{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:43:33Z","timestamp":1787237013059,"version":"build-2736575974"},"reference-count":24,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T00:00:00Z","timestamp":1544745600000},"content-version":"vor","delay-in-days":896,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Anales de Pediatr\u00eda"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.anpedi.2015.07.027","type":"journal-article","created":{"date-parts":[[2015,9,12]],"date-time":"2015-09-12T07:51:55Z","timestamp":1442044315000},"page":"4-12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["El reto de la administraci\u00f3n de antituberculosos en lactantes y preescolares. Proyecto Magistral de pTBred"],"prefix":"10.1016","volume":"85","author":[{"given":"Roi","family":"Pi\u00f1eiro P\u00e9rez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bego\u00f1a","family":"Santiago Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia M.","family":"Fern\u00e1ndez Llamazares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Baquero Artigao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoni","family":"Noguera Julian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Mellado Pe\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.anpedi.2015.07.027_bib0125","doi-asserted-by":"crossref","unstructured":"Grupo de trabajo de Tuberculosis de la Sociedad Espa\u00f1ola de Infectolog\u00eda Pedi\u00e1trica. Interpretaci\u00f3n de la prueba de tuberculina en ni\u00f1os. An Pediatr (Barc). 2003;59:582-585.","DOI":"10.1157\/13054341"},{"key":"10.1016\/j.anpedi.2015.07.027_bib0130","doi-asserted-by":"crossref","unstructured":"Grupo de trabajo de Tuberculosis de la Sociedad Espa\u00f1ola de Infectolog\u00eda Pedi\u00e1trica. Documento de consenso sobre el tratamiento de la exposici\u00f3n a tuberculosis y de la infecci\u00f3n tuberculosa latente en ni\u00f1os. An Pediatr (Barc). 2006;64:59-65.","DOI":"10.1016\/S1695-4033(06)70010-8"},{"key":"10.1016\/j.anpedi.2015.07.027_bib0135","doi-asserted-by":"crossref","unstructured":"Grupo de trabajo de Tuberculosis de la Sociedad Espa\u00f1ola de Infectolog\u00eda Pedi\u00e1trica. Documento de consenso sobre el tratamiento de la tuberculosis extrapulmonar y formas complicadas de tuberculosis pulmonar. An Pediatr (Barc). 2008;69:271-278.","DOI":"10.1157\/13125824"},{"key":"10.1016\/j.anpedi.2015.07.027_bib0140","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.anpedi.2009.07.036","article-title":"Documento de consenso de la SEIP sobre la tuberculosis resistente a f\u00e1rmacos","volume":"71","author":"Mellado Pe\u00f1a","year":"2009","journal-title":"An Pediatr (Barc)."},{"key":"10.1016\/j.anpedi.2015.07.027_bib0145","doi-asserted-by":"crossref","unstructured":"Grupo de trabajo de Tuberculosis de la Sociedad Espa\u00f1ola de Infectolog\u00eda Pedi\u00e1trica. Documento de consenso sobre el tratamiento de la tuberculosis pulmonar en ni\u00f1os. An Pediatr (Barc). 2007;66:597-602.","DOI":"10.1157\/13107395"},{"key":"10.1016\/j.anpedi.2015.07.027_bib0150","doi-asserted-by":"crossref","unstructured":"Moreno-P\u00e9rez D, Andr\u00e9s Mart\u00edn A, Altet G\u00f3mez N, Baquero-Artigao F, Escribano Montaner A, G\u00f3mez-Pastrana Dur\u00e1n D, et al. Diagn\u00f3stico de la tuberculosis en la edad pedi\u00e1trica An Pediatr (Barc). 