{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:34:20Z","timestamp":1791844460190,"version":"4.3.4"},"reference-count":21,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Emergency Medicine"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.annemergmed.2015.03.016","type":"journal-article","created":{"date-parts":[[2015,4,16]],"date-time":"2015-04-16T10:10:06Z","timestamp":1429179006000},"page":"230-238.e1","source":"Crossref","is-referenced-by-count":96,"title":["The Safety and Effectiveness of Droperidol for Sedation of Acute Behavioral Disturbance in the Emergency Department"],"prefix":"10.1016","volume":"66","author":[{"given":"Leonie","family":"Calver","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin B.","family":"Page","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Downes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betty","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances","family":"Kinnear","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Wheatley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Spain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey Kennedy","family":"Isbister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.annemergmed.2015.03.016_bib1","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/j.1742-6723.2009.01182.x","article-title":"Structured team approach to the agitated patient in the emergency department","volume":"21","author":"Downes","year":"2009","journal-title":"Emerg Med Australas"},{"key":"10.1016\/j.annemergmed.2015.03.016_bib2","unstructured":"National Institute of Clinical Excellence. Violence: The Short Term Management of Disturbed\/Violent Behaviour in Inpatient Psychiatric Settings and Emergency Departments. Clinical Guidelines. London, England: NICE;\u00a02005."},{"key":"10.1016\/j.annemergmed.2015.03.016_bib3","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1186\/1471-244X-13-225","article-title":"A\u00a0prospective study of high dose sedation for rapid tranquilisation of acute behavioural disturbance in an acute mental health unit","volume":"13","author":"Calver","year":"2013","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.annemergmed.2015.03.016_bib4","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1111\/j.1553-2712.2002.tb01609.x","article-title":"A\u00a0retrospective review of the use and safety of droperidol in a large, high-risk, inner-city emergency department patient population","volume":"9","author":"Chase","year":"2002","journal-title":"Acad Emerg Med"},{"issue":"11","key":"10.1016\/j.annemergmed.2015.03.016_bib5","first-page":"CD009377","article-title":"Haloperidol for psychosis-induced aggression or agitation (rapid tranquillisation)","author":"Powney","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.annemergmed.2015.03.016_bib6","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/j.1553-2712.2002.tb02301.x","article-title":"Droperidol\u2014behind the black box warning","volume":"9","author":"Horowitz","year":"2002","journal-title":"Acad Emerg Med"},{"key":"10.1016\/j.annemergmed.2015.03.016_bib7","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1067\/mem.2003.110","article-title":"Droperidol, QT prolongation, and sudden death: what is the evidence?","volume":"41","author":"Kao","year":"2003","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.annemergmed.2015.03.016_bib8","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.annemergmed.2010.05.037","article-title":"Randomized controlled trial of intramuscular droperidol versus midazolam for violence and acute behavioral disturbance: the DORM study","volume":"56","author":"Isbister","year":"2010","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.annemergmed.2015.03.016_bib9","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.annemergmed.2005.07.003","article-title":"Randomized clinical trial comparing intravenous midazolam and droperidol for sedation of the acutely agitated patient in the emergency department","volume":"47","author":"Knott","year":"2006","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.annemergmed.2015.03.016_bib10","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1111\/j.1742-6723.2011.01484.x","article-title":"Sedation assessment tool to score acute behavioural disturbance in the emergency department","volume":"23","author":"Calver","year":"2011","journal-title":"Emerg Med Australas"},{"key":"10.1016\/j.annemergmed.2015.03.016_bib11","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/bcp.12040","article-title":"Drug induced QT prolongation: the measurement and assessment of the QT interval in clinical practice","volume":"76","author":"Isbister","year":"2013","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.annemergmed.2015.03.016_bib12","doi-asserted-by":"crossref","first-page":"884","DOI":"10.3109\/15563650903333820","article-title":"Inter-rater reliability of manual QT measurement and prediction of abnormal QT,HR pairs","volume":"47","author":"Isbister","year":"2009","journal-title":"Clin Toxicol (Phila)"},{"key":"10.1016\/j.annemergmed.2015.03.016_bib13","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1093\/qjmed\/hcm072","article-title":"Drug-induced QT prolongation and torsades de pointes: evaluation of a QT nomogram","volume":"100","author":"Chan","year":"2007","journal-title":"QJM"},{"key":"10.1016\/j.annemergmed.2015.03.016_bib14","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3109\/15563650.2015.1014044","article-title":"How do we assess whether the QT interval is abnormal:\u00a0myths,\u00a0formulae and fixed opinion","volume":"53","author":"Isbister","year":"2015","journal-title":"Clin Toxicol (Phila)"},{"key":"10.1016\/j.annemergmed.2015.03.016_bib15","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.annemergmed.2014.12.005","article-title":"Prolonged QT risk assessment in antipsychotic overdose using the QT nomogram","volume":"66","author":"Berling","year":"2015","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.annemergmed.2015.03.016_bib16","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1192\/bjp.bp.114.150227","article-title":"Droperidol v. haloperidol for sedation of aggressive behaviour in acute mental health: randomised controlled trial","volume":"206","author":"Calver","year":"2015","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.annemergmed.2015.03.016_bib17","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.annemergmed.2012.07.118","article-title":"Intravenous droperidol or olanzapine as an adjunct to midazolam for the acutely agitated patient: a multicenter, randomized, double-blind, placebo-controlled clinical trial","volume":"61","author":"Chan","year":"2013","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.annemergmed.2015.03.016_bib18","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1742-6723.2008.01066.x","article-title":"Safety and effectiveness of high-dose midazolam for severe behavioural disturbance in an emergency department with suspected psychostimulant-affected patients","volume":"20","author":"Spain","year":"2008","journal-title":"Emerg Med Australas"},{"key":"10.1016\/j.annemergmed.2015.03.016_bib19","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1111\/j.1553-2712.2005.tb01492.x","article-title":"Management of acute undifferentiated agitation in the emergency department: a randomized double-blind trial of droperidol, ziprasidone, and midazolam","volume":"12","author":"Martel","year":"2005","journal-title":"Acad Emerg Med"},{"key":"10.1016\/j.annemergmed.2015.03.016_bib20","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S0736-4679(98)00045-6","article-title":"Chemical restraint for the agitated patient in the emergency department: lorazepam versus droperidol","volume":"16","author":"Richards","year":"1998","journal-title":"J\u00a0Emerg Med"},{"key":"10.1016\/j.annemergmed.2015.03.016_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/jpet.104.073288","article-title":"Dynamic beat-to-beat modeling of the QT-RR interval relationship: analysis of QT prolongation during alterations of autonomic state versus human ether a-go-go-related gene inhibition","volume":"312","author":"Fossa","year":"2005","journal-title":"J Pharmacol Exp Ther"}],"container-title":["Annals of Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019606441500222X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019606441500222X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T08:33:25Z","timestamp":1717835605000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S019606441500222X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S019606441500222X"],"URL":"https:\/\/doi.org\/10.1016\/j.annemergmed.2015.03.016","relation":{},"ISSN":["0196-0644"],"issn-type":[{"value":"0196-0644","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]}}}