{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T10:42:10Z","timestamp":1781088130948,"version":"3.54.1"},"reference-count":127,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Annals of Otorhinolaryngology, Head and Neck Diseases"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.anorl.2017.06.013","type":"journal-article","created":{"date-parts":[[2018,4,13]],"date-time":"2018-04-13T00:16:17Z","timestamp":1523578577000},"page":"183-190","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Animal models of acute otitis media \u2013 A review with practical implications for laboratory research"],"prefix":"10.1016","volume":"135","author":[{"given":"N.H.","family":"Davidoss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.K.","family":"Varsak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.L.","family":"Santa Maria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3 Pt 2","key":"10.1016\/j.anorl.2017.06.013_bib0640","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1177\/00034894800890S326","article-title":"Microbiology of otitis media","volume":"89","author":"Klein","year":"1980","journal-title":"Ann Otol Rhinol Laryngol Suppl"},{"issue":"5","key":"10.1016\/j.anorl.2017.06.013_bib0645","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S1286-4579(00)00314-2","article-title":"Moraxella catarrhalis: a review of an important human mucosal pathogen","volume":"2","author":"Karalus","year":"2000","journal-title":"Microbes Infect"},{"issue":"10","key":"10.1016\/j.anorl.2017.06.013_bib0650","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1034\/j.1600-0463.2003.1111012.x","article-title":"A mouse model for acute otitis media","volume":"111","author":"Melhus","year":"2003","journal-title":"APMIS"},{"issue":"31","key":"10.1016\/j.anorl.2017.06.013_bib0655","doi-asserted-by":"crossref","first-page":"4539","DOI":"10.1016\/S0264-410X(03)00501-2","article-title":"Bacterial otitis media: a new non-invasive rat model","volume":"21","author":"Tonnaer","year":"2003","journal-title":"Vaccine"},{"issue":"3","key":"10.1016\/j.anorl.2017.06.013_bib0660","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0196-0709(88)80013-9","article-title":"A rat model for pneumococcal otitis media","volume":"9","author":"Hermansson","year":"1988","journal-title":"Am J Otolaryngol"},{"key":"10.1016\/j.anorl.2017.06.013_bib0665","first-page":"9","article-title":"Experimental otitis media in chinchillas. II. Comparison of the middle ear immune responses to S pneumoniae types 3 and 23","volume":"93","author":"Watanabe","year":"1982","journal-title":"Ann Otol Rhinol Laryngol Suppl"},{"issue":"4","key":"10.1016\/j.anorl.2017.06.013_bib0670","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1128\/IAI.67.4.1943-1946.1999","article-title":"Middle ear fluid cytokine and inflammatory cell kinetics in the chinchilla otitis media model","volume":"67","author":"Sato","year":"1999","journal-title":"Infect Immun"},{"issue":"2","key":"10.1016\/j.anorl.2017.06.013_bib0675","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1128\/IAI.36.2.802-810.1982","article-title":"Experimental otitis media in gerbils and chinchillas with Streptococcus pneumoniae, Haemophilus influenzae and other aerobic and anaerobic bacteria","volume":"36","author":"Fulghum","year":"1982","journal-title":"Infect Immun"},{"issue":"8","key":"10.1016\/j.anorl.2017.06.013_bib0680","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/BF00179947","article-title":"Middle ear catalase distribution in an animal model of otitis media","volume":"253","author":"Parks","year":"1996","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"2","key":"10.1016\/j.anorl.2017.06.013_bib0685","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/s10162-002-3015-9","article-title":"The deaf mouse mutant Jeff (Jf) is a single gene model of otitis media","volume":"4","author":"Hardisty","year":"2003","journal-title":"J Assoc Res Otolaryngol"},{"issue":"9","key":"10.1016\/j.anorl.2017.06.013_bib0690","doi-asserted-by":"crossref","first-page":"3536","DOI":"10.1128\/AAC.48.9.3536-3542.2004","article-title":"Beta-lactamase-producing non-typeable Haemophilus influenzae fails to protect Streptococcus pneumoniae from amoxicillin during experimental acute otitis media","volume":"48","author":"Westman","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"issue":"4","key":"10.1016\/j.anorl.2017.06.013_bib0695","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1093\/jac\/dki322","article-title":"Effect of erythromycin treatment delay on therapeutic outcome of experimental acute otitis media caused by Streptococcus pneumoniae","volume":"56","author":"Martinez-Marin","year":"2005","journal-title":"J Antimicrob Chemother"},{"issue":"10","key":"10.1016\/j.anorl.2017.06.013_bib0700","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.jclinepi.2009.06.005","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"62","author":"Moher","year":"2009","journal-title":"J Clin Epidemiol"},{"issue":"5","key":"10.1016\/j.anorl.2017.06.013_bib0705","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1067\/mhn.2002.124935","article-title":"A rat model of otitis media with effusion caused by eustachian tube obstruction with and without Streptococcus pneumoniae infection: methods and disease course","volume":"126","author":"Piltcher","year":"2002","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"9","key":"10.1016\/j.anorl.2017.06.013_bib0710","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1097\/00005537-200209000-00024","article-title":"Cytokine profiles in a rat model of