":"68","author":"Agaimy","year":"2017","journal-title":"Pol J Pathol"},{"key":"10.1016\/j.anndiagpath.2021.151759_bb0195","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1097\/PAS.0b013e318227e4d2","article-title":"Primary pulmonary myxoid sarcoma with EWSR1-CREB1 fusion: a new tumor entity","volume":"35","author":"Thway","year":"2011","journal-title":"Am J Surg Pathol"}],"container-title":["Annals of Diagnostic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1092913421000599?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1092913421000599?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T20:33:09Z","timestamp":1761078789000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1092913421000599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":39,"alternative-id":["S1092913421000599"],"URL":"https:\/\/doi.org\/10.1016\/j.anndiagpath.2021.151759","relation":{},"ISSN":["1092-9134"],"issn-type":[{"value":"1092-9134","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Primary high-grade myoepithelial carcinoma of the lung: A study of three cases illustrating frequent SMARCB1-deficiency and review of the literature","name":"articletitle","label":"Article Title"},{"value":"Annals of Diagnostic Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anndiagpath.2021.151759","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"151759"}}