{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T07:38:21Z","timestamp":1774597101269,"version":"3.50.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T00:00:00Z","timestamp":1548115200000},"content-version":"vor","delay-in-days":386,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Anales de Pediatr\u00eda"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.anpedi.2017.05.013","type":"journal-article","created":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T04:45:38Z","timestamp":1500353138000},"page":"52.e1-52.e12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Actualizaci\u00f3n del tratamiento de la tuberculosis en ni\u00f1os"],"prefix":"10.1016","volume":"88","author":[{"given":"Mar\u00eda Jos\u00e9","family":"Mellado Pe\u00f1a","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bego\u00f1a","family":"Santiago Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Baquero-Artigao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Moreno P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roi","family":"Pi\u00f1eiro P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"M\u00e9ndez Echevarr\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Tom\u00e1s","family":"Ramos Amador","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"G\u00f3mez-Pastrana Dur\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoni","family":"Noguera Julian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.anpedi.2017.05.013_bib0210","unstructured":"World Health Organization. Global Tuberculosis Report 2016. Geneva, Switzerland; 2015 [consultado Mar 2017]. Disponible en: http:\/\/www.who.int\/tb\/publications\/global_report\/en\/"},{"key":"10.1016\/j.anpedi.2017.05.013_bib0215","unstructured":"World Health. Roadmap for childhood tuberculosis. Towards zero deat. Geneva: 2013: WHO\/HTM\/TB\/2013.12 [consultado Mar 2017]. Disponible en: http:\/\/apps.who.int\/iris\/bitstream\/10665\/89506\/1\/9789241506137_eng.pdf"},{"key":"10.1016\/j.anpedi.2017.05.013_bib0220","unstructured":"European Centre for Disease Prevention and Control. Tuberculosis surveillance and monitoring in Europe 2016. Stockholm: 2016 [consultado Mar 2017]. Disponible en: https:\/\/ecdc.europa.eu\/sites\/portal\/files\/media\/en\/publications\/Publications\/ecdc-tuberculosis-surveillance-monitoring-Europe-2016.pdf"},{"key":"10.1016\/j.anpedi.2017.05.013_bib0225","first-page":"1","article-title":"Global burden of drug-resistant tuberculosis in children: A mathematical modelling study","volume":"3099","author":"Dodd","year":"2016","journal-title":"Lancet Inf Dis"},{"key":"10.1016\/j.anpedi.2017.05.013_bib0230","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1097\/INF.0b013e3181d5da11","article-title":"Impact of immigration on pulmonary tuberculosis in Spanish children: A three-decade review","volume":"29","author":"Del Rosal","year":"2010","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.anpedi.2017.05.013_bib0235","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s12969-015-0054-4","article-title":"Tuberculosis in pediatric patients treated with anti-TNF\u03b1 drugs: A cohort study","volume":"13","author":"Calzada-Hern\u00e1ndez","year":"2015","journal-title":"Pediatr Rheumatol"},{"key":"10.1016\/j.anpedi.2017.05.013_bib0240","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1097\/INF.0000000000001270","article-title":"Pediatric extrapulmonary tuberculosis: Clinical spectrum, risk factors and diagnostic challenges in a low prevalence region","volume":"35","author":"Santiago-Garc\u00eda","year":"2016","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.anpedi.2017.05.013_bib0245","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/INF.0000000000000111","article-title":"Pediatric drug-resistant tuberculosis in madrid. family matters","volume":"33","author":"Santiago","year":"2014","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.anpedi.2017.05.013_bib0250","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1157\/13083834","article-title":"Documento de consenso sobre el tratamiento de la exposici\u00f3n a tuberculosis y de la infecci\u00f3n tuberculosa latente en ni\u00f1os","volume":"64","year":"2006","journal-title":"An Pediatr."