{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T08:18:32Z","timestamp":1788337112719,"version":"build-2803163510"},"reference-count":23,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":5223,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Anales de Pediatr\u00eda"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1016\/j.anpedi.2011.11.006","type":"journal-article","created":{"date-parts":[[2012,1,11]],"date-time":"2012-01-11T12:28:02Z","timestamp":1326284882000},"page":"261-267","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Fenotipos cl\u00ednicos asociados a la deficiencia selectiva de IgA: revisi\u00f3n de 330 casos y propuesta de un protocolo de seguimiento"],"prefix":"10.1016","volume":"76","author":[{"given":"O.","family":"Dom\u00ednguez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.T.","family":"Giner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Alsina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.","family":"Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Lozano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.","family":"Plaza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.anpedi.2011.11.006_bib0005","unstructured":"Font\u00e1n G, Garc\u00eda MC, Ferreira A, L\u00f3pez M, Alvarez R, Salsedo P. Inmunodeficiencia primaria. Tratado de medicina interna Medicine. V ed. Madrid; 1991. p. 3869\u201391."},{"key":"10.1016\/j.anpedi.2011.11.006_bib0010","first-page":"390","article-title":"L\u2019ataxie-telangiectasie (7 observations personnelles)","volume":"105","author":"Thieffry","year":"1961","journal-title":"Rev Neurol (Paris)"},{"key":"10.1016\/j.anpedi.2011.11.006_bib0015","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1006\/clim.1999.4799","article-title":"Diagnostic criteria for primary immunodeficiencies","volume":"93","author":"Conley","year":"1999","journal-title":"Clin Immunol"},{"key":"10.1016\/j.anpedi.2011.11.006_bib0020","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0140-6736(86)90940-2","article-title":"Clinical heterogeneity and reversibility of selective immuoglobulin A deficiency in 80 children","volume":"1","author":"Plebani","year":"1986","journal-title":"Lancet"},{"key":"10.1016\/j.anpedi.2011.11.006_bib0025","unstructured":"Hostoffer, R. Selective IgA deficiency: Clinical manifestations, pathophysiology, and diagnosis. Up to Date Febrero 1, 2010."},{"key":"10.1016\/j.anpedi.2011.11.006_bib0030","unstructured":"Bascom R, Dolina MY. Immunoglobulin A Deficency. http:\/\/emedicine.medscape.com\/article\/136580-overview"},{"key":"10.1016\/j.anpedi.2011.11.006_bib0035","first-page":"81","article-title":"Selective IgA deficiency in Japanese blood donors: frecuency and statistical an\u00e1lisis","volume":"50","author":"Kanoh","year":"1986","journal-title":"Vox Sang"},{"key":"10.1016\/j.anpedi.2011.11.006_bib0040","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1042\/bj2710285","article-title":"The structure and function of human IgA","volume":"271","author":"Kerr","year":"1990","journal-title":"Biochem J"},{"key":"10.1016\/j.anpedi.2011.11.006_bib0045","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.it.2004.01.001","article-title":"Transcriptional regulation of the mucosal IgA system","volume":"25","author":"Johansen","year":"2004","journal-title":"Trends Immunol"},{"key":"10.1016\/j.anpedi.2011.11.006_bib0050","first-page":"1390","article-title":"Cyclosporine A induced colitis and acquired selective IgA deficency in a patient with juvenile chronic artritis","volume":"20","author":"Murphy","year":"1993","journal-title":"J Rheumatol"},{"key":"10.1016\/j.anpedi.2011.11.006_bib0055","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1258\/000456307780117993","article-title":"The clinical significance of immunoglobulin A deficiency","volume":"44","author":"Latiff","year":"2007","journal-title":"Ann Clin Biochem"},{"key":"10.1016\/j.anpedi.2011.11.006_bib0060","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s10875-006-9001-y","article-title":"Increased apoptois of CD20+ IgA+B cells is the basis for IgA deficiency: the molecular mechanism for correction in vitro by IL-10 and CD40L","volume":"26","author":"Husain","year":"2006","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.anpedi.2011.11.006_bib0065","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.clim.2009.05.014","article-title":"Selective IgA deficiency in early life: Association to infections and allergic diseases during chilhood","volume":"133","author":"Janzi","year":"2009","journal-title":"Clin Immunol"},{"key":"10.1016\/j.anpedi.2011.11.006_bib0070","unstructured":"Shaffer FM, Chapt 4-IgA deficiency. Immunodeficiencies, Rosen FS, Seligmann M, Harwood Academic Publishers 1993."