{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:50:37Z","timestamp":1790895037149,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Xiaoli Chi"},{"name":"Julie Constantino"},{"name":"Cary Retterer"},{"name":"Dr. Robert"},{"DOI":"10.13039\/100000774","name":"Defense Threat Reduction Agency","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000774","id-type":"DOI","asserted-by":"crossref"}]},{"name":"US Army"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antiviral Research"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1016\/j.antiviral.2011.10.011","type":"journal-article","created":{"date-parts":[[2011,10,19]],"date-time":"2011-10-19T23:21:00Z","timestamp":1319066460000},"page":"23-29","source":"Crossref","is-referenced-by-count":80,"title":["Identification of an antioxidant small-molecule with broad-spectrum antiviral activity"],"prefix":"10.1016","volume":"93","author":[{"given":"Rekha G.","family":"Panchal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St. Patrick","family":"Reid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie P.","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison A.","family":"Bergeron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Wells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna P.","family":"Kota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javad","family":"Aman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sina","family":"Bavari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.antiviral.2011.10.011_b0005","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/rmv.303","article-title":"Role of free radicals in viral pathogenesis and mutation","volume":"11","author":"Akaike","year":"2001","journal-title":"Rev. Med. Virol."},{"key":"10.1016\/j.antiviral.2011.10.011_b0180","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.mam.2007.09.005","article-title":"Ebolavirus and Marburgvirus: insight the Filoviridae family","volume":"29","author":"Ascenzi","year":"2008","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.antiviral.2011.10.011_b0015","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1089\/jir.2009.0076","article-title":"Evasion of interferon responses by Ebola and Marburg viruses","volume":"29","author":"Basler","year":"2009","journal-title":"J. Interferon Cytokine Res."},{"key":"10.1016\/j.antiviral.2011.10.011_b0025","doi-asserted-by":"crossref","first-page":"S438","DOI":"10.1086\/520552","article-title":"Filovirus research: knowledge expands to meet a growing threat","volume":"196","author":"Bray","year":"2007","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.antiviral.2011.10.011_b0020","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1086\/515386","article-title":"A mouse model for evaluation of prophylaxis and therapy of Ebola hemorrhagic fever","volume":"178","author":"Bray","year":"1998","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.antiviral.2011.10.011_b0030","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1164\/rccm.200603-319OC","article-title":"Antioxidant treatment ameliorates respiratory syncytial virus-induced disease and lung inflammation","volume":"174","author":"Castro","year":"2006","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.antiviral.2011.10.011_b0035","doi-asserted-by":"crossref","first-page":"621S","DOI":"10.1093\/ajcn\/71.2.621s","article-title":"Oxidative stress and Alzheimer disease","volume":"71","author":"Christen","year":"2000","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.antiviral.2011.10.011_b0040","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1183\/09031936.97.10071535","article-title":"Attenuation of influenza-like symptomatology and improvement of cell-mediated immunity with long-term N-acetylcysteine treatment","volume":"10","author":"De Flora","year":"1997","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.antiviral.2011.10.011_b0045","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1586\/erv.10.152","article-title":"Progress in filovirusvaccineevelopment: evaluating the potential for clinical use","volume":"10","author":"Falzarano","year":"2011","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.antiviral.2011.10.011_b0050","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0140-6736(10)60667-8","article-title":"Ebola haemorrhagic fever","volume":"377","author":"Feldmann","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.antiviral.2011.10.011_b0055","doi-asserted-by":"crossref","unstructured":"Firuzi, O., Miri, R., Tavakkoli, M., Saso, L., 2011. Antioxidant therapy: current status and future prospects. Curr. Med. Chem., in press.","DOI":"10.2174\/092986711803414368"},{"key":"10.1016\/j.antiviral.2011.10.011_b0060","first-page":"412","article-title":"Biology of disease: free radicals and tissue injury","volume":"47","author":"Freeman","year":"1982","journal-title":"Lab Invest."},{"key":"10.1016\/j.antiviral.2011.10.011_b0065","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1177\/039463200702000215","article-title":"N-acetylcysteine synergizes with oseltamivir in protecting mice from lethal influenza infection","volume":"20","author":"Garozzo","year":"2007","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"10.1016\/j.antiviral.2011.10.011_b0185","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.bcp.2009.08.025","article-title":"N-acetyl-l-cysteine (NAC) inhibits virus replication and expression of pro-inflammatory molecules in A549 cells infected with highly pathogenic H5N1 influenza A virus","volume":"79","author":"Geiler","year":"2010","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.antiviral.2011.10.011_b0075","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1086\/379724","article-title":"Mechanisms underlying coagulation abnormalities in ebola hemorrhagic fever: overexpression of tissue factor in primate monocytes\/macrophages is a key event","volume":"188","author":"Geisbert","year":"2003","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.antiviral.2011.10.011_b0080","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1177\/039463200401700114","article-title":"Synergistic combination of N-acetylcysteine and ribavirin to protect from lethal influenza viral infection in a mouse model","volume":"17","author":"Ghezzi","year":"2004","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"10.1016\/j.antiviral.2011.10.011_b0085","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0165-2478(01)00327-3","article-title":"Proinflammatory response during Ebola virus infection of