{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T04:09:17Z","timestamp":1779336557600,"version":"3.51.4"},"reference-count":46,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antiviral Research"],"published-print":{"date-parts":[[2008,7]]},"DOI":"10.1016\/j.antiviral.2008.02.002","type":"journal-article","created":{"date-parts":[[2008,3,11]],"date-time":"2008-03-11T14:27:42Z","timestamp":1205245662000},"page":"1-5","source":"Crossref","is-referenced-by-count":34,"title":["Rapid sequence-based diagnosis of viral infection"],"prefix":"10.1016","volume":"79","author":[{"given":"Phenix-Lan","family":"Quan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Briese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo","family":"Palacios","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Ian Lipkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.antiviral.2008.02.002_bib1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.antiviral.2007.08.008","article-title":"Activity of the neuraminidase inhibitor A-315675 against oseltamivir-resistant influenza neuraminidases of N1 and N2 subtypes","volume":"77","author":"Abed","year":"2008","journal-title":"Antiviral Res."},{"key":"10.1016\/j.antiviral.2008.02.002_bib2","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1002\/jmv.20689","article-title":"Frequent detection of human rhinoviruses, paramyxoviruses, coronaviruses, and bocavirus during acute respiratory tract infections","volume":"78","author":"Arden","year":"2006","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.antiviral.2008.02.002_bib3","doi-asserted-by":"crossref","first-page":"310","DOI":"10.3201\/eid1102.040492","article-title":"Diagnostic system for rapid and sensitive differential detection of pathogens","volume":"11","author":"Briese","year":"2005","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.antiviral.2008.02.002_bib4","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/01.pdm.0000210430.35340.53","article-title":"Direct screening of clinical specimens for multiple respiratory pathogens using the Genaco Respiratory Panels 1 and 2","volume":"15","author":"Brunstein","year":"2006","journal-title":"Diagn. Mol. Pathol."},{"key":"10.1016\/j.antiviral.2008.02.002_bib5","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0166-0934(97)00035-9","article-title":"Detection of enteroviral RNA and specific DNA of herpesviruses by multiplex genome amplification","volume":"66","author":"Casas","year":"1997","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.antiviral.2008.02.002_bib6","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1056\/NEJMoa065954","article-title":"Neurodevelopment and cognition in children after enterovirus 71 infection","volume":"356","author":"Chang","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.antiviral.2008.02.002_bib7","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1177\/135965359900400404","article-title":"Intravenous ribavirin for hantavirus pulmonary syndrome: safety and tolerance during 1 year of open-label experience. Ribavirin Study Group","volume":"4","author":"Chapman","year":"1999","journal-title":"Antivir. Ther."},{"key":"10.1016\/j.antiviral.2008.02.002_bib8","doi-asserted-by":"crossref","first-page":"e71","DOI":"10.1086\/507896","article-title":"Microarray detection of human parainfluenzavirus 4 infection associated with respiratory failure in an immunocompetent adult","volume":"43","author":"Chiu","year":"2006","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.antiviral.2008.02.002_bib9","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1128\/JCM.00364-07","article-title":"Diagnosis of a critical respiratory illness caused by human metapneumovirus by use of a pan-virus microarray","volume":"45","author":"Chiu","year":"2007","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.antiviral.2008.02.002_bib10","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1056\/NEJMoa053240","article-title":"Transmission of lymphocytic choriomeningitis virus by organ transplantation","volume":"354","author":"Fischer","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.antiviral.2008.02.002_bib11","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1002\/jmv.20858","article-title":"Loop-mediated isothermal amplification method for detection of human papillomavirus type 6, 11, 16, and 18","volume":"79","author":"Hagiwara","year":"2007","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.antiviral.2008.02.002_bib12","doi-asserted-by":"crossref","first-page":"4157","DOI":"10.1128\/JCM.01762-06","article-title":"Simultaneous amplification and identification of 25 human papillomavirus types with templex technology","volume":"44","author":"Han","year":"2006","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.antiviral.2008.02.002_bib13","doi-asserted-by":"crossref","first-page":"S262","DOI":"10.1097\/01.inf.0000144680.39895.ce","article-title":"Pandemic influenza: is an antiviral response realistic?","volume":"23","author":"Hayden","year":"2004","journal-title":"Pediatr. Infect. Dis J."},{"key":"10.1016\/j.antiviral.2008.02.002_bib14","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1101\/gr.6.10.986","article-title":"Real time quantitative PCR","volume":"6","author":"Heid","year":"1996","journal-title":"Genome Res."