{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T13:06:30Z","timestamp":1758891990520,"version":"3.37.3"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002964","name":"\u00c7ukurova \u00dcniversitesi","doi-asserted-by":"publisher","award":["TTU-2020-12770"],"award-info":[{"award-number":["TTU-2020-12770"]}],"id":[{"id":"10.13039\/501100002964","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Diagnostic Pathology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.anndiagpath.2024.152369","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T05:58:58Z","timestamp":1724047138000},"page":"152369","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Papillary microcarcinoma of the thyroid gland: Evaluation of TERT and BRAFV-600E expression and their relationship with clinicopathological findings"],"prefix":"10.1016","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5435-044X","authenticated-orcid":false,"given":"Asl\u0131 Aydo\u011fdu","family":"Ye\u015filo\u011flu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0616-7170","authenticated-orcid":false,"given":"Aysun Hatice","family":"U\u011fuz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4951-8703","authenticated-orcid":false,"given":"K\u0131v\u0131lc\u0131m Eren","family":"Erdo\u011fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3044-9621","authenticated-orcid":false,"given":"G\u00fcrhan","family":"Sakman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.anndiagpath.2024.152369_bb0005","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1002\/ijc.25516","article-title":"Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008","volume":"127","author":"Ferlay","year":"2010","journal-title":"Int J Cancer"},{"key":"10.1016\/j.anndiagpath.2024.152369_bb0010","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.anndiagpath.2024.152369_bb0015","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/965212","article-title":"Worldwide increasing incidence of thyroid cancer: update on epidemiology and risk factors","volume":"2013","author":"Pellegriti","year":"2013","journal-title":"J Cancer Epidemiol"},{"key":"10.1016\/j.anndiagpath.2024.152369_bb0020","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1002\/ijc.29251","article-title":"Thyroid cancer mortality and incidence: a global overview","volume":"136","author":"la Vecchia","year":"2015","journal-title":"Int J Cancer"},{"key":"10.1016\/j.anndiagpath.2024.152369_bb0025","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ejso.2017.03.004","article-title":"Low-risk papillary microcarcinoma of the thyroid: a review of active surveillance trials","volume":"44","author":"Ito","year":"2018","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.anndiagpath.2024.152369_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/thy.2015.0020","article-title":"2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer","volume":"26","author":"Haugen","year":"2016","journal-title":"Thyroid"},{"key":"10.1016\/j.anndiagpath.2024.152369_bb0035","first-page":"269","article-title":"Cancer recurrence in papillary thyroid microcarcinoma: a multivariate analysis on 231 patients with a 12-year follow-up","volume":"38","author":"Pedrazzini","year":"2013","journal-title":"Minerva Endocrinol"},{"key":"10.1016\/j.anndiagpath.2024.152369_bb0040","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1089\/thy.2015.0429","article-title":"Clinical and pathologic predictors of lymph node metastasis and recurrence in papillary thyroid microcarcinoma","volume":"26","author":"Siddiqui","year":"2016","journal-title":"Thyroid"},{"key":"10.1016\/j.anndiagpath.2024.152369_bb0045","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.humpath.2021.04.015","article-title":"Papillary thyroid microcarcinomas: does subtyping predict aggressive clinical behavior?","volume":"114","author":"Gubbiotti","year":"2021","journal-title":"Hum Pathol"},{"key":"10.1016\/j.anndiagpath.2024.152369_bb0050","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.surg.2019.03.030","article-title":"Aggressive variants of papillary thyroid microcarcinoma are associated with high-risk features, but not decreased survival","volume":"167","author":"Holoubek","year":"2020","journal-title":"Surgery"},{"key":"10.1016\/j.anndiagpath.2024.152369_bb0055","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.surg.2021.03.056","article-title":"Presence of TERT \u00b1 BRAF V600E mutation is not a risk factor for the clinical management of patients with papillary thyroid microcarcinoma","volume":"170","author":"Lee","year":"2021","journal-title":"Surgery"},{"key":"10.1016\/j.anndiagpath.2024.152369_bb0060","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s12020-020-02380-8","article-title":"Molecular characterisation and clinical correlation of