{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T07:14:23Z","timestamp":1773904463227,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T00:00:00Z","timestamp":1586476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Anales de Pediatr\u00eda"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.anpedi.2020.04.007","type":"journal-article","created":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T17:39:41Z","timestamp":1590514781000},"page":"376.e1-376.e10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Recomendaciones para el diagn\u00f3stico y manejo pr\u00e1ctico de la esofagitis eosinof\u00edlica pedi\u00e1trica"],"prefix":"10.1016","volume":"92","author":[{"given":"Carolina","family":"Guti\u00e9rrez Junquera","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Fern\u00e1ndez Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria","family":"Dom\u00ednguez-Ortega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00edctor","family":"Vila Miravet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Garc\u00eda Puig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Garc\u00eda Romero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Fern\u00e1ndez de Valderrama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebeca","family":"Andradas Rivas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Alonso Vicente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"\u00c1lvarez Beltr\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josefa","family":"Barrio Torres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Barros Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gemma","family":"Colom\u00e9 Rivero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Javier Eizaguirre Arocena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Fern\u00e1ndez Caama\u00f1o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique la","family":"Orden Izquierdo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosaura","family":"Leis Trabazo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Lorenzo Garrido","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Medina Ben\u00edtez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montserrat","family":"Montraveta Querol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"Vecino L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.anpedi.2020.04.007_bib0205","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/BF01296781","article-title":"Esophageal eosinophilia with dysphagia. A distinct clinicopathologic syndrome","volume":"38","author":"Attwood","year":"1993","journal-title":"Dig Dis Sci."},{"key":"10.1016\/j.anpedi.2020.04.007_bib0210","doi-asserted-by":"crossref","first-page":"24","DOI":"10.18176\/jiaci.0280","article-title":"Increasing incidence of pediatric eosinophilic esophagitis in the Southwest of Madrid, Spain","volume":"29","author":"La Orden Izquierdo","year":"2019","journal-title":"J Investig Allergol Clin Immunol."},{"key":"10.1016\/j.anpedi.2020.04.007_bib0215","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.dld.2018.07.016","article-title":"Incidence and prevalence of eosinophilic oesophagitis increase continiously in adults and children in Central Spain: A 12-year population-based study","volume":"51","author":"Arias","year":"2019","journal-title":"Dig Liver Dis."},{"key":"10.1016\/j.anpedi.2020.04.007_bib0220","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1053\/j.gastro.2007.08.017","article-title":"Eosinophilic esophagitis in children and adults: A systematic review and consensus recommendations for diagnosis and treatment","volume":"133","author":"Furuta","year":"2007","journal-title":"Gastroenterology."},{"key":"10.1016\/j.anpedi.2020.04.007_bib0225","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1177\/2050640616689525","article-title":"Guidelines on eosinophilic esophagitis: Evidence-based statements and recommendations for diagnosis and management in children and adults","volume":"5","author":"Lucendo","year":"2017","journal-title":"United European Gastroenterol J."},{"key":"10.1016\/j.anpedi.2020.04.007_bib0230","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1053\/j.gastro.2018.07.009","article-title":"Updated international consensus diagnostic criteria for eosinophilic esophagitis: Proceedings of the AGREE Conference","volume":"155","author":"Dellon","year":"2018","journal-title":"Gastroenterology."