{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T18:49:30Z","timestamp":1789670970831,"version":"4.0.1"},"reference-count":64,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100010783","name":"Slovensk\u00e1 Akad\u00e9mia Vied","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010783","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003193","name":"Ministerstvo \u0161kolstva, vedy, v\u00fdskumu a \u0161portu Slovenskej republiky","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003193","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005357","name":"Agent\u00fara na Podporu V\u00fdskumu a V\u00fdvoja","doi-asserted-by":"publisher","award":["APVV-0250-10"],"award-info":[{"award-number":["APVV-0250-10"]}],"id":[{"id":"10.13039\/501100005357","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005357","name":"Agent\u00fara na Podporu V\u00fdskumu a V\u00fdvoja","doi-asserted-by":"publisher","award":["DO7RP-APVV-0025-10"],"award-info":[{"award-number":["DO7RP-APVV-0025-10"]}],"id":[{"id":"10.13039\/501100005357","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005357","name":"Agent\u00fara na Podporu V\u00fdskumu a V\u00fdvoja","doi-asserted-by":"publisher","award":["GA310\/08\/0447"],"award-info":[{"award-number":["GA310\/08\/0447"]}],"id":[{"id":"10.13039\/501100005357","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005357","name":"Agent\u00fara na Podporu V\u00fdskumu a V\u00fdvoja","doi-asserted-by":"publisher","award":["GA310\/09\/P582"],"award-info":[{"award-number":["GA310\/09\/P582"]}],"id":[{"id":"10.13039\/501100005357","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006109","name":"Vedeck\u00e1 Grantov\u00e1 Agent\u00fara M\u0160VVa\u0160 SR a SAV","doi-asserted-by":"publisher","award":["2\/0101\/10"],"award-info":[{"award-number":["2\/0101\/10"]}],"id":[{"id":"10.13039\/501100006109","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006109","name":"Vedeck\u00e1 Grantov\u00e1 Agent\u00fara M\u0160VVa\u0160 SR a SAV","doi-asserted-by":"publisher","award":["2\/0154\/09"],"award-info":[{"award-number":["2\/0154\/09"]}],"id":[{"id":"10.13039\/501100006109","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006109","name":"Vedeck\u00e1 Grantov\u00e1 Agent\u00fara M\u0160VVa\u0160 SR a SAV","doi-asserted-by":"publisher","award":["2\/0176\/12"],"award-info":[{"award-number":["2\/0176\/12"]}],"id":[{"id":"10.13039\/501100006109","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007397","name":"Univerzita Karlova v Praze","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Research"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.antiviral.2012.09.008","type":"journal-article","created":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T20:45:44Z","timestamp":1349124344000},"page":"24-35","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Heterosubtypic protection against influenza A induced by adenylate cyclase toxoids delivering conserved HA2 subunit of hemagglutinin"],"prefix":"10.1016","volume":"97","author":[{"given":"Zuzana","family":"Stanekov\u00e1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irena","family":"Adkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Kosov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Janul\u00edkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"\u0160ebo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Vare\u010dkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.antiviral.2012.09.008_b0005","doi-asserted-by":"crossref","first-page":"8847","DOI":"10.1158\/0008-5472.CAN-07-0321","article-title":"Eradication of large tumors in mice by a tritherapy targeting the innate, adaptive, and regulatory components of the immune system","volume":"67","author":"Berraondo","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.antiviral.2012.09.008_b0010","doi-asserted-by":"crossref","first-page":"13701","DOI":"10.1073\/pnas.1007465107","article-title":"Design of an HA2-based Escherichia coli expressed influenza immunogen that protects mice from pathogenic challenge","volume":"107","author":"Bommakanti","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.antiviral.2012.09.008_b0015","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1172\/JCI41902","article-title":"Heterosubtypic neutralizing antibodies are produced by individuals immunized with a seasonal influenza vaccine","volume":"120","author":"Corti","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.antiviral.2012.09.008_b0020","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1126\/science.1205669","article-title":"A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins","volume":"333","author":"Corti","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.antiviral.2012.09.008_b0025","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1128\/IAI.68.7.3867-3872.2000","article-title":"Induction of a polarized Th1 response by insertion of multiple copies of a viral T-cell epitope into adenylate cyclase of Bordetella pertussis","volume":"68","author":"Dadaglio","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.antiviral.2012.09.008_b0030","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.4049\/jimmunol.135.3.2183","article-title":"Influence of antibody isotype on passive serotherapy of lymphoma","volume":"135","author":"Denkers","year":"1985","journal-title":"J. Immunol."