{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T16:10:10Z","timestamp":1747757410836,"version":"3.41.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Anales de Pediatr\u00eda (English Edition)"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.anpede.2025.503840","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T11:23:12Z","timestamp":1747308192000},"page":"503840","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evolution of antibiotic prescription in Primary Health Care according to the indicators of the Spanish Action Plan on Antibiotic Resistance (PRAN)"],"prefix":"10.1016","volume":"102","author":[{"given":"Carlos","family":"Marcilla V\u00e1zquez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"R\u00edos Laorden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1ngeles","family":"Lloret Callejo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Tejada Cifuentes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Tirado Pel\u00e1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"P\u00e1rraga-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"article-title":"F\u00e1rmacos: caracterizaci\u00f3n del consumo de antibi\u00f3ticos (J01)","year":"2023","series-title":"Base de Datos Cl\u00ednicos de Atenci\u00f3n Primaria","key":"10.1016\/j.anpede.2025.503840_bib0005"},{"year":"2023","series-title":"Perfil de utilizaci\u00f3n de medicamentos por edad y sexo. Base de Datos Cl\u00ednicos de Atenci\u00f3n Primaria","key":"10.1016\/j.anpede.2025.503840_bib0010"},{"year":"2020","series-title":"Infecciones respiratorias: cu\u00e1ntas, qui\u00e9nes, cu\u00e1ndo. Base de Datos Cl\u00ednicos de Atenci\u00f3n Primaria","key":"10.1016\/j.anpede.2025.503840_bib0015"},{"key":"10.1016\/j.anpede.2025.503840_bib0020","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.anpedi.2020.11.010","article-title":"Evoluci\u00f3n del consumo de antibi\u00f3ticos a nivel extrahospitalario en Asturias, Espa\u00f1a (2005-2018)","volume":"95","author":"Calle-Miguel","year":"2021","journal-title":"An Pediatr (Barc)"},{"year":"2024","series-title":"Antimicrobial consumption in the EU\/EEA (ESAC-Net) - Annual Epidemiological Report 2023","key":"10.1016\/j.anpede.2025.503840_bib0025"},{"year":"2021","series-title":"Resistencia a los antimicrobianos. Datos y cifras","key":"10.1016\/j.anpede.2025.503840_bib0030"},{"year":"2015","series-title":"Plan estrat\u00e9gico y de acci\u00f3n para reducir el riesgo de selecci\u00f3n y diseminaci\u00f3n de la resistencia a los antibi\u00f3ticos. Agencia Espa\u00f1ola de Medicamentos y Productos Sanitarios (AEMPS)","key":"10.1016\/j.anpede.2025.503840_bib0035"},{"key":"10.1016\/j.anpede.2025.503840_bib0040","unstructured":"Plan Nacional Resistencia Antibi\u00f3ticos. Mapas de consumo en salud humana. Consumo antibi\u00f3ticos sector comunitario [internet]. [Accessed 9 September 2024]. Available from: https:\/\/www.resistenciaantibioticos.es\/es\/lineas-de-accion\/vigilancia\/mapas-de-consumo\/consumo-antibioticos-humana\/consumos-antibioticos-en-atencion-primaria."},{"key":"10.1016\/j.anpede.2025.503840_bib0045","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S1695-4033(07)70574-X","article-title":"Variabilidad de la prescripci\u00f3n de antibi\u00f3ticos en la poblaci\u00f3n pedi\u00e1trica de Castilla y Le\u00f3n durante los a\u00f1os 2001 a 2005 en el medio urbano o rural","volume":"67","author":"V\u00e1zquez","year":"2007","journal-title":"An Pediatr (Barc)"},{"key":"10.1016\/j.anpede.2025.503840_bib0050","first-page":"139","article-title":"Prescripci\u00f3n de antibi\u00f3ticos a la poblaci\u00f3n pedi\u00e1trica de Castilla y Le\u00f3n en la \u00faltima