},{"key":"10.1016\/j.anpedi.2020.04.007_bib0235","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s11894-018-0607-z","article-title":"Eosinophilic esophagitis in children: Endoscopic findings at diagnosis and post-intervention","volume":"20","author":"Bolton","year":"2018","journal-title":"Curr Gastroenterol Rep"},{"key":"10.1016\/j.anpedi.2020.04.007_bib0240","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1136\/gutjnl-2011-301817","article-title":"Endoscopic assessment of the oesophageal features of eosinophilic oesophagitis: Validation of a novel classification and grading system","volume":"62","author":"Hirano","year":"2013","journal-title":"Gut."},{"key":"10.1016\/j.anpedi.2020.04.007_bib0245","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/s41395-018-0052-5","article-title":"The natural course of eosinophilic esophagitis and long-term consequences of undiagnosed disease in a large cohort","volume":"113","author":"Warners","year":"2018","journal-title":"Am J Gastroenterol."},{"key":"10.1016\/j.anpedi.2020.04.007_bib0250","doi-asserted-by":"crossref","first-page":"e50037","DOI":"10.1371\/journal.pone.0050037","article-title":"Omeprazole blocks STAT6 binding to the eotaxin-3 promoter in eosinophilic esophagitis cells","volume":"7","author":"Zhang","year":"2012","journal-title":"PLoS ONE."},{"key":"10.1016\/j.anpedi.2020.04.007_bib0255","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1016\/j.cgh.2014.02.037","article-title":"Proton pump inhibitors partially restore mucosal integrity in patients with proton pump inhibitor-responsive esophageal eosinophilia but not eosinophilic esophagitis","volume":"12","author":"Van Rhijn","year":"2014","journal-title":"Clin Gastroenterol Hepatol."},{"key":"10.1016\/j.anpedi.2020.04.007_bib0260","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jaci.2014.08.043","article-title":"Transcriptome analysis of proton pump inhibitor-responsive esophageal eosinophilia reveals proton pump inhibitor-reversible allergic inflammation","volume":"135","author":"Wen","year":"2015","journal-title":"J Allergy Clin Immunol."},{"key":"10.1016\/j.anpedi.2020.04.007_bib0265","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.cgh.2015.07.041","article-title":"Efficacy of proton pump inhibitor drugs for inducing clinical and histologic remission in patients with symptomatic esophageal eosinophilia: A systematic review and meta-analysis","volume":"14","author":"Lucendo","year":"2016","journal-title":"Clin Gastroenterol Hepatol."},{"key":"10.1016\/j.anpedi.2020.04.007_bib0270","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1097\/MPG.0000000000001019","article-title":"High prevalence of response to proton-pump inhibitor treatment in children with esophageal eosinophilia","volume":"62","author":"Guti\u00e9rrez-Junquera","year":"2016","journal-title":"J Pediatr Gastroenterol Nutr."},{"key":"10.1016\/j.anpedi.2020.04.007_bib0275","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/MPG.0000000000001952","article-title":"Long-term treatment with proton pump inhibitors is effective in children with eosinophilic esophagitis","volume":"67","author":"Guti\u00e9rrez-Junquera","year":"2018","journal-title":"J Pediatr Gastroenterol Nutr."},{"key":"10.1016\/j.anpedi.2020.04.007_bib0280","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1097\/MPG.0000000000002480","article-title":"CYP2C19 and STAT6 variants influence the outcome of proton pump inhibitor therapy in pediatric eosinophilic esophagitis","volume":"69","author":"Mougey","year":"2019","journal-title":"J Pediatr Gastroenterol Nutr."},{"key":"10.1016\/j.anpedi.2020.04.007_bib0285","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1111\/apt.13194","article-title":"Long-term safety of proton pump inhibitor therapy assessed under controlled, randomised clinical trial conditions: Data from the SOPRAN and LOTUS studies","volume":"41","author":"Attwood","year":"2015","journal-title":"Aliment Pharmacol Ther."},{"key":"10.1016\/j.anpedi.2020.04.007_bib0290","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1097\/MPG.0000000000000451","article-title":"Health-related quality of life over time in children with eosinophilic esophagitis and their families","volume":"59","author":"Klinnert","year":"2014","journal-title":"J Pediatr Gastroenterol Nutr."