{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:41:48Z","timestamp":1787794908430,"version":"build-2784847793"},"reference-count":43,"publisher":"Elsevier BV","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Research"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.antiviral.2013.09.025","type":"journal-article","created":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T05:30:16Z","timestamp":1383283816000},"page":"S3-S8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":74,"special_numbering":"S","title":["Development of dapivirine vaginal ring for HIV prevention"],"prefix":"10.1016","volume":"100","author":[{"given":"Br\u00edd","family":"Devlin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Nuttall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Wilder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Woodsong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeda","family":"Rosenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.antiviral.2013.09.025_b0005","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1007\/s10461-012-0402-z","article-title":"An evaluation of methods to improve the reporting of adherence in a placebo gel trial in Andhra Pradesh India","volume":"17","author":"Abbott","year":"2013","journal-title":"AIDS Behav."},{"key":"10.1016\/j.antiviral.2013.09.025_b0010","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s13346-011-0022-6","article-title":"Development and characterization of a vaginal film containing dapivirine, a non-nucleoside reverse transcriptase inhibitor (NNRTI), for prevention of HIV-1 sexual transmission","volume":"1","author":"Ayman Akil","year":"2011","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.antiviral.2013.09.025_b0015","series-title":"Safety of Silicone Breast Implants: Committee on the Safety of Silicone Breast Implants, Division of Helath Promotion and Disease Prevention","author":"Bondurant","year":"1999"},{"issue":"1","key":"10.1016\/j.antiviral.2013.09.025_b0020","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1586\/eri.12.155","article-title":"In search of the optimal delivery method for anti-HIV microbicides: are intravaginal rings the way forward?","volume":"11","author":"Derby","year":"2013","journal-title":"Expert Rev. Anti Infect. Ther."},{"key":"10.1016\/j.antiviral.2013.09.025_b0025","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1097\/00002030-200307250-00003","article-title":"Inhibition of vaginal transmission of HIV-1 in hu-SCID mice by the non-nucleoside reverse transcriptase inhibitor TMC120 in a gel formulation","volume":"17","author":"Di Fabio","year":"2003","journal-title":"AIDS"},{"issue":"3","key":"10.1016\/j.antiviral.2013.09.025_b0030","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.ejps.2012.12.002","article-title":"A silicone elastomer vaginal ring for HIV prevention containing two microbicides with different mechanisms of action","volume":"48","author":"Fetherston","year":"2012","journal-title":"Eur. J. Pharm. Sci."},{"issue":"2","key":"10.1016\/j.antiviral.2013.09.025_b0205","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1128\/AAC.01156-08","article-title":"Inhibition of human immunodeficiency virus type 1 infection by the candidate microbicide dapivirine, a nonnucleoside reverse transcriptase inhibitor","volume":"53","author":"Fletcher","year":"2009","journal-title":"Antimicrobial agents and chemotherapy"},{"issue":"3","key":"10.1016\/j.antiviral.2013.09.025_b0035","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.antiviral.2013.06.021","article-title":"Assessment of topical microbicides to prevention HIV-1 transmission: concepts, testing, lessons learned","volume":"99","author":"Friend","year":"2013","journal-title":"Antiviral Res."},{"issue":"5888","key":"10.1016\/j.antiviral.2013.09.025_b0210","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1126\/science.1160355","article-title":"Whither or wither microbicides?","volume":"321","author":"Grant","year":"2008","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.antiviral.2013.09.025_b0040","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/COH.0b013e32835b809d","article-title":"The promise of pre-exposure prophylaxis with antiretroviral drugs to prevent HIV transmission: a review","volume":"8","author":"Hankins","year":"2013","journal-title":"Curr. Opin. HIV AIDS"},{"issue":"4","key":"10.1016\/j.antiviral.2013.09.025_b0045","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0010-7824(98)00104-8","article-title":"Women\u2019s preferences for vaginal antimicrobial contraceptives III: preferences for formulation, applicator, and packaging","volume":"58","author":"Hardy","year":"1998","journal-title":"Contraception"},{"issue":"10","key":"10.1016\/j.antiviral.2013.09.025_b0050","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1086\/374834","article-title":"Topical microbicides for disease prevention: status and challenges","volume":"36","author":"Harrison","year":"2003","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.antiviral.2013.09.025_b0055","article-title":"Determination of vaginal tissue penetration of dapivirine and tenofovir: an in vivo study in sheep","author":"Holt","year":"2012","journal-title":"Microbicides"},{"issue":"1","key":"10.1016\/j.antiviral.2013.09.025_b0215","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/QCO.0b013e328334fe70","article-title":"Microbicides for HIV prevention: reality or hope?","volume":"23","author":"McGowan","year":"2010","journal-title":"Current opinion in infectious diseases"},{"key":"10.1016\/j.antiviral.2013.09.025_b0060","unstructured":"Microbicides Trial Network (MTN), 2013. Daily HIV Prevention Approaches Didn\u2019t Work for African Women in the VOICE Study. Available from http:\/\/www.mtnstopshiv.org\/node\/4877."