{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T19:51:13Z","timestamp":1787601073322,"version":"build-2736575974"},"reference-count":72,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Epidemiology"],"published-print":{"date-parts":[[2007,5]]},"DOI":"10.1016\/j.annepidem.2007.01.006","type":"journal-article","created":{"date-parts":[[2007,5,2]],"date-time":"2007-05-02T10:37:24Z","timestamp":1178102244000},"page":"S24-S31","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":62,"special_numbering":"S","title":["Mechanism by which Alcohol and Wine Polyphenols Affect Coronary Heart Disease Risk"],"prefix":"10.1016","volume":"17","author":[{"given":"Francois M.","family":"Booyse","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wensheng","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hernan E.","family":"Grenett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale A.","family":"Parks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor M.","family":"Darley-Usmar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelley M.","family":"Bradley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edlue M.","family":"Tabengwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.annepidem.2007.01.006_bib1","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.2105\/AJPH.91.9.1499","article-title":"Local increases in coronary heart disease mortality among blacks and whites in the United States, 1985\u20131995","volume":"91","author":"Barnett","year":"2001","journal-title":"Am J Public Health"},{"key":"10.1016\/j.annepidem.2007.01.006_bib2","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1136\/jech.2004.024349","article-title":"Total and cause specific mortality among participants and non-participants of population based health surveys: a comprehensive follow up of 54 372 Finnish men and women","volume":"59","author":"Jousilahti","year":"2005","journal-title":"J Epidemiol Community Health"},{"key":"10.1016\/j.annepidem.2007.01.006_bib3","first-page":"860","article-title":"First myocardial infarction in a Dutch general practice population: trends in incidence from 1975\u20132003","volume":"55","author":"Bakx","year":"2005","journal-title":"Br J Gen Pract"},{"key":"10.1016\/j.annepidem.2007.01.006_bib4","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.amjcard.2005.11.036","article-title":"Electrocardiographic findings and incident coronary heart disease among participants in the atherosclerosis risk in communities (ARIC) Study","volume":"97","author":"Machado","year":"2006","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.annepidem.2007.01.006_bib5","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.ahj.2005.04.024","article-title":"Trends in community mortality due to coronary heart disease","volume":"151","author":"Goldberg","year":"2006","journal-title":"Am Heart J"},{"key":"10.1016\/j.annepidem.2007.01.006_bib6","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1136\/bmj.309.6959.911","article-title":"Mortality in relation to consumption of alcohol: 13 years' observations on male British doctors.","volume":"309","author":"Doll","year":"1994","journal-title":"BMJ"},{"key":"10.1016\/j.annepidem.2007.01.006_bib7","doi-asserted-by":"crossref","first-page":"652","DOI":"10.15288\/jsa.2000.61.652","article-title":"A moderate intake of wine is associated with reduced total mortality and reduced mortality from cardiovascular disease","volume":"61","author":"Theobald","year":"2000","journal-title":"J Stud Alcohol"},{"key":"10.1016\/j.annepidem.2007.01.006_bib8","first-page":"173","article-title":"Overview of epidemiological studies on wine, health and mortality","volume":"29","author":"Ruf","year":"2003","journal-title":"Drugs Exp Clin Res"},{"key":"10.1016\/j.annepidem.2007.01.006_bib9","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1097\/01.hjr.0000118174.70522.20","article-title":"Changes in alcohol intake and risk of coronary heart disease and all-cause mortality in the MONICA\/KORA-Augsburg cohort 1987\u201397","volume":"11","author":"Wellmann","year":"2004","journal-title":"Eur J Cardiovasc Prev Rehabil"},{"key":"10.1016\/j.annepidem.2007.01.006_bib10","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1093\/ajcn\/80.3.621","article-title":"Moderate wine drinkers have lower hypertension-related mortality: a prospective cohort study in French men","volume":"80","author":"Renaud","year":"2004","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.annepidem.2007.01.006_bib11","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/j.1749-6632.2002.tb02935.x","article-title":"The in vivo antithrombotic effect of wine consumption on human blood platelets and hemostatic factors","volume":"957","author":"Mansvelt","year":"2002","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.annepidem.2007.01.006_bib12","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1161\/01.CIR.0000029745.63708.E9","article-title":"Wine drinking and risks of cardiovascular