otitis media with effusion caused by eustachian tube obstruction with and without Streptococcus pneumoniae infection","volume":"112","author":"Hebda","year":"2002","journal-title":"Laryngoscope"},{"issue":"12","key":"10.1016\/j.anorl.2017.06.013_bib0715","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1097\/00005537-200112000-00001","article-title":"Direct evidence of bacterial biofilms in otitis media","volume":"111","author":"Post","year":"2001","journal-title":"Laryngoscope"},{"issue":"3","key":"10.1016\/j.anorl.2017.06.013_bib0720","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1097\/MAO.0000000000000261","article-title":"OTO-201: non-clinical assessment of a sustained-release ciprofloxacin hydrogel for the treatment of otitis media","volume":"35","author":"Wang","year":"2014","journal-title":"Otol Neurotol"},{"issue":"2","key":"10.1016\/j.anorl.2017.06.013_bib0725","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1017\/S0022215114003430","article-title":"Does systemic clarithromycin therapy have an inhibitory effect on tympanosclerosis? An experimental animal study","volume":"129","author":"Genc","year":"2015","journal-title":"J Laryngol Otol"},{"key":"10.1016\/j.anorl.2017.06.013_bib0730","doi-asserted-by":"crossref","first-page":"246","DOI":"10.12659\/MSMBR.889474","article-title":"Montelukast is as effective as penicillin in treatment of acute otitis media: an experimental rat study","volume":"19","author":"Ucar","year":"2013","journal-title":"Med Sci Monit Basic Res"},{"key":"10.1016\/j.anorl.2017.06.013_bib0735","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1471-2180-7-56","article-title":"Virulence phenotypes of low-passage clinical isolates of non-typeable Haemophilus influenzae assessed using the chinchilla laniger model of otitis media","volume":"7","author":"Buchinsky","year":"2007","journal-title":"BMC Microbiol"},{"issue":"3 Pt 2","key":"10.1016\/j.anorl.2017.06.013_bib0740","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1177\/00034894800890S381","article-title":"Experimental otitis media in chinchillas","volume":"89","author":"Lewis","year":"1980","journal-title":"Ann Otol Rhinol Laryngol Suppl"},{"issue":"6","key":"10.1016\/j.anorl.2017.06.013_bib0745","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1093\/infdis\/134.6.595","article-title":"Experimental otitis media due to Streptococcus pneumoniae: immunopathogenic response in the chinchilla","volume":"134","author":"Giebink","year":"1976","journal-title":"J Infect Dis"},{"key":"10.1016\/j.anorl.2017.06.013_bib0750","doi-asserted-by":"crossref","first-page":"S191","DOI":"10.1093\/infdis\/136.Supplement.S191","article-title":"Comparison otitis media due to types 3 and 23 Streptococcus pneumoniae in the Chinchilla model","volume":"136","author":"Giebink","year":"1977","journal-title":"J Infect Dis"},{"issue":"2","key":"10.1016\/j.anorl.2017.06.013_bib0755","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1128\/iai.30.2.445-450.1980","article-title":"Experimental otitis media after nasal inoculation of Streptococcus pneumoniae and influenza A virus in chinchillas","volume":"30","author":"Giebink","year":"1980","journal-title":"Infect Immun"},{"issue":"3","key":"10.1016\/j.anorl.2017.06.013_bib0760","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1080\/00016480802239091","article-title":"Evaluation of a model for studies on sequelae after acute otitis media in the Mongolian gerbil","volume":"129","author":"Von Unge","year":"2009","journal-title":"Acta Otolaryngol"},{"issue":"1\u20132","key":"10.1016\/j.anorl.2017.06.013_bib0765","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.heares.2006.05.012","article-title":"Evaluation of the mouse model for acute otitis media","volume":"219","author":"MacArthur","year":"2006","journal-title":"Hear Res"},{"issue":"7","key":"10.1016\/j.anorl.2017.06.013_bib0770","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1001\/archotol.1984.00800330011002","article-title":"Scanning electron microscopy of the cochlea in rats with Streptococcus pneumoniae otitis media","volume":"110","author":"Hodges","year":"1984","journal-title":"Arch Otolaryngol"},{"issue":"8","key":"10.1016\/j.anorl.2017.06.013_bib0775","first-page":"661","article-title":"Development of myringosclerosis during acute otitis media caused by Streptococcus pneumoniae and non-typeable Haemophilus influenzae: a clinical otomicroscopical study using the rat model","volume":"41","author":"Raustyte","year":"2005","journal-title":"Medicina (Kaunas)"},{"issue":"1","key":"10.1016\/j.anorl.2017.06.013_bib0780","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1242\/dmm.021659","article-title":"A new model for non-typeable Haemophilus influenzae middle ear infection in the Junbo mutant mouse","volume":"9","author":"Hood","year":"2016","journal-title":"Dis Model Mech"},{"issue":"2","key":"10.1016\/j.anorl.2017.06.013_bib0785","first-page":"1","article-title":"Replication of type 5 adenovirus promotes middle ear infection by Streptococcus pneumoniae in the chinchilla model of otitis media","volume":"73","author":"Murrah","year":"2015","journal-title":"Pathog Dis"},{"issue":"4","key":"10.1016\/j.anorl.2017.06.013_bib0790","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1600-0463.2006.apm_297.x","article-title":"Otomicroscopic findings and systemic interleukin-6 levels in relation to etiologic agent during experimental acute otitis media","volume":"114","author":"Fogle-Ansson","year":"2006","journal-title":"APMIS"},{"issue":"1","key":"10.1016\/j.anorl.2017.06.013_bib0795","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1574-695X.2006.00186.x","article-title":"Role