{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:33:28Z","timestamp":1792020808725,"version":"4.4.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Annals of Otorhinolaryngology, Head and Neck Diseases"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.anorl.2017.12.006","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T19:35:52Z","timestamp":1515785752000},"page":"S29-S32","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":139,"special_numbering":"S","title":["International consensus (ICON) on treatment of M\u00e9ni\u00e8re's disease"],"prefix":"10.1016","volume":"135","author":[{"given":"J.","family":"Nevoux","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Barbara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Dornhoffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0853-7024","authenticated-orcid":false,"given":"W.","family":"Gibson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Kitahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4295-0664","authenticated-orcid":false,"given":"V.","family":"Darrouzet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.anorl.2017.12.006_bib0185","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0194-5998(95)70102-8","article-title":"Committee on hearing equilibrium guidelines for the diagnosis evaluation on therapy in M\u00e9ni\u00e8re's disease","volume":"113","year":"1995","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.anorl.2017.12.006_bib0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/VES-150549","article-title":"Diagnostic criteria for M\u00e9ni\u00e8re's disease","volume":"25","author":"Lopez-Escamez","year":"2015","journal-title":"J vest Res"},{"key":"10.1016\/j.anorl.2017.12.006_bib0195","first-page":"30222","article-title":"Groupe de travail de la SFORL. Diagnostic and therapeutic strategy in M\u00e9ni\u00e8re's disease. Guidelines of the French Otorhinolaryngology-Head and Neck Surgery Society (SFORL)","volume":"16","author":"Nevoux","year":"2017","journal-title":"Eur Ann Otorhinolaryngol Head Neck Dis"},{"key":"10.1016\/j.anorl.2017.12.006_bib0200","doi-asserted-by":"crossref","first-page":"e010269","DOI":"10.1136\/bmjopen-2015-010269","article-title":"Interventions for M\u00e9ni\u00e8re's disease: protocol for an umbrella systematic review and a network meta-analysis","volume":"6","author":"van Esch","year":"2016","journal-title":"BMJ Open"},{"key":"10.1016\/j.anorl.2017.12.006_bib0205","first-page":"71","article-title":"Health profile for patients with M\u00e9ni\u00e8re's disease","volume":"4","author":"Holgers","year":"2001","journal-title":"Noise Health"},{"key":"10.1016\/j.anorl.2017.12.006_bib0210","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.5664\/jcsm.5080","article-title":"A pilot study on the efficacy of contunous positive airway pressure on the manifestations of M\u00e9ni\u00e8re's disease in patients with concomitant obstructive sleep apnea syndrome","volume":"11","author":"Nakayama","year":"2015","journal-title":"J Clin Sleep Med"},{"key":"10.1016\/j.anorl.2017.12.006_bib0215","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1097\/MAO.0b013e3182942261","article-title":"Dietary modification as adjunct treatment in M\u00e9ni\u00e8re's disease: patients willingness and ability to comply","volume":"34","author":"Luxford","year":"2013","journal-title":"Otol Neurotol"},{"key":"10.1016\/j.anorl.2017.12.006_bib0220","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1177\/0194599816678386","article-title":"The effect of vestibular rehabilitation in patients with M\u00e9ni\u00e8re's disease","volume":"156","author":"van Esch","year":"2017","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.anorl.2017.12.006_bib0225","first-page":"CD005397","article-title":"Vestibular rehabilitation for unilateral peripheral vestibular dysfunction","volume":"1","author":"McDonnell","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.anorl.2017.12.006_bib0230","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.amjoto.2011.10.009","article-title":"Cognitive behavior therapy for chronic subjective dizziness: a randomized, controlled trial","volume":"33","author":"Edelman","year":"2012","journal-title":"Am J Otolaryngol"},{"key":"10.1016\/j.anorl.2017.12.006_bib0235","first-page":"CD003599","article-title":"Diuretics for M\u00e9ni\u00e8re's disease or