{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T20:10:54Z","timestamp":1789762254785,"version":"4.0.1"},"reference-count":16,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["annalsofoncology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Oncology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.annonc.2026.07.410","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T20:26:25Z","timestamp":1787948785000},"page":"1322-1324","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["The return of the adult thymus in radiation oncology?"],"prefix":"10.1016","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4798-8899","authenticated-orcid":false,"given":"A.","family":"Levy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Morel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Meziani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Mondini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Shrebati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Botticella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Le P\u00e9choux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Robert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Deutsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.annonc.2026.07.410_bib1","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/d41586-026-00633-6","article-title":"Thymus health is a predictor of lifelong well-being and immunotherapy effectiveness","volume":"652","author":"Anderson","year":"2026","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.annonc.2026.07.410_bib2","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/j.annonc.2026.07.001","article-title":"Thymic radiation is associated with worse outcomes in patients with NSCLC","volume":"37","author":"Prudente","year":"2026","journal-title":"Ann Oncol"},{"key":"10.1016\/j.annonc.2026.07.410_bib3","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1038\/s41586-026-10242-y","article-title":"Thymic health consequences in adults","volume":"652","author":"Bernatz","year":"2026","journal-title":"Nature"},{"key":"10.1016\/j.annonc.2026.07.410_bib4","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1038\/s41586-026-10243-x","article-title":"Thymic health and immunotherapy outcomes in patients with cancer","volume":"652","author":"Bernatz","year":"2026","journal-title":"Nature"},{"key":"10.1016\/j.annonc.2026.07.410_bib5","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1056\/NEJMoa2302892","article-title":"Health consequences of thymus removal in adults","volume":"389","author":"Kooshesh","year":"2023","journal-title":"N Engl J Med"},{"key":"10.1016\/j.annonc.2026.07.410_bib6","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41571-025-01080-4","article-title":"Unresectable stage III non-small-cell lung cancer: state of the art and challenges","volume":"23","author":"Remon","year":"2026","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.annonc.2026.07.410_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctrv.2025.103017","article-title":"Radioimmunotherapy for lung and head and neck cancers: a comparative review of clinical trial results and sequencing strategies","volume":"140","author":"Lavigne","year":"2025","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.annonc.2026.07.410_bib8","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.semradonc.2019.12.003","article-title":"Lymphocyte-sparing radiotherapy: the rationale for protecting lymphocyte-rich organs when combining radiotherapy with immunotherapy","volume":"30","author":"Lambin","year":"2020","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.annonc.2026.07.410_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2023.110030","article-title":"The effective radiation dose to immune cells predicts lymphopenia and inferior cancer control in locally advanced NSCLC","volume":"190","author":"Friedes","year":"2024","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.annonc.2026.07.410_bib10","doi-asserted-by":"crossref","first-page":"5500","DOI":"10.1038\/s41467-024-49873-y","article-title":"Delayed tumor-draining lymph node irradiation preserves the efficacy of combined radiotherapy and immune checkpoint blockade in models of metastatic disease","volume":"15","author":"Telarovic","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.annonc.2026.07.410_bib11","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1158\/1078-0432.CCR-23-3632","article-title":"Translational frontiers and clinical opportunities of immunologically fitted radiotherapy","volume":"30","author":"Morel","year":"2024","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.annonc.2026.07.410_bib12","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.ijrobp.2025.07.1429","article-title":"Radiation-induced lymphopenia: from mathematical modeling toward mechanistic learning","volume":"124","author":"de Kermenguy","year":"2026","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.annonc.2026.07.410_bib13","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.ijrobp.2019.05.064","article-title":"Impact of radiation dose to the host immune system on tumor control and survival for stage III non-small cell lung cancer treated with definitive radiation therapy","volume":"105","author":"Ladbury","year":"2019","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.annonc.2026.07.410_bib14","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.radonc.2022.10.019","article-title":"Lymphocyte sparing normal tissue effects in the clinic (LymphoTEC): a systematic review of dose constraint considerations to mitigate radiation-related lymphopenia in the era of immunotherapy","volume":"177","author":"Venkatesulu","year":"2022","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.annonc.2026.07.410_bib15","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.ccell.2025.02.010","article-title":"Low-dose irradiation of the gut improves the efficacy of PD-L1 blockade in metastatic cancer patients","volume":"43","author":"Chen","year":"2025","journal-title":"Cancer Cell"},{"key":"10.1016\/j.annonc.2026.07.410_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtho.2026.103949","article-title":"Thymic composition predicts radiation pneumonitis in locally advanced NSCLC","author":"Chaunzwa","year":"2026","journal-title":"J Thorac Oncol"}],"container-title":["Annals of Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753426014080?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923753426014080?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:43:24Z","timestamp":1789760604000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923753426014080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":16,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0923753426014080"],"URL":"https:\/\/doi.org\/10.1016\/j.annonc.2026.07.410","relation":{},"ISSN":["0923-7534"],"issn-type":[{"value":"0923-7534","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The return of the adult thymus in radiation oncology?","name":"articletitle","label":"Article Title"},{"value":"Annals of Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.annonc.2026.07.410","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.annonc.2026.07.001","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 European Society for Medical Oncology. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}