{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T05:59:49Z","timestamp":1777269589835,"version":"3.51.4"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Diagnostic Pathology"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.anndiagpath.2021.151878","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T02:02:02Z","timestamp":1639620122000},"page":"151878","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Animal model detects early pathologic changes of Charcot neuropathic arthropathy"],"prefix":"10.1016","volume":"56","author":[{"given":"Christopher M.","family":"Stauch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie C.","family":"Fanburg-Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kempland C.","family":"Walley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesse L.","family":"King","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Murie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morgan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary","family":"Koroneos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Waning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Elfar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael C.","family":"Aynardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.anndiagpath.2021.151878_bb0005","series-title":"Charcot\u2019s Arthropathy of the Foot","first-page":"390","volume":"92","author":"Armstrong","year":"2002"},{"key":"10.1016\/j.anndiagpath.2021.151878_bb0010","doi-asserted-by":"crossref","first-page":"568","DOI":"10.3113\/FAI.2008.0568","article-title":"Radiographic measures as a predictor of ulcer formation in diabetic charcot midfoot","volume":"29","author":"Bevan","year":"2008","journal-title":"Foot Ankle Int"},{"issue":"2","key":"10.1016\/j.anndiagpath.2021.151878_bb0015","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/jns5.12072","article-title":"Phenotyping animal models of diabetic neuropathy: a consensus statement of the diabetic neuropathy study group of the EASD (Neurodiab)","volume":"19","author":"Biessels","year":"2014","journal-title":"J Peripher Nerv Syst"},{"key":"10.1016\/j.anndiagpath.2021.151878_bb0020","series-title":"The 18th Camillo Golgi lecture","first-page":"1353","article-title":"The diabetic foot : from art to science","volume":"1343","author":"Boulton","year":"2004"},{"key":"10.1016\/j.anndiagpath.2021.151878_bb0025","series-title":"Charcot joints","author":"Eichenholtz","year":"1966"},{"key":"10.1016\/j.anndiagpath.2021.151878_bb0030","series-title":"The Mouse in Biomedical Research","first-page":"637","article-title":"Mouse models in aging research","volume":"Vol 3","author":"Flurkey","year":"2007"},{"key":"10.1016\/j.anndiagpath.2021.151878_bb0035","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.foot.2015.11.001","article-title":"Current concepts of charcot foot in diabetic patients","volume":"26","author":"La Fontaine","year":"2016","journal-title":"Foot"},{"key":"10.1016\/j.anndiagpath.2021.151878_bb0040","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1111\/j.1464-5491.2004.01215.x","article-title":"Mortality in patients with diabetic neuropathic osteoarthropathy (Charcot Foot)","volume":"21","author":"Gazis","year":"2004","journal-title":"Diabetes Med."},{"key":"10.1016\/j.anndiagpath.2021.151878_bb0045","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1002\/jor.20546","article-title":"Histological analysis of Achilles tendons in an overuse rat model","volume":"26","author":"Glazebrook","year":"2008","journal-title":"J Orthop Res"},{"key":"10.1016\/j.anndiagpath.2021.151878_bb0050","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.2106\/00004623-200107000-00017","article-title":"The diabetic foot: basic mechanisms of disease","volume":"83","author":"Guyton","year":"2001","journal-title":"J Bone Jt Surg Am"},{"key":"10.1016\/j.anndiagpath.2021.151878_bb0055","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/cpmo.11","article-title":"Peripheral neuropathy in mouse models of diabetes","volume":"6","author":"Jolivalt","year":"2016","journal-title":"Curr Protoc Mouse Biol"},{"issue":"5","key":"10.1016\/j.anndiagpath.2021.151878_bb0060","doi-asserted-by":"crossref","first-page":"e0126892","DOI":"10.1371\/journal.pone.0126892","article-title":"An