2010;72:283.e1-283.e14.","DOI":"10.1016\/j.anpedi.2010.01.002"},{"key":"10.1016\/j.anpedi.2015.07.027_bib0155","unstructured":"Comit\u00e9 de Medicamentos de la Asociaci\u00f3n Espa\u00f1ola de Pediatr\u00eda. Pediam\u00e9cum. Edici\u00f3n 2012. Rifampicina [consultado 1 Jul 2015]. Disponible en: http:\/\/www.pediam\u00e9cum.es"},{"key":"10.1016\/j.anpedi.2015.07.027_bib0160","unstructured":"Grupo de Farmacotecnia (editores). Periodo de validez y caducidad de formas farmac\u00e9uticas no est\u00e9riles orales l\u00edquidas [monograf\u00eda en Internet]. Sociedad Espa\u00f1ola de Farmacia Hospitalaria: Madrid, 2015. [Consultado 01\/07\/15]. Disponible en http:\/\/gruposdetrabajo.sefh.es\/farmacotecnia\/images\/stories\/Boletines\/BOLETIN1_2015.pdf"},{"key":"10.1016\/j.anpedi.2015.07.027_bib0165","unstructured":"Gu\u00eda de buenas pr\u00e1cticas de preparaci\u00f3n de medicamentos en servicios de farmacia hospitalaria [Monograf\u00eda en internet]. Ministerio de Sanidad, Servicios Sociales e Igualdad: Madrid; 2014 [consultado 1 Jul 2015]. Disponible en http:\/\/www.msssi.gob.es\/profesionales\/farmacia\/pdf\/GuiaBPP3.pdf"},{"key":"10.1016\/j.anpedi.2015.07.027_bib0170","doi-asserted-by":"crossref","first-page":"5560","DOI":"10.1128\/AAC.05429-11","article-title":"Pharmacokinetics of isoniazid, rifampin, and pyrazinamide in children younger than two years of age with tuberculosis: Evidence for implementation of revised World Health Organization recommendations","volume":"55","author":"Thee","year":"2011","journal-title":"Antimicrob Agents Chemother."},{"key":"10.1016\/j.anpedi.2015.07.027_bib0175","unstructured":"World Health Organization Dosing instructions for the use of currently available fixed-dose combination TB medicines for children. September 2009 [consultado 1 Jul 2015]. Disponible en; http:\/\/www.who.int\/tb\/challenges\/interim_paediatric_fdc_dosing_instructions_sept09.pdf"},{"key":"10.1016\/j.anpedi.2015.07.027_bib0180","unstructured":"Red Espa\u00f1ola de Estudio de la Tuberculosis Pedi\u00e1trica (pTBred) [consultado 1 Jul 2015]. Disponible en: https:\/\/twitter.com\/ptbred_spain"},{"key":"10.1016\/j.anpedi.2015.07.027_bib0185","unstructured":"Mellado Pe\u00f1a MJ, Pi\u00f1eiro P\u00e9rez R, Medina Claros A, Bravo Acu\u00f1a J, Cabrera Garc\u00eda L, Mart\u00ednez Fern\u00e1ndez-Llamazares C, et al. Informe y recomendaciones del Comit\u00e9 de Medicamentos de la AEP sobre la modificaci\u00f3n de las dosis de los f\u00e1rmacos antituberculosos de primera l\u00ednea. Febrero de 2012 [consultado 1 Jul 2015]. Disponible en: http:\/\/www.aeped.es\/sites\/default\/files\/recomendaciones_cm.dosistb.22.2.12.pdf"},{"key":"10.1016\/j.anpedi.2015.07.027_bib0190","unstructured":"World Health Organization. Guidance for national tuberculosis programmes on the management of tuberculosis in children. 2nd ed. WHO\/HTM\/TB\/2014.03. [consultado 1 Jul 2015]. Disponible en http:\/\/apps.who.int\/medicinedocs\/documents\/s21535en\/s21535en.pdf"},{"key":"10.1016\/j.anpedi.2015.07.027_bib0195","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1111\/tmi.12003","article-title":"Pharmacokinetics of anti-tuberculosis drugs in Venezuelan children younger than 16 years of age: Supportive evidence for the implementation of revised WHO dosing recommendations","volume":"17","author":"Verhagen","year":"2012","journal-title":"Trop Med Int Health."},{"key":"10.1016\/j.anpedi.2015.07.027_bib0200","unstructured":"Web del Grupo Espa\u00f1ol de Farmacia Pedi\u00e1trica [consultado 1 Jul 2015]. Dispobible en: http:\/\/www.sefh.es\/gefp_formulas.php?seccion=A"},{"key":"10.1016\/j.anpedi.2015.07.027_bib0205","first-page":"395","article-title":"Dissolved tuberculostatics. A safe intake method during hospitalization","volume":"25","author":"Ehring","year":"1971","journal-title":"Prax Pneumol."