{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:43:20Z","timestamp":1790405000298,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"National Heart, Lung, and Blood Institute Division of Intramural Research"},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01-HC-25195"],"award-info":[{"award-number":["N01-HC-25195"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01-HL-48157"],"award-info":[{"award-number":["R01-HL-48157"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Epidemiology"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.annepidem.2015.01.010","type":"journal-article","created":{"date-parts":[[2015,1,31]],"date-time":"2015-01-31T00:29:44Z","timestamp":1422664184000},"page":"492-498","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"title":["Cardiovascular correlates of platelet count and volume in the Framingham Heart Study"],"prefix":"10.1016","volume":"25","author":[{"given":"Arielle","family":"Sloan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philimon","family":"Gona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.annepidem.2015.01.010_bib1","first-page":"17","article-title":"Platelet count and MPV, routinely measured but ignored parameters used in conjunction with the diagnosis of acute coronary syndrome: single study center in Iranian population, 2010","volume":"26","author":"Mirzaie","year":"2012","journal-title":"Med J Islam Repub Iran"},{"issue":"2","key":"10.1016\/j.annepidem.2015.01.010_bib2","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1179\/102453311X12902908412110","article-title":"Platelet indices in diabetes mellitus: indicators of diabetic microvascular complications","volume":"16","author":"Jindal","year":"2011","journal-title":"Hematology"},{"issue":"5","key":"10.1016\/j.annepidem.2015.01.010_bib3","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1046\/j.1469-0705.2002.00672.x","article-title":"Platelet changes and subsequent development of pre-eclampsia and fetal growth restriction in women with abnormal uterine artery Doppler screening","volume":"19","author":"Missfelder-Lobos","year":"2002","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"3","key":"10.1016\/j.annepidem.2015.01.010_bib4","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1177\/107602960401000314","article-title":"Effect of smoking on platelet count and platelet parameters: an observation","volume":"10","author":"Suwansaksri","year":"2004","journal-title":"Clin Appl Thromb Hemost"},{"issue":"1","key":"10.1016\/j.annepidem.2015.01.010_bib5","doi-asserted-by":"crossref","first-page":"96","DOI":"10.3324\/haematol.2010.029934","article-title":"Analysis of 12,517 inhabitants of a Sardinian geographic isolate reveals that predispositions to thrombocytopenia and thrombocytosis are inherited traits","volume":"96","author":"Biino","year":"2011","journal-title":"Haematologica"},{"issue":"1","key":"10.1016\/j.annepidem.2015.01.010_bib6","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3109\/09537104.2014.880415","article-title":"Platelet count can predict metabolic syndrome in older women","volume":"26","author":"Chen","year":"2015","journal-title":"Platelets"},{"issue":"1","key":"10.1016\/j.annepidem.2015.01.010_bib7","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0895-4356(92)90191-O","article-title":"Gender differences in platelet count and its association with cigarette smoking in a large cohort in Israel","volume":"45","author":"Green","year":"1991","journal-title":"J\u00a0Clin Epidemiol"},{"issue":"8","key":"10.1016\/j.annepidem.2015.01.010_bib8","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.3324\/haematol.2011.043042","article-title":"White blood cell count, sex and age are major determinants of heterogeneity of platelet indices in an adult general population: results from the MOLI-SANI project","volume":"96","author":"Santimone","year":"2011","journal-title":"Haematologica"},{"issue":"11","key":"10.1016\/j.annepidem.2015.01.010_bib9","first-page":"273","article-title":"The relationship of white blood cell and platelet counts to cigarette smoking in adult Nigerians","volume":"36","author":"Aghaji","year":"1990","journal-title":"Cent Afr J Med"},{"issue":"6","key":"10.1016\/j.annepidem.2015.01.010_bib10","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1080\/00039896.1988.9935859","article-title":"Traffic noise and cardiovascular risk. The Caerphilly study, first phase. Outdoor noise levels and risk factors","volume":"43","author":"Babisch","year":"1988","journal-title":"Arch Environ Health"},{"issue":"2","key":"10.1016\/j.annepidem.2015.01.010_bib11","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.annepidem.2005.06.052","article-title":"Platelet counts differ by sex, ethnicity, and age in the United States","volume":"16","author":"Segal","year":"2006","journal-title":"Ann Epidemiol"},{"issue":"Suppl 1","key":"10.1016\/j.annepidem.2015.01.010_bib12","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/j.1538-7836.2011.04359.x","article-title":"The genetics of common variation affecting platelet development, function and pharmaceutical targeting","volume":"9","author":"Johnson","year":"2011","journal-title":"J\u00a0Thromb Haemost"},{"issue":"1","key":"10.1016\/j.annepidem.2015.01.010_bib13","first-page":"127","article-title":"Use of mean platelet volume improves detection of platelet disorders","volume":"11","author":"Bessman","year":"1985","journal-title":"Blood Cells"},{"key":"10.1016\/j.annepidem.2015.01.010_bib14","unstructured":"NHLBI. What causes thrombocytopenia? 