{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T13:34:29Z","timestamp":1793712869268,"version":"4.6.1"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Epidemiology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.annepidem.2026.110293","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:26:35Z","timestamp":1790436395000},"page":"110293","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Red light, green light: Activity fragmentation and all-cause mortality in United States adults"],"prefix":"10.1016","volume":"123","author":[{"given":"Dritjon","family":"Gruda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.annepidem.2026.110293_bib1","doi-asserted-by":"crossref","first-page":"437","DOI":"10.3945\/ajcn.111.019620","article-title":"Amount of time spent in sedentary behaviors and cause-specific mortality in US adults","volume":"95","author":"Matthews","year":"2012","journal-title":"Am J Clin Nutr"},{"issue":"3","key":"10.1016\/j.annepidem.2026.110293_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0119591","article-title":"Associations of objectively assessed physical activity and sedentary time with all-cause mortality in US adults: the NHANES study","volume":"10","author":"Schmid","year":"2015","journal-title":"PLOS ONE"},{"issue":"10051","key":"10.1016\/j.annepidem.2026.110293_bib3","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/S0140-6736(16)30370-1","article-title":"Does physical activity attenuate, or even eliminate, the detrimental association of sitting time with mortality? A harmonised meta-analysis of data from more than 1 million men and women","volume":"388","author":"Ekelund","year":"2016","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.annepidem.2026.110293_bib4","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1249\/MSS.0000000000000885","article-title":"Association between objectively measured physical activity and mortality in NHANES","volume":"48","author":"Fishman","year":"2016","journal-title":"Med & Sci Sports & Exerc"},{"issue":"19","key":"10.1016\/j.annepidem.2026.110293_bib5","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1001\/jama.2018.14854","article-title":"The physical activity guidelines for Americans","volume":"320","author":"Piercy","year":"2018","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.annepidem.2026.110293_bib6","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.gaitpost.2009.09.002","article-title":"Methods for objective measure, quantification and analysis of sedentary behaviour and inactivity","volume":"31","author":"Chastin","year":"2010","journal-title":"Gait & Posture"},{"issue":"7","key":"10.1016\/j.annepidem.2026.110293_bib7","doi-asserted-by":"crossref","first-page":"465","DOI":"10.7326\/M17-0212","article-title":"Patterns of sedentary behavior and mortality in U.S. middle-aged and older adults: A national cohort study","volume":"167","author":"Diaz","year":"2017","journal-title":"Ann Intern Med"},{"issue":"4","key":"10.1016\/j.annepidem.2026.110293_bib8","doi-asserted-by":"crossref","first-page":"661","DOI":"10.2337\/dc07-2046","article-title":"Breaks in sedentary time: beneficial associations with metabolic risk","volume":"31","author":"Healy","year":"2008","journal-title":"Diabetes Care"},{"issue":"8","key":"10.1016\/j.annepidem.2026.110293_bib9","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1093\/gerona\/glt199","article-title":"Assessing the \u201cphysical cliff\u201d: detailed quantification of age-related differences in daily patterns of physical activity","volume":"69","author":"Schrack","year":"2014","journal-title":"J Gerontol Ser A"},{"issue":"4","key":"10.1016\/j.annepidem.2026.110293_bib10","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1093\/gerona\/gly243","article-title":"Active-to-sedentary behavior transitions, fatigability, and physical functioning in older adults","volume":"74","author":"Schrack","year":"2019","journal-title":"J Gerontol Ser A"},{"issue":"10","key":"10.1016\/j.annepidem.2026.110293_bib11","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.12352","article-title":"Association of total daily physical activity and fragmented physical activity with mortality in older adults","volume":"2","author":"Wanigatunga","year":"2019","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.annepidem.2026.110293_bib12","article-title":"The association of physical activity fragmentation with all-cause mortality in Hispanics: a prospective cohort study","volume":"42","author":"Mediano","year":"2025","journal-title":"Lancet Reg Health Am"},{"issue":"1","key":"10.1016\/j.annepidem.2026.110293_bib13","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1249\/mss.0b013e31815a51b3","article-title":"Physical activity in the United States measured by accelerometer","volume":"40","author":"Troiano","year":"2008","journal-title":"Med & Sci Sports & Exerc"},{"key":"10.1016\/j.annepidem.2026.110293_bib14","unstructured":"National Center for Health Statistics2022. NCHS 2019 public-use linked mortality files. Centers for Disease Control and Prevention. https:\/\/www.cdc.gov\/nchs\/data-linkage\/mortality-public.htm."