of Toll-like receptor 4 in innate immune responses in a mouse model of acute otitis media","volume":"49","author":"Hirano","year":"2007","journal-title":"FEMS Immunol Med Microbiol"},{"issue":"3","key":"10.1016\/j.anorl.2017.06.013_bib0800","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1159\/000205937","article-title":"Survival of bacterial biofilms within neutrophil extracellular traps promotes non-typeable Haemophilus influenzae persistence in the chinchilla model for otitis media","volume":"1","author":"Hong","year":"2009","journal-title":"J Innate Immun"},{"issue":"6","key":"10.1016\/j.anorl.2017.06.013_bib0805","doi-asserted-by":"crossref","first-page":"3454","DOI":"10.1128\/IAI.71.6.3454-3462.2003","article-title":"Non-typeable Haemophilus influenzae gene expression induced in vivo in a chinchilla model of otitis media","volume":"71","author":"Mason","year":"2003","journal-title":"Infect Immun"},{"issue":"1","key":"10.1016\/j.anorl.2017.06.013_bib0810","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1097\/01.mlg.0000240170.48584.73","article-title":"Cochlear cytokine gene expression in murine acute otitis media","volume":"117","author":"Ghaheri","year":"2007","journal-title":"Laryngoscope"},{"issue":"3","key":"10.1016\/j.anorl.2017.06.013_bib0815","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1097\/00005537-200203000-00002","article-title":"Growth factors and their receptors in the middle ear mucosa during otitis media","volume":"112","author":"Palacios","year":"2002","journal-title":"Laryngoscope"},{"issue":"8","key":"10.1016\/j.anorl.2017.06.013_bib0820","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/j.ijporl.2008.04.007","article-title":"Differential expression of cytokine genes and iNOS induced by nonviable non-typeable Haemophilus influenzae or its LOS mutants during acute otitis media in the rat","volume":"72","author":"Tong","year":"2008","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"6","key":"10.1016\/j.anorl.2017.06.013_bib0825","doi-asserted-by":"crossref","first-page":"e40088","DOI":"10.1371\/journal.pone.0040088","article-title":"Respiratory syncytial virus promotes Moraxella catarrhalis-induced ascending experimental otitis media","volume":"7","author":"Brockson","year":"2012","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.anorl.2017.06.013_bib0830","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1080\/00016480600749994","article-title":"Tissular changes induced by Pseudomonas aeruginosa in an otitis media rat model with tubal obstruction","volume":"127","author":"Trinidad","year":"2007","journal-title":"Acta Otolaryngol"},{"issue":"3","key":"10.1016\/j.anorl.2017.06.013_bib0835","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1080\/00016480410022804","article-title":"Pseudomonas aeruginosa infection in the hypoventilated middle ear: an experimental model","volume":"125","author":"Trinidad","year":"2005","journal-title":"Acta Otolaryngol"},{"key":"10.1016\/j.anorl.2017.06.013_bib0840","first-page":"1","article-title":"Experimental otitis media in chinchillas. I. Baseline immunological investigation","volume":"93","author":"Watanabe","year":"1982","journal-title":"Ann Otol Rhinol Laryngol Suppl"},{"issue":"4","key":"10.1016\/j.anorl.2017.06.013_bib0845","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1177\/000348940911800410","article-title":"Demonstration of nasopharyngeal and middle ear mucosal biofilms in an animal model of acute otitis media","volume":"118","author":"Hoa","year":"2009","journal-title":"Ann Otol Rhinol Laryngol"},{"issue":"Pt 12","key":"10.1016\/j.anorl.2017.06.013_bib0850","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.1099\/mic.0.033175-0","article-title":"Development of a non-invasive murine infection model for acute otitis media","volume":"155","author":"Stol","year":"2009","journal-title":"Microbiology"},{"issue":"11","key":"10.1016\/j.anorl.2017.06.013_bib0855","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1016\/j.ijporl.2011.07.026","article-title":"Tissue remodeling in the acute otitis media mouse model","volume":"75","author":"Sautter","year":"2011","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"9","key":"10.1016\/j.anorl.2017.06.013_bib0860","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.micinf.2012.02.008","article-title":"Virulence of Streptococcus pneumoniae serotype 6C in experimental otitis media","volume":"14","author":"Sabharwal","year":"2012","journal-title":"Microbes Infect"},{"issue":"3","key":"10.1016\/j.anorl.2017.06.013_bib0865","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1097\/00129492-200305000-00002","article-title":"Pars flaccida displacement pattern in purulent otitis media in the gerbil","volume":"24","author":"Larsson","year":"2003","journal-title":"Otol Neurotol"},{"issue":"1\u20132","key":"10.1016\/j.anorl.2017.06.013_bib0870","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0378-5955(97)00008-7","article-title":"Tympanic membrane changes in experimental purulent otitis media","volume":"106","author":"von Unge","year":"1997","journal-title":"Hear Res"},{"issue":"4","key":"10.1016\/j.anorl.2017.06.013_bib0875","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.ijbiomac.2012.02.002","article-title":"Effect of orange peel essential oil on oxidative stress in AOM animals","volume":"50","author":"Lv","year":"2012","journal-title":"Int J Biol Macromol"},{"issue":"6","key":"10.1016\/j.anorl.2017.06.013_bib0880","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1097\/00129492-200111000-00010","article-title":"Macrophages