{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T03:26:38Z","timestamp":1787109998338,"version":"build-2736575974"},"reference-count":39,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":3517,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Anales de Pediatr\u00eda"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.anpedi.2016.03.005","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T05:53:25Z","timestamp":1460267605000},"page":"20-27","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Tumores germinales intracraneales: revisi\u00f3n de 21 a\u00f1os"],"prefix":"10.1016","volume":"86","author":[{"given":"Mar\u00eda","family":"Cormenzana Carpio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Nehme \u00c1lvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Hern\u00e1ndez Marq\u00faes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"P\u00e9rez Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Lassaletta Atienza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Madero L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.anpedi.2016.03.005_bib0200","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3340\/jkns.2015.57.5.315","article-title":"Understanding the treatment strategies of intracranial germ cell tumors: Focusing on radiotherapy","volume":"57","author":"Kim","year":"2015","journal-title":"J Korean Neurosurg Soc."},{"key":"10.1016\/j.anpedi.2016.03.005_bib0205","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s11060-006-9282-2","article-title":"Epidemiological survey of central nervous system germ cell tumors in Canadian children","volume":"82","author":"Keene","year":"2007","journal-title":"J Neurooncol."},{"key":"10.1016\/j.anpedi.2016.03.005_bib0210","series-title":"WHO Classification of tumours of the central nervous system","first-page":"197","year":"2007"},{"key":"10.1016\/j.anpedi.2016.03.005_bib0215","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1634\/theoncologist.2008-0037","article-title":"Pediatric central nervous system germ cell tumors: A review","volume":"13","author":"Echevarr\u00eda","year":"2008","journal-title":"Oncologist."},{"key":"10.1016\/j.anpedi.2016.03.005_bib0220","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s11910-004-0046-0","article-title":"Current advances in the diagnosis and management of intracranial germ cell tumors","volume":"4","author":"Balmaceda","year":"2004","journal-title":"Curr Neurol Neurosci Rep."},{"key":"10.1016\/j.anpedi.2016.03.005_bib0225","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1055\/s-2008-1071577","article-title":"Intracranial germ cell tumors: A comprehensive update of the European data","volume":"25","author":"Calaminus","year":"1994","journal-title":"Neuropediatrics."},{"key":"10.1016\/j.anpedi.2016.03.005_bib0230","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1634\/theoncologist.2000-0312","article-title":"Intracranial germ cell tumors","volume":"5","author":"Packer","year":"2000","journal-title":"Oncologist."},{"key":"10.1016\/j.anpedi.2016.03.005_bib0235","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0360-3016(94)90162-7","article-title":"Radiation therapy of pineal region tumors: 25 new cases and a review of 208 previously reported cases","volume":"28","author":"Fuller","year":"1994","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"10.1016\/j.anpedi.2016.03.005_bib0240","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0167-8140(95)01649-X","article-title":"Radiotherapy of intracranial germinomas","volume":"38","author":"Huh","year":"1996","journal-title":"Radiother Oncol."},{"key":"10.1016\/j.anpedi.2016.03.005_bib0245","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.ijrobp.2003.08.028","article-title":"Craniospinal irradiation in the treatment of biopsy-proven intracranial germinomas: Twenty-five year\u015b experience in a single center","volume":"58","author":"Maity","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"10.1016\/j.anpedi.2016.03.005_bib0250","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0094-0143(21)01175-7","article-title":"Chemotherapy for disseminated testicular cancer","volume":"4","author":"Einhorn","year":"1977","journal-title":"Urol Clin North Am."},{"issue":"7-8","key":"10.1016\/j.anpedi.2016.03.005_bib0255","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/sj.bjc.6690192","article-title":"Combined treatment modality for intracranial germinomas: results of a multicenter SFOP experience. Societ\u00e9 Francaise d\u0301Oncologie P\u00e9diatrique","volume":"79","author":"Bouffet","year":"1999","journal-title":"Br J Cancer."