{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T10:33:47Z","timestamp":1758710027397},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Research"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.antiviral.2016.01.003","type":"journal-article","created":{"date-parts":[[2016,1,19]],"date-time":"2016-01-19T03:12:40Z","timestamp":1453173160000},"page":"57-67","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["MicroRNA-based control of tick-borne flavivirus neuropathogenesis: Challenges and perspectives"],"prefix":"10.1016","volume":"127","author":[{"given":"Natalya L.","family":"Teterina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga A.","family":"Maximova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Kenney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander G.","family":"Pletnev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.antiviral.2016.01.003_bib1","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1863-2378.2008.01207.x","article-title":"West Nile Virus in the New World: trends in the spread and proliferation of West Nile Virus in the Western Hemisphere","volume":"56","author":"Artsob","year":"2009","journal-title":"Zoonoses Public Health"},{"key":"10.1016\/j.antiviral.2016.01.003_bib2","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.chom.2008.08.003","article-title":"Harnessing endogenous miRNAs to control virus tissue tropism as a strategy for developing attenuated virus vaccines","volume":"4","author":"Barnes","year":"2008","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.antiviral.2016.01.003_bib3","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/1743-422X-4-115","article-title":"Construction and characterization of recombinant flaviviruses bearing insertions between E and NS1 genes","volume":"4","author":"Bonaldo","year":"2007","journal-title":"Virol. J."},{"key":"10.1016\/j.antiviral.2016.01.003_bib4","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1006\/viro.2000.0220","article-title":"Infectious cDNA clones of Langat tick-borne flavivirus that differ from their parent in peripheral neurovirulence","volume":"269","author":"Campbell","year":"2000","journal-title":"Virology"},{"key":"10.1016\/j.antiviral.2016.01.003_bib5","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0166-3542(04)00125-1","article-title":"Rodent models for the study of therapy against flavivirus infections","volume":"63","author":"Charlier","year":"2004","journal-title":"Antivir. Res."},{"key":"10.1016\/j.antiviral.2016.01.003_bib6","doi-asserted-by":"crossref","first-page":"3812","DOI":"10.3390\/v4123812","article-title":"Immune responses to West Nile virus infection in the central nervous system","volume":"4","author":"Cho","year":"2012","journal-title":"Viruses"},{"key":"10.1016\/j.antiviral.2016.01.003_bib7","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.virol.2010.06.014","article-title":"The neurovirulence and neuroinvasiveness of chimeric tick-borne encephalitis\/dengue virus can be attenuated by introducing defined mutations into the envelope and NS5 protein genes and the 3\u2032 non-coding region of the genome","volume":"405","author":"Engel","year":"2010","journal-title":"Virology"},{"key":"10.1016\/j.antiviral.2016.01.003_bib8","doi-asserted-by":"crossref","first-page":"e92056","DOI":"10.1371\/journal.pone.0092056","article-title":"Molecular archaeology of Flaviviridae untranslated regions: duplicated RNA structures in the replication enhancer of flaviviruses and pestiviruses emerged via convergent evolution","volume":"9","author":"Gritsun","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.antiviral.2016.01.003_bib9","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0168-1702(97)01451-2","article-title":"Complete sequence of two tick-borne flaviviruses isolated from Siberia and the UK: analysis and significance of the 5\u2032 and 3\u2032-UTRs","volume":"49","author":"Gritsun","year":"1997","journal-title":"Virus Res."},{"key":"10.1016\/j.antiviral.2016.01.003_bib10","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/BF01309481","article-title":"Loss of active neuroinvasiveness in attenuated strains of West Nile virus: pathogenicity in immunocompetent and SCID mice","volume":"137","author":"Halevy","year":"1994","journal-title":"Arch. Virol."},{"key":"10.1016\/j.antiviral.2016.01.003_bib11","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1128\/JVI.02091-10","article-title":"Insertion of microRNA targets into the flavivirus genome alters its highly neurovirulent phenotype","volume":"85","author":"Heiss","year":"2011","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.antiviral.2016.01.003_bib12","doi-asserted-by":"crossref","first-page":"5647","DOI":"10.1128\/JVI.07125-11","article-title":"MicroRNA targeting of neurotropic flavivirus: effective control of virus escape and reversion to neurovirulent phenotype","volume":"86","author":"Heiss","year":"2012","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.antiviral.2016.01.003_bib13","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/mt.2008.288","article-title":"MicroRNAs and the regulation of vector tropism","volume":"17","author":"Kelly","year":"2009","journal-title":"Mol. Ther."