early diagnostic tool for diabetic peripheral neuropathy in rats","volume":"10","author":"Kambiz","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.anndiagpath.2021.151878_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3402\/dfa.v4i0.21117","article-title":"An overview of the charcot foot pathophysiology","volume":"4","author":"Kaynak","year":"2013","journal-title":"Diabet Foot Ankle"},{"key":"10.1016\/j.anndiagpath.2021.151878_bb0070","author":"Kim"},{"key":"10.1016\/j.anndiagpath.2021.151878_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.anndiagpath.2020.151509","article-title":"Novel FEMASK-score, a histopathologic assessment for destructive Charcot neuropathic arthropathy, reveals intraneural vasculopathy and correlates with progression and best treatment","volume":"47","author":"King","year":"2020","journal-title":"Ann Diagn Pathol"},{"key":"10.1016\/j.anndiagpath.2021.151878_bb0080","series-title":"Economic Burden of Diabetic Foot Ulcers and Amputations: Data Points #3","first-page":"21","author":"Margolis","year":"2011"},{"key":"10.1016\/j.anndiagpath.2021.151878_bb0085","first-page":"1998","article-title":"Preventive foot care in people with diabetes","volume":"26","author":"Mayfield","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1016\/j.anndiagpath.2021.151878_bb0090","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.bone.2018.03.024","article-title":"Exercise prevents high fat diet-induced bone loss, marrow adiposity and dysbiosis in male mice","volume":"118","author":"Mccabe","year":"2019","journal-title":"Bone"},{"key":"10.1016\/j.anndiagpath.2021.151878_bb0095","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.bone.2018.03.024","article-title":"Exercise prevents high fat diet-induced bone loss, marrow adiposity and dysbiosis in male mice","volume":"118","author":"McCabe","year":"2019","journal-title":"Bone"},{"key":"10.1016\/j.anndiagpath.2021.151878_bb0100","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1093\/ilar\/ilt052","article-title":"Mouse models of diabetic neuropathy","volume":"54","author":"O\u2019Brien","year":"2014","journal-title":"ILAR J"},{"key":"10.1016\/j.anndiagpath.2021.151878_bb0105","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.2337\/db06-1176","article-title":"High-fat diet induced neuropathy of pre-diabetes and obesity: effects of \u201cHealthy\u201d diet and aldose reductase inhibition","volume":"56","author":"Obrosova","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.anndiagpath.2021.151878_bb0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12944-018-0852-z","article-title":"Exercise without dietary changes alleviates nonalcoholic fatty liver disease without weight loss benefits","volume":"17","author":"Ok","year":"2018","journal-title":"Lipids Health Dis"},{"key":"10.1016\/j.anndiagpath.2021.151878_bb0115","author":"Ok"},{"key":"10.1016\/j.anndiagpath.2021.151878_bb0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3402\/dfa.v4i0.20872","article-title":"Etiology, pathophysiology and classifications of the diabetic charcot foot","volume":"4","author":"Papanas","year":"2013","journal-title":"Diabet. Foot Ankle"},{"key":"10.1016\/j.anndiagpath.2021.151878_bb0125","doi-asserted-by":"crossref","first-page":"250","DOI":"10.2337\/diacare.24.2.250","article-title":"Simple screening tests for peripheral neuropathy in the diabetes clinic","volume":"24","author":"Perkins","year":"2001","journal-title":"Diabetes Care"},{"key":"10.1016\/j.anndiagpath.2021.151878_bb0130","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.2337\/dc10-0636","article-title":"A prospective study of calcaneal bone mineral density in acute charcot","volume":"33","author":"Petrova","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/j.anndiagpath.2021.151878_bb0135","series-title":"Calcaneal Bone Mineral Density in Patients with Charcot Neuropathic Osteoarthropathy : Differences Between Type 1 and Type 2 Diabetes","first-page":"756","author":"Petrova","year":"2005"},{"key":"10.1016\/j.anndiagpath.2021.151878_bb0140","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1007\/s00125-002-0885-7","article-title":"Charcot