{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:49:31Z","timestamp":1791618571490,"version":"4.3.4"},"reference-count":78,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Annals of Otorhinolaryngology, Head and Neck Diseases"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.anorl.2020.12.002","type":"journal-article","created":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T05:13:04Z","timestamp":1608873184000},"page":"355-362","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Biotherapy and treatment of adult primary chronic rhinosinusitis with nasal polyps: Cellular and molecular bases"],"prefix":"10.1016","volume":"138","author":[{"given":"S.","family":"Bartier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Coste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"B\u00e9quignon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.anorl.2020.12.002_bib0395","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.anorl.2018.03.004","article-title":"Nasal polyposis (or chronic olfactory rhinitis)","volume":"135","author":"Jankowski","year":"2018","journal-title":"Eur Ann Otorhinolaryngol Head Neck Dis"},{"key":"10.1016\/j.anorl.2020.12.002_bib0400","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.anorl.2017.11.006","article-title":"Chronic nasal dysfunction","volume":"135","author":"Jankowski","year":"2018","journal-title":"Eur Ann Otorhinolaryngol Head Neck Dis"},{"key":"10.1016\/j.anorl.2020.12.002_bib0405","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4193\/Rhino12.000","article-title":"EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012","volume":"50","author":"Fokkens","year":"2012","journal-title":"Rhinology"},{"key":"10.1016\/j.anorl.2020.12.002_bib0410","first-page":"169","article-title":"Nasal polyps in patients with rhinitis and asthma","volume":"23","author":"Grigoreas","year":"2002","journal-title":"Allergy Asthma Proc"},{"key":"10.1016\/j.anorl.2020.12.002_bib0415","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1093\/ije\/28.4.717","article-title":"Prevalence of asthma, aspirin intolerance, nasal polyposis and chronic obstructive pulmonary disease in a population-based study","volume":"28","author":"Hedman","year":"1999","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.anorl.2020.12.002_bib0420","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1398-9995.2005.00688.x","article-title":"Prevalence of nasal polyposis in France: a cross-sectional, case-control study","volume":"60","author":"Klossek","year":"2005","journal-title":"Allergy"},{"key":"10.1016\/j.anorl.2020.12.002_bib0425","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.jaip.2016.05.004","article-title":"Phenotypes and emerging endotypes of chronic rhinosinusitis","volume":"4","author":"Bachert","year":"2016","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.anorl.2020.12.002_bib0430","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2015.12.1324","article-title":"Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers","volume":"137","author":"Tomassen","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anorl.2020.12.002_bib0435","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/j.jaci.2013.02.036","article-title":"Endotypes and phenotypes of chronic rhinosinusitis: a PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology","volume":"131","author":"Akdis","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anorl.2020.12.002_bib0440","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1097\/01.mlg.0000147917.43615.c0","article-title":"Molecular and cellular staging for the severity of chronic rhinosinusitis","volume":"114","author":"Kountakis","year":"2004","journal-title":"The Laryngoscope"},{"key":"10.1016\/j.anorl.2020.12.002_bib0445","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1398-9995.1998.tb03767.x","article-title":"The role of cytokines in infectious sinusitis and nasal polyposis","volume":"53","author":"Bachert","year":"1998","journal-title":"Allergy"},{"key":"10.1016\/j.anorl.2020.12.002_bib0450","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1034\/j.1399-3003.2000.15b24.x","article-title":"Inflammatory cells as well as epithelial cells in nasal polyps express vascular endothelial growth factor","volume":"15","author":"Coste","year":"2000","journal-title":"Eur Respir J"},{"key":"10.1016\/j.anorl.2020.12.002_bib0455","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s12016-018-8712-1","article-title":"Understanding asthma phenotypes, endotypes, and mechanisms of disease","volume":"56","author":"Kuruvilla","year":"2019","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.anorl.2020.12.002_bib0460","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1002\/lary.23259","article-title":"Impact of topical nasal steroid therapy on symptoms of nasal polyposis: a meta-analysis","volume":"122","author":"Rudmik","year":"2012","journal-title":"The