{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T04:17:13Z","timestamp":1779250633585,"version":"3.51.4"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Diagnostic Pathology"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.anndiagpath.2023.152172","type":"journal-article","created":{"date-parts":[[2023,6,17]],"date-time":"2023-06-17T02:08:13Z","timestamp":1686967693000},"page":"152172","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Frequent expression of PD-L1 in lymphocyte-rich hepatocellular carcinoma: A report of 4 cases"],"prefix":"10.1016","volume":"66","author":[{"given":"Mukul","family":"Vij","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fadl H.","family":"Veerankutty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lexmi Priya","family":"Raju","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gowripriya","family":"Gowrishankar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajesh","family":"Rajalingam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dinesh","family":"Jothimani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilankumaran","family":"Kaliamoorthy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashwin","family":"Rammohan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Rela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.anndiagpath.2023.152172_bb0005","doi-asserted-by":"crossref","first-page":"393","DOI":"10.4254\/wjh.v13.i4.393","article-title":"Pathologic and molecular features of hepatocellular carcinoma: an update","volume":"13","author":"Vij","year":"2021","journal-title":"World J Hepatol"},{"key":"10.1016\/j.anndiagpath.2023.152172_bb0010","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.gtc.2017.01.009","article-title":"Morphologic subtypes of hepatocellular carcinoma","volume":"46","author":"Torbenson","year":"2017","journal-title":"Gastroenterol Clin North Am"},{"issue":"6165","key":"10.1016\/j.anndiagpath.2023.152172_bb0015","first-page":"1432","article-title":"Breakthrough of the year 2013","volume":"342","author":"Couzin-Frankel","year":"2013","journal-title":"Cancer Immunother Sci"},{"key":"10.1016\/j.anndiagpath.2023.152172_bb0020","doi-asserted-by":"crossref","first-page":"568931","DOI":"10.3389\/fimmu.2020.568931","article-title":"The extrinsic and intrinsic roles of PD-L1 and its receptor PD-1: implications for immunotherapy treatment","volume":"11","author":"Hudson","year":"2020","journal-title":"Front Immunol"},{"issue":"26","key":"10.1016\/j.anndiagpath.2023.152172_bb0025","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1056\/NEJMoa1200694","article-title":"Safety and activity of anti-PD-L1 antibody inpatients with advanced cancer","volume":"366","author":"Brahmer","year":"2012","journal-title":"N Engl J Med"},{"issue":"7528","key":"10.1016\/j.anndiagpath.2023.152172_bb0030","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/nature13904","article-title":"Vogelzang NJ.MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer","volume":"515","author":"Powles","year":"2014","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.anndiagpath.2023.152172_bb0035","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1097\/PAI.0000000000000594","article-title":"Development ofa PD-L1 complementary diagnostic immunohistochemistry assay (SP142) for atezolizumab","volume":"27","author":"Vennapusa","year":"2019","journal-title":"Appl Immunohistochem Mol Morphol"},{"issue":"11","key":"10.1016\/j.anndiagpath.2023.152172_bb0040","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1038\/s41379-019-0307-8","article-title":"A comparability study of immunohistochemical assays for PD-L1 expression in hepatocellular carcinoma","volume":"32","author":"Shi","year":"2019","journal-title":"Mod Pathol"},{"key":"10.1016\/j.anndiagpath.2023.152172_bb0045","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.jhep.2019.06.001","article-title":"Molecular and histological correlations in liver cancer","volume":"71","author":"Calderaro","year":"2019","journal-title":"J Hepatol"},{"key":"10.1016\/j.anndiagpath.2023.152172_bb0050","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1097\/PAS.0000000000000376","article-title":"Lymphoepithelioma-like hepatocellular