{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T20:49:53Z","timestamp":1761166193545,"version":"build-2065373602"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T00:00:00Z","timestamp":1683849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Diagnostic Pathology"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.anndiagpath.2023.152155","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T12:21:32Z","timestamp":1683548492000},"page":"152155","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["The clinicopathological significance of TOP2A expression in malignant peritoneal mesothelioma"],"prefix":"10.1016","volume":"65","author":[{"given":"Xuemei","family":"Du","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinbao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingdong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zechen","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiran","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yizhi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.anndiagpath.2023.152155_bb0005","doi-asserted-by":"crossref","first-page":"17162","DOI":"10.3390\/ijms150917162","article-title":"Chromatin structure and dynamics in hot environments: architectural proteins and DNA topoisomerases of thermophilic archaea","volume":"15","author":"Visone","year":"2014","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.anndiagpath.2023.152155_bb0010","first-page":"1264209","article-title":"Eukaryotic topoisomerase II cleavage is independent of duplex DNA conformation","author":"Choi","year":"1995","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.anndiagpath.2023.152155_bb0015","first-page":"6","article-title":"DNA topoisomerases","author":"Bush","year":"2015","journal-title":"Eco Sal Plus"},{"key":"10.1016\/j.anndiagpath.2023.152155_bb0020","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.tiv.2015.04.015","article-title":"Resveratrol induces DNA damage in colon cancer cells by poisoning topoisomerase II and activates the ATM kinase to trigger p53-dependent apoptosis","volume":"29","author":"Demoulin","year":"2015","journal-title":"Toxicol In Vitro"},{"key":"10.1016\/j.anndiagpath.2023.152155_bb0025","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1080\/01635581.2014.951733","article-title":"Flavonoid-enriched apple fraction AF4 induces cell cycle arrest, DNA topoisomerase II inhibition, and apoptosis in human liver cancer HepG2 cells","volume":"66","author":"Sudan","year":"2014","journal-title":"Nutr Cancer"},{"key":"10.1016\/j.anndiagpath.2023.152155_bb0030","doi-asserted-by":"crossref","first-page":"232","DOI":"10.3892\/ol.2020.12095","article-title":"High expression of TOP2A in hepatocellular carcinoma is associated with disease progression and poor prognosis","volume":"20","author":"Cai","year":"2020","journal-title":"Oncol Lett"},{"key":"10.1016\/j.anndiagpath.2023.152155_bb0035","doi-asserted-by":"crossref","first-page":"983","DOI":"10.21037\/tcr.2019.12.46","article-title":"High expression of TOP2A gene predicted poor prognosis of hepatocellular carcinoma after radical hepatectomy","volume":"9","author":"Cai","year":"2020","journal-title":"Transl Cancer Res"},{"key":"10.1016\/j.anndiagpath.2023.152155_bb0040","doi-asserted-by":"crossref","DOI":"10.12659\/MSM.929120","article-title":"Expression of the topoisomerase II alpha (TOP2A) gene in lung adenocarcinoma cells and the association with patient outcomes","volume":"26","author":"Du","year":"2020","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.anndiagpath.2023.152155_bb0045","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1159\/000510534","article-title":"Identification of potential hub genes and therapeutic drugs in malignant pleural mesothelioma by integrated bioinformatics analysis","volume":"43","author":"Zhang","year":"2020","journal-title":"Oncol Res Treat"},{"key":"10.1016\/j.anndiagpath.2023.152155_bb0050","article-title":"TOP2A and HER2neu evaluation in malignant pleural mesothelioma","volume":"207","author":"Elkasem","year":"2023","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.anndiagpath.2023.152155_bb0055","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/978-1-4613-1247-5_23","article-title":"Clinical research methodologies in diagnosis and staging of patients with peritoneal carcinomatosis","volume":"82","author":"Jacquet","year":"1996","journal-title":"Cancer Treat Res"},{"journal-title":"International agency for research on cancer","first-page":"204","year":"2021","key":"10.1016\/j.anndiagpath.2023.152155_bb0060"},{"key":"10.1016\/j.anndiagpath.2023.152155_bb0065","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s00428-017-2258-0","article-title":"Ki67 labeling index: assessment and prognostic role in gastroenteropancreatic neuroendocrine neoplasms","volume":"472","author":"Kl\u00f6ppel","year":"2018","journal-title":"Virchows Arch"},{"key":"10.1016\/j.anndiagpath.2023.152155_bb0070","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.7150\/jca.41415","article-title":"TOP2A promotes lung adenocarcinoma cells' malignant progression and predicts poor prognosis in lung adenocarcinoma","volume":"11","author":"Kou","year":"2020","journal-title":"J Cancer"},{"key":"10.1016\/j.anndiagpath.2023.152155_bb0075","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ejca.2017.06.019","article-title":"Topoisomerase expression and amplifcation in solid tumours: analysis of 24,262 patients","volume":"83","author":"Heestand","year":"2017","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.anndiagpath.2023.152155_bb0080","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1002\/1878-0261.12457","article-title":"Mutual regulation of MDM4 and TOP2A in cancer cell proliferation","volume":"13","author":"Liu","year":"2019","journal-title":"Mol Oncol"},{"key":"10.1016\/j.anndiagpath.2023.152155_bb0085","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1186\/s12885-019-5814-y","article-title":"Prognostic