{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:17:47Z","timestamp":1787242667667,"version":"build-2736575974"},"reference-count":49,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":6105,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Anales de Pediatr\u00eda"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1016\/j.anpedi.2009.07.037","type":"journal-article","created":{"date-parts":[[2009,10,22]],"date-time":"2009-10-22T09:16:57Z","timestamp":1256203017000},"page":"495-501","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Esteatosis hep\u00e1tica, resistencia a la insulina y adiponectina en una poblaci\u00f3n con obesidad"],"prefix":"10.1016","volume":"71","author":[{"given":"M.","family":"L\u00f3pez-Capap\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"L\u00f3pez-Bermejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Alonso Blanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Lara Orejas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Corbat\u00f3n Blasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Barrio Castellanos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.anpedi.2009.07.037_bib1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nm0106-75","article-title":"Diabetes and obesity: the twin epidemics","volume":"12","author":"Smyth","year":"2006","journal-title":"Nat Med"},{"key":"10.1016\/j.anpedi.2009.07.037_bib2","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1042\/CS20070402","article-title":"Non-alcoholic fatty liver disease: an overview of prevalence, diagnosis, pathogenesis and treatment considerations","volume":"115","author":"Preiss","year":"2008","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.anpedi.2009.07.037_bib3","first-page":"659","article-title":"Non-alcoholic fatty liver disease: an under-recognized cause with emerging importance","volume":"90","author":"Das","year":"2006","journal-title":"Curr Sci"},{"key":"10.1016\/j.anpedi.2009.07.037_bib4","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.cld.2004.04.013","article-title":"The histologic spectrum of nonalcoholic fatty liver disease","volume":"8","author":"Contos","year":"2004","journal-title":"Clin Liver Dis"},{"key":"10.1016\/j.anpedi.2009.07.037_bib5","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1023\/A:1018850223495","article-title":"Liver involvement in obese children. Ultrasonography and liver enzyme levels at diagnosis and during follow-up in an Italian population","volume":"42","author":"Franzese","year":"1997","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.anpedi.2009.07.037_bib6","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1067\/S0022-3476(03)00325-1","article-title":"Obesity, insulin resistance, and other clinopathological correlates of pediatric non alcoholic fatty liver disease","volume":"143","author":"Schwimmer","year":"2003","journal-title":"J Pediatr"},{"key":"10.1016\/j.anpedi.2009.07.037_bib7","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1038\/sj.ijo.0802734","article-title":"Hepatic steatosis in obese Chinese children","volume":"28","author":"Chan","year":"2004","journal-title":"Int J Obes Relat Metab Disord"},{"key":"10.1016\/j.anpedi.2009.07.037_bib8","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1542\/peds.2006-1212","article-title":"Prevalence of fatty liver in children and adolescents","volume":"118","author":"Schwimmer","year":"2006","journal-title":"Pediatrics"},{"key":"10.1016\/j.anpedi.2009.07.037_bib9","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1007\/BF02208670","article-title":"Prevalence of fatty liver in Japanese children and relationship to obesity","volume":"40","author":"Tominaga","year":"1995","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.anpedi.2009.07.037_bib10","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1515\/JPEM.2007.20.10.1059","article-title":"Non-alcoholic fatty-liver disease in pediatric populations","volume":"20","author":"Ch\u00e1vez-Tapia","year":"2007","journal-title":"J Pediatr Endocrinol Metab"},{"key":"10.1016\/j.anpedi.2009.07.037_bib11","doi-asserted-by":"crossref","first-page":"4753","DOI":"10.1210\/jc.2006-0587","article-title":"Review: The role of insulin resistance in non alcoholic fatty liver disease","volume":"91","author":"Utzschneider","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.anpedi.2009.07.037_bib12","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.hepres.2005.09.012","article-title":"Insulin resistance and clinical aspects of non-alcoholic steatohepatitis (NASH)","volume":"33","author":"Agarwal","year":"2005","journal-title":"Hepatol Res"},{"key":"10.1016\/j.anpedi.2009.07.037_bib13","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1210\/jc.2006-2294","article-title":"Adiponectin independently predicts metabolic syndrome in overweight latino youth","volume":"92","author":"Shaibi","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.anpedi.2009.07.037_bib14","series-title":"Curvas y tablas de crecimiento. Instituto de Investigaci\u00f3n sobre Crecimiento y Desarrollo. Fundaci\u00f3n Faustino Orbegozo","author":"Hern\u00e1ndez","year":"1988"},{"key":"10.1016\/j.anpedi.2009.07.037_bib15","doi-asserted-by":"crossref","unstructured":"The fourth report on the diagnosis, evaluation and treatment of high blood pressure in children and adolescents. National High Blood Pressure Education Program Working group on High Blood Pressure in children and adolescents. Pediatrics. 