complications after recent acute myocardial infarction","volume":"106","author":"de Lorgeril","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.annepidem.2007.01.006_bib13","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/clc.4950260704","article-title":"Type of alcoholic beverage and first acute myocardial infarction: a case-control study in a Mediterranean country","volume":"26","author":"Fernandez-Jarne","year":"2003","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.annepidem.2007.01.006_bib14","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1097\/01.ede.0000142146.36594.9a","article-title":"Alcohol consumption and acute myocardial infarction: a benefit of alcohol consumed with meals?","volume":"15","author":"Augustin","year":"2004","journal-title":"Epidemiology"},{"key":"10.1016\/j.annepidem.2007.01.006_bib15","doi-asserted-by":"crossref","first-page":"881","DOI":"10.7326\/0003-4819-116-11-881","article-title":"The Multiple Risk Factor Intervention Trial Research Group. Alcohol use and mortality form coronary heart disease: the role of high-density lipoprotein cholesterol","volume":"116","author":"Suh","year":"1992","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.annepidem.2007.01.006_bib16","doi-asserted-by":"crossref","first-page":"183","DOI":"10.4067\/S0716-97602004000200002","article-title":"Alcohol and mortality from all causes","volume":"37","author":"Renaud","year":"2004","journal-title":"Biol Res"},{"key":"10.1016\/j.annepidem.2007.01.006_bib17","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1161\/CIRCULATIONAHA.105.537704","article-title":"Drinking frequency, mediating biomarkers, and risk of myocardial infarction in women and men","volume":"112","author":"Mukamal","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.annepidem.2007.01.006_bib18","first-page":"528","article-title":"Effects of acute, moderate ethanol consumption on human platelet aggregation in platelet-rich plasma and whole blood","volume":"24","author":"Zhang","year":"2000","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.annepidem.2007.01.006_bib19","doi-asserted-by":"crossref","first-page":"209","DOI":"10.4067\/S0716-97602004000200006","article-title":"Alcohol, wine and platelet function","volume":"37","author":"Ruf","year":"2004","journal-title":"Biol Res"},{"key":"10.1016\/j.annepidem.2007.01.006_bib20","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1073\/pnas.94.7.3235","article-title":"Regular alcohol consumption mimics cardiac preconditioning by protecting against ischemia-reperfusion injury","volume":"94","author":"Miyamae","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.annepidem.2007.01.006_bib21","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.yjmcc.2004.02.003","article-title":"Cardioprotective effect of chronic low dose ethanol drinking: insights into the concept of ethanol preconditioning","volume":"36","author":"Guiraud","year":"2004","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.annepidem.2007.01.006_bib22","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1097\/00005344-200108000-00007","article-title":"Effects of red wine, alcohol, and quercetin on coronary resistance and conductance arteries","volume":"38","author":"Rendig","year":"2001","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.annepidem.2007.01.006_bib23","doi-asserted-by":"crossref","first-page":"20927","DOI":"10.1074\/jbc.M110712200","article-title":"Dose-dependent activation of antiapoptotic and proapoptotic pathways by ethanol treatment in human vascular endothelial cells. differential involvement of adenosine","volume":"277","author":"Liu","year":"2002","journal-title":"J Biol Chem"},{"issue":"Suppl","key":"10.1016\/j.annepidem.2007.01.006_bib24","first-page":"S96","article-title":"Effects of alcohol on hemostasis","volume":"123","author":"Salem","year":"2005","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.annepidem.2007.01.006_bib25","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1111\/j.1530-0277.1999.tb04093.x","article-title":"Alcohol at moderate levels decrease fibrinogen expression in vivo and in vitro","volume":"23","author":"Wang","year":"1999","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.annepidem.2007.01.006_bib26","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1001\/jama.1994.03520120039028","article-title":"Association of moderate alcohol consumption and plasma concentration of endogenous tissue-type plasminogen activator","volume":"272","author":"Ridker","year":"1994","journal-title":"JAMA"},{"key":"10.1016\/j.annepidem.2007.01.006_bib27","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/0268-9499(90)90362-N","article-title":"Alcohol and fibrinolysis","volume":"4","author":"Veenstra","year":"1995","journal-title":"Fibrinolysis"},{"key":"10.1016\/j.annepidem.2007.01.006_bib28","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1111\/j.1530-0277.1997.tb04478.x","article-title":"Ethanol increases surface-localized