},{"key":"10.1016\/j.anpedi.2011.11.006_bib0075","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1159\/000135694","article-title":"Progression of Selective IgA Deficiency to Common Variable Immunodeficiency","volume":"147","author":"Aghamohammadi","year":"2008","journal-title":"Int Arch Allergy Immunol"},{"issue":"Suppl 1","key":"10.1016\/j.anpedi.2011.11.006_bib0080","first-page":"48","article-title":"Deficiencia de IgA en ni\u00f1os menores de 5 a\u00f1os. \u00bfEs correcto el diagn\u00f3stico?","volume":"36","author":"Maruri Elizalde","year":"2008","journal-title":"Allergol Immunopathol"},{"key":"10.1016\/j.anpedi.2011.11.006_bib0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/j.1536-4801.2005.tb00917.x","article-title":"Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the Nort American Society for Pediatric Gastroenterology, Hepatology and Nutrition","volume":"40","author":"Hill","year":"2005","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.anpedi.2011.11.006_bib0090","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/S0022-3476(97)70172-0","article-title":"Celiac disease and selective immunoglobulin A deficiency","volume":"131","author":"Cataldo","year":"1997","journal-title":"J Pediatr"},{"key":"10.1016\/j.anpedi.2011.11.006_bib0095","unstructured":"Cruz M. Tratado de Pediatria. Cap\u00edtulos 4.13; 12.20; and 15.25. Majadahonda (Madird): Ergon, 2006."},{"key":"10.1016\/j.anpedi.2011.11.006_bib0100","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1399-3038.1997.tb00156.x","article-title":"Worlwide variations in prevalence of symptoms of allergic rhinoconjunctivitis in children: the International Study of Asthma and Allergies in Childhood (ISAAC)","volume":"8","author":"Strachan","year":"1997","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.anpedi.2011.11.006_bib0105","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0140-6736(06)69283-0","article-title":"Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry Cross-sectional surveys","volume":"368","author":"Asher","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.anpedi.2011.11.006_bib0110","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1006\/clin.1996.0132","article-title":"Development of a common variable immunodeficiency in IgA-deficient patients","volume":"80","author":"Espanol","year":"1996","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1016\/j.anpedi.2011.11.006_bib0115","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0090-1229(88)90072-4","article-title":"Anti-IgA antibodies in selective IgA deficiency and in primary immunodeficient patients treated with gammaglobulin","volume":"47","author":"Ferreira","year":"1988","journal-title":"Clin Immunol Immunopathol"}],"container-title":["Anales de Pediatr\u00eda"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1695403311005522?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1695403311005522?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T02:32:43Z","timestamp":1787106763000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1695403311005522"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["S1695403311005522"],"URL":"https:\/\/doi.org\/10.1016\/j.anpedi.2011.11.006","relation":{},"ISSN":["1695-4033"],"issn-type":[{"value":"1695-4033","type":"print"}],"subject":[],"published":{"date-parts":[[2012,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fenotipos cl\u00ednicos asociados a la deficiencia selectiva de IgA: revisi\u00f3n de 330 casos y propuesta de un protocolo de seguimiento","name":"articletitle","label":"Article Title"},{"value":"Anales de Pediatr\u00eda","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anpedi.2011.11.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Asociaci\u00f3n Espa\u00f1ola de Pediatr\u00eda. Published by Elsevier Espa\u00f1a S.L. All rights reserved.","name":"copyright","label":"Copyright"}]}}