2004;114:555\u201376.","DOI":"10.1542\/peds.114.2.S2.555"},{"key":"10.1016\/j.anpedi.2009.07.037_bib16","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1530\/eje.1.02206","article-title":"Frequency of the metabolic syndrome in obese Spanish pediatric population","volume":"155","author":"L\u00f3pez-Capap\u00e9","year":"2006","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.anpedi.2009.07.037_bib17","doi-asserted-by":"crossref","first-page":"5","DOI":"10.2337\/diacare.27.2007.S5","article-title":"Diagnosis and classification of diabetes mellitus","volume":"27","author":"American Diabetes Association","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.anpedi.2009.07.037_bib18","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1001\/archpedi.157.8.821","article-title":"Prevalence of a metabolic syndrome phenotype in adolescents. Findings from the Third National Health and Nutrition Examination Survey. 1988\u20131994","volume":"157","author":"Cook","year":"2003","journal-title":"Arch Pediatr Adolesc Med"},{"key":"10.1016\/j.anpedi.2009.07.037_bib19","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.jpeds.2005.07.030","article-title":"Decrease serum adiponectin: an early event in pediatric non-alcoholic fatty liver disease","volume":"147","author":"Louthan","year":"2005","journal-title":"J Pediatr"},{"key":"10.1016\/j.anpedi.2009.07.037_bib20","first-page":"48","article-title":"Non-alcoholic steato-hepatitis in children","volume":"30","author":"Rashid","year":"2000","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.anpedi.2009.07.037_bib21","doi-asserted-by":"crossref","first-page":"314","DOI":"10.2337\/diacare.27.2.314","article-title":"Indexes of insulin resistance and secretion in obese children and adolescents","volume":"27","author":"Conwell","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.anpedi.2009.07.037_bib22","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1478-3231.2008.01790.x","article-title":"Non-alcoholic fatty liver disease prevalence among school-age children and adolescents in Iran and its association with biochemical and anthropometric measures","volume":"29","author":"Alavian","year":"2009","journal-title":"Liver Int"},{"key":"10.1016\/j.anpedi.2009.07.037_bib23","first-page":"374","article-title":"Steatohepatitis in obese children. A cause of chronic liver dysfunction","volume":"78","author":"Moran","year":"1983","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.anpedi.2009.07.037_bib24","doi-asserted-by":"crossref","first-page":"A701","DOI":"10.1016\/S0016-5085(03)83544-8","article-title":"Non alcoholic fatty liver disease in children: a follow-up study for up to 16 years","volume":"124","author":"Feldstein","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.anpedi.2009.07.037_bib25","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/S0022-3476(95)70156-7","article-title":"Idiopathic steatohepatitis in childhood. A multicenter retrospective study","volume":"127","author":"Baldridge","year":"1995","journal-title":"J Pediatr"},{"key":"10.1016\/j.anpedi.2009.07.037_bib26","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/hep.21262","article-title":"NAFLD in children: a prospective clinical-pathological study and effect of lifestyle advice","volume":"44","author":"Nobili","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.anpedi.2009.07.037_bib27","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1507\/endocrj.52.519","article-title":"Serum adiponectin, resistin levels and non-alcoholic fatty liver disease in obese children","volume":"52","author":"Zou","year":"2005","journal-title":"Endocr J"},{"key":"10.1016\/j.anpedi.2009.07.037_bib28","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1038\/sj.ijo.0802734","article-title":"Hepatic steatosis in obese Chinese children","volume":"28","author":"Chan","year":"2004","journal-title":"Int J Obes Relat Metab Disord"},{"key":"10.1016\/j.anpedi.2009.07.037_bib29","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/sj.ejcn.1602588","article-title":"Predictors of non-alcoholic fatty liver disease in obese children","volume":"61","author":"Sartorio","year":"2007","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.anpedi.2009.07.037_bib30","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1080\/09637480701780088","article-title":"Is there any association between high-density lipoprotein, insulin resistance and non-alcoholic fatty liver disease in obese children?","volume":"60","author":"Papandreou","year":"2009","journal-title":"Int J Food Sci Nutr"},{"key":"10.1016\/j.anpedi.2009.07.037_bib31","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1053\/gast.2002.35354","article-title":"The utility of radiological imaging in non-alcoholic fatty liver disease","volume":"123","author":"Saadeh","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.anpedi.2009.07.037_bib32","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0009-9260(05)80350-2","article-title":"Comparison of liver histology with ultrasonography in assessing difuse parenchymal liver disease","volume":"43","author":"Joseph","year":"1991","journal-title":"Clin Radiol"},{"key":"10.1016\/j.anpedi.2009.07.037_bib33","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/S1695-4033(00)77472-8","article-title":"Valores elevados de alanina aminotransferasa y colinesterasa en ni\u00f1os obesos prep\u00faberes: correlaci\u00f3n con la concentraci\u00f3n de insulina basal e \u00edndices antropom\u00e9tricos","volume":"53","author":"Martos Estepa","year":"2000","journal-title":"An Pediatr (Barc)"},{"key":"10.1016\/j.anpedi.2009.07.037_bib34","first-page":"54","article-title":"The spectrum of fatty liver in obese children and the relationship of serum aminotransferases to severity of