{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:10:24Z","timestamp":1784128224613,"version":"3.55.0"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Diagnostic Pathology"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.anndiagpath.2021.151761","type":"journal-article","created":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T02:04:42Z","timestamp":1620612282000},"page":"151761","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Clinical utility of next generation sequencing to detect IGH\/IL3 rearrangements [t(5;14)(q31.1;q32.1)] in B-lymphoblastic leukemia\/lymphoma"],"prefix":"10.1016","volume":"53","author":[{"given":"Adam J.","family":"Guenzel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B.","family":"Smadbeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crystal L.","family":"Golden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia M.","family":"Williamson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonna C.","family":"Benevides Demasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Vasmatzis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn E.","family":"Pearce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horatiu","family":"Olteanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjie","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole L.","family":"Hoppman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia T.","family":"Greipp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda B.","family":"Baughn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhett P.","family":"Ketterling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jess F.","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.anndiagpath.2021.151761_bb0005","series-title":"SEER preliminary cancer incidence rate estimates for 2017, and diagnosis years 2000 to 2017","author":"Howlader","year":"2019"},{"key":"10.1016\/j.anndiagpath.2021.151761_bb0010","series-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","first-page":"203","article-title":"B-lymphoblastic leukaemia\/lymphoma with recurrent genetic abnormalities","author":"Borowitz","year":"2017"},{"key":"10.1016\/j.anndiagpath.2021.151761_bb0015","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1200\/JCO.1987.5.3.382","article-title":"Acute lymphoblastic leukemia with chromosomal 5;14 translocation and hypereosinophilia: case report and literature review","volume":"5","author":"Hogan","year":"1987","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.anndiagpath.2021.151761_bb0020","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1182\/blood.V73.8.2081.2081","article-title":"The t(5;14) chromosomal translocation in a case of acute lymphocytic leukemia joins the interleukin-3 gene to the immunoglobulin heavy chain gene","volume":"73","author":"Grimaldi","year":"1989","journal-title":"Blood"},{"key":"10.1016\/j.anndiagpath.2021.151761_bb0025","first-page":"429","article-title":"Essential mechanisms of differential activation of eosinophils by IL-3 compared to GM-CSF and IL-5","volume":"36","author":"Esnault","year":"2016","journal-title":"Crit Rev Immunol"},{"key":"10.1016\/j.anndiagpath.2021.151761_bb0030","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1182\/blood.V76.2.285.285","article-title":"Activation of the interleukin-3 gene by chromosome translocation in acute lymphocytic leukemia with eosinophilia","volume":"76","author":"Meeker","year":"1990","journal-title":"Blood"},{"key":"10.1016\/j.anndiagpath.2021.151761_bb0035","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/mpo.2950120109","article-title":"Hypereosinophilic syndrome in acute lymphoblastic leukemia with a chromosome translocation [t(5q;14q)]","volume":"12","author":"Tono-oka","year":"1984","journal-title":"Med Pediatr Oncol"},{"key":"10.1016\/j.anndiagpath.2021.151761_bb0040","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.3389\/fonc.2019.01374","article-title":"B-ALL with t(5;14)(q31;q32); IGH-IL3 rearrangement and eosinophilia: a comprehensive analysis of a peculiar IGH-rearranged B-ALL","volume":"9","author":"Fournier","year":"2019","journal-title":"Front Oncol"},{"key":"10.1016\/j.anndiagpath.2021.151761_bb0045","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1159\/000108319","article-title":"Molecular cytogenetics of IGH rearrangments in non-Hodgkin B-cell lymphoma","volume":"118","author":"Bernicot","year":"2007","journal-title":"Cytogenet Genome Res"},{"key":"10.1016\/j.anndiagpath.2021.151761_bb0050","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1182\/blood-2006-08-041012","article-title":"Five members of the CEBP transcription factor family are targeted by recurrent IGH translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL)","volume":"109","author":"Akasaka","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.anndiagpath.2021.151761_bb0055","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1200\/JCO.2013.51.3242","article-title":"IGH@ translocations are prevalent in teenagers and young adults with acute lymphoblastic leukemia and are associated with a poor outcome","volume":"32","author":"Russell","year":"2014","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.anndiagpath.2021.151761_bb0060","doi-asserted-by":"crossref","first-page":"151533","DOI":"10.1016\/j.anndiagpath.2020.151533","article-title":"Detection of cryptic CCND1 rearrangements in mantle cell lymphoma by next generation sequencing","volume":"46","author":"Polonis","year":"2020","journal-title":"Ann Diagn Pathol"},{"key":"10.1016\/j.anndiagpath.2021.151761_bb0065","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/s41408-019-0255-z","article-title":"Mate pair sequencing outperforms fluorescence in situ hybridization in the genomic characterization of multiple myeloma","volume":"9","author":"Smadbeck","year":"2019","journal-title":"Blood Cancer J"},{"key":"10.1016\/j.anndiagpath.2021.151761_bb0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0193928","article-title":"High-resolution detection of chromosomal rearrangements in leukemias through mate pair whole genome sequencing","volume":"13","author":"Tran","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.anndiagpath.2021.151761_bb0075","series-title":"ISCN 2020: an international system for human cytogenomic nomenclature","author":"McGowan-Jordan","year":"2020"},{"key":"10.1016\/j.anndiagpath.2021.151761_bb0080","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1002\/pbc.25318","article-title":"Cutaneous B-lymphoblastic lymphoma with IL3\/IgH translocation presenting with hypereosinophilia and acute endocarditis","volume":"62","author":"Bomken","year":"2015","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.anndiagpath.2021.151761_bb0085","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1002\/ajh.24266","article-title":"Marked eosinophilia masking B lymphoblastic leukemia","volume":"91","author":"Yu","year":"2016","journal-title":"Am J Hematol"},{"key":"10.1016\/j.anndiagpath.2021.151761_bb0090","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1182\/blood-2016-10-695973","article-title":"Myeloid neoplasms with eosinophilia","volume":"129","author":"Reiter","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.anndiagpath.2021.151761_bb0095","doi-asserted-by":"crossref","DOI":"10.1101\/mcs.a004077","article-title":"Elucidating a false-negative MYC break-apart fluorescence in situ hybridization probe study by next-generation sequencing in a patient with high-grade B-cell lymphoma with IGH\/MYC and IGH\/BCL2 rearrangements","volume":"5","author":"Peterson","year":"2019","journal-title":"Cold Spring Harb Mol Case Stud"},{"key":"10.1016\/j.anndiagpath.2021.151761_bb0100","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/s41408-019-0239-z","article-title":"Characterization of TCF3 rearrangements in pediatric B-lymphoblastic leukemia\/lymphoma by mate-pair sequencing (MPseq) idetifies complex genomic rearrangements and a novel TCF3\/TEF gene fusion","volume":"9","author":"Rowsey","year":"2019","journal-title":"Blood Cancer J"}],"container-title":["Annals of Diagnostic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1092913421000617?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1092913421000617?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T20:32:40Z","timestamp":1761078760000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1092913421000617"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":20,"alternative-id":["S1092913421000617"],"URL":"https:\/\/doi.org\/10.1016\/j.anndiagpath.2021.151761","relation":{},"ISSN":["1092-9134"],"issn-type":[{"value":"1092-9134","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical utility of next generation sequencing to detect IGH\/IL3 rearrangements [t(5;14)(q31.1;q32.1)] in B-lymphoblastic leukemia\/lymphoma","name":"articletitle","label":"Article Title"},{"value":"Annals of Diagnostic Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anndiagpath.2021.151761","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"151761"}}