and possible osteoclast differentiation in the rat bullar bone during experimental acute otitis media, with reference to tympanosclerosis","volume":"22","author":"Forseni Flodin","year":"2001","journal-title":"Otol Neurotol"},{"issue":"2","key":"10.1016\/j.anorl.2017.06.013_bib0885","doi-asserted-by":"crossref","first-page":"230","DOI":"10.3346\/jkms.2002.17.2.230","article-title":"Ultrastructural characteristics of the round window membrane during pneumococcal otitis media in rat","volume":"17","author":"Yoon","year":"2002","journal-title":"J Korean Med Sci"},{"issue":"6","key":"10.1016\/j.anorl.2017.06.013_bib0890","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1177\/000348940311200614","article-title":"First forty-eight hours of developing otitis media: an experimental study","volume":"112","author":"Eriksson","year":"2003","journal-title":"Ann Otol Rhinol Laryngol"},{"issue":"11","key":"10.1016\/j.anorl.2017.06.013_bib0895","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1097\/00005537-200311000-00036","article-title":"Acute otitis media develops in the rat after intranasal challenge of Streptococcus pneumoniae","volume":"113","author":"Eriksson","year":"2003","journal-title":"Laryngoscope"},{"issue":"8 Pt 1","key":"10.1016\/j.anorl.2017.06.013_bib0900","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1097\/00005537-200208000-00027","article-title":"Myringotomy delays the tympanic membrane recovery in acute otitis media: a study in the rat model","volume":"112","author":"Spratley","year":"2002","journal-title":"Laryngoscope"},{"key":"10.1016\/j.anorl.2017.06.013_bib0905","first-page":"144","article-title":"A rat model for bacterial otitis media","volume":"457","author":"Hermansson","year":"1989","journal-title":"Acta Otolaryngol Suppl"},{"issue":"7","key":"10.1016\/j.anorl.2017.06.013_bib0910","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/BF00181964","article-title":"Early structural changes in the rat tympanic membrane during pneumococcal otitis media","volume":"251","author":"Magnuson","year":"1994","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"11","key":"10.1016\/j.anorl.2017.06.013_bib0915","doi-asserted-by":"crossref","first-page":"6098","DOI":"10.1128\/IAI.67.11.6098-6103.1999","article-title":"A new rat model of otitis media caused by Streptococcus pneumoniae: conditions and application in immunization protocols","volume":"67","author":"van der Ven","year":"1999","journal-title":"Infect Immun"},{"issue":"7","key":"10.1016\/j.anorl.2017.06.013_bib0920","doi-asserted-by":"crossref","first-page":"4024","DOI":"10.1128\/IAI.68.7.4024-4031.2000","article-title":"Expression of cytokine genes during pneumococcal and non-typeable Haemophilus influenzae acute otitis media in the rat","volume":"68","author":"Melhus","year":"2000","journal-title":"Infect Immun"},{"issue":"3","key":"10.1016\/j.anorl.2017.06.013_bib0925","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1006\/mpat.2000.0414","article-title":"Expression of molecular markers for bone formation increases during experimental acute otitis media","volume":"30","author":"Melhus","year":"2001","journal-title":"Microb Pathog"},{"issue":"6","key":"10.1016\/j.anorl.2017.06.013_bib0930","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1097\/00005537-200406000-00014","article-title":"Cathepsin gene expression profile in rat acute pneumococcal otitis media","volume":"114","author":"Li-Korotky","year":"2004","journal-title":"Laryngoscope"},{"issue":"6","key":"10.1016\/j.anorl.2017.06.013_bib0935","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1177\/000348949810700608","article-title":"Upregulation of messenger RNA for inflammatory cytokines in middle ear mucosa in a rat model of acute otitis media","volume":"107","author":"Hebda","year":"1998","journal-title":"Ann Otol Rhinol Laryngol"},{"issue":"1","key":"10.1016\/j.anorl.2017.06.013_bib0940","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0165-5876(01)00540-7","article-title":"Pattern changes of mucin gene expression with pneumococcal otitis media","volume":"61","author":"Tsuboi","year":"2001","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"2","key":"10.1016\/j.anorl.2017.06.013_bib0945","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0165-5876(01)00641-3","article-title":"Histopathologic differences due to bacterial species in acute otitis media","volume":"63","author":"Caye-Thomasen","year":"2002","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"10","key":"10.1016\/j.anorl.2017.06.013_bib0950","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/j.ijporl.2005.03.033","article-title":"Gene expression profiles of early pneumococcal otitis media in the rat","volume":"69","author":"Chen","year":"2005","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"4","key":"10.1016\/j.anorl.2017.06.013_bib0955","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.ijporl.2006.12.019","article-title":"Efficacy of vitamin A in experimentally induced acute otitis media","volume":"71","author":"Aladag","year":"2007","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"5","key":"10.1016\/j.anorl.2017.06.013_bib0960","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1177\/000348949610500513","article-title":"Healing of tympanic membrane after myringotomy during Streptococcus pneumoniae otitis media. An otomicroscopic and histologic study in the rat","volume":"105","author":"Magnuson","year":"1996","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"10.1016\/j.anorl.2017.06.013_bib0965","doi-asserted-by":"crossref","first-page":"7828","DOI":"10.1038\/ncomms8828","article-title":"A