fibrinolytic activity in cultured endothelial cells","volume":"21","author":"Aikens","year":"1997","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.annepidem.2007.01.006_bib29","first-page":"351","article-title":"Ethanol-induced increased surface-localized fibrinolytic activity in cultured human endothelial cells: kinetic analysis","volume":"25","author":"Abou-Agag","year":"2001","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.annepidem.2007.01.006_bib30","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1001\/archinte.163.19.2368","article-title":"Effects of lifestyle on hemostasis, fibrinolysis, and platelet reactivity: a systematic review","volume":"163","author":"Lee","year":"2003","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.annepidem.2007.01.006_bib31","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1055\/s-2004-835376","article-title":"Drink to prevent: review on the cardioprotective mechanisms of alcohol and red wine polyphenols","volume":"4","author":"de Lange","year":"2004","journal-title":"Semin Vasc Med"},{"key":"10.1016\/j.annepidem.2007.01.006_bib32","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0014-2999(96)00644-9","article-title":"Effect of chronic moderate ethanol consumption on heart brain natriuretic peptide","volume":"316","author":"Guillaume","year":"1996","journal-title":"Eur J Pharmacol"},{"issue":"9","key":"10.1016\/j.annepidem.2007.01.006_bib33","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1111\/j.1530-0277.2000.tb02117.x","article-title":"Alcohol inhibits the progression as well as the initiation of atherosclerotic lesions in C57Bl\/6 hyperlipidemic mice","volume":"24","author":"Emeson","year":"2000","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.annepidem.2007.01.006_bib34","doi-asserted-by":"crossref","first-page":"384","DOI":"10.7326\/0003-4819-125-5-199609010-00005","article-title":"Relation between intake of flavonoids and risk for coronary heart disease in male health professionals","volume":"125","author":"Rimm","year":"1996","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.annepidem.2007.01.006_bib35","first-page":"H1183","article-title":"Effects of red and white wine on endothelium-dependent vasorelaxation of rat aorta and human coronary arteries","volume":"275","author":"Flesch","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.annepidem.2007.01.006_bib36","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1097\/00005344-199902000-00011","article-title":"Mechanism of endothelial nitric oxide-dependent vasorelaxation induced by wine polyphenols in rat thoracic aorta","volume":"33","author":"Andriambeloson","year":"1999","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.annepidem.2007.01.006_bib37","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.ijcard.2005.01.013","article-title":"Effects of resveratrol on vascular tone and endothelial function of human saphenous vein and internal mammary artery","volume":"105","author":"Rakici","year":"2005","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.annepidem.2007.01.006_bib38","doi-asserted-by":"crossref","first-page":"2744","DOI":"10.1161\/01.ATV.17.11.2744","article-title":"Reduced progression of atherosclerosis in apolipoprotein E-deficient mice following consumption of red wine, or its polyphenols quercetin or catechin, is associated with reduced susceptibility of LDL to oxidation and aggregation","volume":"17","author":"Hayek","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.annepidem.2007.01.006_bib39","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1749-6632.2002.tb02913.x","article-title":"Wine flavonoids protect against LDL oxidation and atherosclerosis 3","volume":"957","author":"Aviram","year":"2002","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.annepidem.2007.01.006_bib40","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/414863a","article-title":"Endothelin-1 synthesis reduced by red wine","volume":"414","author":"Corder","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.annepidem.2007.01.006_bib41","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.ejphar.2004.07.034","article-title":"Vascular protection by dietary polyphenols","volume":"500","author":"Stoclet","year":"2004","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.annepidem.2007.01.006_bib42","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1046\/j.1538-7836.2003.00217.x","article-title":"Resveratrol and quercetin down-regulate tissue factor expression by human stimulated vascular cells","volume":"1","author":"Di Santo","year":"2003","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.annepidem.2007.01.006_bib43","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1161\/01.CIR.0000136027.98303.4D","article-title":"Moderate daily intake of red wine inhibits mural thrombosis and monocyte tissue factor expression in an experimental porcine