},{"key":"10.1016\/j.anpedi.2017.05.013_bib0255","doi-asserted-by":"crossref","first-page":"S179","DOI":"10.1093\/cid\/civ581","article-title":"Clinical case definitions for classification of intrathoracic tuberculosis in children: An update","volume":"61","author":"Graham","year":"2015","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.anpedi.2017.05.013_bib0260","unstructured":"American Academy of Pediatrics. Tuberculosis. En: Pickering L, Baker C, Kimberlin D, Long S, editores. Red Book: 2009 Report of the Committee on Infectious Diseases. Elk Grove Village, IL; 2009. p. 680-701."},{"key":"10.1016\/j.anpedi.2017.05.013_bib0265","unstructured":"World Health Organization. Guidance for National Tuberculosis Programmes on the Management of Tuberculosis in Children. Geneva: 2014 [consultado Mar 2017]. Disponible en: http:\/\/apps.who.int\/iris\/bitstream\/10665\/112360\/1\/9789241548748_eng.pdf"},{"key":"10.1016\/j.anpedi.2017.05.013_bib0270","unstructured":"American Academy of Pediatrics. Tuberculosis. En: Kimberlin D, Brady M, Jackson M, Long S, editores. Red Book: 2015 Report of the Committee on Infectious Diseases. Elk Grove Village, IL; 2015."},{"key":"10.1016\/j.anpedi.2017.05.013_bib0275","unstructured":"National Institute for Health and Clinical Excellence N. Tuberculosis. London, UK: 2016 [consultado Feb 2017]. Disponible en: https:\/\/www.nice.org.uk\/guidance\/ng33"},{"key":"10.1016\/j.anpedi.2017.05.013_bib0280","unstructured":"Grupo de Trabajo de la Guia Pr\u00e1ctica sobre el Diagn\u00f3stico el Tratamiento y la Prevenci\u00f3n de la Tuberculosis, Centro Cochrane Iberoamericano. Gu\u00eda de pr\u00e1ctica cl\u00ednica sobre el diagn\u00f3stico, el tratamiento y la prevenci\u00f3n de la tuberculosis. Madrid: 2010 [consultado Mar 2017]. Disponible en: http:\/\/www.guiasalud.es\/GPC\/GPC_473_Tuberculosis_AIAQS_compl.pdf"},{"key":"10.1016\/j.anpedi.2017.05.013_bib0285","first-page":"285.e1L 8","article-title":"Gu\u00eda de la Sociedad Espa\u00f1ola de Infectolog\u00eda Pedi\u00e1trica sobre tuberculosis en la embarazada y el reci\u00e9n nacido (I): Epidemiolog\u00eda y diagn\u00f3stico","volume":"83","author":"Baquero-Artigao","year":"2015","journal-title":"An Pediatr (Barc)"},{"key":"10.1016\/j.anpedi.2017.05.013_bib0290","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1093\/cid\/ciw694","article-title":"Official American Thoracic Society\/Infectious Diseases Society of America\/Centers for Disease Control and Prevention Clinical Practice Guidelines: Diagnosis of tuberculosis in adults and children","volume":"64","author":"Lewinsohn","year":"2017","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.anpedi.2017.05.013_bib0295","unstructured":"World Health Organization, The End TB Strategy. Guidelines on the management of latent tuberculosis infection. Geneva: 2015: WHO\/HTYM\/TB\/2015.01 [consultado Ene 2017]. Disponible en: http:\/\/apps.who.int\/medicinedocs\/documents\/s21682en\/s21682en.pdf"},{"key":"10.1016\/j.anpedi.2017.05.013_bib0300","unstructured":"Centre for Disease Control and Prevention. Latent tuberculosis infection: A guide for primary health care providers. Rutgers, NJ: 2013 [consultado Mar 2017]. Disponible en: https:\/\/www.cdc.gov\/tb\/publications\/ltbi\/pdf\/targetedltbi.pdf"},{"key":"10.1016\/j.anpedi.2017.05.013_bib0305","doi-asserted-by":"crossref","first-page":"e147","DOI":"10.1093\/cid\/ciw376","article-title":"Official American Thoracic Society\/Centers for Disease Control and Prevention\/Infectious Diseases Society of America Clinical Practice Guidelines: Treatment of drug-susceptible tuberculosis","volume":"63","author":"Nahid","year":"2016","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.anpedi.2017.05.013_bib0310","doi-asserted-by":"crossref","first-page":"323e1","DOI":"10.1016\/j.anpedi.2016.06.012","article-title":"Recomendaciones para la elaboraci\u00f3n y administraci\u00f3n de f\u00e1rmacos antituberculosos en ni\u00f1os. Segunda fase del Proyecto Magistral de la Red Espa\u00f1ola de Estudio de la Tuberculosis Pedi\u00e1trica (pTBred)","volume":"85","author":"Pi\u00f1eiro P\u00e9rez","year":"2016","journal-title":"An Pediatr (Barc)."