biphasic epigenetic switch controls immunoevasion, virulence and niche adaptation in non-typeable Haemophilus influenzae","volume":"6","author":"Atack","year":"2015","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.anorl.2017.06.013_bib0970","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/emmm.201202150","article-title":"A live-attenuated pneumococcal vaccine elicits CD4+ T-cell dependent class switching and provides serotype independent protection against acute otitis media","volume":"6","author":"Rosch","year":"2014","journal-title":"EMBO Mol Med"},{"issue":"7","key":"10.1016\/j.anorl.2017.06.013_bib0975","doi-asserted-by":"crossref","first-page":"e102739","DOI":"10.1371\/journal.pone.0102739","article-title":"A mouse model of otitis media identifies HB-EGF as a mediator of inflammation-induced mucosal proliferation","volume":"9","author":"Suzukawa","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.anorl.2017.06.013_bib0980","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1128\/IAI.01128-15","article-title":"Accumulation of regulatory T cells and chronic inflammation in the middle ear in a mouse model of chronic otitis media with effusion induced by combined eustachian tube blockage and Non-typeable Haemophilus influenzae Infection","volume":"84","author":"Hirano","year":"2016","journal-title":"Infect Immun"},{"issue":"2","key":"10.1016\/j.anorl.2017.06.013_bib0985","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/mmi.12934","article-title":"Antibodies against the majority subunit of type IV Pili disperse non-typeable Haemophilus influenzae biofilms in a LuxS-dependent manner and confer therapeutic resolution of experimental otitis media","volume":"96","author":"Novotny","year":"2015","journal-title":"Mol Microbiol"},{"issue":"1","key":"10.1016\/j.anorl.2017.06.013_bib0990","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1128\/IAI.01104-13","article-title":"Antibodies mediate formation of neutrophil extracellular traps in the middle ear and facilitate secondary pneumococcal otitis media","volume":"82","author":"Short","year":"2014","journal-title":"Infect Immun"},{"issue":"7","key":"10.1016\/j.anorl.2017.06.013_bib0995","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1097\/MAO.0b013e3182941a95","article-title":"Comparison of eardrum mobility in acute otitis media and otitis media with effusion models","volume":"34","author":"Guan","year":"2013","journal-title":"Otol Neurotol"},{"key":"10.1016\/j.anorl.2017.06.013_bib1000","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1186\/1471-2164-14-925","article-title":"Comparison of transcription of the Haemophilus influenzae iron\/heme modulon genes in vitro and in vivo in the chinchilla middle ear","volume":"14","author":"Whitby","year":"2013","journal-title":"BMC Genomics"},{"issue":"3","key":"10.1016\/j.anorl.2017.06.013_bib1005","doi-asserted-by":"crossref","first-page":"e0119228","DOI":"10.1371\/journal.pone.0119228","article-title":"Control of middle ear inflammatory and ion homeostasis genes by transtympanic glucocorticoid and mineralocorticoid treatments","volume":"10","author":"Lighthall","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.anorl.2017.06.013_bib1010","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.heares.2013.01.001","article-title":"Dynamic properties of round window membrane in guinea pig otitis media model measured with electromagnetic stimulation","volume":"301","author":"Gan","year":"2013","journal-title":"Hear Res"},{"issue":"8","key":"10.1016\/j.anorl.2017.06.013_bib1015","doi-asserted-by":"crossref","first-page":"081006","DOI":"10.1115\/1.4030410","article-title":"Dynamic properties of tympanic membrane in a chinchilla otitis media model measured with acoustic loading","volume":"137","author":"Yokell","year":"2015","journal-title":"J Biomech Eng"},{"key":"10.1016\/j.anorl.2017.06.013_bib1020","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.heares.2013.12.005","article-title":"Factors affecting loss of tympanic membrane mobility in acute otitis media model of chinchilla","volume":"309","author":"Guan","year":"2014","journal-title":"Hear Res"},{"issue":"10","key":"10.1016\/j.anorl.2017.06.013_bib1025","doi-asserted-by":"crossref","first-page":"e1003709","DOI":"10.1371\/journal.ppat.1003709","article-title":"Haemophilus responses to nutritional immunity: epigenetic and morphological contribution to biofilm architecture, invasion, persistence and disease severity","volume":"9","author":"Szelestey","year":"2013","journal-title":"PLoS Pathog"},{"issue":"5","key":"10.1016\/j.anorl.2017.06.013_bib1030","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s00430-014-0344-3","article-title":"Helminth infections predispose mice to pneumococcal pneumonia but not to other pneumonic pathogens","volume":"203","author":"Apiwattanakul","year":"2014","journal-title":"Med Microbiol Immunol"},{"issue":"6","key":"10.1016\/j.anorl.2017.06.013_bib1035","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1128\/IAI.00006-14","article-title":"Interleukin 17A promotes pneumococcal clearance by recruiting neutrophils and inducing apoptosis through a p38 mitogen-activated protein kinase-dependent mechanism in acute otitis media","volume":"82","author":"Wang","year":"2014","journal-title":"Infect Immun"},{"issue":"5","key":"10.1016\/j.anorl.2017.06.013_bib1040","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1093\/infdis\/jiw243","article-title":"ModA2 phasevarion switching in non-typeable