},{"key":"10.1016\/j.antiviral.2016.01.003_bib14","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nbt.1635","article-title":"Rationalizing the development of live attenuated virus vaccines","volume":"28","author":"Lauring","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.antiviral.2016.01.003_bib15","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0065-3527(03)59002-9","article-title":"Molecular biology of flaviviruses","volume":"59","author":"Lindenbach","year":"2003","journal-title":"Adv. Virus Res."},{"key":"10.1016\/j.antiviral.2016.01.003_bib16","doi-asserted-by":"crossref","first-page":"S98","DOI":"10.1038\/nm1144","article-title":"Emerging flaviviruses: the spread and resurgence of Japanese encephalitis, West Nile and dengue viruses","volume":"10","author":"Mackenzie","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.antiviral.2016.01.003_bib42","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/0042-6822(91)90567-U","article-title":"Sequence of the genes encoding the structural proteins of the low-virulence tick-borne flaviviruses Langat TP21 and Yelantsev","volume":"185","author":"Mandl","year":"1991","journal-title":"Virology"},{"key":"10.1016\/j.antiviral.2016.01.003_bib17","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.virusres.2005.04.007","article-title":"Steps of the tick-borne encephalitis virus replication cycle that affect neuropathogenesis","volume":"111","author":"Mandl","year":"2005","journal-title":"Virus Res."},{"key":"10.1016\/j.antiviral.2016.01.003_bib18","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1128\/JVI.72.3.2132-2140.1998","article-title":"Spontaneous and engineered deletions in the 3\u2032 noncoding region of tick-borne encephalitis virus: construction of highly attenuated mutants of a flavivirus","volume":"72","author":"Mandl","year":"1998","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.antiviral.2016.01.003_bib19","doi-asserted-by":"crossref","first-page":"e00614","DOI":"10.1128\/mBio.00614-15","article-title":"Development of a model system for tick-borne flavivirus persistence in HEK 293T cells","volume":"6","author":"Mlera","year":"2015","journal-title":"MBio"},{"key":"10.1016\/j.antiviral.2016.01.003_bib20","doi-asserted-by":"crossref","first-page":"9322","DOI":"10.1073\/pnas.142287799","article-title":"Positional cloning of the murine flavivirus resistance gene","volume":"99","author":"Perelygin","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.antiviral.2016.01.003_bib21","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1006\/viro.2001.0846","article-title":"Infectious cDNA clone of attenuated Langat tick-borne flavivirus (strain E5) and a 3\u2032 deletion mutant constructed from it exhibit decreased neuroinvasiveness in immunodeficient mice","volume":"282","author":"Pletnev","year":"2001","journal-title":"Virology"},{"key":"10.1016\/j.antiviral.2016.01.003_bib22","doi-asserted-by":"crossref","first-page":"8259","DOI":"10.1128\/JVI.75.17.8259-8267.2001","article-title":"Tick-borne Langat\/mosquito-borne dengue flavivirus chimera, a candidate live attenuated vaccine for protection against disease caused by members of the tick-borne encephalitis virus complex: evaluation in rhesus monkeys and in mosquitoes","volume":"75","author":"Pletnev","year":"2001","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.antiviral.2016.01.003_bib23","doi-asserted-by":"crossref","first-page":"10532","DOI":"10.1073\/pnas.89.21.10532","article-title":"Construction and characterization of chimeric tick-borne encephalitis\/dengue type 4 viruses","volume":"89","author":"Pletnev","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.antiviral.2016.01.003_bib24","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1073\/pnas.95.4.1746","article-title":"Attenuation of the Langat tick-borne flavivirus by chimerization with mosquito-borne flavivirus dengue type 4","volume":"95","author":"Pletnev","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.antiviral.2016.01.003_bib25","doi-asserted-by":"crossref","first-page":"6392","DOI":"10.1016\/j.vaccine.2006.06.008","article-title":"Chimeric West Nile\/dengue virus vaccine candidate: preclinical evaluation in mice, geese and monkeys for safety and immunogenicity","volume":"24","author":"Pletnev","year":"2006","journal-title":"Vaccine"},{"issue":"Suppl.\u00a01","key":"10.1016\/j.antiviral.2016.01.003_bib26","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1093\/infdis\/jiu568","article-title":"Increasing complexity of vaccine development","volume":"212","author":"Plotkin","year":"2015","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.antiviral.2016.01.003_bib27","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1002\/jmv.21587","article-title":"Safety evaluation of chimeric Langat\/Dengue 4 flavivirus, a live vaccine candidate against tick-borne encephalitis","volume":"81","author":"Pripuzova","year":"2009","journal-title":"J.\u00a0Med. Virol."