},{"key":"10.1016\/j.antiviral.2012.09.008_b0035","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1006\/viro.2000.0631","article-title":"Two influenza A virus-specific Fabs neutralize by inhibiting virus attachment to target cells, while neutralization by their IgGs is complex and occurs simultaneously through fusion inhibition and attachment inhibition","volume":"278","author":"Edwards","year":"2000","journal-title":"Virology"},{"key":"10.1016\/j.antiviral.2012.09.008_b0040","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1099\/0022-1317-82-6-1387","article-title":"A haemagglutinin (HA1)-specific FAb neutralizes influenza A virus by inhibiting fusion activity","volume":"82","author":"Edwards","year":"2001","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.antiviral.2012.09.008_b0045","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1126\/science.1171491","article-title":"Antibody recognition of highly conserved influenza virus epitope","volume":"324","author":"Ekiert","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.antiviral.2012.09.008_b0050","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1126\/science.1204839","article-title":"A highly conserved neutralizing epitope on group 2 influenza A viruses","volume":"333","author":"Ekiert","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.antiviral.2012.09.008_b0055","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.4049\/jimmunol.156.12.4697","article-title":"In vivo induction of CTL responses by recombinant adenylate cyclase of Bordetella pertussis carrying viral CD8 T cell epitopes","volume":"156","author":"Fayolle","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.antiviral.2012.09.008_b0060","doi-asserted-by":"crossref","first-page":"4157","DOI":"10.4049\/jimmunol.162.7.4157","article-title":"Therapy of murine tumors with recombinant Bordetella pertussis adenylate cyclase carrying a cytotoxic T cell epitope","volume":"162","author":"Fayolle","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.antiviral.2012.09.008_b0065","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1006\/prep.1999.1162","article-title":"Purification of His-tagged proteins by immobilized chelate affinity chromatography: the benefits from the use of organic solvent","volume":"18","author":"Franken","year":"2000","journal-title":"Protein Expr. Purif."},{"key":"10.1016\/j.antiviral.2012.09.008_b0070","doi-asserted-by":"crossref","first-page":"569","DOI":"10.3201\/eid1204.051020","article-title":"Prospects for universal influenza virus vaccine","volume":"12","author":"Gerhard","year":"2006","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.antiviral.2012.09.008_b0320","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1099\/vir.0.82563-0","article-title":"Antibodies specific to the HA2 glycopolypeptide of influenza A virus haemagglutinin with fusion\u2013inhibition activity contribute to the protection of mice against lethal infection","volume":"88","author":"Gocn\u00edk","year":"2007","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.antiviral.2012.09.008_b0075","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1099\/vir.0.83524-0","article-title":"Antibodies induced by the HA2 glycopolypeptide of influenza virus haemagglutinin improve recovery from influenza A virus infection","volume":"89","author":"Gocn\u00edk","year":"2008","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.antiviral.2012.09.008_b0080","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.4049\/jimmunol.162.4.1910","article-title":"Direct delivery of the Bordetella pertussis adenylate cyclase toxin to the MHC class I antigen presentation pathway","volume":"162","author":"Guermonprez","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.antiviral.2012.09.008_b0085","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1084\/jem.193.9.1035","article-title":"The adenylate cyclase toxin of Bordetella pertussis binds to target cells via the alpha(M)beta(2) integrin (CD11b\/CD18)","volume":"193","author":"Guermonprez","year":"2001","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.antiviral.2012.09.008_b0090","doi-asserted-by":"crossref","first-page":"3071","DOI":"10.1002\/1521-4141(200211)32:11<3071::AID-IMMU3071>3.0.CO;2-A","article-title":"In vivo receptor-mediated delivery of a recombinant invasive bacterial toxoid to CD11c + CD8 alpha-CD11bhigh dendritic cells","volume":"32","author":"Guermonprez","year":"2002","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.antiviral.2012.09.008_b0095","doi-asserted-by":"crossref","first-page":"8967","DOI":"10.1073\/pnas.96.16.8967","article-title":"N- and C-terminal residues combine in the fusion-pH influenza hemagglutinin HA2 subunit to form an N cap that terminates the triple-strained coiled coil","volume":"96","author":"Chen","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.antiviral.2012.09.008_b0110","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1128\/IAI.05711-11","article-title":"Delivery of large heterologous polypeptides across the cytoplasmic membrane of antigen presenting cells by Bordetella RTX, hemolysin\u2019 moiety lacking the adenylyl cyclase domain","volume":"80","author":"Holubova","year":"2012","journal-title":"Infect. Immun."