Laryngoscope"},{"key":"10.1016\/j.anorl.2020.12.002_bib0465","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1001\/archotol.124.5.513","article-title":"Effect of fluticasone in severe polyposis","volume":"124","author":"Lund","year":"1998","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.anorl.2020.12.002_bib0470","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1111\/all.13411","article-title":"Multidimensional endotypes of chronic rhinosinusitis and their association with treatment outcomes","volume":"73","author":"Liao","year":"2018","journal-title":"Allergy"},{"key":"10.1016\/j.anorl.2020.12.002_bib0475","doi-asserted-by":"crossref","first-page":"134","DOI":"10.2500\/ajra.2016.30.4297","article-title":"Chronic rhinosinusitis: epidemiology and burden of disease","volume":"30","author":"DeConde","year":"2016","journal-title":"Am J Rhinol Allergy"},{"key":"10.1016\/j.anorl.2020.12.002_bib0480","doi-asserted-by":"crossref","first-page":"e011857","DOI":"10.1136\/bmjopen-2016-011857","article-title":"Impact of omalizumab on treatment of severe allergic asthma in UK clinical practice: a UK multicentre observational study (the APEX II study)","volume":"6","author":"Niven","year":"2016","journal-title":"BMJ Open"},{"key":"10.1016\/j.anorl.2020.12.002_bib0485","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s12890-018-0689-2","article-title":"Anti-IL-5 therapy in patients with severe eosinophilic asthma - clinical efficacy and possible criteria for treatment response","volume":"18","author":"Drick","year":"2018","journal-title":"BMC Pulm Med"},{"key":"10.1016\/j.anorl.2020.12.002_bib0490","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1097\/00005537-199602000-00017","article-title":"Experimentally induced polyps in the sinus mucosa: a structural analysis of the initial stages","volume":"106","author":"Norlander","year":"1996","journal-title":"The Laryngoscope"},{"key":"10.1016\/j.anorl.2020.12.002_bib0495","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/j.jaci.2015.10.009","article-title":"Chronic rhinosinusitis pathogenesis","volume":"136","author":"Stevens","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anorl.2020.12.002_bib0500","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/j.lpm.2007.01.021","article-title":"Injury and epithelial wound healing: a pathophysiologic hypothesis for nasal and sinus polyposis","volume":"36","author":"Lazard","year":"2007","journal-title":"Presse Medicale Paris Fr"},{"key":"10.1016\/j.anorl.2020.12.002_bib0505","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s11882-015-0531-3","article-title":"Remodeling and repair in rhinosinusitis","volume":"15","author":"Watelet","year":"2015","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.anorl.2020.12.002_bib0510","first-page":"145","article-title":"Eosinophilic nasal polyps are a rich source of eotaxin, eotaxin-2 and eotaxin-3","volume":"44","author":"Olze","year":"2006","journal-title":"Rhinology"},{"key":"10.1016\/j.anorl.2020.12.002_bib0515","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1002\/lary.20191","article-title":"Eotaxin-1, -2, and -3 immunoreactivity and protein concentration in the nasal polyps of eosinophilic chronic rhinosinusitis patients","volume":"119","author":"Yao","year":"2009","journal-title":"The Laryngoscope"},{"key":"10.1016\/j.anorl.2020.12.002_bib0520","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2008.02.018","article-title":"T-cell regulation in chronic paranasal sinus disease","volume":"121","author":"Van Bruaene","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anorl.2020.12.002_bib0525","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1111\/j.1398-9995.2006.01225.x","article-title":"Differentiation of chronic sinus diseases by measurement of inflammatory mediators","volume":"61","author":"Van Zele","year":"2006","journal-title":"Allergy"},{"key":"10.1016\/j.anorl.2020.12.002_bib0530","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1164\/rccm.201412-2278OC","article-title":"Cytokines in chronic rhinosinusitis, role in eosinophilia and aspirin-exacerbated respiratory disease","volume":"192","author":"Stevens","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.anorl.2020.12.002_bib0535","doi-asserted-by":"crossref","first-page":"e97581","DOI":"10.1371\/journal.pone.0097581","article-title":"Mixed T helper cell signatures in chronic rhinosinusitis with and without polyps","volume":"9","author":"Derycke","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.anorl.2020.12.002_bib0540","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD006990.pub2","article-title":"Surgical interventions for chronic rhinosinusitis with nasal polyps","author":"Sharma","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.anorl.2020.12.002_bib0545","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.anorl.2019.02.013","article-title":"Intraoperative bacterial analysis in nasal polyposis: clinical and functional impact","volume":"136","author":"Gendre","year":"2019","journal-title":"Eur Ann