2012. Retrieved 1\/7\/2015 from http:\/\/www.nhlbi.nih.gov\/health\/health-topics\/topics\/thcp Ref Type: Online Source."},{"issue":"10","key":"10.1016\/j.annepidem.2015.01.010_bib15","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1111\/j.1742-1241.2009.02070.x","article-title":"The relationship of mean platelet volume with\u00a0the risk and prognosis of cardiovascular diseases","volume":"63","author":"Vizioli","year":"2009","journal-title":"Int J Clin Pract"},{"issue":"3","key":"10.1016\/j.annepidem.2015.01.010_bib16","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.thromres.2012.05.009","article-title":"Large population study for the reference range of mean platelet volume in Korean individuals","volume":"130","author":"Cho","year":"2012","journal-title":"Thromb Res"},{"key":"10.1016\/j.annepidem.2015.01.010_bib17","doi-asserted-by":"crossref","unstructured":"Nebe T, Bentzien F, Bruegel M, Fiedler GM, Gutensohn K, Heimpel H, et\u00a0al. Multi-centric determination of reference ranges for automated blood counts. Laboratoriums Medizin 35(1). 4\u20135-0011.","DOI":"10.1515\/JLM.2011.004_engl"},{"issue":"1","key":"10.1016\/j.annepidem.2015.01.010_bib18","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/j.1538-7836.2009.03584.x","article-title":"Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis","volume":"8","author":"Chu","year":"2010","journal-title":"J\u00a0Thromb Haemost"},{"issue":"6","key":"10.1016\/j.annepidem.2015.01.010_bib19","doi-asserted-by":"crossref","first-page":"447","DOI":"10.3109\/09537104.2011.565431","article-title":"Increased mean platelet volume is associated with arterial stiffness","volume":"22","author":"Wang","year":"2011","journal-title":"Platelets"},{"issue":"1","key":"10.1016\/j.annepidem.2015.01.010_bib20","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1471-2261-13-40","article-title":"Mean platelet volume is associated with the presence of left atrial stasis in patients with non-valvular atrial fibrillation","volume":"13","author":"Providencia","year":"2013","journal-title":"BMC Cardiovasc Disord"},{"issue":"9","key":"10.1016\/j.annepidem.2015.01.010_bib21","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1136\/jcp.2009.066787","article-title":"Significance of platelet volume indices and platelet count in ischaemic heart disease","volume":"62","author":"Ranjith","year":"2009","journal-title":"J\u00a0Clin Pathol"},{"issue":"9","key":"10.1016\/j.annepidem.2015.01.010_bib22","first-page":"1133","article-title":"Role of platelet parameters and haematological indices in myocardial infarction and unstable angina","volume":"63","author":"Yaghoubi","year":"2013","journal-title":"J\u00a0Pak Med Assoc"},{"issue":"3","key":"10.1016\/j.annepidem.2015.01.010_bib23","doi-asserted-by":"crossref","first-page":"279","DOI":"10.2105\/AJPH.41.3.279","article-title":"Epidemiological approaches to heart disease: the Framingham Study","volume":"41","author":"Dawber","year":"1951","journal-title":"Am J Public Health Nations Health"},{"issue":"4","key":"10.1016\/j.annepidem.2015.01.010_bib24","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/0091-7435(75)90037-7","article-title":"The Framingham Offspring Study. Design and preliminary data","volume":"4","author":"Feinleib","year":"1975","journal-title":"Prev Med"},{"issue":"11","key":"10.1016\/j.annepidem.2015.01.010_bib25","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1093\/aje\/kwm021","article-title":"The third generation cohort of the National Heart, Lung, and Blood Institute's Framingham Heart Study: design, recruitment, and initial examination","volume":"165","author":"Splansky","year":"2007","journal-title":"Am J Epidemiol"},{"issue":"Suppl 2","key":"10.1016\/j.annepidem.2015.01.010_bib26","first-page":"B5","article-title":"Type 2 diabetes worldwide according to the new classification and criteria","volume":"23","author":"Shaw","year":"2000","journal-title":"Diabetes Care"},{"issue":"2","key":"10.1016\/j.annepidem.2015.01.010_bib27","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s11357-011-9349-7","article-title":"Changing prediction of mortality by systolic blood pressure with increasing age: the Rotterdam study","volume":"35","author":"Blom","year":"2013","journal-title":"Age (Dordr)"},{"issue":"5","key":"10.1016\/j.annepidem.2015.01.010_bib28","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1001\/jama.2012.39","article-title":"Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010","volume":"307","author":"Flegal","year":"2012","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.annepidem.2015.01.010_bib29","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.thromres.2005.06.021","article-title":"Platelet count, mean platelet volume and thrombocytopoietic indices in healthy women and men","volume":"118","author":"Butkiewicz","year":"2006","journal-title":"Thromb Res"},{"issue":"3","key":"10.1016\/j.annepidem.2015.01.010_bib30","first-page":"367","article-title":"Effect of cigarette smoking and 3.2% ethanol alone or together on RBC and platelet counts in rats","volume":"46","author":"Nagvekar","year":"2002","journal-title":"Indian J Physiol