},{"key":"10.1016\/j.antiviral.2008.02.002_bib15","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/mas.20016","article-title":"Analysis of nucleic acids by FTICR MS","volume":"24","author":"Hofstadler","year":"2005","journal-title":"Mass Spectrom. Rev."},{"key":"10.1016\/j.antiviral.2008.02.002_bib16","doi-asserted-by":"crossref","first-page":"6605","DOI":"10.1093\/nar\/gkl966","article-title":"Greene SCPrimer: a rapid comprehensive tool for designing degenerate primers from multiple sequence alignments","volume":"34","author":"Jabado","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.antiviral.2008.02.002_bib17","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1056\/NEJMoa011232","article-title":"Treatment of acute hepatitis C with interferon alfa-2b","volume":"345","author":"Jaeckel","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.antiviral.2008.02.002_bib18","doi-asserted-by":"crossref","first-page":"899","DOI":"10.3201\/eid1306.061572","article-title":"Loop-mediated isothermal amplification for influenza A (H5N1) virus","volume":"13","author":"Jayawardena","year":"2007","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.antiviral.2008.02.002_bib19","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1086\/520816","article-title":"Pan-viral screening of respiratory tract infections in adults with and without asthma reveals unexpected human coronavirus and human rhinovirus diversity","volume":"196","author":"Kistler","year":"2007","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.antiviral.2008.02.002_bib20","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1086\/508551","article-title":"MassTag polymerase-chain-reaction detection of respiratory pathogens, including a new rhinovirus genotype, that caused influenza-like illness in New York State during 2004\u20132005","volume":"194","author":"Lamson","year":"2006","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.antiviral.2008.02.002_bib21","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.1128\/JCM.01254-07","article-title":"Clinical features and complete genome characterization of a distinct human rhinovirus (HRV) genetic cluster, probably representing a previously undetected HRV species, HRV-C, associated with acute respiratory illness in children","volume":"45","author":"Lau","year":"2007","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.antiviral.2008.02.002_bib22","doi-asserted-by":"crossref","first-page":"e966","DOI":"10.1371\/journal.pone.0000966","article-title":"A diverse group of previously unrecognized human rhinoviruses are common causes of respiratory illnesses in infants","volume":"2","author":"Lee","year":"2007","journal-title":"PLoS ONE"},{"key":"10.1016\/j.antiviral.2008.02.002_bib23","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1128\/JCM.00210-07","article-title":"Simultaneous detection and high-throughput identification of a panel of RNA viruses causing respiratory tract infections","volume":"45","author":"Li","year":"2007","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.antiviral.2008.02.002_bib24","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1128\/JCM.01870-06","article-title":"Using a resequencing microarray as a multiple respiratory pathogen detection assay","volume":"45","author":"Lin","year":"2007","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.antiviral.2008.02.002_bib25","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature03959","article-title":"Genome sequencing in microfabricated high-density picolitre reactors","volume":"437","author":"Margulies","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.antiviral.2008.02.002_bib26","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jcv.2007.03.012","article-title":"Characterisation of a newly identified human rhinovirus, HRV-QPM, discovered in infants with bronchiolitis","volume":"39","author":"McErlean","year":"2007","journal-title":"J. Clin. Virol."},{"key":"10.1016\/j.antiviral.2008.02.002_bib27","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1099\/vir.0.82459-0","article-title":"Ribavirin, human convalescent plasma and anti-beta3 integrin antibody inhibit infection by Sin Nombre virus in the deer mouse model","volume":"88","author":"Medina","year":"2007","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.antiviral.2008.02.002_bib28","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1086\/425007","article-title":"Placebo-controlled, double-blind trial of intravenous ribavirin for the treatment of hantavirus cardiopulmonary syndrome in North America","volume":"39","author":"Mertz","year":"2004","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.antiviral.2008.02.002_bib29","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3201\/eid0101.950102","article-title":"Factors in the emergence of infectious diseases","volume":"1","author":"Morse","year":"1995","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.antiviral.2008.02.002_bib30","doi-asserted-by":"crossref","first-page":"E63","DOI":"10.1093\/nar\/28.12.e63","article-title":"Loop-mediated isothermal amplification of DNA","volume":"28","author":"Notomi","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.antiviral.2008.02.002_bib31","doi-asserted-by":"crossref","first-page":"692","DOI":"10.3201\/eid1204.051515","article-title":"MassTag polymerase chain reaction for differential diagnosis of viral hemorrhagic fever","volume":"12","author":"Palacios","year":"2006","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.antiviral.2008.02.002_bib32","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3201\/eid1301.060837","article-title":"Panmicrobial oligonucleotide array for diagnosis of infectious diseases","volume":"13","author":"Palacios","year":"2007","journal-title":"Emerg. Infect. Dis."