{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T23:31:56Z","timestamp":1781566316488,"version":"3.54.5"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Diagnostic Pathology"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.anndiagpath.2022.152070","type":"journal-article","created":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T04:04:37Z","timestamp":1669176277000},"page":"152070","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Malignant germ cell tumors in men aged 50\u00a0years and over are associated with adverse pathologic features and higher stage at presentation"],"prefix":"10.1016","volume":"62","author":[{"given":"Fawaz","family":"Almutairi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Geisler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rayan","family":"Rammal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Korentzelos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheldon","family":"Bastacky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv","family":"Dhir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Bhattu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela M.","family":"Quiroga-Garza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.anndiagpath.2022.152070_bb0005","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/andr.293","article-title":"International patterns and trends in testicular cancer incidence, overall and by histologic subtype, 1973\u20132007","volume":"3","author":"Trabert","year":"2015","journal-title":"Andrology"},{"issue":"1","key":"10.1016\/j.anndiagpath.2022.152070_bb0010","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/andr.288","article-title":"Recent trends in the incidence of testicular germ cell tumors in the United States","volume":"3","author":"Ghazarian","year":"2015","journal-title":"Andrology"},{"key":"10.1016\/j.anndiagpath.2022.152070_bb0015","series-title":"WHO Classification of Tumours Editorial Board. Urinary and male genital tumours","article-title":"The World Health Organization 2022 classification of testicular germ cell tumours","author":"Tickoo","year":"2022"},{"key":"10.1016\/j.anndiagpath.2022.152070_bb0020","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/1748-717X-6-90","article-title":"Pure seminoma: a review and update","volume":"6","author":"Boujelbene","year":"2011","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.anndiagpath.2022.152070_bb0025","unstructured":"National Comprehensive Cancer Network. Testicular cancer (Version 2.2022). https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/testicular.pdf Accessed June 26, 2022."},{"key":"10.1016\/j.anndiagpath.2022.152070_bb0030","series-title":"Cancer statistics factsheets: testicular cancer","author":"SEER","year":"2022"},{"issue":"3","key":"10.1016\/j.anndiagpath.2022.152070_bb0035","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1620\/tjem.252.219","article-title":"Trends in age and histology of testicular cancer from 1980\u20132019: a single-center study","volume":"252","author":"Yamashita","year":"2020","journal-title":"Tohoku J Exp Med"},{"issue":"2","key":"10.1016\/j.anndiagpath.2022.152070_bb0040","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1093\/annonc\/mds460","article-title":"Testicular cancer in Europe and the USA: survival still rising among older patients","volume":"24","author":"Verhoeven","year":"2013","journal-title":"Ann Oncol"},{"key":"10.1016\/j.anndiagpath.2022.152070_bb0045","series-title":"Pathology of the testis","first-page":"139","article-title":"Testicular tumours-Introduction","author":"Pugh","year":"1976"},{"issue":"14","key":"10.1016\/j.anndiagpath.2022.152070_bb0050","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1002\/cncr.28025","article-title":"Clinical features, presentation, and tolerance of platinum-based chemotherapy in germ cell tumor patients 50 years of age and older","volume":"119","author":"Feldman","year":"2013","journal-title":"Cancer"},{"issue":"1","key":"10.1016\/j.anndiagpath.2022.152070_bb0055","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/modpathol.3800978","article-title":"Malignant germ cell tumours in the elderly: a histopathological review of 50 cases in men aged 60 years or over","volume":"21","author":"Berney","year":"2008","journal-title":"Mod Pathol"},{"issue":"22","key":"10.1016\/j.anndiagpath.2022.152070_bb0060","doi-asserted-by":"crossref","first-page":"4448","DOI":"10.1200\/JCO.2002.01.038","article-title":"Prognostic factors for relapse in stage I seminoma managed by surveillance: a