Pharmacol"},{"issue":"11","key":"10.1016\/j.annepidem.2015.01.010_bib31","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1194\/jlr.P037614","article-title":"Relationship between serum cholesterol and indices of erythrocytes and platelets in the US population","volume":"54","author":"Fessler","year":"2013","journal-title":"J\u00a0Lipid Res"},{"issue":"23","key":"10.1016\/j.annepidem.2015.01.010_bib32","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1101\/gad.1128003","article-title":"Proplatelet formation of megakaryocytes is triggered by autocrine-synthesized estradiol","volume":"17","author":"Nagata","year":"2003","journal-title":"Genes Dev"},{"issue":"1","key":"10.1016\/j.annepidem.2015.01.010_bib33","doi-asserted-by":"crossref","first-page":"e54289","DOI":"10.1371\/journal.pone.0054289","article-title":"Age- and sex-related variations in platelet count in Italy: a proposal of reference ranges based on 40987 subjects' data","volume":"8","author":"Biino","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.annepidem.2015.01.010_bib34","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.ijcard.2005.06.037","article-title":"The effect of oestrogen on megakaryocyte differentiation and platelet counts in\u00a0vivo","volume":"109","author":"Fox","year":"2006","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.annepidem.2015.01.010_bib35","doi-asserted-by":"crossref","first-page":"834153","DOI":"10.1155\/2008\/834153","article-title":"Platelet counts and platelet activation markers in obese subjects","volume":"2008","author":"Samocha-Bonet","year":"2008","journal-title":"Mediators Inflamm"},{"issue":"3","key":"10.1016\/j.annepidem.2015.01.010_bib36","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1515\/CCLM.2007.063","article-title":"Clustered components of the metabolic syndrome and platelet counts in Japanese females","volume":"45","author":"Kotani","year":"2007","journal-title":"Clin Chem Lab Med"},{"issue":"2","key":"10.1016\/j.annepidem.2015.01.010_bib37","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1161\/CIRCULATIONAHA.109.928192","article-title":"Relation of platelet and leukocyte inflammatory transcripts to body mass index in the Framingham Heart Study","volume":"122","author":"Freedman","year":"2010","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.annepidem.2015.01.010_bib38","doi-asserted-by":"crossref","first-page":"75","DOI":"10.5505\/tjb.2013.68077","article-title":"Effect of cigarette smoking based on hematological parameters: comparison between male smokers and non-smokers","volume":"38","author":"Asif","year":"2013","journal-title":"Turkish J Biochem"},{"issue":"7","key":"10.1016\/j.annepidem.2015.01.010_bib39","doi-asserted-by":"crossref","first-page":"560","DOI":"10.5551\/jat.6288","article-title":"Association of platelet aggregation with lipid levels in the Japanese population: the Suita study","volume":"18","author":"Kameda","year":"2011","journal-title":"J\u00a0Atheroscler Thromb"},{"issue":"11","key":"10.1016\/j.annepidem.2015.01.010_bib40","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1161\/ATVBAHA.112.301112","article-title":"Relationship among circulating inflammatory proteins, platelet gene expression, and cardiovascular risk","volume":"33","author":"McManus","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"3","key":"10.1016\/j.annepidem.2015.01.010_bib41","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1159\/000040940","article-title":"Influence of aspirin on platelet count and volume in humans","volume":"101","author":"Erhart","year":"1999","journal-title":"Acta Haematol"},{"issue":"19","key":"10.1016\/j.annepidem.2015.01.010_bib42","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1182\/blood-2013-12-541672","article-title":"Adherence to the Mediterranean diet is associated with lower platelet and leukocyte counts: results from the Moli-sani study","volume":"123","author":"Bonaccio","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.annepidem.2015.01.010_bib43","article-title":"Short- and long-term exercise induced alterations in haemostasis: a review of the literature","author":"Posthuma","year":"2014","journal-title":"Blood Rev"},{"issue":"1","key":"10.1016\/j.annepidem.2015.01.010_bib44","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1249\/MSS.0b013e31826beae5","article-title":"Sustained and shorter bouts of physical activity are related to cardiovascular health","volume":"45","author":"Glazer","year":"2013","journal-title":"Med Sci Sports Exerc"}],"container-title":["Annals of Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1047279715000381?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1047279715000381?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T02:16:14Z","timestamp":1760926574000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1047279715000381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":44,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S1047279715000381"],"URL":"https:\/\/doi.org\/10.1016\/j.annepidem.2015.01.010","relation":{},"ISSN":["1047-2797"],"issn-type":[{"value":"1047-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardiovascular correlates of platelet count and volume in the Framingham Heart Study","name":"articletitle","label":"Article Title"},{"value":"Annals of Epidemiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.annepidem.2015.01.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}