syndrome","volume":"3","author":"Thirlwall","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.anorl.2017.12.006_bib0240","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1177\/0194599816630733","article-title":"A systematic review of diuretics in the medical management of M\u00e9ni\u00e8re's disease","volume":"154","author":"Crowson","year":"2016","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.anorl.2017.12.006_bib0245","first-page":"CD001873","article-title":"Betahistine for M\u00e9ni\u00e8re's disease or syndrome","volume":"1","author":"James","year":"2001","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.anorl.2017.12.006_bib0250","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/nyas.12774","article-title":"Pharmacotherapy of vestibular and cerebellar disorders and downbeat nystagmus: translational and back-translational research","volume":"1343","author":"Strupp","year":"2015","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.anorl.2017.12.006_bib0255","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1007\/s00405-011-1647-2","article-title":"High-dosage Betahistine dihydrochloride between 288 and 480mg\/day in patients with severe M\u00e9ni\u00e8re's disease: a case series","volume":"268","author":"Lezius","year":"2011","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"10.1016\/j.anorl.2017.12.006_bib0260","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.amjoto.2014.10.032","article-title":"Intratympanic dexamethasone versus high dosage of betahistine in the treatment of intractable unilateral M\u00e9ni\u00e8re disease","volume":"36","author":"Albu","year":"2015","journal-title":"Am J Otolaryngol"},{"key":"10.1016\/j.anorl.2017.12.006_bib0265","doi-asserted-by":"crossref","first-page":"h6816","DOI":"10.1136\/bmj.h6816","article-title":"Efficacy and safety of betahistine treatment in patients with M\u00e9ni\u00e8re's disease: primary results of a long term, multicentre, double blind, randomised, placebo controlled, dose defining trial (BEMED trial)","volume":"352","author":"Adrion","year":"2016","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.anorl.2017.12.006_bib0270","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1159\/000472245","article-title":"Delayed effect of active pressure treatment on endolymphatic hydrops","volume":"22","author":"Covelli","year":"2017","journal-title":"Audiol Neurootol"},{"key":"10.1016\/j.anorl.2017.12.006_bib0275","first-page":"CD008419","article-title":"Positive pressure therapy for M\u00e9ni\u00e8re's disease or syndrome","volume":"3","author":"van Sonsbeek","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.anorl.2017.12.006_bib0280","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1080\/000164800750044461","article-title":"A review of medical treatment for M\u00e9ni\u00e8re's disease","volume":"544","author":"Claes","year":"2000","journal-title":"Acta Otolaryngol Suppl"},{"key":"10.1016\/j.anorl.2017.12.006_bib0285","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1097\/MAO.0000000000000831","article-title":"M\u00e9ni\u00e8re's syndrome or disease: tie trends in management and quality of evidence over the last two decades","volume":"36","author":"Syed","year":"2015","journal-title":"Otol Neurotol"},{"key":"10.1016\/j.anorl.2017.12.006_bib0290","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.otohns.2005.05.010","article-title":"Dexamethasone inner ear perfusion by intratympanic injection in unilateral M\u00e9ni\u00e8re's disease: a two-year prospective, placebo-controlled, double-blind, randomized trial","volume":"133","author":"Garduno-Anaya","year":"2005","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.anorl.2017.12.006_bib0295","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1016\/S0140-6736(16)31461-1","article-title":"Intratympanic methylprednisolone versus gentamicin in patients with unilateral M\u00e9ni\u00e8re's disease: a randomised, double-blind, comparative effectiveness trial","volume":"388","author":"Patel","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.anorl.2017.12.006_bib0300","first-page":"CD008514","article-title":"Intratympanic steroids for M\u00e9ni\u00e8re's disease or syndrome","volume":"7","author":"Philips","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.anorl.2017.12.006_bib0305","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1111\/coa.12449","article-title":"Intratympanic