},{"key":"10.1016\/j.anpedi.2016.03.005_bib0260","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/pbc.20815","article-title":"Pre-radiation chemotherapy with response-based radiation therapy in children with central nervous system germ cell tumors: A report from the Children's Oncology Group","volume":"48","author":"Kretschmar","year":"2007","journal-title":"Pediatr Blood Cancer."},{"key":"10.1016\/j.anpedi.2016.03.005_bib0265","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.jocn.2012.04.017","article-title":"Pediatric germ cell tumours of the central nervous system: Results and experience from a tertiary-referral pediatric institution in Australia","volume":"20","author":"Chung","year":"2013","journal-title":"J Clin Neurosci."},{"key":"10.1016\/j.anpedi.2016.03.005_bib0270","doi-asserted-by":"crossref","first-page":"446","DOI":"10.3171\/jns.1997.86.3.0446","article-title":"Primary intracranial germ cell tumors: A clinical analysis of 153 histologically verified cases","volume":"86","author":"Matsutani","year":"1997","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.anpedi.2016.03.005_bib0275","doi-asserted-by":"crossref","first-page":"545","DOI":"10.3171\/jns.1991.74.4.0545","article-title":"Intracranial germ-cell tumors in children","volume":"74","author":"Hoffman","year":"1991","journal-title":"J Neurosurg."},{"key":"10.1016\/j.anpedi.2016.03.005_bib0280","series-title":"Pathology of tumors of the nervous system","author":"Russell","year":"1984"},{"key":"10.1016\/j.anpedi.2016.03.005_bib0285","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0887-8994(01)00419-2","article-title":"Intracranial germ cell tumors: A retrospective study of 44 children","volume":"26","author":"Jaing","year":"2002","journal-title":"Pediatr Neurol."},{"key":"10.1016\/j.anpedi.2016.03.005_bib0290","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s11060-010-0119-7","article-title":"Germinomas in the basal ganglia: Magnetic resonance imaging classification and the prognosis","volume":"99","author":"Phi","year":"2010","journal-title":"J Neurooncol."},{"key":"10.1016\/j.anpedi.2016.03.005_bib0295","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3171\/jns.1985.63.2.0155","article-title":"Intracranial germ-cell tumors: Natural history and pathogenesis","volume":"63","author":"Jennings","year":"1985","journal-title":"J Neurosurg."},{"key":"10.1016\/j.anpedi.2016.03.005_bib0300","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/1097-0142(19890115)63:2<340::AID-CNCR2820630223>3.0.CO;2-N","article-title":"Suprasellar germinomas in childhood: A reappraisal","volume":"63","author":"Legido","year":"1989","journal-title":"Cancer."},{"key":"10.1016\/j.anpedi.2016.03.005_bib0305","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3109\/0284186X.2011.586000","article-title":"Intracranial germ cell tumors. A review with special reference to endocrine manifestations","volume":"51","author":"Jorsal","year":"2012","journal-title":"Acta Oncol."},{"key":"10.1016\/j.anpedi.2016.03.005_bib0310","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0733-8619(18)30295-0","article-title":"Controversies in the management of intracranial germ-cell tumors","volume":"9","author":"Allen","year":"1991","journal-title":"Neurol Clin."},{"key":"10.1016\/j.anpedi.2016.03.005_bib0315","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1016\/j.jpeds.2013.06.024","article-title":"Delayed diagnosis in children with intracranial germ cell tumors","volume":"163","author":"Sethi","year":"2013","journal-title":"J Pediatr."},{"key":"10.1016\/j.anpedi.2016.03.005_bib0320","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S0959-8049(97)10045-4","article-title":"Germ cell tumors of the central nervous system: treatments considerations bases on 111 cases and their long-term clinical outcome","volume":"34","author":"Sawamura","year":"1998","journal-title":"Eur J Cancer."},{"key":"10.1016\/j.anpedi.2016.03.005_bib0325","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0167-8140(95)01649-X","article-title":"Raddiotheraphy of intracranial germinomas","volume":"38","author":"Huh","year":"1996","journal-title":"Radiother Oncol."},{"key":"10.1016\/j.anpedi.2016.03.005_bib0330","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1023\/A:1008303429718","article-title":"Long-term follow up and residual sequelae after treatment for intracerebral germ-cell tumor in children and adolescents","volume":"11","author":"Schmugge","year":"2000","journal-title":"Ann Oncol."