},{"key":"10.1016\/j.anpedi.2020.04.007_bib0295","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1053\/j.gastro.2014.02.006","article-title":"Efficacy of dietary interventions for inducing histologic remission in patients with eosinophilic esophagitis: A systematic review and meta-analysis","volume":"146","author":"Arias","year":"2014","journal-title":"Gastroenterology."},{"key":"10.1016\/j.anpedi.2020.04.007_bib0300","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/apt.13676","article-title":"Allergy tests do not predict food triggers in adult patients with eosinophilic oesophagitis. A comprehensive prospective study using five modalities","volume":"44","author":"Philpott","year":"2016","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.anpedi.2020.04.007_bib0305","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1111\/all.12846","article-title":"Eosinophilic esophagitis is characterized by a non-IgE-mediated food hypersensitivity","volume":"71","author":"Simon","year":"2016","journal-title":"Allergy."},{"key":"10.1016\/j.anpedi.2020.04.007_bib0310","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.cgh.2006.05.026","article-title":"Effect of six-food elimination diet on clinical and histologic outcomes in eosinophilic esophagitis","volume":"4","author":"Kagalwalla","year":"2006","journal-title":"Clin Gastroenterol Hepatol."},{"key":"10.1016\/j.anpedi.2020.04.007_bib0315","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.jaci.2012.12.664","article-title":"Empiric 6-food elimination diet induced and maintained prolonged remission in patients with adult eosinophilic esophagitis: A prospective study on the food cause of the disease","volume":"131","author":"Lucendo","year":"2013","journal-title":"J Allergy Clin Immunol."},{"key":"10.1016\/j.anpedi.2020.04.007_bib0320","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/MPG.0b013e31821cf503","article-title":"Identification of specific foods responsible for inflammation in children with eosinophilic esophagitis successfully treated with empiric elimination diet","volume":"53","author":"Kagalwalla","year":"2011","journal-title":"J Pediatr Gastroenterol Nutr."},{"key":"10.1016\/j.anpedi.2020.04.007_bib0325","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.jaci.2014.07.023","article-title":"Four-food group elimination diet for adult eosinophilic esophagitis: A prospective multicenter study","volume":"134","author":"Molina-Infante","year":"2014","journal-title":"J Allergy Clin Immunol."},{"key":"10.1016\/j.anpedi.2020.04.007_bib0330","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1016\/j.cgh.2017.05.048","article-title":"Efficacy of a 4-food elimination diet for children with eosinophilic esophagitis","volume":"15","author":"Kagalwalla","year":"2017","journal-title":"Clin Gastroenterol Hepatol."},{"key":"10.1016\/j.anpedi.2020.04.007_bib0335","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/j.jaci.2017.08.038","article-title":"Step-up empiric elimination diet for pediatric and adult eosinophilic esophagitis: The 2-4-6 study","volume":"141","author":"Molina-Infante","year":"2018","journal-title":"J Allergy Clin Immunol"},{"issue":"6 Suppl1","key":"10.1016\/j.anpedi.2020.04.007_bib0340","doi-asserted-by":"crossref","first-page":"S172","DOI":"10.1016\/S0016-5085(19)37223-3","article-title":"Efficacy of 1-food and 4-food elimination diets for pediatric eosinophilic esophagitis in a randomized multi-site study","volume":"156","author":"Kliewer","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.anpedi.2020.04.007_bib0345","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1111\/apt.14290","article-title":"Food elimination diets are effective for long-term treatment of adults with eosinophilic oesophagitis","volume":"46","author":"Reed","year":"2017","journal-title":"Aliment Pharmacol Ther."},{"key":"10.1016\/j.anpedi.2020.04.007_bib0350","first-page":"210","article-title":"Dietary treatment of eosinophilic gastrointestinal disorders in children","volume":"23","author":"Guti\u00e9rrez-Junquera","year":"2020","journal-title":"Curr Opin Clin Nutr Metab Care."