primate models: possible involvement of the tumor necrosis factor receptor superfamily","volume":"80","author":"Hensley","year":"2002","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.antiviral.2011.10.011_b0090","doi-asserted-by":"crossref","first-page":"7266","DOI":"10.3390\/molecules15107266","article-title":"The Nrf2 system as a potential target for the development of indirect antioxidants","volume":"15","author":"Jung","year":"2010","journal-title":"Molecules"},{"key":"10.1016\/j.antiviral.2011.10.011_b0190","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1073\/pnas.88.3.986","article-title":"Suppression of human immunodeficiency virus expression in chronically infected monocytic cells by glutathione, glutathione ester, and N-acetylcysteine","volume":"88","author":"Kalebic","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.antiviral.2011.10.011_b0100","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1083\/jcb.131.5.1149","article-title":"Thiol agents and Bcl-2 identify an alphavirus-induced apoptotic pathway that requires activation of the transcription factor NF-kappa B","volume":"131","author":"Lin","year":"1995","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.antiviral.2011.10.011_b0105","doi-asserted-by":"crossref","first-page":"481","DOI":"10.2217\/fvl.10.33","article-title":"Viral and host proteins that modulate filovirus budding","volume":"5","author":"Liu","year":"2010","journal-title":"Future Virol."},{"key":"10.1016\/j.antiviral.2011.10.011_b0195","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.2353\/ajpath.2009.090102","article-title":"Tacrolimus ameliorates metabolic disturbance and oxidative stress caused by hepatitis C virus core protein: analysis using mouse model and cultured cells","volume":"175","author":"Moriya","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.antiviral.2011.10.011_b0115","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1146\/annurev.pharmtox.43.100901.140229","article-title":"Regulatory mechanisms controlling gene expression mediated by the antioxidant response element","volume":"43","author":"Nguyen","year":"2003","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.antiviral.2011.10.011_b0120","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1126\/science.2543070","article-title":"Oxygen radicals in influenza-induced pathogenesis and treatment with pyran polymer-conjugated SOD","volume":"244","author":"Oda","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.antiviral.2011.10.011_b0200","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1177\/1087057110374357","article-title":"Development of high-content imaging assays for lethal viral pathogens","volume":"15","author":"Panchal","year":"2010","journal-title":"J. Biomol. Screen."},{"key":"10.1016\/j.antiviral.2011.10.011_b0130","doi-asserted-by":"crossref","first-page":"962S","DOI":"10.1093\/jn\/127.5.962S","article-title":"Oxidants and antioxidants in viral diseases: disease mechanisms and metabolic regulation","volume":"127","author":"Peterhans","year":"1997","journal-title":"J. Nutr."},{"key":"10.1016\/j.antiviral.2011.10.011_b0205","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1161\/01.RES.86.2.119","article-title":"Mitochondrial oxidative stress in heart failure: \u201coxygen wastage\u201d revisited","volume":"86","author":"Sawyer","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.antiviral.2011.10.011_b0140","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/0891-5849(96)00131-1","article-title":"Oxidative stress during viral infection: a review","volume":"21","author":"Schwarz","year":"1996","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.antiviral.2011.10.011_b0210","doi-asserted-by":"crossref","first-page":"8014","DOI":"10.1128\/JVI.79.13.8014-8023.2005","article-title":"Pyrrolidine dithiocarbamate reduces coxsackievirus B3 replication through inhibition of the ubiquitin-proteasome pathway","volume":"79","author":"Si","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.antiviral.2011.10.011_b0150","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1074\/mcp.M110.003418","article-title":"Identification of essential filovirion-associated host factors by serial proteomic analysis and RNAi screen","volume":"9","author":"Spurgers","year":"2010","journal-title":"Mol. Cell.Proteomics"},{"key":"10.1016\/j.antiviral.2011.10.011_b0155","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.virol.2004.10.048","article-title":"Generation of eGFP expressing recombinant Zaire ebolavirus for analysis of early pathogenesis events and high-throughput antiviral drug screening","volume":"332","author":"Towner","year":"2005","journal-title":"Virology"},{"key":"10.1016\/j.antiviral.2011.10.011_b0160","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0166-3542(02)00109-2","article-title":"Effect of antioxidants on apoptosis induced by influenza virus infection: inhibition of viral gene replication and transcription with pyrrolidine dithiocarbamate","volume":"56","author":"Uchide","year":"2002","journal-title":"Antiviral Res."},{"key":"10.1016\/j.antiviral.2011.10.011_b0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbi.2005.12.009","article-title":"Free radicals, metals and antioxidants in oxidative stress-induced cancer","volume":"160","author":"Valko","year":"2006","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.antiviral.2011.10.011_b0170","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1126\/science.1057269","article-title":"Recovery of infectious Ebola virus from complementary DNA: RNA editing of the GP gene and viral cytotoxicity","volume":"291","author":"Volchkov","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.antiviral.2011.10.011_b0175","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1089\/ars.2010.3216","article-title":"When NRF2 talks, who\u2019s listening?","volume":"13","author":"Wakabayashi","year":"2010","journal-title":"Antioxid. Redox Signal"}],"container-title":["Antiviral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016635421100461X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016635421100461X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T00:52:49Z","timestamp":1560819169000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016635421100461X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["S016635421100461X"],"URL":"https:\/\/doi.org\/10.1016\/j.antiviral.2011.10.011","relation":{},"ISSN":["0166-3542"],"issn-type":[{"value":"0166-3542","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1]]}}}