{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:33:38Z","timestamp":1759937618841},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100005612","name":"Shionogi","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005612","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Research"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1016\/j.antiviral.2015.02.012","type":"journal-article","created":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T14:03:49Z","timestamp":1425650629000},"page":"52-59","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Intravenous peramivir inhibits viral replication, and leads to bacterial clearance and prevention of mortality during murine bacterial co-infection caused by influenza A(H1N1)pdm09 virus and Streptococcus pneumoniae"],"prefix":"10.1016","volume":"117","author":[{"given":"Motoyasu","family":"Onishi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsutaka","family":"Kitano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Homma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomokazu","family":"Yoshinaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Naito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.antiviral.2015.02.012_b0005","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1056\/NEJMp0910479","article-title":"The emergency use authorization of peramivir for treatment of 2009 H1N1 influenza","volume":"361","author":"Birnkrant","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.antiviral.2015.02.012_b0010","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1001\/jama.2012.194139","article-title":"Bacterial coinfection in influenza: a grand rounds review","volume":"309","author":"Chertow","year":"2013","journal-title":"JAMA"},{"issue":"Suppl. 1","key":"10.1016\/j.antiviral.2015.02.012_b0015","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1093\/cid\/ciq011","article-title":"2009 Pandemic influenza A (H1N1) deaths among children\u2013United States, 2009\u20132010","volume":"52","author":"Cox","year":"2011","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.antiviral.2015.02.012_b0020","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/377435a0","article-title":"Streptococcus pneumoniae anchor to activated human cells by the receptor for platelet-activating factor","volume":"377","author":"Cundell","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.antiviral.2015.02.012_b0025","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1093\/cid\/cir400","article-title":"Oseltamivir and risk of lower respiratory tract complications in patients with flu symptoms: a meta-analysis of eleven randomized clinical trials","volume":"53","author":"Hernan","year":"2011","journal-title":"Clin. Infect. Dis."},{"issue":"Suppl. 2","key":"10.1016\/j.antiviral.2015.02.012_b0030","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/irv.12089","article-title":"Bacterial and viral infections associated with influenza","volume":"7","author":"Joseph","year":"2013","journal-title":"Influenza Other Respir. Viruses"},{"key":"10.1016\/j.antiviral.2015.02.012_b0035","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1128\/AAC.02324-12","article-title":"Efficacy of repeated intravenous injection of peramivir against influenza A (H1N1) 2009 virus infection in immunosuppressed mice","volume":"57","author":"Kitano","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.antiviral.2015.02.012_b0040","doi-asserted-by":"crossref","first-page":"4568","DOI":"10.1128\/AAC.00474-10","article-title":"Efficacy and safety of intravenous peramivir for treatment of seasonal influenza virus infection","volume":"54","author":"Kohno","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.antiviral.2015.02.012_b0045","doi-asserted-by":"crossref","first-page":"5267","DOI":"10.1128\/AAC.00360-11","article-title":"Phase III randomized, double-blind study comparing single-dose intravenous peramivir with oral oseltamivir in patients with seasonal influenza virus infection","volume":"55","author":"Kohno","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.antiviral.2015.02.012_b0050","doi-asserted-by":"crossref","first-page":"4014","DOI":"10.1128\/IAI.01237-05","article-title":"Pneumococcal neuraminidases A and B both have essential roles during infection of the respiratory tract and sepsis","volume":"74","author":"Manco","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.antiviral.2015.02.012_b0055","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1086\/421525","article-title":"Effect of antiviral treatment on the outcome of secondary bacterial pneumonia after influenza","volume":"190","author":"McCullers","year":"2004","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.antiviral.2015.02.012_b0060","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1086\/341462","article-title":"Lethal synergism between influenza virus and Streptococcus pneumoniae: characterization of a mouse model and the role of platelet-activating factor receptor","volume":"186","author":"McCullers","year":"2002","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.antiviral.2015.02.012_b0065","doi-asserted-by":"crossref","first-page":"3722","DOI":"10.1128\/IAI.00228-09","article-title":"The NanA neuraminidase of Streptococcus pneumoniae is involved in biofilm formation","volume":"77","author":"Parker","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.antiviral.2015.02.012_b0070","doi-asserted-by":"crossref","first-page":"6","DOI":"10.7883\/yoken.JJID.2009.6","article-title":"Expression and DNA microarray analysis of a platelet activating factor-related molecule in severe pneumonia in mice due to influenza virus and bacterial co-infection","volume":"62","author":"Seki","year":"2009","journal-title":"Jpn. J. Infect. Dis."},{"key":"10.1016\/j.antiviral.2015.02.012_b0075","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1159\/000345112","article-title":"TLR7 contributes to the rapid progression but not to the overall fatal outcome of secondary pneumococcal disease following influenza A virus infection","volume":"5","author":"Stegemann-Koniszewski","year":"2013","journal-title":"J. Innate Immun."},{"key":"10.1016\/j.antiviral.2015.02.012_b0080","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/nm1765","article-title":"Inhibition of pulmonary antibacterial defense by interferon-gamma during recovery from influenza infection","volume":"14","author":"Sun","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.antiviral.2015.02.012_b0085","doi-asserted-by":"crossref","unstructured":"Tanaka, A., Nakamura, S., Seki, M., Iwanaga, N., Kajihara, T., Kitano, M., Homma, T., Kurihara, S., Imamura, Y., Miyazaki, T., Izumikawa, K., Kakeya, H., Yanagihara, K., Kohno, S., 2014. The effect of intravenous peramivir, compared with oral oseltamivir, on the outcome of post-influenza pneumococcal pneumonia in mice. Antivir. Ther. (in press).","DOI":"10.3851\/IMP2744"},{"key":"10.1016\/j.antiviral.2015.02.012_b0090","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1001\/jama.283.8.1016","article-title":"Efficacy and safety of the oral neuraminidase inhibitor oseltamivir in treating acute influenza: a randomized controlled trial. US Oral Neuraminidase Study Group","volume":"283","author":"Treanor","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.antiviral.2015.02.012_b0095","doi-asserted-by":"crossref","first-page":"L194","DOI":"10.1152\/ajplung.00050.2005","article-title":"Involvement of the platelet-activating factor receptor in host defense against Streptococcus pneumoniae during postinfluenza pneumonia","volume":"290","author":"van der Sluijs","year":"2006","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"issue":"Suppl. 1","key":"10.1016\/j.antiviral.2015.02.012_b0100","doi-asserted-by":"crossref","first-page":"i5","DOI":"10.1093\/jac\/dki018","article-title":"Oseltamivir (Tamiflu) and its potential for use in the event of an influenza pandemic","volume":"55","author":"Ward","year":"2005","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.antiviral.2015.02.012_b0105","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1097\/00006454-200102000-00002","article-title":"Oral oseltamivir treatment of influenza in children","volume":"20","author":"Whitley","year":"2001","journal-title":"Pediatr. Infect. Dis. J."}],"container-title":["Antiviral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166354215000510?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166354215000510?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T16:17:49Z","timestamp":1691511469000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166354215000510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":21,"alternative-id":["S0166354215000510"],"URL":"https:\/\/doi.org\/10.1016\/j.antiviral.2015.02.012","relation":{},"ISSN":["0166-3542"],"issn-type":[{"value":"0166-3542","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intravenous peramivir inhibits viral replication, and leads to bacterial clearance and prevention of mortality during murine bacterial co-infection caused by influenza A(H1N1)pdm09 virus and Streptococcus pneumoniae","name":"articletitle","label":"Article Title"},{"value":"Antiviral Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.antiviral.2015.02.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}