model","volume":"110","author":"Casani","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.annepidem.2007.01.006_bib44","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1046\/j.1538-7836.2003.00217.x","article-title":"Resveratrol and quercetin down-regulate tissue factor expression by human stimulated vascular cells","volume":"1","author":"Di Santo","year":"2003","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.annepidem.2007.01.006_bib45","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/j.1538-7836.2005.01126.x","article-title":"Alcohol-free red wine prevents arterial thrombosis in dietary-induced hypercholesterolemic rats: experimental support for the \u2018French paradox\u2019","volume":"3","author":"De Curtis","year":"2005","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.annepidem.2007.01.006_bib46","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1093\/jn\/135.10.2291","article-title":"Cardioprotective effects of dietary polyphenols","volume":"135","author":"Zern","year":"2005","journal-title":"J Nutr"},{"key":"10.1016\/j.annepidem.2007.01.006_bib47","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/sj.ejcn.1602265","article-title":"Effects of moderate Sicilian red wine consumption on inflammatory biomarkers of atherosclerosis","volume":"60","author":"Avellone","year":"2006","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.annepidem.2007.01.006_bib48","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1046\/j.1538-7836.2003.00294.x","article-title":"Flavonoid inhibition of platelet procoagulant activity and phosphoinositide synthesis","volume":"1","author":"Bucki","year":"2003","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.annepidem.2007.01.006_bib49","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1111\/j.1538-7836.2004.01067.x","article-title":"Ingestion of quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in humans","volume":"2","author":"Hubbard","year":"2004","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.annepidem.2007.01.006_bib50","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1161\/01.CIR.101.7.805","article-title":"Red wine polyphenols inhibit proliferation of vascular smooth muscle cells and downregulate expression of cyclin A gene","volume":"101","author":"Iijima","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.annepidem.2007.01.006_bib51","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1067\/msy.2002.119190","article-title":"Quercetin inhibits human vascular smooth muscle cell proliferation and migration","volume":"131","author":"Alcocer","year":"2002","journal-title":"Surgery"},{"key":"10.1016\/j.annepidem.2007.01.006_bib52","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0378-8741(99)00055-0","article-title":"Effects of quercetin on the release of\u00a0endothelin, prostacyclin and tissue plasminogen activator from human endothelial cells in culture","volume":"67","author":"Zhao","year":"1999","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.annepidem.2007.01.006_bib53","first-page":"155","article-title":"Polyphyenolics increase t-PA and u-PA gene transcription in cultured human endothelial cells","volume":"25","author":"Abou-Agag","year":"2001","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.annepidem.2007.01.006_bib54","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1749-6632.2001.tb03511.x","article-title":"Elements of the fibrinolytic system","volume":"936","author":"Lijnen","year":"2001","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.annepidem.2007.01.006_bib55","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1172\/JCI115405","article-title":"The plasminogen activator\/plasmin system","volume":"88","author":"Vassalli","year":"1991","journal-title":"J Clin Invest"},{"key":"10.1016\/j.annepidem.2007.01.006_bib56","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0950-3536(05)80268-9","article-title":"Mechanisms of physiological fibrinolysis","volume":"8","author":"Lijnen","year":"1995","journal-title":"Baillieres Clin Haematol"},{"key":"10.1016\/j.annepidem.2007.01.006_bib57","doi-asserted-by":"crossref","first-page":"21198","DOI":"10.1016\/S0021-9258(17)31948-8","article-title":"An endothelial cell receptor for plasminogen\/tissue plasminogen activator (t-PA). II. Annexin II-mediated enhancement of t-PA-dependent plasminogen activator","volume":"269","author":"Cesarman","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/j.annepidem.2007.01.006_bib58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0268-9499(92)90086-W","article-title":"Characterization and regulation of the urokinase receptor of human endothelial cells","volume":"6","author":"Barnathan","year":"1992","journal-title":"Fibrinolysis"},{"key":"10.1016\/j.annepidem.2007.01.006_bib59","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1001\/jama.1983.03340060050025","article-title":"Ethyl alcohol enhances plasminogen activator secretion by endothelial