{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:44:01Z","timestamp":1790909041768,"version":"4.1.0"},"reference-count":17,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T00:00:00Z","timestamp":1107216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antiviral Research"],"published-print":{"date-parts":[[2005,2]]},"DOI":"10.1016\/j.antiviral.2004.10.003","type":"journal-article","created":{"date-parts":[[2004,12,10]],"date-time":"2004-12-10T14:36:13Z","timestamp":1102689373000},"page":"97-105","source":"Crossref","is-referenced-by-count":59,"title":["Inhibition of herpesvirus replication by a series of 4-oxo-dihydroquinolines with viral polymerase activity"],"prefix":"10.1016","volume":"65","author":[{"given":"Caroll B.","family":"Hartline","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma A.","family":"Harden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie L.","family":"Williams-Aziz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole L.","family":"Kushner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger J.","family":"Brideau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Earl R.","family":"Kern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.antiviral.2004.10.003_bib1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0166-3542(01)00208-X","article-title":"Broad-spectrum antiviral activity of PNU-183792, a 4-oxo-dihydroquinoline, against human and animal herpesviruses","volume":"54","author":"Brideau","year":"2002","journal-title":"Antiviral Res."},{"key":"10.1016\/j.antiviral.2004.10.003_bib2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0166-3542(98)00021-7","article-title":"Summary of the III International Consensus Symposium on Combined Antiviral Therapy","volume":"38","author":"Cohen-Stuart","year":"1998","journal-title":"Antiviral Res."},{"key":"10.1016\/j.antiviral.2004.10.003_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0166-3542(97)00059-4","article-title":"Summary of the International Consensus Symposium on Management of HIV, CMV, and Hepatitis Virus Infections","volume":"37","author":"de Jong","year":"1998","journal-title":"Antiviral Res."},{"key":"10.1016\/j.antiviral.2004.10.003_bib4","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0166-3542(98)00044-8","article-title":"Summary of the Second International Symposium on Cytomegalovirus","volume":"39","author":"de Jong","year":"1998","journal-title":"Antiviral Res."},{"key":"10.1016\/j.antiviral.2004.10.003_bib5","doi-asserted-by":"crossref","first-page":"8039","DOI":"10.1073\/pnas.140123497","article-title":"Prediction of cytomegalovirus load and resistance patterns after antiviral chemotherapy","volume":"97","author":"Emery","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.antiviral.2004.10.003_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/CMR.7.1.1","article-title":"\u201cThe end of innocence\u201d revisited: resistance of herpesvirus to antiviral drugs","volume":"7","author":"Field","year":"1994","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.antiviral.2004.10.003_bib7","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1517\/13543784.9.2.207","article-title":"Therapeutic developments in cytomegalovirus retinitis","volume":"9","author":"Hoffman","year":"2000","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.antiviral.2004.10.003_bib8","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/jmv.10193","article-title":"Inhibition of clinical isolates of human cytomegalovirus and varicella zoster virus by PNU-183792, a 4-oxo-dihydroquinoline","volume":"68","author":"Knechtel","year":"2002","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.antiviral.2004.10.003_bib9","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1081\/NCN-120026633","article-title":"Efficacy of methylenecyclopropane analogs of nucleosides against herpesvirus replication in vitro","volume":"22","author":"Kushner","year":"2003","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"key":"10.1016\/j.antiviral.2004.10.003_bib10","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1128\/AAC.46.3.724-730.2002","article-title":"Broad-spectrum antiherpes activities of 4-hydroxyquinoline carboxamides, a novel class of herpesvirus polymerase inhibitors","volume":"46","author":"Oien","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.antiviral.2004.10.003_bib11","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0166-3542(97)00054-5","article-title":"Penciclovir and pathogenesis phenotypes of drug-resistant herpes simplex virus mutants","volume":"37","author":"Pelosi","year":"1998","journal-title":"Antiviral Res."},{"key":"10.1016\/j.antiviral.2004.10.003_bib12","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1093\/jac\/45.6.729","article-title":"Management of herpes virus infections following transplantation","volume":"45","author":"Pillay","year":"2000","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.antiviral.2004.10.003_bib13","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0166-3542(90)90001-N","article-title":"A three-dimensional model to analyze drug-drug interactions","volume":"14","author":"Prichard","year":"1990","journal-title":"Antiviral. Res."},{"key":"10.1016\/j.antiviral.2004.10.003_bib14","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1128\/JVI.67.2.1024-1033.1993","article-title":"Analysis of the thymidine kinase genes from acyclovir-resistant mutants of varicella-zoster virus isolated from patients with AIDS","volume":"67","author":"Talarico","year":"1993","journal-title":"J. Virol."},{"key":"10.1016\/j.antiviral.2004.10.003_bib15","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1128\/JVI.77.3.1868-1876.2003","article-title":"Amino acid changes within conserved region III of the herpes simplex virus and human cytomegalovirus DNA polymerases confer resistance to 4-oxo-dihydroquinolines, a novel class of herpesvirus antiviral agents","volume":"77","author":"Thomsen","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.antiviral.2004.10.003_bib16","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1016\/S0960-894X(00)00402-9","article-title":"Napthalene carboxamides as inhibitors of human cytomegalovirus DNA polymerase","volume":"10","author":"Vaillancourt","year":"2000","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.antiviral.2004.10.003_bib17","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1128\/AAC.47.7.2186-2192.2003","article-title":"In vitro activities of benzimidazole d-and l-ribonucleosides against herpesviruses","volume":"47","author":"Williams","year":"2003","journal-title":"Antimicrob. Agents Chemother."}],"container-title":["Antiviral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166354204002426?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166354204002426?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,4]],"date-time":"2020-04-04T16:53:34Z","timestamp":1586019214000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166354204002426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,2]]}},"alternative-id":["S0166354204002426"],"URL":"https:\/\/doi.org\/10.1016\/j.antiviral.2004.10.003","relation":{},"ISSN":["0166-3542"],"issn-type":[{"value":"0166-3542","type":"print"}],"subject":[],"published":{"date-parts":[[2005,2]]}}}