d\u00e9cada: tendencias, fluctuaciones estacionales y diferencias geogr\u00e1ficas","volume":"25","author":"V\u00e1zquez","year":"2012","journal-title":"Rev Esp Quimioter"},{"key":"10.1016\/j.anpede.2025.503840_bib0055","doi-asserted-by":"crossref","first-page":"107","DOI":"10.37201\/req\/108.2020","article-title":"Variabilidad entre \u00e1reas sanitarias en el consumo extrahospitalario de antibi\u00f3ticos de uso sist\u00e9mico en la poblaci\u00f3n pedi\u00e1trica del Principado de Asturias, Espa\u00f1a (2005-2018)","volume":"34","author":"Calle-Miguel","year":"2021","journal-title":"Rev Esp Quimioter"},{"key":"10.1016\/j.anpede.2025.503840_bib0060","first-page":"363","article-title":"Prescripci\u00f3n de antibi\u00f3ticos en ni\u00f1os en Atenci\u00f3n Primaria. Estudio en un \u00e1rea administrativa de Osakidetza-Servicio Vasco de Salud","volume":"22","author":"Arginzoniz Marzana","year":"2020","journal-title":"Rev Pediatr Aten Primaria"},{"key":"10.1016\/j.anpede.2025.503840_bib0065","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.eimc.2012.03.004","article-title":"Prescripci\u00f3n extrahospitalaria de antibi\u00f3ticos en Arag\u00f3n y sus diferencias por g\u00e9nero y edad","volume":"30","author":"Lallana-Alvarez","year":"2012","journal-title":"Enferm Infecc Microbiol Clin"},{"year":"2017","series-title":"Objetivos de mejora prioritarios en Atenci\u00f3n Primaria (Pediatr\u00eda)","key":"10.1016\/j.anpede.2025.503840_bib0070"},{"year":"2022","series-title":"Plan estrat\u00e9gico 2022-2024 del plan nacional frente a la resistencia a los antibi\u00f3ticos (PRAN)","key":"10.1016\/j.anpede.2025.503840_bib0075"},{"year":"2020","series-title":"Real Decreto-ley 11\/2020, de 31 de marzo, por el que se adoptan medidas urgentes complementarias en el \u00e1mbito social y econ\u00f3mico para hacer frente al COVID-19","key":"10.1016\/j.anpede.2025.503840_bib0080"},{"key":"10.1016\/j.anpede.2025.503840_bib0085","doi-asserted-by":"crossref","first-page":"196","DOI":"10.3390\/antibiotics10020196","article-title":"Impact of the COVID-19 pandemic on antibiotic prescribing for common infections in The Netherlands: a primary care-based observational cohort study","volume":"10","author":"Van de Pol","year":"2021","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.anpede.2025.503840_bib0090","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.3390\/antibiotics10091040","article-title":"The impact of the COVID-19 pandemic on antibiotic prescribing trends in outpatient care: a nationwide, quasi-experimental approach","volume":"10","author":"Silva","year":"2021","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.anpede.2025.503840_bib0095","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1111\/bcp.15000","article-title":"Changes in antibiotic prescribing following COVID-19 restrictions: lessons for post-pandemic antibiotic stewardship","volume":"88","author":"Gillies","year":"2022","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.anpede.2025.503840_bib0100","doi-asserted-by":"crossref","first-page":"591","DOI":"10.3390\/antibiotics10050591","article-title":"Impact of the COVID-19 pandemic on the prescribing patterns of first-line antibiotics in English primary Care: a longitudinal analysis of national prescribing dataset","volume":"10","author":"Hussain","year":"2021","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.anpede.2025.503840_bib0105","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.cmi.2021.01.021","article-title":"Effect of the coronavirus disease 2019 pandemic on antibiotic use in primary care","volume":"27","author":"Pe\u00f1alva","year":"2021","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.anpede.2025.503840_bib0110","doi-asserted-by":"crossref","first-page":"136.e1","DOI":"10.1016\/j.anpedi.2022.12.005","article-title":"Programas de optimizaci\u00f3n del uso de antibi\u00f3ticos (PROA) en pediatr\u00eda de atenci\u00f3n primaria","volume":"98","author":"Alba\u00f1il Ballesteros","year":"2023","journal-title":"An Pediatr\u00eda."