haemophilus influenzae increases the severity of experimental otitis media","volume":"214","author":"Brockman","year":"2016","journal-title":"J Infect Dis"},{"issue":"5","key":"10.1016\/j.anorl.2017.06.013_bib1045","doi-asserted-by":"crossref","DOI":"10.1093\/femspd\/ftu011","article-title":"Non-encapsulated Streptococcus pneumoniae causes otitis media during single-species infection and during polymicrobial infection with non-typeable Haemophilus influenzae","volume":"73","author":"Murrah","year":"2015","journal-title":"Pathog Dis"},{"issue":"11","key":"10.1016\/j.anorl.2017.06.013_bib1050","doi-asserted-by":"crossref","first-page":"E66","DOI":"10.1002\/lary.24097","article-title":"NTHi induction of Cxcl2 and middle ear mucosal metaplasia in mice","volume":"123","author":"Preciado","year":"2013","journal-title":"Laryngoscope"},{"issue":"10","key":"10.1016\/j.anorl.2017.06.013_bib1055","doi-asserted-by":"crossref","first-page":"e75213","DOI":"10.1371\/journal.pone.0075213","article-title":"Otitis media impacts hundreds of mouse middle and inner ear genes","volume":"8","author":"MacArthur","year":"2013","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.anorl.2017.06.013_bib1060","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.3109\/00016489.2014.940554","article-title":"PAI-1 inhibits development of chronic otitis media and tympanosclerosis in a mouse model of otitis media","volume":"134","author":"Shin","year":"2014","journal-title":"Acta Otolaryngol"},{"issue":"12","key":"10.1016\/j.anorl.2017.06.013_bib1065","doi-asserted-by":"crossref","first-page":"3148","DOI":"10.1002\/lary.24166","article-title":"Pathological study of otitis media with effusion after treatment with intranasal pulmonary surfactant","volume":"123","author":"Zhu","year":"2013","journal-title":"Laryngoscope"},{"issue":"1","key":"10.1016\/j.anorl.2017.06.013_bib1070","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1128\/IAI.02390-14","article-title":"Peroxiredoxin-glutaredoxin and catalase promote resistance of non-typeable Haemophilus influenzae 86-028NP to oxidants and survival within neutrophil extracellular traps","volume":"83","author":"Juneau","year":"2015","journal-title":"Infect Immun"},{"issue":"9","key":"10.1016\/j.anorl.2017.06.013_bib1075","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1016\/j.ijporl.2014.06.024","article-title":"Pneumococcal PspA and PspC proteins: potential vaccine candidates for experimental otitis media","volume":"78","author":"Schachern","year":"2014","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"6","key":"10.1016\/j.anorl.2017.06.013_bib1080","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1007\/s00405-014-2942-5","article-title":"Preliminary results of a novel quorum sensing inhibitor against pneumococcal infection and biofilm formation with special interest to otitis media and cochlear implantation","volume":"272","author":"Cevizci","year":"2015","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"3","key":"10.1016\/j.anorl.2017.06.013_bib1085","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/2049-632X.12129","article-title":"Residence of Streptococcus pneumoniae and Moraxella catarrhalis within polymicrobial biofilm promotes antibiotic resistance and bacterial persistence in vivo","volume":"70","author":"Perez","year":"2014","journal-title":"Pathog Dis"},{"key":"10.1016\/j.anorl.2017.06.013_bib1090","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.ijporl.2016.07.001","article-title":"Role of group 3 innate lymphoid cells during experimental otitis media in a rat model","volume":"88","author":"Cho","year":"2016","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"2","key":"10.1016\/j.anorl.2017.06.013_bib1095","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1177\/1753425914526074","article-title":"The inflammasome adaptor ASC contributes to multiple innate immune processes in the resolution of otitis media","volume":"21","author":"Kurabi","year":"2015","journal-title":"Innate Immun"},{"key":"10.1016\/j.anorl.2017.06.013_bib1100","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1186\/s12864-015-1475-7","article-title":"The transcriptome of a complete episode of acute otitis media","volume":"16","author":"Hernandez","year":"2015","journal-title":"BMC Genomics"},{"issue":"8","key":"10.1016\/j.anorl.2017.06.013_bib1105","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1128\/CVI.00090-15","article-title":"Therapeutic transcutaneous immunization with a band-aid vaccine resolves experimental otitis media","volume":"22","author":"Novotny","year":"2015","journal-title":"Clin Vaccine Immunol"},{"issue":"9","key":"10.1016\/j.anorl.2017.06.013_bib1110","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1001\/jamaoto.2013.4104","article-title":"Viability and virulence of pneumolysin, pneumococcal surface protein A and pneumolysin\/pneumococcal surface protein A mutants in the ear","volume":"139","author":"Schachern","year":"2013","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"issue":"12","key":"10.1016\/j.anorl.2017.06.013_bib1115","doi-asserted-by":"crossref","first-page":"5990","DOI":"10.4049\/jimmunol.1401489","article-title":"Vinpocetine inhibits Streptococcus pneumoniae-induced upregulation of mucin MUC5AC expression via induction of MKP-1 phosphatase in the pathogenesis of otitis media","volume":"194","author":"Lee","year":"2015","journal-title":"J Immunol"},{"issue":"1 Pt 1","key":"10.1016\/j.anorl.2017.06.013_bib1120","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1177\/000348948209100118","article-title":"Comparative