},{"issue":"10","key":"10.1016\/j.antiviral.2008.02.002_bib33","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1056\/NEJMoa073785","article-title":"A new arenavirus in a cluster of fatal transplant-associated diseases","volume":"358","author":"Palacios","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.antiviral.2008.02.002_bib34","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1086\/521895","article-title":"Outbreak of neurologic enterovirus type 71 disease: a diagnostic challenge","volume":"45","author":"Perez-Velez","year":"2007","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.antiviral.2008.02.002_bib35","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1086\/341405","article-title":"Outcome of and prognostic factors for herpes simplex encephalitis in adult patients: results of a multicenter study","volume":"35","author":"Raschilas","year":"2002","journal-title":"Clin. Infect. Dis."},{"issue":"12","key":"10.1016\/j.antiviral.2008.02.002_bib36","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1086\/524312","article-title":"A recently identified rhinovirus genotype is associated with severe respiratory-tract infection in children in Germany","volume":"196","author":"Renwick","year":"2007","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.antiviral.2008.02.002_bib37","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1016\/S0140-6736(07)61779-6","article-title":"Infection with chikungunya virus in Italy: an outbreak in a temperate region","volume":"370","author":"Rezza","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.antiviral.2008.02.002_bib38","doi-asserted-by":"crossref","first-page":"e489","DOI":"10.1371\/journal.pone.0000489","article-title":"Global surveillance of emerging Influenza virus genotypes by mass spectrometry","volume":"2","author":"Sampath","year":"2007","journal-title":"PLoS ONE"},{"key":"10.1016\/j.antiviral.2008.02.002_bib39","doi-asserted-by":"crossref","unstructured":"Saunders, N., Jeffries, A., 2000. The growing utility of microbial genome sequences. Genome Biol. Reports 410\u2013Reports 413.","DOI":"10.1186\/gb-2000-1-1-reports410"},{"key":"10.1016\/j.antiviral.2008.02.002_bib40","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jviromet.2006.09.014","article-title":"Diagnosis of human respiratory syncytial virus infection using reverse transcription loop-mediated isothermal amplification","volume":"139","author":"Shirato","year":"2007","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.antiviral.2008.02.002_bib41","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1128\/JCM.42.4.1564-1569.2004","article-title":"Rapid and sensitive method using multiplex real-time PCR for diagnosis of infections by influenza a and influenza B viruses, respiratory syncytial virus, and parainfluenza viruses 1, 2, 3, and 4","volume":"42","author":"Templeton","year":"2004","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.antiviral.2008.02.002_bib42","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/nbt0396-303","article-title":"Molecular beacons: probes that fluoresce upon hybridization","volume":"14","author":"Tyagi","year":"1996","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.antiviral.2008.02.002_bib43","doi-asserted-by":"crossref","first-page":"642","DOI":"10.2144\/04374RR01","article-title":"Mass spectrometry provides accurate characterization of two genetic marker types in Bacillus anthracis","volume":"37","author":"Van Ert","year":"2004","journal-title":"Biotechniques"},{"key":"10.1016\/j.antiviral.2008.02.002_bib44","doi-asserted-by":"crossref","first-page":"E2","DOI":"10.1371\/journal.pbio.0000002","article-title":"Viral discovery and sequence recovery using DNA microarrays","volume":"1","author":"Wang","year":"2003","journal-title":"PLoS Biol."},{"key":"10.1016\/j.antiviral.2008.02.002_bib45","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1056\/NEJM197708112970601","article-title":"Adenine arabinoside therapy of biopsy-proved herpes simplex encephalitis. National Institute of Allergy and Infectious Diseases collaborative antiviral study","volume":"297","author":"Whitley","year":"1977","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.antiviral.2008.02.002_bib46","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1101\/gr.2141004","article-title":"Tracking the evolution of the SARS coronavirus using high-throughput, high-density resequencing arrays","volume":"14","author":"Wong","year":"2004","journal-title":"Genome Res."}],"container-title":["Antiviral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166354208002088?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166354208002088?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:03:14Z","timestamp":1684281794000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166354208002088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["S0166354208002088"],"URL":"https:\/\/doi.org\/10.1016\/j.antiviral.2008.02.002","relation":{},"ISSN":["0166-3542"],"issn-type":[{"value":"0166-3542","type":"print"}],"subject":[],"published":{"date-parts":[[2008,7]]}}}