},{"key":"10.1016\/j.antiviral.2016.01.003_bib28","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.3201\/eid1608.100483","article-title":"West Nile virus range expansion into British Columbia","volume":"16","author":"Roth","year":"2010","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.antiviral.2016.01.003_bib29","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/oxfordjournals.aje.a118408","article-title":"A\u00a0simple method of estimating fifty per cent endpoint","volume":"27","author":"Reed","year":"1938","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.antiviral.2016.01.003_bib30","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.vaccine.2005.07.067","article-title":"Comparison of live and inactivated tick-borne encephalitis virus vaccines for safety, immunogenicity and efficacy in rhesus monkeys","volume":"24","author":"Rumyantsev","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.antiviral.2016.01.003_bib31","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1128\/JVI.80.3.1427-1439.2006","article-title":"A\u00a0tick-borne Langat virus mutant that is temperature sensitive and host range restricted in neuroblastoma cells and lacks neuroinvasiveness for immunodeficient mice","volume":"80","author":"Rumyantsev","year":"2006","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.antiviral.2016.01.003_bib32","doi-asserted-by":"crossref","first-page":"13103","DOI":"10.1073\/pnas.1306245110","article-title":"Single-dose vaccine against tick-borne encephalitis","volume":"110","author":"Rumyantsev","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.antiviral.2016.01.003_bib33","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1099\/vir.0.060046-0","article-title":"Variable region of the 3\u2032 UTR is a critical virulence factor in the Far-Eastern subtype of tick-borne encephalitis virus in a mouse model","volume":"95","author":"Sakai","year":"2014","journal-title":"J.\u00a0Gen. Virol."},{"key":"10.1016\/j.antiviral.2016.01.003_bib34","series-title":"Molecular Cloning","author":"Sambrook","year":"2001"},{"key":"10.1016\/j.antiviral.2016.01.003_bib35","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/rmv.712","article-title":"Neuroinvasive flavivirus infections","volume":"22","author":"Sips","year":"2012","journal-title":"Rev. Med. Virol."},{"key":"10.1016\/j.antiviral.2016.01.003_bib36","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nrmicro2971","article-title":"RNA viruses and the host microRNA machinery","volume":"11","author":"tenOever","year":"2013","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.antiviral.2016.01.003_bib37","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.virol.2014.04.001","article-title":"Silencing of neurotropic flavivirus replication in the central nervous system by combining multiple microRNA target insertions in two distinct viral genome regions","volume":"456\u2013457","author":"Teterina","year":"2014","journal-title":"Virology"},{"key":"10.1016\/j.antiviral.2016.01.003_bib38","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/oxfordjournals.aje.a120633","article-title":"A\u00a0chick embryo attenuated strain (TP21 E5) of Langat virus. I. Virulence of the virus for mice and monkeys","volume":"84","author":"Thind","year":"1966","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.antiviral.2016.01.003_bib39","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1093\/oxfordjournals.aje.a120634","article-title":"A\u00a0chick embryo attenuated strain (TP21 E5) of Langat virus. II. Stability after passage in various laboratory animals and tissue cultures","volume":"84","author":"Thind","year":"1966","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.antiviral.2016.01.003_bib40","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1006\/viro.1995.1557","article-title":"The flavivirus 3\u2032-noncoding region: extensive size heterogeneity independent of evolutionary relationships among strains of tick-borne encephalitis virus","volume":"213","author":"Wallner","year":"1995","journal-title":"Virology"},{"key":"10.1016\/j.antiviral.2016.01.003_bib41","doi-asserted-by":"crossref","first-page":"e24744","DOI":"10.1371\/journal.pone.0024744","article-title":"Mice with different susceptibility to Japanese encephalitis virus infection show selective neutralizing antibody response and myeloid cell infectivity","volume":"6","author":"Wang","year":"2011","journal-title":"PLoS One"}],"container-title":["Antiviral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166354216300055?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166354216300055?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,13]],"date-time":"2020-09-13T23:44:27Z","timestamp":1600040667000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166354216300055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":42,"alternative-id":["S0166354216300055"],"URL":"https:\/\/doi.org\/10.1016\/j.antiviral.2016.01.003","relation":{},"ISSN":["0166-3542"],"issn-type":[{"value":"0166-3542","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MicroRNA-based control of tick-borne flavivirus neuropathogenesis: Challenges and perspectives","name":"articletitle","label":"Article Title"},{"value":"Antiviral Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.antiviral.2016.01.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}