Otorhinolaryngol Head Neck Dis"},{"key":"10.1016\/j.anorl.2020.12.002_bib0550","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.jaci.2004.07.013","article-title":"Staphylococcus aureus colonization and IgE antibody formation to enterotoxins is increased in nasal polyposis","volume":"114","author":"Van Zele","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anorl.2020.12.002_bib0555","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/alr.21517","article-title":"Staphylococcus aureus impairs the airway epithelial barrier in vitro","volume":"5","author":"Malik","year":"2015","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.anorl.2020.12.002_bib0560","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s11882-019-0853-7","article-title":"The role of Staphylococcus aureus in patients with chronic sinusitis and nasal polyposis","volume":"19","author":"Vickery","year":"2019","journal-title":"Curr Allergy Asthma Rep"},{"issue":"Suppl. 57","key":"10.1016\/j.anorl.2020.12.002_bib0565","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.1398-9995.1999.tb04413.x","article-title":"Effect of intranasal corticosteroids on release of cytokines and inflammatory mediators","volume":"54","author":"Bachert","year":"1999","journal-title":"Allergy"},{"key":"10.1016\/j.anorl.2020.12.002_bib0570","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1001\/archotol.124.12.1361","article-title":"Expression of the transforming growth factor beta isoforms in inflammatory cells of nasal polyps","volume":"124","author":"Coste","year":"1998","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.anorl.2020.12.002_bib0575","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.3389\/fimmu.2018.02220","article-title":"Involvement and possible role of eosinophils in asthma exacerbation","volume":"9","author":"Nakagome","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.anorl.2020.12.002_bib0580","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1089\/dna.2014.2712","article-title":"Expression of POSTN, IL-4, and IL-13 in chronic rhinosinusitis with nasal polyps","volume":"34","author":"Milonski","year":"2015","journal-title":"DNA Cell Biol"},{"key":"10.1016\/j.anorl.2020.12.002_bib0585","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1165\/ajrcmb.13.1.7598937","article-title":"Interleukin-4 is required for the induction of lung Th2 mucosal immunity","volume":"13","author":"Coyle","year":"1995","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.anorl.2020.12.002_bib0590","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.2147\/TCRM.S111862","article-title":"Role of biologics in severe eosinophilic asthma - focus on reslizumab","volume":"12","author":"Pelaia","year":"2016","journal-title":"Ther Clin Risk Manag"},{"key":"10.1016\/j.anorl.2020.12.002_bib0595","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2010.07.007","article-title":"Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma","volume":"126","author":"Bachert","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anorl.2020.12.002_bib0600","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.3889\/oamjms.2019.327","article-title":"Association of inflammation mediator in mucosal and tissue of chronic rhinosinusitis with recurrent nasal polyp","volume":"7","author":"Huriyati","year":"2019","journal-title":"Open Access Maced J Med Sci"},{"key":"10.1016\/j.anorl.2020.12.002_bib0605","first-page":"3283","article-title":"A brief history of IL-9","volume":"186","author":"Goswami","year":"2011","journal-title":"J Immunol Baltim Md"},{"key":"10.1016\/j.anorl.2020.12.002_bib0610","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1182\/blood.V96.6.2163","article-title":"Interleukin-9 enhances interleukin-5 receptor expression, differentiation, and survival of human eosinophils","volume":"96","author":"Gounni","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.anorl.2020.12.002_bib0615","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s004080000018","article-title":"Interleukin-9 receptor expression in asthmatic airways In vivo","volume":"178","author":"Bhathena","year":"2000","journal-title":"Lung"},{"key":"10.1016\/j.anorl.2020.12.002_bib0620","article-title":"Immune profile modulation of blood and mucosal eosinophils in nasal polyposis with concomitant asthma","volume":"114","author":"Mortuaire","year":"2015","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.anorl.2020.12.002_bib0625","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1007\/s00405-005-1031-1","article-title":"Interleukin 5, IL6, IL12, IFN-gamma, RANTES and Fractalkine in human nasal polyps, turbinate mucosa and serum","volume":"263","author":"Danielsen","year":"2006","journal-title":"Eur Arch Oto-Rhino-Laryngol"},{"key":"10.1016\/j.anorl.2020.12.002_bib0630","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.3389\/fimmu.2018.02718","article-title":"Non-redundant functions of IL-6 produced by macrophages and dendritic cells in allergic airway