},{"key":"10.1016\/j.anpedi.2016.03.005_bib0335","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S1470-2045(05)70245-X","article-title":"Radiotherapy of localized intracranial germinoma: Time to sever historical ties","volume":"6","author":"Rogers","year":"2005","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.anpedi.2016.03.005_bib0340","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1200\/JCO.2004.05.186","article-title":"Change in neurocognitive functioning after treatment with cranial radiation in childhood","volume":"22","author":"Spiegler","year":"2004","journal-title":"J Clin Oncol."},{"key":"10.1016\/j.anpedi.2016.03.005_bib0345","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s00381-001-0547-y","article-title":"Pediatric brain tumors: Statistics of SNUH Korea (1959-2000)","volume":"18","author":"Cho","year":"2002","journal-title":"Chlid Nerv Syst."},{"key":"10.1016\/j.anpedi.2016.03.005_bib0350","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/0090-3019(89)90032-3","article-title":"Occipital transtentorial approach for removal of pineal region tumors. Report of 64 consecutive cases","volume":"32","author":"Luo","year":"1989","journal-title":"Surg Neuro"},{"key":"10.1016\/j.anpedi.2016.03.005_bib0355","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1200\/JCO.1996.14.11.2908","article-title":"Chemotherapy without irradiation \u2014a novel approach for newly diagnosed central nervous system germ cell tumors: Results of an international cooperative trial","volume":"14","author":"Balmaceda","year":"1996","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.anpedi.2016.03.005_bib0360","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/BF02112027","article-title":"Prognosis of intracranial germ cell tumors: Effectiveness of chemotherapy with cisplatin and etoposide (CDDP and VP-16)","volume":"120","author":"Yoshida","year":"1993","journal-title":"Acta Neurochir."},{"key":"10.1016\/j.anpedi.2016.03.005_bib0365","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1097\/00019052-199912000-00006","article-title":"Recent advances in the diagnoses and treatment of central nervous system germ-cell tumors","volume":"12","author":"Hooda","year":"1999","journal-title":"Curr Opin Neurol."},{"key":"10.1016\/j.anpedi.2016.03.005_bib0370","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/0360-3016(90)90553-V","article-title":"Radiation therapy for intracranial germinoma: The case for limited volume treatment","volume":"19","author":"Dattoli","year":"1990","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"10.1016\/j.anpedi.2016.03.005_bib0375","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s11060-008-9649-7","article-title":"Late recurrence and salvage therapy of CNS germinomas","volume":"90","author":"Kamoshima","year":"2008","journal-title":"J Neurooncol."},{"key":"10.1016\/j.anpedi.2016.03.005_bib0380","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1200\/JCO.2004.11.053","article-title":"Thiotepa-based-high-dose-chemotherapy with autologous stem-cell rescue in patients with recurrent or progressive CNS germ cell tumors","volume":"22","author":"Modak","year":"2004","journal-title":"J Clin Oncol."},{"key":"10.1016\/j.anpedi.2016.03.005_bib0385","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.1200\/JCO.1996.14.10.2638","article-title":"High-dose chemotherapy as salvage treatment in germ cell tumors: A multivariate analysis of prognostic variables","volume":"14","author":"Beyer","year":"1996","journal-title":"J Clin Oncol."},{"key":"10.1016\/j.anpedi.2016.03.005_bib0390","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1200\/JCO.1994.12.6.1223","article-title":"High-dose treatment with carboplatin, etoposide, and ifosfamide followed by autologous stem-cell transplantation in relapsed or refractory germ cell cancer: A phase i\/ii study. The German Testicular Cancer Cooperative Study Group","volume":"12","author":"Siegert","year":"1994","journal-title":"J Clin Oncol"}],"container-title":["Anales de Pediatr\u00eda"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1695403316300108?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1695403316300108?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T02:43:49Z","timestamp":1787107429000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1695403316300108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["S1695403316300108"],"URL":"https:\/\/doi.org\/10.1016\/j.anpedi.2016.03.005","relation":{},"ISSN":["1695-4033"],"issn-type":[{"value":"1695-4033","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tumores germinales intracraneales: revisi\u00f3n de 21 a\u00f1os","name":"articletitle","label":"Article Title"},{"value":"Anales de Pediatr\u00eda","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anpedi.2016.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 Asociaci\u00f3n Espa\u00f1ola de Pediatr\u00eda. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}]}}