anatomy of eustachian tube and middle ear cavity in animal models for otitis media","volume":"91","author":"Daniel","year":"1982","journal-title":"Ann Otol Rhinol Laryngol"},{"issue":"4","key":"10.1016\/j.anorl.2017.06.013_bib1125","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/j.1748-1716.1983.tb07280.x","article-title":"The pressure equilibrating function of pars flaccida in middle ear mechanics","volume":"118","author":"Hellstrom","year":"1983","journal-title":"Acta Physiol Scand"},{"issue":"8","key":"10.1016\/j.anorl.2017.06.013_bib1130","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1016\/j.vaccine.2010.12.076","article-title":"Novel method for non-invasive induction of a middle ear biofilm in the rat","volume":"29","author":"Chaney","year":"2011","journal-title":"Vaccine"},{"issue":"1","key":"10.1016\/j.anorl.2017.06.013_bib1135","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1089\/mdr.1999.5.73","article-title":"Immunization and protection in pneumococcal otitis media studied in a rat model","volume":"5","author":"Prellner","year":"1999","journal-title":"Microb Drug Resist"},{"issue":"8","key":"10.1016\/j.anorl.2017.06.013_bib1140","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1586\/erv.09.63","article-title":"Chinchilla as a robust, reproducible and polymicrobial model of otitis media and its prevention","volume":"8","author":"Bakaletz","year":"2009","journal-title":"Expert Rev Vaccines"},{"issue":"4","key":"10.1016\/j.anorl.2017.06.013_bib1145","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1177\/0194599812449986","article-title":"Mouse models of otitis media: strengths and limitations","volume":"147","author":"Bhutta","year":"2012","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"2","key":"10.1016\/j.anorl.2017.06.013_bib1150","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1017\/S002221510013659X","article-title":"Fat graft myringoplasty in children \u2013 a safe and successful day-stay procedure","volume":"111","author":"Mitchell","year":"1997","journal-title":"J Laryngol Otol"},{"issue":"1\u20132","key":"10.1016\/j.anorl.2017.06.013_bib1155","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s00335-010-9295-1","article-title":"Unraveling the genetics of otitis media: from mouse to human and back again","volume":"22","author":"Rye","year":"2011","journal-title":"Mammalian Genome"},{"issue":"5","key":"10.1016\/j.anorl.2017.06.013_bib1160","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s11882-013-0360-1","article-title":"What have we learned from murine models of otitis media?","volume":"13","author":"Tyrer","year":"2013","journal-title":"Curr Allergy Asthma Rep"},{"issue":"1","key":"10.1016\/j.anorl.2017.06.013_bib1165","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3109\/00016489.2015.1082191","article-title":"Mouse model of experimental Eustachian tube occlusion: a surgical technique","volume":"136","author":"Varsak","year":"2016","journal-title":"Acta Otolaryngol"},{"issue":"2","key":"10.1016\/j.anorl.2017.06.013_bib1170","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0165-5876(85)80010-0","article-title":"Longitudinal studies of experimental otitis media with Haemophilus influenzae in the gerbil","volume":"9","author":"Fulghum","year":"1985","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"3","key":"10.1016\/j.anorl.2017.06.013_bib1175","first-page":"204","article-title":"Cholesteatoma: spontaneous occurrence in the Mongolian gerbil Meriones unguiculatis","volume":"2","author":"Chole","year":"1981","journal-title":"Am J Otol"},{"issue":"8","key":"10.1016\/j.anorl.2017.06.013_bib1180","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1111\/j.1699-0463.1999.tb01468.x","article-title":"Moraxella catarrhalis-induced purulent otitis media in the rat middle ear. Structure, protection and serum antibodies","volume":"107","author":"Westman","year":"1999","journal-title":"Apmis"},{"issue":"6","key":"10.1016\/j.anorl.2017.06.013_bib1185","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1097\/01.mao.0000231603.25961.f1","article-title":"Pneumococcal meningitis: development of a new animal model","volume":"27","author":"Wei","year":"2006","journal-title":"Otol Neurotol"},{"issue":"5 Suppl 3","key":"10.1016\/j.anorl.2017.06.013_bib1190","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1016\/j.otohns.2010.08.010","article-title":"Pneumococcal meningitis post-cochlear implantation: potential routes of infection and pathophysiology","volume":"143","author":"Wei","year":"2010","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"12","key":"10.1016\/j.anorl.2017.06.013_bib1195","doi-asserted-by":"crossref","first-page":"7318","DOI":"10.1128\/IAI.69.12.7318-7325.2001","article-title":"Streptococcus pneumoniae causes experimental meningitis following intranasal and otitis media infections via a non-hematogenous route","volume":"69","author":"Marra","year":"2001","journal-title":"Infect Immun"},{"issue":"9","key":"10.1016\/j.anorl.2017.06.013_bib1200","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1001\/archotol.1994.01880330015004","article-title":"Otogenic meningoencephalitis induced by Streptococcus pneumoniae in gerbils","volume":"120","author":"Muffat-Joly","year":"1994","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"4","key":"10.1016\/j.anorl.2017.06.013_bib1205","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1093\/infdis\/138.4.480","article-title":"Modification of otitis media following vaccination with the capsular polysaccharide of Streptococcus pneumoniae in