},{"key":"10.1016\/j.antiviral.2012.09.008_b0115","doi-asserted-by":"crossref","first-page":"7381","DOI":"10.4049\/jimmunol.166.12.7381","article-title":"Fc receptor-mediated phagocytosis makes a significant contribution to clearance of influenza virus infections","volume":"166","author":"Huber","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.antiviral.2012.09.008_b0340","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/bmt.2011.68","article-title":"In vitro activation of CMV-specific human CD8+T cells by CyaA toxoids delivering pp 65 epitopes","volume":"47","author":"Jelinek","year":"2012","journal-title":"Bone Marrow Transpl."},{"key":"10.1016\/j.antiviral.2012.09.008_b0120","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1006\/viro.1994.1073","article-title":"Conserved determinants for CD4+ T cells within the light chain of the H3 hemagglutinin molecule ofinfluenzavirus","volume":"198","author":"Jackson","year":"1994","journal-title":"Virology"},{"key":"10.1016\/j.antiviral.2012.09.008_b0345","doi-asserted-by":"crossref","first-page":"169","DOI":"10.4149\/av_2012_03_169","article-title":"Two distinct regions of HA2 glycopolypeptide of influenza virus hemagglutinin elicit cross-protective immunity against influenza","volume":"56","author":"Janul\u00edkov\u00e1","year":"2012","journal-title":"Acta Virol."},{"key":"10.1016\/j.antiviral.2012.09.008_b0125","doi-asserted-by":"crossref","first-page":"12532","DOI":"10.1073\/pnas.95.21.12532","article-title":"Charge-dependent translocation of Bordetella pertussis adenylate cyclase toxin into eukaryotic cells: implication for the in vivo delivery of CD8+ T cell epitopes into eukaryotic cells","volume":"95","author":"Karimova","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.antiviral.2012.09.008_b0130","doi-asserted-by":"crossref","first-page":"6020","DOI":"10.1073\/pnas.89.13.6020","article-title":"Detection of rare antigen-presenting cells by the lacZ T cell activation assay suggests an expression cloning strategy for T cell antigens","volume":"89","author":"Karttunen","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.antiviral.2012.09.008_b0325","doi-asserted-by":"crossref","first-page":"5986","DOI":"10.1073\/pnas.0801367105","article-title":"Combinatorial antibody libraries from survivors of the Turkish H5N1 avian influenza outbreak reveal virus neutralization strategies","volume":"105","author":"Kashyap","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.antiviral.2012.09.008_b0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1084\/jem.161.1.1","article-title":"Importance of immunoglobulin isotype in human antibody-dependent, cell-mediated cytotoxicity directed by murine monoclonal antibodies","volume":"161","author":"Kipps","year":"1985","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.antiviral.2012.09.008_b0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1743-422X-5-130","article-title":"Neutralizing human monoclonal antibody against H5N1 influenza HA selected from A Fab-phage display library","volume":"5","author":"Lim","year":"2008","journal-title":"Virol. J."},{"key":"10.1016\/j.antiviral.2012.09.008_b0150","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1128\/IAI.70.2.1002-1005.2002","article-title":"Delivery of a MalE CD4(+) T-cell epitope into the major histocompatibility complex class II antigen presentation pathway by Bordetella pertussis adenylate cyclase","volume":"70","author":"Loucka","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.antiviral.2012.09.008_b0155","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0022-1759(98)00204-X","article-title":"An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow","volume":"223","author":"Lutz","year":"1999","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.antiviral.2012.09.008_b0160","doi-asserted-by":"crossref","first-page":"9872","DOI":"10.1128\/JVI.79.15.9872-9884.2005","article-title":"Induction of neutralizing antibodies and Th1-polarized and CD4-independent CD8+ T-cell responses following delivery of human immunodeficiency virus type 1 Tat protein by recombinant adenylate cyclase of Bordetella pertussis","volume":"79","author":"Mascarell","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.antiviral.2012.09.008_b0165","doi-asserted-by":"crossref","first-page":"148","DOI":"10.4161\/hv.4.2.5169","article-title":"A call to cellular & humoral arms: enlisting cognate T cell help to develop broad-spectrum vaccines against influenza A","volume":"4","author":"McMurry","year":"2008","journal-title":"Hum. Vaccin."},{"key":"10.1016\/j.antiviral.2012.09.008_b0170","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1038\/nm1210-1389","article-title":"Induction of unnatural immunity: prospects for a broadly protective universal vaccine","volume":"16","author":"Nabel","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.antiviral.2012.09.008_b0175","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1128\/jvi.67.5.2552-2558.1993","article-title":"A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains","volume":"67","author":"Okuno","year":"1993","journal-title":"J. Virol."