therapy in M\u00e9ni\u00e8re's syndrome or disease: up to date evidence for clinical practice","volume":"40","author":"Syed","year":"2015","journal-title":"Clin Otolaryngol"},{"key":"10.1016\/j.anorl.2017.12.006_bib0310","first-page":"CD005395","article-title":"Surgery for M\u00e9ni\u00e8re's disease","volume":"1","author":"Pullens","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.anorl.2017.12.006_bib0315","first-page":"CD005395","article-title":"Surgery for M\u00e9ni\u00e8re's disease","volume":"2","author":"Pullens","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.anorl.2017.12.006_bib0320","doi-asserted-by":"crossref","first-page":"593","DOI":"10.11622\/smedj.2015166","article-title":"Current evidence for endolymphatic sac surgery in the treatment of M\u00e9ni\u00e8re's disease: a systematic review","volume":"56","author":"Lim","year":"2015","journal-title":"Singapore Med J"},{"key":"10.1016\/j.anorl.2017.12.006_bib0325","first-page":"CD008234","article-title":"Intratympanic gentamicin for M\u00e9ni\u00e8re's disease or syndrome","volume":"3","author":"Pullens","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.anorl.2017.12.006_bib0330","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1007\/s00405-013-2597-7","article-title":"Intratympanic gentamicin treatment \u201cas needed\u201d for M\u00e9ni\u00e8re's disease. Long-term analysis using the Kaplan-Meier method","volume":"271","author":"Quaglieri","year":"2014","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"10.1016\/j.anorl.2017.12.006_bib0335","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/ng0793-289","article-title":"Mitochondrial ribosomal RNA mutation associated with both antibiotic-induced and non-syndromic deafness","volume":"4","author":"Prezant","year":"1993","journal-title":"Nat Genet"},{"key":"10.1016\/j.anorl.2017.12.006_bib0340","first-page":"23","article-title":"Vestibular neurectomy in the United States 1990","volume":"13","author":"Silverstein","year":"1992","journal-title":"Am J Otol"},{"key":"10.1016\/j.anorl.2017.12.006_bib0345","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0003-438X(05)82361-8","article-title":"Vestibular neurotomy versus chemical labyrinthectomy for disabling M\u00e9ni\u00e8re disease","volume":"122","author":"Morel","year":"2005","journal-title":"Ann Otolaryngol Chir Cervicofac"},{"key":"10.1016\/j.anorl.2017.12.006_bib0350","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1097\/MAO.0b013e3180a726af","article-title":"Transmastoid labyrinthectomy versus translabyrinthine vestibular nerve section: does cutting the vestibular nerve make a difference in outcome?","volume":"28","author":"De La Cruz","year":"2007","journal-title":"Otol Neurotol"},{"key":"10.1016\/j.anorl.2017.12.006_bib0355","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/00129492-200604000-00011","article-title":"M\u00e9ni\u00e8re's disease: prevalence of contralateral ear involvement","volume":"27","author":"House","year":"2006","journal-title":"Otol Neurotol"},{"key":"10.1016\/j.anorl.2017.12.006_bib0360","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/B978-0-444-63437-5.00019-4","article-title":"M\u00e9ni\u00e8re's disease","volume":"137","author":"Espinosa-Sanchez","year":"2016","journal-title":"Handb Clin Neurol"}],"updated-by":[{"DOI":"10.1016\/j.anorl.2020.03.003","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000}}],"container-title":["European Annals of Otorhinolaryngology, Head and Neck Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1879729618300024?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1879729618300024?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T10:11:39Z","timestamp":1761819099000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1879729618300024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["S1879729618300024"],"URL":"https:\/\/doi.org\/10.1016\/j.anorl.2017.12.006","relation":{},"ISSN":["1879-7296"],"issn-type":[{"value":"1879-7296","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"International consensus (ICON) on treatment of M\u00e9ni\u00e8re's disease","name":"articletitle","label":"Article Title"},{"value":"European Annals of Otorhinolaryngology, Head and Neck Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anorl.2017.12.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}