papillary thyroid microcarcinoma","volume":"71","author":"Sam\u00e0","year":"2021","journal-title":"Endocrine"},{"key":"10.1016\/j.anndiagpath.2024.152369_bb0065","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s10147-017-1170-6","article-title":"Impact of major different variants of papillary thyroid microcarcinoma on the clinicopathological characteristics: the study of 1041 cases","volume":"23","author":"Zhi","year":"2018","journal-title":"Int J Clin Oncol"},{"key":"10.1016\/j.anndiagpath.2024.152369_bb0070","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1089\/thy.2012.0563","article-title":"Aggressive variants of papillary thyroid microcarcinoma are associated with extrathyroidal spread and lymph-node metastases: a population-level analysis","volume":"23","author":"Kuo","year":"2013","journal-title":"Thyroid"},{"key":"10.1016\/j.anndiagpath.2024.152369_bb0075","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1089\/thy.2019.0159","article-title":"Active surveillance for small papillary thyroid cancer: a systematic review and meta-analysis","volume":"29","author":"Cho","year":"2019","journal-title":"Thyroid"},{"key":"10.1016\/j.anndiagpath.2024.152369_bb0080","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s12022-022-09707-3","article-title":"Overview of the 2022 WHO classification of thyroid neoplasms","volume":"33","author":"Baloch","year":"2022","journal-title":"Endocr Pathol"},{"key":"10.1016\/j.anndiagpath.2024.152369_bb0085","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/modpathol.2012.152","article-title":"BRAFV600E mutation in papillary thyroid microcarcinoma: a genotype\u2013phenotype correlation","volume":"26","author":"Virk","year":"2013","journal-title":"Mod Pathol"},{"key":"10.1016\/j.anndiagpath.2024.152369_bb0090","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1245\/s10434-008-0233-3","article-title":"Analysis of differential BRAFV600E mutational status in high aggressive papillary thyroid microcarcinoma","volume":"16","author":"Lee","year":"2009","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.anndiagpath.2024.152369_bb0095","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s11596-015-1476-4","article-title":"BRAFV600E mutation and its association with clinicopathological features of papillary thyroid microcarcinoma: a meta-analysis","volume":"35","author":"Ma","year":"2015","journal-title":"J Huazhong Univ Sci Technolog Med Sci"},{"key":"10.1016\/j.anndiagpath.2024.152369_bb0100","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1245\/s10434-010-1129-6","article-title":"The BRAF mutation is predictive of aggressive clinicopathological characteristics in papillary thyroid microcarcinoma","volume":"17","author":"Lin","year":"2010","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.anndiagpath.2024.152369_bb0105","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1038\/modpathol.2015.92","article-title":"BRAF V600E and risk stratification of thyroid microcarcinoma: a multicenter pathological and clinical study","volume":"28","author":"Tallini","year":"2015","journal-title":"Mod Pathol"},{"key":"10.1016\/j.anndiagpath.2024.152369_bb0110","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1089\/thy.2015.0101","article-title":"TERT promoter mutations in papillary thyroid microcarcinomas","volume":"25","author":"De Biase","year":"2015","journal-title":"Thyroid"},{"key":"10.1016\/j.anndiagpath.2024.152369_bb0115","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/gcc.22928","article-title":"Characterization of TERT and BRAF copy number variation in papillary thyroid carcinoma: an analysis of the Cancer Genome Atlas study","volume":"60","author":"McKelvey","year":"2021","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.anndiagpath.2024.152369_bb0120","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1530\/ERC-18-0050","article-title":"TERT aberrancies: a screening tool for malignancy in follicular thyroid tumours","volume":"25","author":"Paulsson","year":"2018","journal-title":"Endocr Relat Cancer"},{"key":"10.1016\/j.anndiagpath.2024.152369_bb0125","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1089\/thy.2018.0695","article-title":"TERT mRNA expression as a novel prognostic marker in papillary thyroid carcinomas","volume":"29","author":"Tanaka","year":"2019","journal-title":"Thyroid"},{"key":"10.1016\/j.anndiagpath.2024.152369_bb0130","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1245\/s10434-012-2851-z","article-title":"Papillary microcarcinoma of the thyroid: clinical characteristics and BRAFV600E mutational status of 977 cases","volume":"20","author":"Zheng","year":"2013","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.anndiagpath.2024.152369_bb0135","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/modpathol.2012.152","article-title":"BRAFV600E