{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:43:22Z","timestamp":1791315802111,"version":"4.3.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Anales de Pediatr\u00eda (English Edition)"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.anpede.2025.503814","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T19:22:05Z","timestamp":1744399325000},"page":"503814","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prognostic role of novel variables in sudden cardiac death risk associated to hypertrophic cardiomyopathy"],"prefix":"10.1016","volume":"102","author":[{"given":"Mar\u00eda","family":"L\u00f3pez Bl\u00e1zquez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda \u00c1ngeles","family":"Espinosa Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reyes","family":"\u00c1lvarez Garc\u00eda-Rov\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Centeno Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Isabel","family":"Fern\u00e1ndez \u00c1vila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Javier","family":"Bermejo Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constancio","family":"Medrano L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.anpede.2025.503814_bib0005","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.jchf.2018.02.010","article-title":"Hypertrophic cardiomyopathy: clinical update","volume":"6","author":"Geske","year":"2018","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.anpede.2025.503814_bib0010","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1161\/CIRCULATIONAHA.117.033200","article-title":"Genotype and lifetime burden of disease in hypertrophic cardiomyopathy: insights from the sarcomeric human cardiomyopathy registry (SHaRe)","volume":"138","author":"Ho","year":"2018","journal-title":"Circulation."},{"key":"10.1016\/j.anpede.2025.503814_bib0015","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1161\/01.CIR.0000066323.15244.54","article-title":"Hypertrophic cardiomyopathy: distribution of disease genes, spectrum of mutations, and implications for a molecular diagnosis strategy","volume":"107","author":"Richard","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.anpede.2025.503814_bib0020","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.jacc.2021.12.002","article-title":"Diagnosis and evaluation of hypertrophic cardiomyopathy: JACC state-of-the-art review","volume":"79","author":"Maron","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.anpede.2025.503814_bib0025","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1093\/eurheartj\/ehy798","article-title":"Clinical presentation and survival of childhood hypertrophic cardiomyopathy: a retrospective study in United Kingdom","volume":"40","author":"Norrish","year":"2019","journal-title":"Eur Heart J"},{"key":"10.1016\/j.anpede.2025.503814_bib0030","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1093\/eurheartj\/ehae109","article-title":"Cardiomyopathies in children and adolescents: aetiology, management, and outcomes in the European Society of Cardiology EURObservational Research Programme Cardiomyopathy and Myocarditis Registry","volume":"45","author":"Kaski","year":"2024","journal-title":"Eur Heart J"},{"issue":"1","key":"10.1016\/j.anpede.2025.503814_bib0035","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.hfc.2021.07.012","article-title":"The risk of sudden death in children with hypertrophic cardiomyopathy","volume":"18","author":"Norrish","year":"2022","journal-title":"Heart Fail Clin"},{"key":"10.1016\/j.anpede.2025.503814_bib0040","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1177\/2047487317702519","article-title":"Risk factors for sudden cardiac death in childhood hypertrophic cardiomyopathy: a systematic review and meta-analysis","volume":"24","author":"Norrish","year":"2017","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.anpede.2025.503814_bib0045","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1017\/S1047951123000872","article-title":"Indications and management of implantable cardioverter-defibrillator therapy in childhood hypertrophic cardiomyopathy","volume":"33","author":"Kaski","year":"2023","journal-title":"Cardiol Young"},{"key":"10.1016\/j.anpede.2025.503814_bib0050","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1093\/europace\/euz118","article-title":"A validation study of the European Society of Cardiology guidelines for risk stratification of sudden cardiac death in childhood hypertrophic cardiomyopathy","volume":"21","author":"Norrish","year":"2019","journal-title":"Europace"},{"key":"10.1016\/j.anpede.2025.503814_bib0055","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1093\/eurheartj\/eht439","article-title":"A novel clinical risk prediction model for sudden cardiac death in hypertrophic cardiomyopathy (HCM risk-SCD)","volume":"35","author":"O\u00b4Mahony","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.anpede.2025.503814_bib0060","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1093\/eurheartj\/ehu284","article-title":"2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy: the Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC)","volume":"35","author":"Elliot","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.anpede.2025.503814_bib0065","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1001\/jamacardio.2019.2861","article-title":"Development of a novel risk prediction model for sudden cardiac death in childhood hypertrophic cardiomyopathy (HCM Risk-Kids)","volume":"4","author":"Norrish","year":"2019","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.anpede.2025.503814_bib0070","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1093\/eurjpc\/zwab181","article-title":"External validation of the HCM Risk-Kids model for predicting sudden cardiac death in childhood hypertrophic cardiomyopathy","volume":"29","author":"Norrish","year":"2022","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.anpede.2025.503814_bib0075","first-page":"623","article-title":"Effectiveness of the 2014 European Society of Cardiology guideline on sudden cardiac death in hypertrophic cardiomyopathy: a systematic review and meta-analysis","volume":"105","author":"O\u00b4Mahony","year":"2019","journal-title":"Heart"},{"key":"10.1016\/j.anpede.2025.503814_bib0080","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1161\/CIRCULATIONAHA.117.032966","article-title":"Prevalence and progression of late gadolinium enhancement in children and adolescents with hypertrophic cardiomyopathy","volume":"138","author":"Raja","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.anpede.2025.503814_bib0085","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1111\/echo.13878","article-title":"Echocardiographic advances in hypertrophic cardiomyopathy: three-dimensional and strain imaging