{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T09:46:27Z","timestamp":1794476787393,"version":"4.9.1"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Russian Federation"},{"name":"Russian Scientific Foundation","award":["15-13-00017"],"award-info":[{"award-number":["15-13-00017"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Research"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.antiviral.2015.06.004","type":"journal-article","created":{"date-parts":[[2015,6,13]],"date-time":"2015-06-13T06:22:44Z","timestamp":1434176564000},"page":"126-133","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":68,"special_numbering":"C","title":["Broad range of inhibiting action of novel camphor-based compound with anti-hemagglutinin activity against influenza viruses in vitro and in vivo"],"prefix":"10.1016","volume":"120","author":[{"given":"V.V.","family":"Zarubaev","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.V.","family":"Garshinina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.S.","family":"Tretiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.A.","family":"Fedorova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.A.","family":"Shtro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.S.","family":"Sokolova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.I.","family":"Yarovaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.F.","family":"Salakhutdinov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.antiviral.2015.06.004_b0005","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1128\/AAC.49.2.556-559.2005","article-title":"Generation and characterization of recombinant influenza A (H1N1) viruses harboring amantadine resistance mutations","volume":"49","author":"Abed","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"issue":"7281","key":"10.1016\/j.antiviral.2015.06.004_b0015","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/nature08722","article-title":"Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers","volume":"463","author":"Cady","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.antiviral.2015.06.004_b0025","unstructured":"CDC, 2011. Influenza: The Disease. Centers for Disease Control Prevention. Available: http:\/\/www.cdc.gov\/flu\/about\/disease\/index.htm."},{"key":"10.1016\/j.antiviral.2015.06.004_b0030","unstructured":"Duque, M.D., Torres, E., Valverde, E., Barniol, M., Guardiola, S., Rey, M., V\u00e1zquez, S., 2011. Inhibitors of the M2 channel of influenza A virus. In: Recent Advances in Pharmaceutical Sciences, 35\u201364 ISBN: 978-81-7895-528-5 Ed. Diego Mu\u00f1oz-Torrero."},{"key":"10.1016\/j.antiviral.2015.06.004_b0035","doi-asserted-by":"crossref","first-page":"4457","DOI":"10.1128\/AAC.00650-09","article-title":"Large-scale sequence analysis of M gene of influenza A viruses from different species: mechanisms for emergence and spread of amantadine resistance","volume":"53","author":"Furuse","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.antiviral.2015.06.004_b0040","doi-asserted-by":"crossref","first-page":"4474","DOI":"10.1021\/jm00022a012","article-title":"Synthesis of substituted 1-norbornylamines with antiviral activity","volume":"38","author":"Garc\u00eda Mart\u00ednez","year":"1995","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.antiviral.2015.06.004_b0045","first-page":"1717","article-title":"P,N-bidentate phosphites with a chiral ketimine fragment, their application in enantioselective allylic substitution and comparison with phosphine analogues","volume":"11","author":"Gavrilov","year":"2007","journal-title":"Synthesis"},{"key":"10.1016\/j.antiviral.2015.06.004_b0050","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00430-010-0173-y","article-title":"Comparison of pro-inflammatory cytokine expression and cellular signal transduction in human macrophages infected with different influenza A viruses","volume":"200","author":"Geiler","year":"2011","journal-title":"Med. Microbiol. Immunol."},{"key":"10.1016\/j.antiviral.2015.06.004_b0055","unstructured":"Gregory, W.A. (E. I. Du Pont de Nnemours & Co), 1971, US 3558704."},{"issue":"Suppl. 3","key":"10.1016\/j.antiviral.2015.06.004_b0065","first-page":"1","article-title":"Clinical use of approved influenza antivirals: therapy and prophylaxis. Influenza Other Respir","volume":"3","author":"Ison","year":"2013","journal-title":"Influenza Other Respir. Viruses"},{"key":"10.1016\/j.antiviral.2015.06.004_b0070","doi-asserted-by":"crossref","first-page":"4629","DOI":"10.1021\/jm500598u","article-title":"Aminoadamantanes with persistent in vitro efficacy against H1N1 (2009) influenza A","volume":"57","author":"Kolocouris","year":"2014","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.antiviral.2015.06.004_b0075","first-page":"33","article-title":"The change in functional activity and primary structure of the M2 protein in variants of the influenza virus resistant to remantadine and deitiforin: common and individual differences from the original strain","volume":"6","author":"Kozeletskaia","year":"1989","journal-title":"Mol. Gen. Mikrobiol. Virusol."},{"key":"10.1016\/j.antiviral.2015.06.004_b0080","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.antiviral.2012.09.013","article-title":"Targeting the host or the virus: current and novel concepts for antiviral approaches against influenza virus infection","volume":"96","author":"Lee","year":"2012","journal-title":"Antiviral Res."},{"key":"10.1016\/j.antiviral.2015.06.004_b0085","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0014-5793(80)80457-1","article-title":"Activation of influenza virus by acidic media causes hemolysis and fusion of erythrocytes","volume":"122","author":"Maeda","year":"1980","journal-title":"FEBS Lett."