value of TOP2A in bladder urothelial carcinoma and potential molecular mechanisms","volume":"19","author":"Zeng","year":"2019","journal-title":"BMC Cancer"},{"key":"10.1016\/j.anndiagpath.2023.152155_bb0090","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1097\/PAI.0000000000000574","article-title":"FISH analysis of TOP2A and HER-2 aberrations in female breast carcinoma on archived material: egyptian NCI experience","volume":"27","author":"Badawy","year":"2019","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"10.1016\/j.anndiagpath.2023.152155_bb0095","doi-asserted-by":"crossref","first-page":"7256","DOI":"10.1002\/jcb.26916","article-title":"Proliferation and invasion of colon cancer cells are suppressed by knockdown of TOP2A","volume":"119","author":"Zhang","year":"2018","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.anndiagpath.2023.152155_bb0100","doi-asserted-by":"crossref","first-page":"3912","DOI":"10.7150\/jca.25900","article-title":"Identifying a novel biomarker TOP2A of clear cell renal cell carcinoma (ccRCC) associated with smoking by co-expression network analysis","volume":"9","author":"Xiong","year":"2018","journal-title":"J Cancer"},{"key":"10.1016\/j.anndiagpath.2023.152155_bb0105","first-page":"107","article-title":"The structure of the nucleus in normal and neoplastic prostate cells: untangling the role of type 2 DNA topoisomerases","volume":"6","author":"Nelson","year":"2018","journal-title":"Am J Clin Exp Urol"},{"key":"10.1016\/j.anndiagpath.2023.152155_bb0110","doi-asserted-by":"crossref","first-page":"4877","DOI":"10.3390\/cancers13194877","article-title":"Expression patterns of TOP2A and SIRT1 are predictive of survival in patients with high-risk soft tissue sarcomas treated with a neoadjuvant anthracycline-based chemotherapy","volume":"13","author":"Berclaz","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.anndiagpath.2023.152155_bb0115","article-title":"TOP2A correlates with poor prognosis and affects radio resistance of medulloblastoma","volume":"12","author":"Zhang","year":"2022","journal-title":"Front Oncol"},{"key":"10.1016\/j.anndiagpath.2023.152155_bb0120","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/j.ejca.2011.02.010","article-title":"Topoisomerase II-alpha protein expression and histological response following doxorubicin-based induction chemotherapy predict survival of locally advanced soft tissues sarcomas","volume":"47","author":"Rodrigo","year":"2011","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.anndiagpath.2023.152155_bb0125","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1158\/1078-0432.CCR-04-1988","article-title":"Predicting response to methotrexate, vinblastine, doxorubicin, and cisplatin neoadjuvant chemotherapy for bladder cancers through genome-wide gene expression profiling","volume":"11","author":"Takata","year":"2005","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.anndiagpath.2023.152155_bb0130","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s11060-011-0758-3","article-title":"Higher topoisomerase 2 alpha gene transcript levels predict better prognosis in GBM patients receiving temozolomide chemotherapy: identification of temozolomide as a TOP2A inhibitor","volume":"107","author":"Arivazhagan","year":"2012","journal-title":"J Neurooncol"},{"key":"10.1016\/j.anndiagpath.2023.152155_bb0135","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.prp.2014.06.017","article-title":"Topoisomerase II-alfa gene as a predictive marker of response to anthracyclines in breast cancer","volume":"210","author":"Almeida","year":"2014","journal-title":"Pathol Res Pract"},{"key":"10.1016\/j.anndiagpath.2023.152155_bb0140","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s11060-007-9360-0","article-title":"Enhanced expression of DNA topoisomerase II genes in human medulloblastoma and its possible association with etoposide sensitivity","volume":"84","author":"Uesaka","year":"2007","journal-title":"J Neuro Oncol"},{"key":"10.1016\/j.anndiagpath.2023.152155_bb0145","article-title":"Association between TOP2A, RRM1, HER2, ERCC1 expression and response to chemotherapy in patients with non-muscle invasive bladder cancer","volume":"8","author":"Liu","year":"2022","journal-title":"Heliyon"},{"key":"10.1016\/j.anndiagpath.2023.152155_bb0150","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1097\/JTO.0b013e3181ccb27b","article-title":"Features of potentially predictive biomarkers of chemotherapeutic efficacy in small cell lung cancer","volume":"5","author":"Chiappori","year":"2010","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.anndiagpath.2023.152155_bb0155","first-page":"11537","article-title":"Multidrug resistance protein and topoisomerase 2 alpha expression in non-small cell lung cancer are related with brain metastasis postoperatively","volume":"8","author":"Huang","year":"2015","journal-title":"Int J Clin Exp Pathol"}],"container-title":["Annals of Diagnostic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1092913423000539?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1092913423000539?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T20:35:58Z","timestamp":1761078958000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1092913423000539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":31,"alternative-id":["S1092913423000539"],"URL":"https:\/\/doi.org\/10.1016\/j.anndiagpath.2023.152155","relation":{},"ISSN":["1092-9134"],"issn-type":[{"type":"print","value":"1092-9134"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The clinicopathological significance of TOP2A expression in malignant peritoneal mesothelioma","name":"articletitle","label":"Article Title"},{"value":"Annals of Diagnostic Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anndiagpath.2023.152155","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"152155"}}