cells","volume":"250","author":"Laug","year":"1983","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.annepidem.2007.01.006_bib60","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0268-9499(97)80104-X","article-title":"Ethanol-induced alterations in the expression of endothelial-derived fibrinolytic components","volume":"11","author":"Venkov","year":"1997","journal-title":"Fibrinol Proteol"},{"key":"10.1016\/j.annepidem.2007.01.006_bib61","doi-asserted-by":"crossref","first-page":"12055","DOI":"10.1074\/jbc.274.17.12055","article-title":"Activation of guanine nucleotide-binding proteins and induction of endothelial tissue-type plasminogen activator gene transcription by alcohol","volume":"274","author":"Miyamoto","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.annepidem.2007.01.006_bib62","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1530-0277.1998.tb03663.x","article-title":"Alcohol-induced up-regulation of plasminogen activators and fibrinolytic activity in cultured human endothelial cells","volume":"22","author":"Aikens","year":"1998","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.annepidem.2007.01.006_bib63","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1111\/j.1530-0277.1998.tb03878.x","article-title":"Ethanol transcriptionally upregulates t-PA and u-PA gene expression in cultured human endothelial cells","volume":"22","author":"Grenett","year":"1998","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.annepidem.2007.01.006_bib64","first-page":"754","article-title":"Ethanol-induced up-regulation of candidate plasminogen receptor annexin II in cultured human endothelial cells","volume":"24","author":"Tabengwa","year":"2000","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.annepidem.2007.01.006_bib65","first-page":"163","article-title":"Ethanol-induced up-regulation of the urokinase receptor in cultured human endothelial cells","volume":"25","author":"Tabengwa","year":"2001","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.annepidem.2007.01.006_bib66","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0049-3848(99)00172-3","article-title":"Ethanol downregulates transcription of the PAI-1 gene in cultured human endothelial cells","volume":"97","author":"Grenett","year":"2000","journal-title":"Thromb Res"},{"key":"10.1016\/j.annepidem.2007.01.006_bib67","first-page":"629","article-title":"Identification of a 251-bp fragment of the PAI-1 gene promoter that mediates the ethanol-induced suppression of PAI-1 expression","volume":"25","author":"Grenett","year":"2001","journal-title":"Alcohol Clin Exp Res"},{"issue":"3 Suppl A","key":"10.1016\/j.annepidem.2007.01.006_bib68","first-page":"367A","article-title":"Wine components activate t-PA gene transcription through the JNK and p38 mitogen activated protein kinase pathways","volume":"45","author":"Tabengwa","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.annepidem.2007.01.006_bib69","unstructured":"Pan W, Booyse FM, Grenett HE, Pasten MC, Drawz SL, Tabengwa EM. Alcohol induction of tissue plasminogen activator expression in human endothelial cells through Sp1 and NFkappaB activation: involvement of p38 MAPK pathway. Arterioscler Thromb Vasc Biol. In press."},{"key":"10.1016\/j.annepidem.2007.01.006_bib70","unstructured":"Pan W, Booyse FM, Bradley KM, Tabengwa EM. Transcriptional activation of tissue plasminogen activator by dietary polyphenols catechin and quercetin is mediated through Sp1 and NFkappaB: involvement of p38 MAPK pathway. Arterioscler Thromb Vasc Biol. In press."},{"key":"10.1016\/j.annepidem.2007.01.006_bib71","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1182\/blood.V96.5.1820","article-title":"Urokinase mediates fibrinolysis in the pulmonary microvasculature","volume":"96","author":"Bdeir","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.annepidem.2007.01.006_bib72","unstructured":"Pan W, Booyse FM, Grenett HE, Parks DA, Zinn K, Tabengwa EM. Development of a real-time fluorescence imaging in vivo clot lysis method: alcohol- and polyphenol (catechin and quercetin)-induced effects. Thromb Haemost. In press."}],"container-title":["Annals of Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1047279707000087?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1047279707000087?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T02:03:14Z","timestamp":1760925794000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1047279707000087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":72,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["S1047279707000087"],"URL":"https:\/\/doi.org\/10.1016\/j.annepidem.2007.01.006","relation":{},"ISSN":["1047-2797"],"issn-type":[{"value":"1047-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2007,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanism by which Alcohol and Wine Polyphenols Affect Coronary Heart Disease Risk","name":"articletitle","label":"Article Title"},{"value":"Annals of Epidemiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.annepidem.2007.01.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}