carcinoma: an uncommon variant of hepatocellular carcinoma with favorable outcome","volume":"39","author":"Chan","year":"2015","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.anndiagpath.2023.152172_bb0055","doi-asserted-by":"crossref","unstructured":"Hsu H-C, Chen C-C, Huang G-T, Lee P-H. Clonal epstein-barr virus associated cholangiocarcinoma with lymphoepithelioma-like component. Hum Pathol [Internet] 1996;27:848\u201350, DOI:https:\/\/doi.org\/10.1016\/S0046-8177(96)90460-8. Available from: https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817796904608.","DOI":"10.1016\/S0046-8177(96)90460-8"},{"key":"10.1016\/j.anndiagpath.2023.152172_bb0060","unstructured":"Shirabe K, Matsumata T, Maeda T, Sadanaga N, Kuwano H, Sugimachi K. A long-term surviving patient with hepatocellular carcinoma including lymphocytes infiltration\u2014a clinicopathological study. Hepatogastroenterology [Internet] 42:996\u20131001 [PMID: 8847059] Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8847059."},{"key":"10.1016\/j.anndiagpath.2023.152172_bb0065","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1046\/j.1365-2559.2000.00952.x","article-title":"Hepatocellular carcinoma with lymphoid stroma: a tumour with good prognosis after liver transplantation","volume":"37","author":"Emile","year":"2000","journal-title":"Histopathology"},{"key":"10.1016\/j.anndiagpath.2023.152172_bb0070","first-page":"540","article-title":"Hepatocellular carcinoma with lymphoid stroma: \u2018lymphoepithelioma-like carcinoma\u2019?","volume":"39","author":"Szekely","year":"2001","journal-title":"Histopathology"},{"key":"10.1016\/j.anndiagpath.2023.152172_bb0075","unstructured":"Torbenson MS, Ng IOL, Park YN, Roncalli M, Sakamoto M. Hepatocellular carcinoma. In: WHO Classification of Tumours Editorial Board, editor. Digestive system tumours. WHO classification of tumours series. 5th ed. Lyon: International Agency for Research on Cancer, 2019:229\u201339."},{"issue":"15","key":"10.1016\/j.anndiagpath.2023.152172_bb0080","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s13000-020-01035-6","article-title":"Lymphoepithelioma-like carcinoma in liver not associated with Epstein-Barr virus: a report of 3 cases and literature review","volume":"23","author":"Zhang","year":"2020","journal-title":"Diagn Pathol"},{"key":"10.1016\/j.anndiagpath.2023.152172_bb0085","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1016\/j.ajpath.2017.02.022","article-title":"Lymphoepithelioma-like carcinoma in liver","volume":"187","author":"Labgaa","year":"2017","journal-title":"Am J Pathol"},{"key":"10.1016\/j.anndiagpath.2023.152172_bb0090","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000009416","article-title":"Lymphoepithelioma-like hepatocellular carcinoma: a case report and brief review of literature","volume":"96","author":"Wang","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.anndiagpath.2023.152172_bb0095","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/hep.510270214","article-title":"Clinicopathological study on hepatocellular carcinoma with lymphocytic infiltration","volume":"27","author":"Wada","year":"1998","journal-title":"Hepatology"},{"key":"10.1016\/j.anndiagpath.2023.152172_bb0100","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.cld.2020.07.010","article-title":"Hepatocellular carcinoma: role of pathology in the era of precision medicine","volume":"24","author":"Vyas","year":"2020","journal-title":"Clin Liver Dis"},{"key":"10.1016\/j.anndiagpath.2023.152172_bb0105","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/01.pas.0000124336.90615.8d","article-title":"Hepatocellular lymphoepithelioma-like carcinoma associated with Epstein Barr virus","volume":"13","author":"Si","year":"2004","journal-title":"Diagn Mol Pathol"},{"key":"10.1016\/j.anndiagpath.2023.152172_bb0110","article-title":"Very rare liver neoplasm: lymphoepithelioma-like (LEL) hepatocellular carcinoma","volume":"2018","author":"Filotico","year":"2018","journal-title":"Case Rep Pathol"},{"key":"10.1016\/j.anndiagpath.2023.152172_bb0115","doi-asserted-by":"crossref","unstructured":"Kythreotou A, Siddique A, Mauri FA, Bower M, Pinato DJ. PD-L1. J Clin Pathol 2018 Mar;71(3):189\u201394. doi:https:\/\/doi.org\/10.1136\/jclinpath-2017-204853. Epub 2017 Nov 2.PMID: 29097600.","DOI":"10.1136\/jclinpath-2017-204853"},{"key":"10.1016\/j.anndiagpath.2023.152172_bb0120","doi-asserted-by":"crossref","unstructured":"Montasser A, Beaufr\u00e8re A, Cauchy F, Bouattour M, Soubrane O, Albuquerque M,Paradis V. Transarterial chemoembolisation enhances programmed death-1 and programmed death-ligand 1 expression in hepatocellular carcinoma. Histopathology. 