steatosis","volume":"36","author":"Fishbein","year":"2003","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.anpedi.2009.07.037_bib35","first-page":"727","article-title":"Prevalence of abnormal serum aminotransferase values in overweight and obese adolescents","volume":"136","author":"Strauss","year":"2000","journal-title":"J Pediatr"},{"key":"10.1016\/j.anpedi.2009.07.037_bib36","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1210\/jc.2004-1024","article-title":"Insulin resistance, the metabolic syndrome and non alcoholic fatty liver disease","volume":"90","author":"Angelico","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.anpedi.2009.07.037_bib37","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/S0002-9343(99)00271-5","article-title":"Association of non alcoholic fatty liver disease with insulin resistance","volume":"107","author":"Marchesini","year":"1999","journal-title":"Am J Med"},{"key":"10.1016\/j.anpedi.2009.07.037_bib38","doi-asserted-by":"crossref","first-page":"4287","DOI":"10.1210\/jc.2006-1010","article-title":"Alanine aminotransferase levels and fatty liver in childhood obesity: associations with insulin resistance, adiponectin and visceral fat","volume":"91","author":"Burgert","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.anpedi.2009.07.037_bib39","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jpeds.2005.02.028","article-title":"Metabolic, hormonal, oxidative and inflamatory factors in pediatric obesity-related liver disease","volume":"147","author":"Mandato","year":"2005","journal-title":"J Pediatr"},{"key":"10.1016\/j.anpedi.2009.07.037_bib40","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S1695-4033(02)77816-8","article-title":"Esteatosis y cirrosis hep\u00e1tica asociada a resistencia insul\u00ednica. Posibles mecanismos fisiopatol\u00f3gicos","volume":"56","author":"Bonet Serra","year":"2002","journal-title":"An Esp Pediatr"},{"key":"10.1016\/j.anpedi.2009.07.037_bib41","first-page":"419","article-title":"Esteatosis hep\u00e1tica no alcoh\u00f3lica. Puesta al d\u00eda","volume":"40","author":"Caballer\u00eda Rovira","year":"2008","journal-title":"Pediatr (Barc)"},{"key":"10.1016\/j.anpedi.2009.07.037_bib42","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1097\/01.mop.0000172816.79637.c5","article-title":"Non alcoholic fatty liver disease in the pediatric population: a review","volume":"17","author":"Wieckowska","year":"2005","journal-title":"Curr Opin Pediatr"},{"key":"10.1016\/j.anpedi.2009.07.037_bib43","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.clnu.2004.04.010","article-title":"Adiponectin, the missing link in insulin resistance and obesity","volume":"23","author":"Gil-Campos","year":"2004","journal-title":"Clin Nutr"},{"key":"10.1016\/j.anpedi.2009.07.037_bib44","doi-asserted-by":"crossref","first-page":"4415","DOI":"10.1210\/jc.2006-0733","article-title":"Adiponectin in childhood and adolescent obesity and its association with inflammatory markers and components of the metabolic syndrome","volume":"91","author":"Winer","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.anpedi.2009.07.037_bib45","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1503\/cmaj.045232","article-title":"Non alcoholic fatty liver disease","volume":"172","author":"Adams","year":"2005","journal-title":"Can Med Assoc J"},{"key":"10.1016\/j.anpedi.2009.07.037_bib46","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1530\/eje.1.02287","article-title":"Low plasma adiponectin is an indicator of the metabolic syndrome","volume":"155","author":"Santaniemi","year":"2006","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.anpedi.2009.07.037_bib47","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/hep.20283","article-title":"Free fatty acids promote hepatic lipotoxicity by stimulating TNF-\u03b1 expression via a lysosomal pathway","volume":"40","author":"Feldstein","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.anpedi.2009.07.037_bib48","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/hep.20280","article-title":"Beyond insulin resistance in NASH: TNF-alpha or adiponectin?","volume":"40","author":"Hui","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.anpedi.2009.07.037_bib49","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/hep.20282","article-title":"Adiponectin protects LPS-induced liver injury through modulation of TNF-\u03b1 in KK-Ay obese mice","volume":"40","author":"Masaki","year":"2004","journal-title":"Hepatology"}],"container-title":["Anales de Pediatr\u00eda"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S169540330900486X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S169540330900486X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T02:29:16Z","timestamp":1787106556000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S169540330900486X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["S169540330900486X"],"URL":"https:\/\/doi.org\/10.1016\/j.anpedi.2009.07.037","relation":{},"ISSN":["1695-4033"],"issn-type":[{"value":"1695-4033","type":"print"}],"subject":[],"published":{"date-parts":[[2009,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Esteatosis hep\u00e1tica, resistencia a la insulina y adiponectina en una poblaci\u00f3n con obesidad","name":"articletitle","label":"Article Title"},{"value":"Anales de Pediatr\u00eda","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anpedi.2009.07.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Asociaci\u00f3n Espa\u00f1ola de Pediatr\u00eda. Published by Elsevier Espa\u00f1a S.L. All rights reserved.","name":"copyright","label":"Copyright"}]}}