chinchillas","volume":"138","author":"Giebink","year":"1978","journal-title":"J Infect Dis"},{"issue":"3 Pt 1","key":"10.1016\/j.anorl.2017.06.013_bib1210","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1177\/000348948209100305","article-title":"Longitudinal study of the efficacy of ampicillin in the treatment of pneumococcal otitis media in a chinchilla animal model","volume":"91","author":"Supance","year":"1982","journal-title":"Ann Otol Rhinol Laryngol"},{"issue":"3","key":"10.1016\/j.anorl.2017.06.013_bib1215","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/00001432-200206000-00007","article-title":"Current concepts in the pathogenesis of meningitis caused by Streptococcus pneumoniae","volume":"15","author":"Meli","year":"2002","journal-title":"Curr Opin Infect Dis"},{"issue":"2","key":"10.1016\/j.anorl.2017.06.013_bib1220","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1172\/JCI2406","article-title":"Pneumococcal trafficking across the blood-brain barrier. Molecular analysis of a novel bidirectional pathway","volume":"102","author":"Ring","year":"1998","journal-title":"J Clin Invest"},{"issue":"1","key":"10.1016\/j.anorl.2017.06.013_bib1225","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1001\/archotol.1992.01880010057016","article-title":"Bacterial tympanogenic labyrinthitis, meningitis and sensorineural damage","volume":"118","author":"Schachern","year":"1992","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"4","key":"10.1016\/j.anorl.2017.06.013_bib1230","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/mi.2011.6","article-title":"Transcutaneous immunization as preventative and therapeutic regimens to protect against experimental otitis media due to non-typeable Haemophilus influenzae","volume":"4","author":"Novotny","year":"2011","journal-title":"Mucosal Immunol"},{"issue":"5","key":"10.1016\/j.anorl.2017.06.013_bib1235","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1067\/mhn.2001.115370","article-title":"Ventral approach to the rat middle ear for otologic research","volume":"124","author":"Pinilla","year":"2001","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"5\u20136","key":"10.1016\/j.anorl.2017.06.013_bib1240","doi-asserted-by":"crossref","first-page":"421","DOI":"10.3109\/00016489009125164","article-title":"Persistent structural changes in the middle ear mucosa of the rat, after an experimentally induced episode of pneumococcal otitis media","volume":"109","author":"Hermansson","year":"1990","journal-title":"Acta Otolaryngol"},{"key":"10.1016\/j.anorl.2017.06.013_bib1245","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ijporl.2016.02.018","article-title":"Otitis media with effusion in an allergic animal model: a functional and morphological study","volume":"84","author":"Kim","year":"2016","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"3","key":"10.1016\/j.anorl.2017.06.013_bib1250","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1177\/0194599815587699","article-title":"Expression of surfactant protein-A during LPS-induced otitis media with effusion in mice","volume":"153","author":"Li","year":"2015","journal-title":"Otolaryngology Head Neck Surg"},{"issue":"3","key":"10.1016\/j.anorl.2017.06.013_bib1255","doi-asserted-by":"crossref","first-page":"e0122572","DOI":"10.1371\/journal.pone.0122572","article-title":"Lipopolysaccharide-induced middle ear inflammation disrupts the cochlear intra-strial fluid-blood barrier through down-regulation of tight junction proteins","volume":"10","author":"Zhang","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.anorl.2017.06.013_bib1260","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.meegid.2015.08.019","article-title":"Otitis media induced by peptidoglycan-polysaccharide (PGPS) in TLR2-deficient (Tlr2[-\/-]) mice for developing drug therapy","volume":"35","author":"Zhang","year":"2015","journal-title":"Infect Genet Evol"},{"issue":"3","key":"10.1016\/j.anorl.2017.06.013_bib1265","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3109\/00016489.2013.859395","article-title":"An experimental study of inner ear injury in an animal model of eosinophilic otitis media","volume":"134","author":"Matsubara","year":"2014","journal-title":"Acta oto-laryngologica"},{"issue":"10","key":"10.1016\/j.anorl.2017.06.013_bib1270","doi-asserted-by":"crossref","first-page":"978","DOI":"10.3109\/00016489.2015.1058526","article-title":"Effect of systemic clarithromycin and prednisolone on histamine-induced otitis media in guinea pigs","volume":"135","author":"Kozan","year":"2015","journal-title":"Acta oto-laryngologica"}],"container-title":["European Annals of Otorhinolaryngology, Head and Neck Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1879729618300498?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1879729618300498?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T09:21:43Z","timestamp":1660900903000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1879729618300498"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":127,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["S1879729618300498"],"URL":"https:\/\/doi.org\/10.1016\/j.anorl.2017.06.013","relation":{},"ISSN":["1879-7296"],"issn-type":[{"value":"1879-7296","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Animal models of acute otitis media \u2013 A review with practical implications for laboratory research","name":"articletitle","label":"Article Title"},{"value":"European Annals of Otorhinolaryngology, Head and Neck Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anorl.2017.06.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}