},{"key":"10.1016\/j.anpedi.2020.04.007_bib0355","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.jaip.2016.12.026","article-title":"Dietary therapy and nutrition management of eosinophilic esophagitis: A Work Group Report of the American Academy of Allergy Asthma, and Immunology","volume":"5","author":"Groetch","year":"2017","journal-title":"J Allergy Clin Immunol Pract."},{"key":"10.1016\/j.anpedi.2020.04.007_bib0360","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/s12016-017-8660-1","article-title":"Dietary therapy for eosinophilic esophagitis: Elimination and reintroduction","volume":"55","author":"Kliewer","year":"2018","journal-title":"Clin Rev Allergy Immunol."},{"key":"10.1016\/j.anpedi.2020.04.007_bib0365","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.anai.2019.01.010","article-title":"New IgE immediate hypersensitivity reactions on reintroduction of food restricted for treatment of eosinophilic esophagitis","volume":"122","author":"Gottlieb","year":"2019","journal-title":"Ann Allergy Asthma Immunol."},{"key":"10.1016\/j.anpedi.2020.04.007_bib0370","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.cgh.2007.11.008","article-title":"Comparison of oral prednisone and topical fluticasone in the treatment of eosinophilic esophagitis: A randomized trial in children","volume":"6","author":"Schaefer","year":"2008","journal-title":"Clin Gastroenterol Hepatol."},{"key":"10.1016\/j.anpedi.2020.04.007_bib0375","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1007\/s10620-017-4642-7","article-title":"Six-food elimination diet and topical steroids are effective for eosinophilic esophagitis: A meta-regression","volume":"62","author":"Cotton","year":"2017","journal-title":"Dig Dis Sci."},{"key":"10.1016\/j.anpedi.2020.04.007_bib0380","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1053\/j.gastro.2012.04.049","article-title":"Viscous topical is more effective than nebulized steroid therapy for patients with eosinophilic esophagitis","volume":"143","author":"Dellon","year":"2012","journal-title":"Gastroenterology."},{"key":"10.1016\/j.anpedi.2020.04.007_bib0385","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1053\/j.gastro.2019.03.025","article-title":"Efficacy of budesonide orodispersible tablets as induction therapy for eosinophilic esophagitis in a randomized placebo-controlled trial","volume":"157","author":"Lucendo","year":"2019","journal-title":"Gastroenterology."},{"key":"10.1016\/j.anpedi.2020.04.007_bib0390","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/ajg.2016.238","article-title":"Swallowed fluticasone propionate is an effective long-term maintenance therapy for children with eosinophilic esophagitis","volume":"111","author":"Andreae","year":"2016","journal-title":"Am J Gastroenterol."},{"key":"10.1016\/j.anpedi.2020.04.007_bib0395","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1053\/j.gastro.2006.08.033","article-title":"A randomized, double-blind, placebo-controlled trial of fluticasone propionate for pediatric eosinophilic esophagitis","volume":"131","author":"Konikoff","year":"2006","journal-title":"Gastroenterology."},{"key":"10.1016\/j.anpedi.2020.04.007_bib0400","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1111\/apt.14573","article-title":"Systematic review: Adrenal insufficiency secondary to swallowed topical corticosteroids in eosinophilic oesophagitis","volume":"47","author":"Philpott","year":"2018","journal-title":"Aliment Pharmacol Ther."}],"container-title":["Anales de Pediatr\u00eda"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1695403320301594?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1695403320301594?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T14:50:53Z","timestamp":1761663053000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1695403320301594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["S1695403320301594"],"URL":"https:\/\/doi.org\/10.1016\/j.anpedi.2020.04.007","relation":{},"ISSN":["1695-4033"],"issn-type":[{"value":"1695-4033","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Recomendaciones para el diagn\u00f3stico y manejo pr\u00e1ctico de la esofagitis eosinof\u00edlica pedi\u00e1trica","name":"articletitle","label":"Article Title"},{"value":"Anales de Pediatr\u00eda","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.anpedi.2020.04.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Asociaci\u00f3n Espa\u00f1ola de Pediatr\u00eda. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}]}}