},{"issue":"1\u20132","key":"10.1016\/j.antiviral.2015.06.004_b0090","first-page":"55","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1980","journal-title":"J. Immunol. Methods"},{"issue":"1","key":"10.1016\/j.antiviral.2015.06.004_b0095","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1750-2659.2006.00006.x","article-title":"Antivirals for the treatment and prevention of epidemic and pandemic influenza","volume":"1","author":"Oxford","year":"2007","journal-title":"Influenza Other Respir. Viruses"},{"issue":"8","key":"10.1016\/j.antiviral.2015.06.004_b0100","doi-asserted-by":"crossref","first-page":"e1000115","DOI":"10.1371\/journal.ppat.1000115","article-title":"H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice","volume":"4","author":"Perrone","year":"2008","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.antiviral.2015.06.004_b0105","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/0092-8674(92)90452-I","article-title":"Influenza virus M2 protein has ion channel activity","volume":"69","author":"Pinto","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.antiviral.2015.06.004_b0110","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1128\/JVI.73.1.140-151.1999","article-title":"Inhibition of influenza A virus replication by compounds interfering with the fusogenic function of the viral hemagglutinin","volume":"73","author":"Plotch","year":"1999","journal-title":"J. Virol."},{"key":"10.1016\/j.antiviral.2015.06.004_b0115","first-page":"493","article-title":"A simple method of estimating fifty percent endpoints","volume":"27","author":"Reed","year":"1938","journal-title":"Am. J. Hyg."},{"key":"10.1016\/j.antiviral.2015.06.004_b0120","doi-asserted-by":"crossref","first-page":"17736","DOI":"10.1073\/pnas.0807142105","article-title":"Structure of influenza hemagglutinin in complex with an inhibitor of membrane fusion","volume":"105","author":"Russell","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.antiviral.2015.06.004_b0125","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.antiviral.2013.03.014","article-title":"Influenza virus resistance to neuraminidase inhibitors","volume":"98","author":"Samson","year":"2013","journal-title":"Antiviral Res."},{"key":"10.1016\/j.antiviral.2015.06.004_b0130","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0166-3542(97)00061-2","article-title":"How to overcome resistance of influenza A viruses against adamantane derivatives","volume":"37","author":"Scholtissek","year":"1998","journal-title":"Antiviral Res."},{"issue":"Suppl. 2","key":"10.1016\/j.antiviral.2015.06.004_b0135","first-page":"S149","article-title":"Novel hemagglutinin-based influenza virus inhibitors","volume":"5","author":"Shen","year":"2013","journal-title":"J. Thorac. Dis."},{"key":"10.1016\/j.antiviral.2015.06.004_b0140","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1016\/j.bmc.2014.02.038","article-title":"Camphor-based symmetric diimines as inhibitors of influenza virus reproduction","volume":"22","author":"Sokolova","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.antiviral.2015.06.004_b0145","doi-asserted-by":"crossref","first-page":"6690","DOI":"10.1016\/j.bmc.2013.08.014","article-title":"New quaternary ammonium camphor derivatives and their antiviral activity, genotoxic effects and cytotoxicity","volume":"21","author":"Sokolova","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.antiviral.2015.06.004_b0150","first-page":"36","article-title":"Deitiforine, an antiinfluenza chemotherapeutic","volume":"58","author":"Tandura","year":"2013","journal-title":"Antibiot. Khimioter."},{"key":"10.1016\/j.antiviral.2015.06.004_b0155","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1056\/NEJMoa040842","article-title":"Peginterferon Alfa-2a plus ribavirin for chronic hepatitis C virus infection in HIV-infected patients","volume":"351","author":"Torriani","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.antiviral.2015.06.004_b0160","doi-asserted-by":"crossref","first-page":"4277","DOI":"10.1128\/JVI.02325-09","article-title":"Novel inhibitors of influenza virus fusion: structure-activity relationship and interaction with the viral hemagglutinin","volume":"84","author":"Vanderlinden","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.antiviral.2015.06.004_b0165","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1021\/ml100297w","article-title":"Exploring the requirements for the hydrophobic scaffold and polar amine in inhibitors of M2 from influenza A virus","volume":"2","author":"Wang","year":"2011","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.antiviral.2015.06.004_b0170","doi-asserted-by":"crossref","first-page":"12834","DOI":"10.1021\/ja204969m","article-title":"Molecular dynamics simulation directed rational design of inhibitors targeting drug-resistant mutants of influenza A virus M2","volume":"133","author":"Wang","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.antiviral.2015.06.004_b0175","doi-asserted-by":"crossref","first-page":"13844","DOI":"10.1021\/ja2050666","article-title":"Exploring organosilane amines as potent inhibitors and structural probes of influenza A virus M2 proton channel","volume":"133","author":"Wang","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.antiviral.2015.06.004_b0185","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.antiviral.2012.09.001","article-title":"Design and synthesis of pinanamine derivatives as anti-influenza A M2 ion channel inhibitors","volume":"96","author":"Zhao","year":"2012","journal-title":"Antiviral Res."},{"key":"10.1016\/j.antiviral.2015.06.004_b0190","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ejmech.2010.10.010","article-title":"Discovery of highly potent agents against influenza A virus","volume":"46","author":"Zhao","year":"2011","journal-title":"Eur. J. Med. Chem."}],"container-title":["Antiviral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166354215001357?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166354215001357?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T07:19:51Z","timestamp":1599117591000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166354215001357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":34,"alternative-id":["S0166354215001357"],"URL":"https:\/\/doi.org\/10.1016\/j.antiviral.2015.06.004","relation":{},"ISSN":["0166-3542"],"issn-type":[{"value":"0166-3542","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Broad range of inhibiting action of novel camphor-based compound with anti-hemagglutinin activity against influenza viruses in vitro and in vivo","name":"articletitle","label":"Article Title"},{"value":"Antiviral Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.antiviral.2015.06.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}