},{"key":"10.1016\/j.antiviral.2012.09.008_b0180","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1128\/IAI.68.1.247-256.2000","article-title":"Delivery of CD8(+) T-cell epitopes into major histocompatibility complex class I antigen presentation pathway by Bordetella pertussis adenylate cyclase: delineation of cell invasive structures and permissive insertion sites","volume":"68","author":"Osicka","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.antiviral.2012.09.008_b0185","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1128\/JVI.02165-08","article-title":"Monoclonal antibodies against the fusion peptide of hemagglutinin protect mice from lethal influenza A virus H5N1 infection","volume":"83","author":"Prabhu","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.antiviral.2012.09.008_b0190","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1158\/0008-5472.641.65.2","article-title":"Eradication of established tumors by vaccination with recombinant Bordetella pertussis adenylate cyclase carrying the human papillomavirus 16 E7 oncoprotein","volume":"65","author":"Pr\u00e9ville","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.antiviral.2012.09.008_b0330","first-page":"299","article-title":"Steric effects in the reaction of influenza virus neuraminidase with antibodies","volume":"18","author":"Russ.","year":"1974","journal-title":"Acta Virol."},{"key":"10.1016\/j.antiviral.2012.09.008_b0200","doi-asserted-by":"crossref","unstructured":"Saikh, K.U., Martin, J.D., Nishikawa, A.H., Dillon, S.B., 1995. Influenza A virus-specific H-2d restricted cross-reactive cytotoxic T lymphoocyte epitope(s) detected in the hemagglutinin HA2 subunit of A\/Udorn\/72. 214, 445\u2013452.","DOI":"10.1006\/viro.1995.0055"},{"key":"10.1016\/j.antiviral.2012.09.008_b0205","doi-asserted-by":"crossref","first-page":"13598","DOI":"10.1016\/S0021-9258(18)42254-5","article-title":"Bordetella pertussis adenylate cyclase toxin. Structural and functional independence of the catalytic and hemolytic activities","volume":"267","author":"Sakamoto","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.antiviral.2012.09.008_b0210","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1073\/pnas.94.7.3314","article-title":"Anti-viral protection conferred by recombinant adenylate cyclase toxins from Bordetella pertussis carrying a CD8+ T cell epitope from lymphocytic choriomeningitis virus","volume":"94","author":"Saron","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.antiviral.2012.09.008_b0350","doi-asserted-by":"crossref","first-page":"3309","DOI":"10.1128\/iai.63.10.3851-3857.1995","article-title":"Cell-invasive activity of the epitope-tagged adenylate cyclase of Bordetella pertussis allows in vitro presentation of foreign epitope to CD8+ cytotoxic T-cells","volume":"63","author":"Sebo","year":"1995","journal-title":"Infect. Immun."},{"key":"10.1016\/j.antiviral.2012.09.008_b0220","doi-asserted-by":"crossref","first-page":"6089","DOI":"10.4049\/jimmunol.173.10.6089","article-title":"Antigen targeting to CD11b allows efficient presentation of CD4+ and CD8+ T cell epitopes and in vivo Th1-polarized T cell priming","volume":"173","author":"Schlecht","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.antiviral.2012.09.008_b0225","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1078\/1438-4221-00291","article-title":"The adenylate cyclase toxin from Bordetella pertussis \u2013 a novel promising vehicle for antigen delivery to dendritic cells","volume":"293","author":"Simsova","year":"2004","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1016\/j.antiviral.2012.09.008_b0230","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1146\/annurev.biochem.69.1.531","article-title":"Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin","volume":"69","author":"Skehel","year":"2000","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.antiviral.2012.09.008_b0235","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1186\/1743-422X-7-351","article-title":"Conserved epitopes of influenza A virus inducing protective immunity and their prospects for universal vaccine development","volume":"7","author":"Stanekov\u00e1","year":"2010","journal-title":"Virol. J."},{"key":"10.1016\/j.antiviral.2012.09.008_b0240","doi-asserted-by":"crossref","first-page":"e00010","DOI":"10.1128\/mBio.00018-10","article-title":"An influenza virus vaccine based on the conserved hemagglutinin stalk domain","volume":"1","author":"Steel","year":"2010","journal-title":"mBio"},{"key":"10.1016\/j.antiviral.2012.09.008_b0245","doi-asserted-by":"crossref","first-page":"7","DOI":"10.4149\/av_2010_01_7","article-title":"Trends in development of the influenza vaccine with broader cross-protection","volume":"54","author":"Stropkovsk\u00e1","year":"2010","journal-title":"Acta Virol."},{"key":"10.1016\/j.antiviral.2012.09.008_b0250","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4149\/av_2009_01_15","article-title":"Broadly cross-reactive monoclonal antibodies against HA2 glycopeptide of Influenza A virus hemagglutinin of H3 subtype reduce replication of influenza A viruses of human and avian origin","volume":"53","author":"Stropkovsk\u00e1","year":"2009","journal-title":"Acta Virol."