},{"key":"10.1016\/j.anpedi.2015.07.027_bib0210","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.anpedi.2013.10.004","article-title":"Conocimiento sobre el uso de f\u00e1rmacos off-label en pediatr\u00eda. Resultados de una encuesta pedi\u00e1trica nacional 2012-2013 (estudio OL-PED)","volume":"81","author":"Pi\u00f1eiro P\u00e9rez","year":"2014","journal-title":"An Pediatr (Barc)."},{"key":"10.1016\/j.anpedi.2015.07.027_bib0215","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1183\/09031936.00180612","article-title":"Fixed-dose combination antituberculosis therapy: A systematic review and meta-analysis","volume":"42","author":"Albanna","year":"2013","journal-title":"Eur Respir J."},{"key":"10.1016\/j.anpedi.2015.07.027_bib0220","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ijpharm.2004.02.019","article-title":"Comparative bioavailability of rifampicin, isoniazid and pyrazinamide from a four drug fixed dose combination with separate formulations at the same dose levels","volume":"276","author":"Agrawal","year":"2004","journal-title":"Int J Pharm."},{"key":"10.1016\/j.anpedi.2015.07.027_bib0225","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1001\/jama.2011.436","article-title":"Efficacy and safety of a 4-drug fixed-dose combination regimen compared with separate drugs for treatment of pulmonary tuberculosis: The Study C randomized controlled trial","volume":"305","author":"Lienhardt","year":"2011","journal-title":"JAMA."},{"key":"10.1016\/j.anpedi.2015.07.027_bib0230","unstructured":"American Academy of Pediatrics 2011, editores. Nutrition: What every parent needs to know. [monograf\u00eda en Internet] [\u00faltima actualizaci\u00f3n 5 Jun 2015; consultado 1 Jul 2015]. American Academy of Pediatrics: Elk Grove Village Disponible en https:\/\/www.healthychildren.org\/Spanish\/healthy-living\/nutrition\/Paginas\/Food-and-Medication-Interactions.aspx"},{"key":"10.1016\/j.anpedi.2015.07.027_bib0235","doi-asserted-by":"crossref","unstructured":"Levy M, Rigaudi\u00e8re F, de Lauzanne A, Koehl B, Melki I, Lorrot M, et al. Ethambutol-related impaired visual function in childrens less than five years of age treated for a mycobacterial infection: Diagnosis and evolution. Pediatr Infect Dis J. 2015 [ahead-of-print] DOI: 10.1097\/INF.0000000000000589.","DOI":"10.1097\/INF.0000000000000589"},{"key":"10.1016\/j.anpedi.2015.07.027_bib0240","first-page":"1318","article-title":"Ethambutol dosage for the treatment of children: Literature review and recommendations","volume":"10","author":"Donald","year":"2006","journal-title":"Int J Tuberc Lung Dis."}],"container-title":["Anales de Pediatr\u00eda"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1695403315003318?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1695403315003318?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T08:19:13Z","timestamp":1567153153000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1695403315003318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["S1695403315003318"],"URL":"https:\/\/doi.org\/10.1016\/j.anpedi.2015.07.027","relation":{},"ISSN":["1695-4033"],"issn-type":[{"value":"1695-4033","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"El reto de la administraci\u00f3n de antituberculosos en lactantes y preescolares. Proyecto Magistral de pTBred","name":"articletitle","label":"Article Title"},{"value":"Anales de Pediatr\u00eda","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anpedi.2015.07.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 Asociaci\u00f3n Espa\u00f1ola de Pediatr\u00eda. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}]}}