},{"key":"10.1016\/j.anpedi.2017.05.013_bib0315","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ijid.2016.08.009","article-title":"Paradoxical reaction in immunocompetent children with tuberculosis","volume":"51","author":"Carazo Gallego","year":"2016","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.anpedi.2017.05.013_bib0320","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1093\/jpids\/pit012","article-title":"Consensus statement on research definitions for drug-resistant tuberculosis in children","volume":"2","author":"Seddon","year":"2013","journal-title":"J Pediatric Infect Dis Soc"},{"key":"10.1016\/j.anpedi.2017.05.013_bib0325","unstructured":"World Health Organization. WHO treatment guidelines for drug-resistant tuberculosis 2016 update. Geneva, Switzerland; 2016 [consultado Mar 2017]. Disponible en: http:\/\/apps.who.int\/iris\/bitstream\/10665\/250125\/1\/9789241549639-eng.pdf"},{"key":"10.1016\/j.anpedi.2017.05.013_bib0330","unstructured":"World Health Organization. The use of molecular line probe assays for the detection of resistance to second-line anti-tuberculosis drugs. Policy guidance. Geneva, Switzerland: 2016 [consultado Mar 2017]. Disponible en: http:\/\/www.who.int\/tb\/WHOPolicyStatementSLLPA.pdf"},{"key":"10.1016\/j.anpedi.2017.05.013_bib0335","first-page":"61","article-title":"Management of persons exposed to multidrug-resistant tuberculosis","volume":"41","author":"Villarino","year":"1992","journal-title":"MMWR Morb Mortal Wkly Rep."},{"key":"10.1016\/j.anpedi.2017.05.013_bib0340","series-title":"Post-exposure management of multidrug-resistant tuberculosis contacts: Evidence based recommendations. Policy Brief N\u00b0 1.","author":"Seddon","year":"2015"},{"key":"10.1016\/j.anpedi.2017.05.013_bib0345","unstructured":"European Centre for Disease Prevention and Control. Management of contacts of MDR TB and XDR TB patients. Stockholm; 2012 [consultado Mar 2017]. Disponible en: https:\/\/ecdc.europa.eu\/sites\/portal\/files\/media\/en\/publications\/Publications\/201203-Guidance-MDR-TB-contacts.pdf"},{"key":"10.1016\/j.anpedi.2017.05.013_bib0350","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1093\/cid\/ciu868","article-title":"Pharmacokinetics and safety of moxifloxacin in children with multidrug-resistant tuberculosis","volume":"60","author":"Thee","year":"2015","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.anpedi.2017.05.013_bib0355","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1093\/cid\/cit655","article-title":"Preventive therapy for child contacts of MDR TB: A prospective cohort study","volume":"57","author":"Seddon","year":"2013","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.anpedi.2017.05.013_bib0360","unstructured":"The Sentinel Project on Pediatric Drug-Resistant Tuberculosis. The use of delamanid and bedaquiline for children with drug-resistant tuberculosis. 2016 [consultado Mar 2017]. Disponible en: http:\/\/sentinel-project.org\/2016\/05\/16\/advancing-access-for-new-tb-drugs-for-children\/."