pooled analysis","volume":"20","author":"Warde","year":"2002","journal-title":"J Clin Oncol"},{"issue":"11","key":"10.1016\/j.anndiagpath.2022.152070_bb0065","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1111\/j.1464-410X.2011.10252.x","article-title":"The clinical features and management of testicular germ cell tumours in patients aged 60 years and older","volume":"108","author":"Wheater","year":"2011","journal-title":"BJU Int"},{"key":"10.1016\/j.anndiagpath.2022.152070_bb0070","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.canep.2018.05.007","article-title":"Testicular cancer among US men aged 50 years and older","volume":"55","author":"Ghazarian","year":"2018","journal-title":"Cancer Epidemiol"},{"issue":"5","key":"10.1016\/j.anndiagpath.2022.152070_bb0075","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0090-4295(02)01886-1","article-title":"Difference in stage and morphology-adjusted survival between young and elderly patients with a testicular germ cell tumor","volume":"60","author":"Spermon","year":"2002","journal-title":"Urology"},{"key":"10.1016\/j.anndiagpath.2022.152070_bb0080","first-page":"4391015","article-title":"Classic testicular seminoma in men aged 50 years or over: a case report and review of the literature","volume":"2019","author":"Abou Zahr","year":"2019","journal-title":"Case Rep Urol"},{"issue":"5","key":"10.1016\/j.anndiagpath.2022.152070_bb0085","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1053\/j.seminoncol.2009.07.006","article-title":"Testicular cancer: a prototypic tumor of young adults","volume":"36","author":"Hayes-Lattin","year":"2009","journal-title":"Semin Oncol"},{"key":"10.1016\/j.anndiagpath.2022.152070_bb0090","author":"LAG"},{"key":"10.1016\/j.anndiagpath.2022.152070_bb0095","first-page":"239","article-title":"Testicular germ cell tumours in Denmark 1976\u20131980. Pathology of 1058 consecutive cases","volume":"23","author":"Krag","year":"1984","journal-title":"Acta radiolOncologia"},{"key":"10.1016\/j.anndiagpath.2022.152070_bb0100","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1002\/1097-0142(196805)21:5<852::AID-CNCR2820210509>3.0.CO;2-Z","article-title":"Testicular and paratesticular neoplasms in patients 60 years of age and older","volume":"21","author":"Abell","year":"1968","journal-title":"Cancer"},{"issue":"6","key":"10.1016\/j.anndiagpath.2022.152070_bb0105","first-page":"555","article-title":"Frequency of intratubular germ cell neoplasia with invasive testicular germ cell tumors. Histologic and immunocytochemical features","volume":"109","author":"Coffin","year":"1985","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.anndiagpath.2022.152070_bb0110","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.1002\/1097-0142(19810601)47:11<2660::AID-CNCR2820471123>3.0.CO;2-6","article-title":"Carcinoma in situ of testicular tissue adjacent to malignant germ-cell tumors: a study of 105 cases","volume":"47","author":"Jacobsen","year":"1981","journal-title":"Cancer"},{"key":"10.1016\/j.anndiagpath.2022.152070_bb0115","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1034\/j.1600-0463.2003.11101061.x","volume":"111","author":"Oosterhuis","year":"2003","journal-title":"APMIS"},{"issue":"5","key":"10.1016\/j.anndiagpath.2022.152070_bb0120","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0090-4295(02)01886-1","article-title":"Difference in stage and morphology-adjusted survival between young and elderly patients with a testicular germ cell tumor","volume":"60","author":"Spermon","year":"2002","journal-title":"Urology"}],"container-title":["Annals of Diagnostic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1092913422001721?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1092913422001721?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T20:34:53Z","timestamp":1761078893000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1092913422001721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":24,"alternative-id":["S1092913422001721"],"URL":"https:\/\/doi.org\/10.1016\/j.anndiagpath.2022.152070","relation":{},"ISSN":["1092-9134"],"issn-type":[{"value":"1092-9134","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Malignant germ cell tumors in men aged 50\u00a0years and over are associated with adverse pathologic features and higher stage at presentation","name":"articletitle","label":"Article Title"},{"value":"Annals of Diagnostic Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anndiagpath.2022.152070","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"152070"}}