2021 Jul;79(1):36\u201346. doi:https:\/\/doi.org\/10.1111\/his.14317. Epub 2021 Mar 28.PMID: 33326644.","DOI":"10.1111\/his.14317"},{"key":"10.1016\/j.anndiagpath.2023.152172_bb0125","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1002\/hep.28710","article-title":"Programmed death ligand 1 expression in hepatocellular carcinoma: relationship with clinical and pathological features","volume":"64","author":"Calderaro","year":"2016","journal-title":"Hepatology."},{"issue":"9","key":"10.1016\/j.anndiagpath.2023.152172_bb0130","doi-asserted-by":"crossref","first-page":"e04764","DOI":"10.1002\/ccr3.4764","article-title":"Programmed cell death ligand 1 expression in a case of poorly differentiatedlymphocyte-rich hepatocellular carcinoma","volume":"9","author":"Omori","year":"2021","journal-title":"Clin Case Rep"},{"issue":"5","key":"10.1016\/j.anndiagpath.2023.152172_bb0135","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1111\/cas.15339","article-title":"High PD-L1 level of advanced hepatic lymphoepithelioma-like carcinoma response favorably to lenvatinib plustoripalimab","volume":"113","author":"Zhu","year":"2022","journal-title":"Cancer Sci"},{"key":"10.1016\/j.anndiagpath.2023.152172_bb0140","doi-asserted-by":"crossref","first-page":"200402","DOI":"10.1016\/j.ehpc.2020.200402","article-title":"Case report of a lymphoepithelioma-like hepatocellular carcinoma with prominent lymphoplasmacytic infiltration","volume":"21","author":"Noguchi","year":"2020","journal-title":"Hum Pathol Case Rep"},{"issue":"2","key":"10.1016\/j.anndiagpath.2023.152172_bb0145","first-page":"265","article-title":"Checkpoint inhibition in the treatment of unresectable, advanced lymphoepithelioma-like hepatocellular carcinoma","volume":"9","author":"Hermel","year":"2021","journal-title":"J Clin Transl Hepatol"},{"issue":"1","key":"10.1016\/j.anndiagpath.2023.152172_bb0150","doi-asserted-by":"crossref","first-page":"157","DOI":"10.5604\/16652681.1226936","article-title":"Metastatic lymphoepithelioma-like hepatocellular carcinoma: a potential diagnostic pitfalland demonstration of PD-L1 expression","volume":"16","author":"Putra","year":"2017","journal-title":"Ann Hepatol"},{"issue":"3","key":"10.1016\/j.anndiagpath.2023.152172_bb0155","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1053\/j.gastro.2017.06.007","article-title":"Identification of an immune-specific class of hepatocellular carcinoma, based on molecular features","volume":"153","author":"Sia","year":"2017","journal-title":"Gastroenterology."},{"issue":"2","key":"10.1016\/j.anndiagpath.2023.152172_bb0160","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/path.5313","article-title":"Genomic landscape of lymphoepithelioma-like hepatocellular carcinoma","volume":"249","author":"Chan","year":"2019","journal-title":"J Pathol"}],"container-title":["Annals of Diagnostic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1092913423000709?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1092913423000709?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T20:35:52Z","timestamp":1761078952000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1092913423000709"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":32,"alternative-id":["S1092913423000709"],"URL":"https:\/\/doi.org\/10.1016\/j.anndiagpath.2023.152172","relation":{},"ISSN":["1092-9134"],"issn-type":[{"value":"1092-9134","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Frequent expression of PD-L1 in lymphocyte-rich hepatocellular carcinoma: A report of 4 cases","name":"articletitle","label":"Article Title"},{"value":"Annals of Diagnostic Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anndiagpath.2023.152172","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"152172"}}