},{"issue":"7","key":"10.1016\/j.antiviral.2013.09.025_b0065","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1007\/s10461-012-0248-4","article-title":"Vaginal ring adherence in sub-saharan Africa: expulsion, removal, and perfect use","volume":"6","author":"Montgomery","year":"2012","journal-title":"AIDS Behav."},{"key":"10.1016\/j.antiviral.2013.09.025_b0070","unstructured":"Nel, A., Kamupira, M., Woodsong, C., van der Straten, A., Montgomery, E., Nuttall, J., 2012. Safety, Acceptability and Pharmacokinetic Assessment (Adherence) of Monthly Dapivirine Vaginal Microbicide Rings (Ring-004) for HIV Prevention. Paper presented at the 19th Conference on Retroviruses and Opportunistic Infections, Seattle, Washington, U.S."},{"issue":"8","key":"10.1016\/j.antiviral.2013.09.025_b0075","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1089\/jwh.2010.2476","article-title":"Acceptability of vaginal film, soft-gel capsule, and tablet as potential microbicide delivery methods among African women","volume":"20","author":"Nel","year":"2011","journal-title":"J. Womens Health."},{"issue":"11","key":"10.1016\/j.antiviral.2013.09.025_b0080","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1089\/aid.2009.0227","article-title":"Pharmacokinetic assessment of dapivirine vaginal microbicide gel in healthy, HIV-negative women","volume":"26","author":"Nel","year":"2010","journal-title":"AIDS Res. Hum. Retroviruses."},{"issue":"11","key":"10.1016\/j.antiviral.2013.09.025_b0085","first-page":"1181","article-title":"Pharmacokinetics of 2 dapivirine vaginal microbicide gels and their safety vs. Hydroxyethyl cellulose-based universal placebo gel","volume":"26","author":"Nel","year":"2010","journal-title":"J. Acquir. Immune Defic. Syndr."},{"issue":"12","key":"10.1016\/j.antiviral.2013.09.025_b0090","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1097\/QAD.0b013e32832c413d","article-title":"Safety, tolerability, and systemic absorption of dapivirine vaginal microbicide gel in healthy, HIV-negative women","volume":"23","author":"Nel","year":"2009","journal-title":"AIDS"},{"issue":"4","key":"10.1016\/j.antiviral.2013.09.025_b0095","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1097\/QAI.0b013e3181acb536","article-title":"Safety and pharmacokinetics of dapivirine delivery from matrix and reservoir intravaginal rings to HIV-negative women","volume":"51","author":"Nel","year":"2009","journal-title":"J. Acquir. Immune Defic. Syndr."},{"issue":"1","key":"10.1016\/j.antiviral.2013.09.025_b0100","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1471-2334-3-27","article-title":"Water dispersible microbicidal cellulose acetate phthalate film","volume":"3","author":"Neurath","year":"2003","journal-title":"BMC Infect. Dis."},{"issue":"3","key":"10.1016\/j.antiviral.2013.09.025_b0105","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0010-7824(02)00514-0","article-title":"The combined contraceptive vaginal ring, NuvaRing: an international study of user acceptability","volume":"67","author":"Novak","year":"2003","journal-title":"Contraception"},{"key":"10.1016\/j.antiviral.2013.09.025_b0110","doi-asserted-by":"crossref","first-page":"725","DOI":"10.2217\/14750708.4.6.725","article-title":"Challenges of producing a drug primarily for use in developing countries: microbicides for HIV prevention","author":"Nuttall","year":"2007","journal-title":"Therapy"},{"key":"10.1016\/j.antiviral.2013.09.025_b0115","unstructured":"Nuttall, J., Hettema, W., Van Niekerk, N., Nel, A., 2012. Pharmacokinetics of Monthly Dapivirine Vaginal Microbicide Rings (Ring-004) for HIV Prevention. 2012. Microbicides 2012, Sydney, Australia, April 15\u201318."},{"issue":"1","key":"10.1016\/j.antiviral.2013.09.025_b0120","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.idc.2007.01.009","article-title":"The future of HIV prevention: prospects for an effective anti-HIV microbicide","volume":"21","author":"Nuttall","year":"2007","journal-title":"Infect. Dis. Clin. North Am."},{"issue":"6","key":"10.1016\/j.antiviral.2013.09.025_b0125","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.contraception.2004.12.023","article-title":"Acceptability of five nonoxynol-9 spermicides","volume":"71","author":"Raymond","year":"2005","journal-title":"Contraception"},{"key":"10.1016\/j.antiviral.2013.09.025_b0130","doi-asserted-by":"crossref","first-page":"9","DOI":"10.2174\/157016212799304625","article-title":"Non-specific microbicide product development: then and now","volume":"10","author":"Romano","year":"2013","journal-title":"Cur.HIV Res."