},{"key":"10.1016\/j.antiviral.2012.09.008_b0255","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/nsmb.1566","article-title":"Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses","volume":"16","author":"Sui","year":"2009","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.antiviral.2012.09.008_b0260","doi-asserted-by":"crossref","first-page":"e3942","DOI":"10.1371\/journal.pone.0003942","article-title":"Heterosubtypic neutralizing monoclonal antibodies cross-protective against H5N1 and H1N1 recovered from human IgM+ memory B cells","volume":"3","author":"Throsby","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1016\/j.antiviral.2012.09.008_b0265","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1128\/jcm.35.5.1196-1198.1997","article-title":"Evaluation of monoclonal antibodies for subtyping of currently circulating human type A influenza viruses","volume":"35","author":"Tk\u00e1\u010dov\u00e1","year":"1997","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.antiviral.2012.09.008_b0335","doi-asserted-by":"crossref","first-page":"4269","DOI":"10.1073\/pnas.1116200109","article-title":"A distinct lineage of influenza A virus from bats","volume":"109","author":"Tong","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.antiviral.2012.09.008_b0275","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0022-1759(94)00307-I","article-title":"Preparation of monoclonal antibodies for the diagnosis of influenza A infection using different immunization protocols","volume":"180","author":"Vare\u010dkov\u00e1","year":"1995","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.antiviral.2012.09.008_b0280","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s00705-002-0932-1","article-title":"Inhibition of fusion activity of influenza A haemagglutinin mediated by HA2-specific monoclonal antibodies","volume":"148","author":"Vare\u010dkov\u00e1","year":"2003","journal-title":"Arch. Virol."},{"key":"10.1016\/j.antiviral.2012.09.008_b0285","first-page":"229","article-title":"A monoclonal antibody specific to the HA2 glycoprotein of influenza A virus hemagglutinin that inhibits its fusion activity reduces replication of the virus","volume":"49","author":"Vare\u010dkov\u00e1","year":"2003","journal-title":"Acta Virol."},{"key":"10.1016\/j.antiviral.2012.09.008_b0290","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.virusres.2007.10.004","article-title":"HA2-specific monoclonal antibodies as tools for differential recognition of influenza A virus antigenic subtypes","volume":"132","author":"Vare\u010dkov\u00e1","year":"2008","journal-title":"Virus Res."},{"key":"10.1016\/j.antiviral.2012.09.008_b0295","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nsmb.1574","article-title":"Universal epitopes of influenza hemagglutinin","volume":"16","author":"Wang","year":"2009","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.antiviral.2012.09.008_b0300","doi-asserted-by":"crossref","first-page":"e1000796","DOI":"10.1371\/journal.ppat.1000796","article-title":"Broadly protective monoclonal antibodies against H3 influenza viruses following sequential immunization with different hemagglutinins","volume":"6","author":"Wang","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.antiviral.2012.09.008_b0305","doi-asserted-by":"crossref","first-page":"18979","DOI":"10.1073\/pnas.1013387107","article-title":"Vaccination with a synthetic peptide from the influenza virus hemagglutinin provides protection against distinct viral subtypes","volume":"44","author":"Wang","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"6","key":"10.1016\/j.antiviral.2012.09.008_b0310","doi-asserted-by":"crossref","first-page":"e1002081","DOI":"10.1371\/journal.ppat.1002081","article-title":"Cross-neutralizing antibodies to pandemic 2009 H1N1 and recent seasonal H1N1 influenza A strains influenced by a mutation in hemagglutinin subunit 2","volume":"7","author":"Wang","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.antiviral.2012.09.008_b0315","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1126\/science.1192517","article-title":"Induction of broadly neutralizing H1N1 influenza antibodies by vaccination","volume":"329","author":"Wei","year":"2010","journal-title":"Science"}],"container-title":["Antiviral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166354212002057?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166354212002057?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T10:32:28Z","timestamp":1762252348000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166354212002057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":64,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S0166354212002057"],"URL":"https:\/\/doi.org\/10.1016\/j.antiviral.2012.09.008","relation":{},"ISSN":["0166-3542"],"issn-type":[{"value":"0166-3542","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Heterosubtypic protection against influenza A induced by adenylate cyclase toxoids delivering conserved HA2 subunit of hemagglutinin","name":"articletitle","label":"Article Title"},{"value":"Antiviral Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.antiviral.2012.09.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}