mutation in papillary thyroid microcarcinoma: a genotype\u2013phenotype correlation","volume":"26","author":"Virk","year":"2013","journal-title":"Mod Pathol"},{"key":"10.1016\/j.anndiagpath.2024.152369_bb0140","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.1200\/JCO.2014.55.5094","article-title":"BRAF V600E and TERT promoter mutations cooperatively identify the most aggressive papillary thyroid cancer with highest recurrence","volume":"32","author":"Xing","year":"2014","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.anndiagpath.2024.152369_bb0145","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1530\/EJE-14-0837","article-title":"TERT promoter mutations are associated with distant metastases in papillary thyroid carcinoma","volume":"172","author":"Gandolfi","year":"2015","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.anndiagpath.2024.152369_bb0150","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1089\/thy.2016.0350","article-title":"Effects of coexistent BRAFV600E and TERT promoter mutations on poor clinical outcomes in papillary thyroid cancer: a meta-analysis","volume":"27","author":"Moon","year":"2017","journal-title":"Thyroid"},{"issue":"3","key":"10.1016\/j.anndiagpath.2024.152369_bb0155","first-page":"932","article-title":"Risk factors for central lymph node metastasis of patients with papillary thyroid microcarcinoma: a meta-analysis","volume":"7","author":"Liu","year":"2014"},{"issue":"5","key":"10.1016\/j.anndiagpath.2024.152369_bb0160","doi-asserted-by":"crossref","first-page":"550","DOI":"10.21037\/gs.2019.10.04","article-title":"Risk factors for high-volume lymph node metastases in cN0 papillary thyroid microcarcinoma","volume":"8","author":"Liu","year":"2019","journal-title":"Gland Surg"},{"issue":"85","key":"10.1016\/j.anndiagpath.2024.152369_bb0165","first-page":"35553","article-title":"Retrospective analysis of prognostic factors in patients of papillary thyroid microcarcinoma","volume":"9","author":"Xiang","year":"2018"},{"issue":"2","key":"10.1016\/j.anndiagpath.2024.152369_bb0170","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s40618-018-0908-y","article-title":"Clinical analysis of cervical lymph node metastasis risk factors in patients with papillary thyroid microcarcinoma","volume":"42","author":"Luo","year":"2019","journal-title":"J Endocrinol Invest"},{"issue":"1","key":"10.1016\/j.anndiagpath.2024.152369_bb0175","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/cncr.11442","article-title":"Papillary microcarcinoma of the thyroid- prognostic significance of lymph node metastasis and multifocality","volume":"98","author":"Chow","year":"2003","journal-title":"Cancer"},{"key":"10.1016\/j.anndiagpath.2024.152369_bb0180","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.2147\/CMAR.S163263","article-title":"Multifocality is associated with central neck lymph node metastases in papillary thyroid microcarcinoma","volume":"10","author":"Zheng","year":"2018","journal-title":"Cancer Manag Res"},{"issue":"3","key":"10.1016\/j.anndiagpath.2024.152369_bb0185","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1245\/s10434-012-2654-2","article-title":"Multifocality and total tumor diameter predict central neck lymph node metastases in papillary thyroid microcarcinoma","volume":"20","author":"Zhao","year":"2013","journal-title":"Ann Surg Oncol"},{"issue":"6","key":"10.1016\/j.anndiagpath.2024.152369_bb0190","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1097\/01.mnm.0000126625.17166.36","article-title":"Natural history, diagnosis, treatment and outcome of papillary thyroid microcarcinoma (PTMC): a mono-institutional 12-year experience","volume":"25","author":"Pelizzo","year":"2004","journal-title":"Nucl Med Commun"}],"container-title":["Annals of Diagnostic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1092913424001060?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1092913424001060?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T06:29:31Z","timestamp":1731652171000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1092913424001060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":38,"alternative-id":["S1092913424001060"],"URL":"https:\/\/doi.org\/10.1016\/j.anndiagpath.2024.152369","relation":{},"ISSN":["1092-9134"],"issn-type":[{"type":"print","value":"1092-9134"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Papillary microcarcinoma of the thyroid gland: Evaluation of TERT and BRAFV-600E expression and their relationship with clinicopathological findings","name":"articletitle","label":"Article Title"},{"value":"Annals of Diagnostic Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anndiagpath.2024.152369","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"152369"}}