},{"key":"10.1016\/j.annepidem.2026.110293_bib15","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/1479-5868-9-116","article-title":"Socioeconomic inequalities in occupational, leisure-time, and transport related physical activity among European adults: a systematic review","volume":"9","author":"Beenackers","year":"2012","journal-title":"Int J Behav Nutr Phys Act"},{"issue":"1","key":"10.1016\/j.annepidem.2026.110293_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0190737","article-title":"Socio-economic determinants of physical activity across the life course: A \u201cDEterminants of DIet and Physical ACtivity\u201d (DEDIPAC) umbrella literature review","volume":"13","author":"O\u2019Donoghue","year":"2018","journal-title":"PLOS ONE"},{"key":"10.1016\/j.annepidem.2026.110293_bib17","doi-asserted-by":"crossref","first-page":"80","DOI":"10.2307\/2626958","article-title":"Social conditions as fundamental causes of disease","volume":"35","author":"Link","year":"1995","journal-title":"J Health Social Behav"},{"issue":"1_","key":"10.1016\/j.annepidem.2026.110293_bib18","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1177\/0022146510383498","article-title":"Social conditions as fundamental causes of health inequalities: theory, evidence, and policy implications","volume":"51","author":"Phelan","year":"2010","journal-title":"J Health Social Behav"},{"issue":"3","key":"10.1016\/j.annepidem.2026.110293_bib19","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1001\/jamainternmed.2016.8014","article-title":"Association of \u201cweekend warrior\u201d and other leisure time physical activity patterns with risks for all-cause, cardiovascular disease, and cancer mortality","volume":"177","author":"O\u2019Donovan","year":"2017","journal-title":"JAMA Intern Med"},{"issue":"8","key":"10.1016\/j.annepidem.2026.110293_bib20","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1001\/jamainternmed.2022.2488","article-title":"Association of the \u201cweekend warrior\u201d and other leisure-time physical activity patterns with all-cause and cause-specific mortality: a nationwide cohort study","volume":"182","author":"dos Santos","year":"2022","journal-title":"JAMA Intern Med"},{"issue":"1","key":"10.1016\/j.annepidem.2026.110293_bib21","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1249\/JES.0000000000000275","article-title":"Exercise snacks: a novel strategy to improve cardiometabolic health","volume":"50","author":"Islam","year":"2022","journal-title":"Exerc Sport Sci Rev"},{"issue":"12","key":"10.1016\/j.annepidem.2026.110293_bib22","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1038\/s41591-022-02100-x","article-title":"Association of wearable device-measured vigorous intermittent lifestyle physical activity with mortality","volume":"28","author":"Stamatakis","year":"2022","journal-title":"Nat Med"},{"issue":"10","key":"10.1016\/j.annepidem.2026.110293_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0139984","article-title":"Combined effects of time spent in physical activity, sedentary behaviors and sleep on obesity and cardio-metabolic health markers: a novel compositional data analysis approach","volume":"10","author":"Chastin","year":"2015","journal-title":"PLOS ONE"}],"container-title":["Annals of Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1047279726002917?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1047279726002917?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T12:59:46Z","timestamp":1793710786000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1047279726002917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":23,"alternative-id":["S1047279726002917"],"URL":"https:\/\/doi.org\/10.1016\/j.annepidem.2026.110293","relation":{},"ISSN":["1047-2797"],"issn-type":[{"value":"1047-2797","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Red light, green light: Activity fragmentation and all-cause mortality in United States adults","name":"articletitle","label":"Article Title"},{"value":"Annals of Epidemiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.annepidem.2026.110293","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110293"}}