},{"year":"2017","series-title":"Indicadores de uso de antibi\u00f3ticos en Atenci\u00f3n Primaria","key":"10.1016\/j.anpede.2025.503840_bib0115"},{"key":"10.1016\/j.anpede.2025.503840_bib0120","doi-asserted-by":"crossref","first-page":"e126","DOI":"10.1097\/INF.0000000000003446","article-title":"Monitoring antibiotic consumption in pediatrics how close to reality are days of therapy and recommended daily dose methods?","volume":"41","author":"Baier","year":"2022","journal-title":"Pediatr Infect Dis J"},{"year":"2021","series-title":"F\u00e1rmacos: \u00bfc\u00f3mo medir el consumo? ATC, DDD, DHD, dispensaci\u00f3n. Base de Datos Cl\u00ednicos de Atenci\u00f3n Primaria","key":"10.1016\/j.anpede.2025.503840_bib0125"},{"key":"10.1016\/j.anpede.2025.503840_bib0130","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.eimc.2014.07.011","article-title":"Selecci\u00f3n de indicadores para la monitorizaci\u00f3n continua del impacto de programas de optimizaci\u00f3n de uso de antimicrobianos en Atenci\u00f3n Primaria","volume":"33","author":"Fern\u00e1ndez-Urrusuno","year":"2015","journal-title":"Enferm Infecc Microbiol Clin"},{"key":"10.1016\/j.anpede.2025.503840_bib0135","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.eimc.2022.06.014","article-title":"Consumo de antibi\u00f3ticos en pediatr\u00eda de atenci\u00f3n primaria antes y durante la pandemia de COVID-19","volume":"41","author":"P\u00e9rez Sol\u00eds","year":"2023","journal-title":"Enferm Infecc Microbiol Cl\u00edn"},{"key":"10.1016\/j.anpede.2025.503840_bib0140","doi-asserted-by":"crossref","first-page":"e144","DOI":"10.1016\/S1473-3099(20)30917-8","article-title":"Antibiotic prescribing in general practice during COVID-19","volume":"21","author":"Armitage","year":"2021","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.anpede.2025.503840_bib0145","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1097\/INF.0000000000001757","article-title":"Age-specific antibiotic prescribing and adherence to guidelines in pediatric patients in primary care","volume":"37","author":"Ivanovska","year":"2018","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.anpede.2025.503840_bib0150","first-page":"139","article-title":"Infecciones respiratorias virales","volume":"2","author":"Francisco-Gonz\u00e1lez","year":"2023","journal-title":"Protoc Diagn Ter Pediatr"},{"key":"10.1016\/j.anpede.2025.503840_bib0155","first-page":"51","article-title":"Faringoamigdalitis aguda y sus complicaciones","volume":"2","author":"Otero P\u00e9rez","year":"2023","journal-title":"Protoc Diagn Ter Pediatr"},{"key":"10.1016\/j.anpede.2025.503840_bib0160","first-page":"151","article-title":"Neumon\u00eda adquirida en la comunidad","volume":"2","author":"Manzanares Casteleiro","year":"2023","journal-title":"Protoc diagn ter pediatr"},{"key":"10.1016\/j.anpede.2025.503840_bib0165","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.anpedi.2023.03.003","article-title":"Actualizaci\u00f3n del documento de consenso sobre etiolog\u00eda, diagn\u00f3stico y tratamiento de la otitis media agua y sinusitis","volume":"98","author":"L\u00f3pez Mart\u00edn","year":"2023","journal-title":"An Pediatr (Barc)"},{"key":"10.1016\/j.anpede.2025.503840_bib0170","doi-asserted-by":"crossref","first-page":"206.e1","DOI":"10.1016\/j.anpedi.2020.05.004","article-title":"Actualizaci\u00f3n