neuroarthropathy in diabetes mellitus","volume":"45","author":"Rajbhandari","year":"2002","journal-title":"Diabetologia"},{"key":"10.1016\/j.anndiagpath.2021.151878_bb0145","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.2337\/dc11-0844","article-title":"The charcot foot in diabetes","volume":"34","author":"Rogers","year":"2011","journal-title":"Diabetes Care"},{"key":"10.1016\/j.anndiagpath.2021.151878_bb0150","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1177\/107110070202300106","article-title":"The acquired midtarsus deformity classification system-interobserver reliability and intraobserver reproducibility","volume":"23","author":"Schon","year":"2002","journal-title":"Foot Ankle Int"},{"key":"10.1016\/j.anndiagpath.2021.151878_bb0155","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1529-8027.2012.00390.x","article-title":"Impaired glucose tolerance and metabolic syndrome in idiopathic neuropathy","volume":"17","author":"Smith","year":"2012","journal-title":"J Peripher Nerv Syst"},{"key":"10.1016\/j.anndiagpath.2021.151878_bb0160","doi-asserted-by":"crossref","first-page":"816","DOI":"10.2337\/dc08-1695","article-title":"Mortality risk of charcot arthropathy compared with that of diabetic foot ulcer and diabetes alone","volume":"32","author":"Sohn","year":"2009","journal-title":"Diabetes Care"},{"key":"10.1016\/j.anndiagpath.2021.151878_bb0165","doi-asserted-by":"crossref","first-page":"98","DOI":"10.2337\/dc09-1497","article-title":"Lower-extremity amputation risk after charcot arthropathy and diabetic foot ulcer","volume":"33","author":"Sohn","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/j.anndiagpath.2021.151878_bb0170","series-title":"The Role of oxLDL\/LOX-1","first-page":"58","author":"Vincent","year":"2009"},{"key":"10.1016\/j.anndiagpath.2021.151878_bb0175","article-title":"A mouse model of diet-induced obesity and insulin resistance","volume":"421\u2013433","author":"Wang","year":"2013","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.anndiagpath.2021.151878_bb0180","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1177\/1071100714547218","article-title":"Radiographic analsysis of diabetic midfoot charcot neuroarthropathy with and without midfoot ulceration","volume":"35","author":"Wukich","year":"2014","journal-title":"Foot Ankle Int"},{"key":"10.1016\/j.anndiagpath.2021.151878_bb0185","first-page":"1","article-title":"Effect of high-fat diet on peripheral neuropathy in C57BL\/6 mice","volume":"2014","author":"Xu","year":"2014","journal-title":"Int J Endocrinol"},{"key":"10.1016\/j.anndiagpath.2021.151878_bb0190","doi-asserted-by":"crossref","first-page":"34","DOI":"10.2337\/diacare.18.1.34","article-title":"Osteopenia, neurological dysfunction, and the development of charcot neuroarthropathy","volume":"18","author":"Young","year":"1995","journal-title":"Diabetes Care"},{"issue":"72","key":"10.1016\/j.anndiagpath.2021.151878_bb0195","doi-asserted-by":"crossref","first-page":"42","DOI":"10.15557\/JoU.2018.0007","article-title":"Diabetic foot syndrome: charcot arthropathy or osteomyelitis? Part I: clinical picture and radiography","volume":"18","author":"Konarzewska","year":"2018","journal-title":"J Ultrason."}],"container-title":["Annals of Diagnostic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1092913421001787?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1092913421001787?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T20:35:02Z","timestamp":1761078902000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1092913421001787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":39,"alternative-id":["S1092913421001787"],"URL":"https:\/\/doi.org\/10.1016\/j.anndiagpath.2021.151878","relation":{},"ISSN":["1092-9134"],"issn-type":[{"value":"1092-9134","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Animal model detects early pathologic changes of Charcot neuropathic arthropathy","name":"articletitle","label":"Article Title"},{"value":"Annals of Diagnostic Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anndiagpath.2021.151878","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"151878"}}