inflammation","volume":"9","author":"Gubernatorova","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.anorl.2020.12.002_bib0635","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/s12967-020-02309-9","article-title":"Pathogenesis of chronic rhinosinusitis with nasal polyps: role of IL-6 in airway epithelial cell dysfunction","volume":"18","author":"Bequignon","year":"2020","journal-title":"J Transl Med"},{"key":"10.1016\/j.anorl.2020.12.002_bib0640","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1600-065X.2008.00706.x","article-title":"Interleukin-10: new perspectives on an old cytokine","volume":"226","author":"Mosser","year":"2008","journal-title":"Immunol Rev"},{"key":"10.1016\/j.anorl.2020.12.002_bib0645","doi-asserted-by":"crossref","first-page":"9479","DOI":"10.1038\/s41598-017-08375-2","article-title":"The role of periostin in the occurrence and progression of eosinophilic chronic sinusitis with nasal polyps","volume":"7","author":"Xu","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.anorl.2020.12.002_bib0650","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1067\/mai.2001.112374","article-title":"Total and specific IgE in nasal polyps is related to local eosinophilic inflammation","volume":"107","author":"Bachert","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anorl.2020.12.002_bib0655","doi-asserted-by":"crossref","first-page":"7582057","DOI":"10.1155\/2018\/7582057","article-title":"Eosinophils target therapy for severe asthma: critical points","volume":"2018","author":"Brussino","year":"2018","journal-title":"BioMed Res Int"},{"key":"10.1016\/j.anorl.2020.12.002_bib0660","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1016\/j.jaip.2017.04.024","article-title":"Biotherapeutics in chronic rhinosinusitis with and without nasal polyps","volume":"5","author":"Bachert","year":"2017","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.anorl.2020.12.002_bib0665","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.jaci.2020.01.020","article-title":"Biologics for chronic rhinosinusitis with nasal polyps","volume":"145","author":"Bachert","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anorl.2020.12.002_bib0670","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaip.2014.02.001","article-title":"Omalizumab for the treatment of inadequately controlled allergic rhinitis: a systematic review and meta-analysis of randomized clinical trials","volume":"2","author":"Tsabouri","year":"2014","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.anorl.2020.12.002_bib0675","doi-asserted-by":"crossref","first-page":"11581","DOI":"10.1038\/srep11581","article-title":"Structural and physical basis for Anti-IgE therapy","volume":"5","author":"Wright","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.anorl.2020.12.002_bib0680","doi-asserted-by":"crossref","first-page":"318","DOI":"10.4193\/Rhino09.144","article-title":"A randomized, double-blind, placebo-controlled trial of anti-IgE for chronic rhinosinusitis","volume":"48","author":"Pinto","year":"2010","journal-title":"Rhinology"},{"key":"10.1016\/j.anorl.2020.12.002_bib0685","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2012.07.047","article-title":"Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma","volume":"131","author":"Gevaert","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anorl.2020.12.002_bib0690","doi-asserted-by":"crossref","first-page":"49","DOI":"10.18176\/jiaci.0391","article-title":"Effectiveness of omalizumab in severe allergic asthma and nasal polyposis: a real-life study","volume":"30","author":"Tiotiu","year":"2020","journal-title":"J Investig Allergol Clin Immunol"},{"key":"10.1016\/j.anorl.2020.12.002_bib0695","doi-asserted-by":"crossref","first-page":"42","DOI":"10.4193\/Rhin17.139","article-title":"Omalizumab treats chronic rhinosinusitis with nasal polyps and asthma together-a real life study","volume":"56","author":"Bidder","year":"2018","journal-title":"Rhinology"},{"key":"10.1016\/j.anorl.2020.12.002_bib0700","article-title":"Efficacy and safety of omalizumab in patients with chronic rhinosinusitis with nasal polyps: results from two, multicenter, randomized, double-blind, placebo-controlled phase III trials (POLYP 1 and POLYP 2)","author":"Gevaert","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anorl.2020.12.002_bib0705","first-page":"779","article-title":"Effect of Sch 55700, a humanized monoclonal antibody to human interleukin-5, on eosinophilic responses and bronchial hyperreactivity","volume":"49","author":"Egan","year":"1999","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.anorl.2020.12.002_bib0710","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.jaci.2006.05.031","article-title":"Nasal IL-5 levels determine the response to anti-IL-5 treatment in patients with nasal polyps","volume":"118","author":"Gevaert","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anorl.2020.12.002_bib0715","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/cpdd.205","article-title":"Pharmacokinetics