{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:25Z","timestamp":1788393625294,"version":"build-2803163510"},"reference-count":19,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T00:00:00Z","timestamp":1543190400000},"content-version":"vor","delay-in-days":1366,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Anales de Pediatr\u00eda"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1016\/j.anpedi.2014.08.013","type":"journal-article","created":{"date-parts":[[2014,10,17]],"date-time":"2014-10-17T01:01:13Z","timestamp":1413507673000},"page":"166-171","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Agammaglobulinemia ligada al cromosoma X: experiencia en un hospital portugu\u00e9s"],"prefix":"10.1016","volume":"82","author":[{"given":"A.","family":"Fernandes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Guedes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Vasconcelos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Neves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Marques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.anpedi.2014.08.013_bib0005","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3349\/ymj.2008.49.1.28","article-title":"Analysis of clinical presentations of Bruton disease: A review of 20 years of accumulated data from pediatric patients at severance hospital","volume":"49","author":"Chun","year":"2008","journal-title":"Yonsei Med J"},{"key":"10.1016\/j.anpedi.2014.08.013_bib0010","series-title":"Primary Immunodeficiency Diseases","first-page":"97","article-title":"Predominantly antibody deficiencies","author":"Aghamohammadi","year":"2008"},{"key":"10.1016\/j.anpedi.2014.08.013_bib0015","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/01.md.0000229482.27398.ad","article-title":"X-linked agammaglobulinemia: Report on a United States registry of 201 patients","volume":"85","author":"Winkelstein","year":"2006","journal-title":"Medicine"},{"key":"10.1016\/j.anpedi.2014.08.013_bib0020","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.aller.2010.12.003","article-title":"Pulmonary complications in patients with antibody deficiency","volume":"39","author":"Costa-Carvalho","year":"2011","journal-title":"Allergol Immunopathol"},{"key":"10.1016\/j.anpedi.2014.08.013_bib0025","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s10875-008-9227-y","article-title":"Clinical and molecular analysis of 49 patients with X-linked agammaglobulinemia from a single center in Argentina","volume":"29","author":"Basile","year":"2009","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.anpedi.2014.08.013_bib0030","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1007\/s10038-006-0052-y","article-title":"Four novel and three recurrent mutations of the BTK gene and pathogenic effects of putative splice mutations","volume":"51","author":"Wattanasirichaigoon","year":"2006","journal-title":"J Hum Genet"},{"key":"10.1016\/j.anpedi.2014.08.013_bib0035","series-title":"GeneReviews\u2122 [Internet]","article-title":"X-linked agammaglobulinemia","author":"Conley","year":"2011"},{"key":"10.1016\/j.anpedi.2014.08.013_bib0040","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1590\/S0100-879X2010007500079","article-title":"Mutations of Bruton's tyrosine kinase gene in Brazilian patients with X-linked agammaglobulinemia","volume":"43","author":"Ramalho","year":"2010","journal-title":"Braz J Med Biol Res"},{"key":"10.1016\/j.anpedi.2014.08.013_bib0045","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s12519-013-0400-x","article-title":"Clinical features and mutation analysis of X-linked agammaglobulinemia in 20 Chinese patients","volume":"9","author":"Qin","year":"2013","journal-title":"World J Pediatr"},{"key":"10.1016\/j.anpedi.2014.08.013_bib0050","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s12098-013-1113-9","article-title":"X-linked Agammaglobulinemia: A single centre experience from India","volume":"81","author":"Merchant","year":"2014","journal-title":"Indian J Pediatr"},{"key":"10.1016\/j.anpedi.2014.08.013_bib0055","unstructured":"European Society for Immunodeficiencies. Diagnostic criteria for PID [consultado 17 Dic 2013]. Disponible en: http:\/\/esid.org\/Working-Parties\/Clinical\/Resources\/Diagnostic-criteria-for-PID"},{"key":"10.1016\/j.anpedi.2014.08.013_bib0060","first-page":"187","article-title":"X-linked agammaglobulinemia in nine patients: review of the literature","volume":"52","author":"Ganem","year":"1997","journal-title":"Rev Hosp Clin Fac Med Sao Paulo"},{"key":"10.1016\/j.anpedi.2014.08.013_bib0065","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1006\/clim.2002.5241","article-title":"Clinical, immunological, and molecular analysis in a large cohort of patients with X-linked agammaglobulinemia: An Italian multicenter study","volume":"104","author":"Plebani","year":"2002","journal-title":"Clin Immunol"},{"key":"10.1016\/j.anpedi.2014.08.013_bib0070","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1067\/mpd.2002.127711","article-title":"Clinical findings leading to the diagnosis of X-linked agammaglobulinemia","volume":"141","author":"Conley","year":"2002","journal-title":"J Pediatr"},{"key":"10.1016\/j.anpedi.2014.08.013_bib0075","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1053\/shem.2002.31916","article-title":"Neutropenia associated with primary immunodeficiency syndromes","volume":"39","author":"Cham","year":"2002","journal-title":"Semin Hematol"},{"key":"10.1016\/j.anpedi.2014.08.013_bib0080","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1006\/clin.1996.0188","article-title":"Neutropenia in X-linked agammaglobulinemia","volume":"81","author":"Farrar","year":"1996","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1016\/j.anpedi.2014.08.013_bib0085","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s10875-005-5370-x","article-title":"Severe neutropenia in Japanese patients with X-linked agammaglobulinemia","volume":"25","author":"Kanegane","year":"2005","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.anpedi.2014.08.013_bib0090","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S0022-3476(99)70246-5","article-title":"Early and prolonged intravenous immunoglobulin replacement therapy in childhood agammaglobulinemia: A retrospective survey of 31 patients","volume":"134","author":"Quartier","year":"1999","journal-title":"J Pediatr"},{"key":"10.1016\/j.anpedi.2014.08.013_bib0095","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/j.jaci.2011.02.047","article-title":"Primary immunodeficiency diseases associated with increased susceptibility to viral infections and malignancies","volume":"127","author":"Rezaei","year":"2011","journal-title":"J Allergy Clin Immunol."}],"container-title":["Anales de Pediatr\u00eda"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1695403314004263?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1695403314004263?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,25]],"date-time":"2018-11-25T19:27:32Z","timestamp":1543174052000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1695403314004263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["S1695403314004263"],"URL":"https:\/\/doi.org\/10.1016\/j.anpedi.2014.08.013","relation":{},"ISSN":["1695-4033"],"issn-type":[{"value":"1695-4033","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Agammaglobulinemia ligada al cromosoma X: experiencia en un hospital portugu\u00e9s","name":"articletitle","label":"Article Title"},{"value":"Anales de Pediatr\u00eda","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anpedi.2014.08.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Asociaci\u00f3n Espa\u00f1ola de Pediatr\u00eda. Published by Elsevier Espa\u00f1a, S.L. All rights reserved.","name":"copyright","label":"Copyright"}]}}