del documento de consenso sobre el diagn\u00f3stico y tratamiento de la faringoamigdalitis aguda","volume":"93","author":"Pi\u00f1eiro P\u00e9rez","year":"2020","journal-title":"An Pediatr\u00eda"},{"key":"10.1016\/j.anpede.2025.503840_bib0175","doi-asserted-by":"crossref","first-page":"3576","DOI":"10.1128\/AAC.06393-11","article-title":"Spanish multicenter study of the epidemiology and mechanisms of amoxicillin-clavulanate resistance in Escherichia coli","volume":"56","author":"Ortega","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.anpede.2025.503840_bib0180","first-page":"353","article-title":"Encuesta sobre el manejo diagn\u00f3stico y el uso racional de los antibi\u00f3ticos en patolog\u00eda respiratoria pedi\u00e1trica en Atenci\u00f3n Primaria","volume":"23","author":"Fern\u00e1ndez Romero","year":"2021","journal-title":"Rev Pediatr Aten Primaria"},{"key":"10.1016\/j.anpede.2025.503840_bib0185","doi-asserted-by":"crossref","first-page":"99.e1","DOI":"10.1016\/j.anpedi.2016.06.003","article-title":"Documento de consenso de la SEIP, SEICAP, AEPap y SEPEAP sobre antibioterapia en alergia a penicilina o amoxicilina","volume":"86","author":"Baquero-Artigao","year":"2017","journal-title":"An Pediatr\u00eda"},{"year":"2020","series-title":"Recommendations to restrict use of fosfomycin antibiotics. The Netherlands","key":"10.1016\/j.anpede.2025.503840_bib0190"},{"key":"10.1016\/j.anpede.2025.503840_bib0195","first-page":"49","article-title":"Desabastecimiento de antibi\u00f3ticos pedi\u00e1tricos","volume":"55","author":"Goienetxea","year":"2023","journal-title":"Bol S Vasco-Nav Pediatr"},{"year":"2022","series-title":"La AEMPS actualiza la situaci\u00f3n ocasionada por los problemas de suministros con las suspensiones pedi\u00e1tricas de amoxicilina 250mg\/5ml","key":"10.1016\/j.anpede.2025.503840_bib0200"},{"key":"10.1016\/j.anpede.2025.503840_bib0205","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2020-040295","article-title":"Antibiotic stewardship in pediatrics","volume":"147","author":"Gerber","year":"2021","journal-title":"Pediatrics"},{"key":"10.1016\/j.anpede.2025.503840_bib0210","first-page":"373","article-title":"Resultados de la implementaci\u00f3n de un programa piloto de optimizaci\u00f3n de antimicrobianos (PROA) en Atenci\u00f3n Primaria","volume":"43","author":"Alzueta Isturiz","year":"2020","journal-title":"An Sist Sanit Navar"}],"container-title":["Anales de Pediatr\u00eda (English Edition)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2341287925001279?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2341287925001279?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T15:35:31Z","timestamp":1747755331000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2341287925001279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S2341287925001279"],"URL":"https:\/\/doi.org\/10.1016\/j.anpede.2025.503840","relation":{},"ISSN":["2341-2879"],"issn-type":[{"type":"print","value":"2341-2879"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evolution of antibiotic prescription in Primary Health Care according to the indicators of the Spanish Action Plan on Antibiotic Resistance (PRAN)","name":"articletitle","label":"Article Title"},{"value":"Anales de Pediatr\u00eda (English Edition)","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anpede.2025.503840","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.anpedi.2025.503840","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Asociaci\u00f3n Espa\u00f1ola de Pediatr\u00eda. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}],"article-number":"503840"}}