and pharmacodynamics of mepolizumab, an anti-interleukin 5 monoclonal antibody, in healthy Japanese male subjects","volume":"5","author":"Tsukamoto","year":"2016","journal-title":"Clin Pharmacol Drug Dev"},{"key":"10.1016\/j.anorl.2020.12.002_bib0720","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1517\/14712598.2015.1041911","article-title":"Mepolizumab for eosinophilic severe asthma: recent studies","volume":"15","author":"Robinson","year":"2015","journal-title":"Expert Opin Biol Ther"},{"key":"10.1016\/j.anorl.2020.12.002_bib0725","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2011.07.056","article-title":"Mepolizumab, a humanized anti-IL-5 mAb, as a treatment option for severe nasal polyposis","volume":"128","author":"Gevaert","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anorl.2020.12.002_bib0730","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2017.05.044","article-title":"Reduced need for surgery in severe nasal polyposis with mepolizumab: randomized trial","volume":"140","author":"Bachert","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anorl.2020.12.002_bib0735","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2010.04.004","article-title":"MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function","volume":"125","author":"Kolbeck","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.anorl.2020.12.002_bib0740","first-page":"55","article-title":"Rapid effect of benralizumab for hypereosinophilia in a case of severe asthma with eosinophilic chronic rhinosinusitis","author":"Tsurumaki","year":"2019","journal-title":"Med Kaunas Lith"},{"key":"10.1016\/j.anorl.2020.12.002_bib0745","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1001\/jama.2015.19330","article-title":"Effect of subcutaneous dupilumab on nasal polyp burden in patients with chronic sinusitis and nasal polyposis: a randomized clinical trial","volume":"315","author":"Bachert","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.anorl.2020.12.002_bib0750","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1016\/S0140-6736(19)31881-1","volume":"394","author":"Bachert","year":"2019","journal-title":"Lancet Lond Engl"},{"key":"10.1016\/j.anorl.2020.12.002_bib0755","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2147\/DDDT.S150580","article-title":"Tocilizumab in the treatment of rheumatoid arthritis: an evidence-based review and patient selection","volume":"13","author":"Biggioggero","year":"2019","journal-title":"Drug Des Devel Ther"},{"key":"10.1016\/j.anorl.2020.12.002_bib0760","doi-asserted-by":"crossref","first-page":"389","DOI":"10.3892\/etm.2017.4024","article-title":"From bench to bedside: therapeutic potential of interleukin-9 in the treatment of asthma","volume":"13","author":"Gong","year":"2017","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.anorl.2020.12.002_bib0765","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1111\/all.13875","article-title":"EUFOREA consensus on biologics for CRSwCRSwNP with or without asthma","volume":"74","author":"Fokkens","year":"2019","journal-title":"Allergy"},{"key":"10.1016\/j.anorl.2020.12.002_bib0770","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1056\/NEJMoa1804092","article-title":"Dupilumab efficacy and safety in moderate-to-severe uncontrolled asthma","volume":"378","author":"Castro","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.anorl.2020.12.002_bib0775","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.anorl.2018.05.006","article-title":"Updating nasalisation: from concept to technique and results","volume":"135","author":"Jankowski","year":"2018","journal-title":"Eur Ann Otorhinolaryngol Head Neck Dis"},{"key":"10.1016\/j.anorl.2020.12.002_bib0780","article-title":"Cost utility analysis of dupilumab versus endoscopic sinus surgery for chronic rhinosinusitis with nasal polyps","author":"Scangas","year":"2020","journal-title":"Laryngoscope"}],"container-title":["European Annals of Otorhinolaryngology, Head and Neck Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1879729620302854?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1879729620302854?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:30:24Z","timestamp":1791617424000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1879729620302854"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":78,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["S1879729620302854"],"URL":"https:\/\/doi.org\/10.1016\/j.anorl.2020.12.002","relation":{},"ISSN":["1879-7296"],"issn-type":[{"value":"1879-7296","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biotherapy and treatment of adult primary chronic rhinosinusitis with nasal polyps: Cellular and molecular bases","name":"articletitle","label":"Article Title"},{"value":"European Annals of Otorhinolaryngology, Head and Neck Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anorl.2020.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}