},{"issue":"5","key":"10.1016\/j.antiviral.2013.09.025_b0135","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1089\/aid.2008.0184","article-title":"Safety and availability of dapivirine (TMC120) delivered from an intravaginal ring","volume":"25","author":"Romano","year":"2009","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1016\/j.antiviral.2013.09.025_b0140","doi-asserted-by":"crossref","unstructured":"Rosenberg, Z.F., Devlin, B., 2012. Future strategies in microbicide development. Best Prac and Res Clin Obs and Gyn. doi: http:\/\/dx.doi.org\/10.1016\/j.bpobgyn.2012.02.001.","DOI":"10.1016\/j.bpobgyn.2012.02.001"},{"issue":"6","key":"10.1016\/j.antiviral.2013.09.025_b0145","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1097\/01.COH.0000247386.62743.b4","article-title":"Microbicides for the prevention of HIV infection in women: an overview of recent trials","volume":"1","author":"Rosenberg","year":"2006","journal-title":"Curr. Opin. HIV AIDS"},{"issue":"8","key":"10.1016\/j.antiviral.2013.09.025_b0150","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1097\/QAD.0b013e32832af57c","article-title":"Sustained release of microbicides by newly engineered vaginal rings","volume":"23","author":"Saxena","year":"2009","journal-title":"AIDS"},{"key":"10.1016\/j.antiviral.2013.09.025_b0155","doi-asserted-by":"crossref","unstructured":"Smith, J.M., Rastogi, R., Teller, R.S., Srinivasan, P., Mesquita, P.M.M., Nagaraja, U., McNicholl, J.M., Hendry, R.M., Dinh, C.T., Martin, A., Herold, B.C., Kiser, P.F. 2013 Intravaginal ring eluting tenofovir disoproxil fumarate completely protects macaques from mulitple vaginal simian-HIV challenges. PNAS Early Edition \u2013 published ahead of print September 16, 2013, doi: http:\/\/dx.doi.org\/10.1073\/pnas.1311355110.","DOI":"10.1073\/pnas.1311355110"},{"issue":"3","key":"10.1016\/j.antiviral.2013.09.025_b0160","doi-asserted-by":"crossref","first-page":"104","DOI":"10.2307\/2133183","article-title":"Acceptability of spermicidal film and foaming tablets among women in three countries","volume":"21","author":"Steiner","year":"1995","journal-title":"Internat. Fam. Plan. Persp."},{"key":"10.1016\/j.antiviral.2013.09.025_b0165","unstructured":"UNAIDS, 2011. AIDS at 30: Nations at the crossroads. http:\/\/www.unaids.org\/unaids_resources\/aidsat30\/aids-at-30.pdf."},{"key":"10.1016\/j.antiviral.2013.09.025_b0170","unstructured":"UNAIDS, 2012. UNAIDS Report on the Global AIDS Epidemic. http:\/\/www.unaids.org\/en\/media\/unaids\/contentassets\/documents\/epidemiology\/2012\/gr2012\/20121120_UNAIDS_Global_Report_2012_with_annexes_en.pdf."},{"issue":"5","key":"10.1016\/j.antiviral.2013.09.025_b0175","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1056\/NEJMoa1202614","article-title":"Preexposure prophylaxis for HIV infection among African women","volume":"367","author":"Van Damme","year":"2012","journal-title":"N. Engl. J. Med."},{"issue":"7","key":"10.1016\/j.antiviral.2013.09.025_b0180","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1007\/s10461-012-0215-0","article-title":"High acceptability of a vaginal ring intended as a microbicide delivery method for HIV prevention in African women","volume":"6","author":"van der Straten","year":"2012","journal-title":"AIDS Behav."},{"issue":"1","key":"10.1016\/j.antiviral.2013.09.025_b0185","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s11904-012-0141-9","article-title":"Methodological lessons from clinical trials and the future of microbicide research","volume":"10","author":"van der Straten","year":"2013","journal-title":"Curr. HIV\/AIDS Rev."},{"key":"10.1016\/j.antiviral.2013.09.025_b0190","unstructured":"Warner Chilcott, 2010. Femring\u00ae Full U.S. Prescribing Information (Vol. 2011). http:\/\/www.wcrx.com\/pdfs\/pi\/pi_femring.pdf."},{"issue":"1","key":"10.1016\/j.antiviral.2013.09.025_b0195","doi-asserted-by":"crossref","first-page":"18505","DOI":"10.7448\/IAS.16.1.18505","article-title":"Microbicide clinical trial adherence: insights for introduction","volume":"16","author":"Woodsong","year":"2013","journal-title":"J. Internat. AIDS Soc."},{"issue":"1\u20132","key":"10.1016\/j.antiviral.2013.09.025_b0200","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ijpharm.2006.06.026","article-title":"Intravaginal ring delivery of the reverse transcriptase inhibitor TMC 120 as an HIV microbicide","volume":"325","author":"Woolfson","year":"2006","journal-title":"Int. J. Pharm."}],"container-title":["Antiviral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166354213002854?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166354213002854?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T23:53:08Z","timestamp":1539215588000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166354213002854"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":43,"alternative-id":["S0166354213002854"],"URL":"https:\/\/doi.org\/10.1016\/j.antiviral.2013.09.025","relation":{},"ISSN":["0166-3542"],"issn-type":[{"value":"0166-3542","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of dapivirine vaginal ring for HIV prevention","name":"articletitle","label":"Article Title"},{"value":"Antiviral Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.antiviral.2013.09.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}