},{"key":"10.1016\/j.anpedi.2017.05.013_bib0365","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1186\/1745-6215-15-353","article-title":"Evaluation of a standardized treatment regimen of anti-tuberculosis drugs for patients with multi-drug-resistant tuberculosis (STREAM): Study protocol for a randomized controlled trial","volume":"15","author":"Nunn","year":"2014","journal-title":"Trials"},{"key":"10.1016\/j.anpedi.2017.05.013_bib0370","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1164\/rccm.201001-0077OC","article-title":"Short, highly effective, and inexpensive standardized treatment of multidrug-resistant tuberculosis","volume":"182","author":"Van Deun","year":"2010","journal-title":"Am J Resp Crit Care Med"},{"key":"10.1016\/j.anpedi.2017.05.013_bib0375","doi-asserted-by":"crossref","first-page":"517","DOI":"10.5588\/ijtld.14.0535","article-title":"High effectiveness of a 12-month regimen for MDR-TB patients in Cameroon","volume":"19","author":"Kuaban","year":"2015","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.1016\/j.anpedi.2017.05.013_bib0380","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.5588\/ijtld.13.0075","article-title":"High cure rate with standardised short-course multidrug- resistant tuberculosis treatment in Niger: No relapses","volume":"18","author":"Piubello","year":"2014","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.1016\/j.anpedi.2017.05.013_bib0385","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1164\/rccm.201606-1097LE","article-title":"Limited benefit of the new shorter multidrug-resistant tuberculosis regimen in Europe","volume":"194","author":"Lange","year":"2016","journal-title":"Am J Resp Crit Care Med"},{"key":"10.1016\/j.anpedi.2017.05.013_bib0390","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1016\/S0140-6736(16)30729-2","article-title":"WHO recommendations on shorter treatment of multidrug-resistant tuberculosis","volume":"387","author":"Sotgiu","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.anpedi.2017.05.013_bib0395","unstructured":"Agencia Espa\u00f1ola del Medicamento y Productos Sanitarios (AEMPS), Ministerio de Sanidad Consumo y Asuntos Sociales. Centro de Informaci\u00f3n online de Medicamentos de la AEMPS - CIMA. 2017 [consultado 1 Abril 2017]. Disponible en: http:\/\/www.aemps.gob.es\/informa\/info-atencion-ciudadano\/home.htm"},{"key":"10.1016\/j.anpedi.2017.05.013_bib0400","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1097\/INF.0000000000000065","article-title":"Short intensified treatment in children with drug-susceptible tuberculous meningitis","volume":"33","author":"Van Toorn","year":"2014","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.anpedi.2017.05.013_bib0405","unstructured":"The Sentinel Project on Pediatric Drug-Resistant Tuberculosis. Management of tuberculosis in children: A field guide. 2nd ed. Boston: 2015 [consultado Mar 2017]. Disponible en: https:\/\/sentinelproject.files.wordpress.com\/2012\/11\/sentinel_project_field_guide_2012.pdf"},{"key":"10.1016\/j.anpedi.2017.05.013_bib0410","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s41479-016-0019-5","article-title":"Drug-resistant tuberculosis and advances in the treatment of childhood tuberculosis","volume":"8","author":"Seddon","year":"2016","journal-title":"Pneumonia"}],"container-title":["Anales de Pediatr\u00eda"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1695403317302254?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1695403317302254?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T03:57:27Z","timestamp":1548129447000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1695403317302254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["S1695403317302254"],"URL":"https:\/\/doi.org\/10.1016\/j.anpedi.2017.05.013","relation":{},"ISSN":["1695-4033"],"issn-type":[{"value":"1695-4033","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Actualizaci\u00f3n del tratamiento de la tuberculosis en ni\u00f1os","name":"articletitle","label":"Article Title"},{"value":"Anales de Pediatr\u00eda","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anpedi.2017.05.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Asociaci\u00f3n Espa\u00f1ola de Pediatr\u00eda. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}]}}