echocardiography","volume":"35","author":"Inciardi","year":"2018","journal-title":"Echocardiography"},{"key":"10.1016\/j.anpede.2025.503814_bib0090","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1007\/s00392-018-1354-8","article-title":"Genetic basis of hypertrophic cardiomyopathy in children","volume":"108","author":"Rupp","year":"2019","journal-title":"Clin Res Cardiol"},{"key":"10.1016\/j.anpede.2025.503814_bib0095","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.012531","article-title":"RIKADA study reveals risk factors in pediatric primary cardiomyopathy","volume":"8","author":"Al-Wakeel-Marquard","year":"2019","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.anpede.2025.503814_bib0100","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med"},{"key":"10.1016\/j.anpede.2025.503814_bib0105","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1016\/j.jacc.2020.08.044","article-title":"2020 AHA\/ACC guideline for the diagnosis and treatment of patients with hypertrophic cardiomyopathy: executive summary: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"76","author":"Ommen","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.anpede.2025.503814_bib0110","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/s12872-021-01927-5","article-title":"Diagnostic yield of genetic testing in a heterogeneous cohort of 1376 HCM patients","volume":"21","author":"Hathaway","year":"2021","journal-title":"BMC Cardiovasc Disord"},{"issue":"2","key":"10.1016\/j.anpede.2025.503814_bib0115","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/cge.13157","article-title":"Utility of genetics for risk stratification in pediatric hypertrophic cardiomyopathy","volume":"93","author":"Mathew","year":"2018","journal-title":"Clin Genet"},{"key":"10.1016\/j.anpede.2025.503814_bib0120","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1161\/CIRCULATIONAHA.120.047235","article-title":"A validated model for sudden cardiac death risk prediction in pediatric hypertrophic cardiomyopathy","volume":"142","author":"Miron","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.anpede.2025.503814_bib0125","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1001\/jamacardio.2018.0789","article-title":"Long-term outcomes of pediatric-onset hypertrophic cardiomyopathy and age-specific risk factors for lethal arrhythmic events","volume":"3","author":"Maurizi","year":"2018","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.anpede.2025.503814_bib0130","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1016\/j.jcmg.2018.07.016","article-title":"Prognostic value of global longitudinal strain in hypertrophic cardiomyopathy: a systematic review of existing literature","volume":"12","author":"Tower-Rader","year":"2019","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.anpede.2025.503814_bib0135","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.1016\/j.jcmg.2020.06.009","article-title":"LGE for risk stratification in primary prevention in children with HCM","volume":"13","author":"Petryka-Mazurkiewicz","year":"2020","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.anpede.2025.503814_bib0140","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/j.amjcard.2019.07.023","article-title":"Prognostic role of late gadolinium enhancement in patients with hypertrophic cardiomyopathy and low-to-intermediate sudden cardiac death risk score","volume":"124","author":"Todiere","year":"2019","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.anpede.2025.503814_bib0145","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s12968-019-0561-4","article-title":"The amount of late gadolinium enhancement outperforms current guideline-recommended criteria in the identification of patients with hypertrophic cardiomyopathy at risk of sudden cardiac death","volume":"21","author":"Freitas","year":"2019","journal-title":"J Cardiovasc Magn Reson"},{"key":"10.1016\/j.anpede.2025.503814_bib0150","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1093\/eurheartj\/ehad194","article-title":"2023 ESC Guidelines for the management of cardiomyopathies. Developed by the task force on the management of cardiomyopathies of the European Society of Cardiology (ESC)","volume":"44","author":"Arbelo","year":"2023","journal-title":"Eur Heart J"},{"key":"10.1016\/j.anpede.2025.503814_bib0155","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1016\/j.jacc.2024.02.014","article-title":"Guideline for the Management of Hypertrophic Cardiomyopathy: A Report of the American Heart Association\/American College of Cardiology Joint Committee on Clinical Practice Guidelines","volume":"83","author":"Ommen","year":"2024","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.anpede.2025.503814_bib0160","article-title":"Description of a novel variant in the FHL1 gene associated with hypertrophic cardiomyopathy with early and aggressive presentation","author":"L\u00f3pez Bl\u00e1zquez","year":"2022","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"key":"10.1016\/j.anpede.2025.503814_bib0165","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s00392-017-1155-5","article-title":"Clinical outcomes associated with sarcomere mutations in hypertrophic cardiomyopathy: a meta-analysis on 7675 individuals","volume":"107","author":"Sedaghat-Hamedani","year":"2018","journal-title":"Clin Res Cardiol"},{"key":"10.1016\/j.anpede.2025.503814_bib0170","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1111\/apa.16045","article-title":"Sudden cardiac death in childhood hypertrophic cardiomyopathy is best predicted by a combination of electrocardiogram risk-score and HCM Risk-Kids score","volume":"110","author":"\u00d6stman-Smith","year":"2021","journal-title":"Acta Paediatr"}],"container-title":["Anales de Pediatr\u00eda (English Edition)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2341287925000997?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2341287925000997?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T11:08:02Z","timestamp":1745406482000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2341287925000997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S2341287925000997"],"URL":"https:\/\/doi.org\/10.1016\/j.anpede.2025.503814","relation":{},"ISSN":["2341-2879"],"issn-type":[{"value":"2341-2879","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prognostic role of novel variables in sudden cardiac death risk associated to hypertrophic cardiomyopathy","name":"articletitle","label":"Article Title"},{"value":"Anales de Pediatr\u00eda (English Edition)","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anpede.2025.503814","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.anpedi.2025.503814","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Asociaci\u00f3n Espa\u00f1ola de Pediatr\u00eda. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}],"article-number":"503814"}}