{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T13:43:48Z","timestamp":1773323028629,"version":"3.50.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Spanish Ministry of Economy and Competitiveness","award":["SAF2011-24899"],"award-info":[{"award-number":["SAF2011-24899"]}]},{"name":"Spanish Ministry of Economy and Competitiveness","award":["AGL2014-52395-C2"],"award-info":[{"award-number":["AGL2014-52395-C2"]}]},{"name":"Spanish Ministry of Economy and Competitiveness","award":["AGL2013-48923-C2"],"award-info":[{"award-number":["AGL2013-48923-C2"]}]},{"name":"European Community's Seventh Framework Programme","award":["FP7, 2007\u20132013"],"award-info":[{"award-number":["FP7, 2007\u20132013"]}]},{"name":"Research Infrastructures action (NADIR)","award":["FP7-228394"],"award-info":[{"award-number":["FP7-228394"]}]},{"DOI":"10.13039\/100012818","name":"Comunidad de Madrid","doi-asserted-by":"crossref","award":["S2013\/ABI-2906-PLATESA"],"award-info":[{"award-number":["S2013\/ABI-2906-PLATESA"]}],"id":[{"id":"10.13039\/100012818","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["2009SGR492"],"award-info":[{"award-number":["2009SGR492"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008054","name":"Fundaci\u00f3n Ram\u00f3n Areces","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Research"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.antiviral.2016.03.005","type":"journal-article","created":{"date-parts":[[2016,3,6]],"date-time":"2016-03-06T00:10:05Z","timestamp":1457223005000},"page":"74-80","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":55,"special_numbering":"C","title":["Full protection of swine against foot-and-mouth disease by a bivalent B-cell epitope dendrimer peptide"],"prefix":"10.1016","volume":"129","author":[{"given":"Esther","family":"Blanco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Guerra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz G.","family":"de la Torre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sira","family":"Defaus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldo","family":"Dekker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Andreu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Sobrino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6209","key":"10.1016\/j.antiviral.2016.03.005_bib1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/337709a0","article-title":"The three-dimensional structure of foot-and-mouth disease virus at 2.9 A resolution","volume":"337","author":"Acharya","year":"1989","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.antiviral.2016.03.005_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0021-9975(03)00041-0","article-title":"The pathogenesis and diagnosis of foot-and-mouth disease","volume":"129","author":"Alexandersen","year":"2003","journal-title":"J.\u00a0Comp. Pathol."},{"issue":"5138","key":"10.1016\/j.antiviral.2016.03.005_bib3","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1126\/science.8248784","article-title":"The influence of antigen organization on B cell responsiveness","volume":"262","author":"Bachmann","year":"1993","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.antiviral.2016.03.005_bib4","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0165-2427(99)00095-1","article-title":"Differential complement activation by bovine IgG2 allotypes","volume":"71","author":"Bastida-Corcuera","year":"1999","journal-title":"Vet. Immunol. Immunopathol."},{"issue":"5869","key":"10.1016\/j.antiviral.2016.03.005_bib5","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/298030a0","article-title":"Protection against foot-and-mouth disease by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequence","volume":"298","author":"Bittle","year":"1982","journal-title":"Nature"},{"key":"10.1016\/j.antiviral.2016.03.005_bib6","doi-asserted-by":"crossref","first-page":"475960","DOI":"10.1155\/2013\/475960","article-title":"B\u00a0epitope multiplicity and B\/T epitope orientation influence immunogenicity of foot-and-mouth disease peptide vaccines","volume":"2013","author":"Blanco","year":"2013","journal-title":"Clin. Dev. Immunol."},{"issue":"7","key":"10.1016\/j.antiviral.2016.03.005_bib7","doi-asserted-by":"crossref","first-page":"3164","DOI":"10.1128\/JVI.75.7.3164-3174.2001","article-title":"Identification of T-cell epitopes in nonstructural proteins of foot-and-mouth disease virus","volume":"75","author":"Blanco","year":"2001","journal-title":"J.\u00a0Virol."},{"issue":"1","key":"10.1016\/j.antiviral.2016.03.005_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.virusres.2011.02.006","article-title":"Current strategies for subunit and genetic viral veterinary vaccine development","volume":"157","author":"Brun","year":"2011","journal-title":"Virus Res."},{"issue":"4","key":"10.1016\/j.antiviral.2016.03.005_bib9","doi-asserted-by":"crossref","first-page":"e1000050","DOI":"10.1371\/journal.ppat.1000050","article-title":"Transmission pathways of foot-and-mouth disease virus in the United Kingdom in 2007","volume":"4","author":"Cottam","year":"2008","journal-title":"PLoS Pathog."},{"issue":"21\u201322","key":"10.1016\/j.antiviral.2016.03.005_bib10","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1016\/S0264-410X(03)00142-7","article-title":"Porcine Ig isotypes: function and molecular characteristics","volume":"21","author":"Crawley","year":"2003","journal-title":"Vaccine"},{"key":"10.1016\/j.antiviral.2016.03.005_bib11","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1743-422X-9-66","article-title":"Inclusion of a specific T cell epitope increases the protection conferred against foot-and-mouth disease virus in pigs by a linear peptide containing an immunodominant B cell site","volume":"9","author":"Cubillos","year":"2012","journal-title":"Virol. J."},{"issue":"14","key":"10.1016\/j.antiviral.2016.03.005_bib12","doi-asserted-by":"crossref","first-page":"7223","DOI":"10.1128\/JVI.00401-08","article-title":"Enhanced mucosal immunoglobulin A response and solid protection against foot-and-mouth disease virus challenge induced by a novel dendrimeric peptide","volume":"82","author":"Cubillos","year":"2008","journal-title":"J.\u00a0Virol."},{"issue":"6","key":"10.1016\/j.antiviral.2016.03.005_bib13","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.vaccine.2006.09.066","article-title":"Serological and mucosal immune responses after vaccination and infection with FMDV in pigs","volume":"25","author":"Eble","year":"2007","journal-title":"Vaccine"},{"issue":"2","key":"10.1016\/j.antiviral.2016.03.005_bib14","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1017\/S0022172400060344","article-title":"Antibody response in pig nasal fluid and serum following foot-and-mouth disease infection or vaccination","volume":"91","author":"Francis","year":"1983","journal-title":"J.\u00a0Hyg. (Lond)"},{"issue":"1","key":"10.1016\/j.antiviral.2016.03.005_bib15","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0034-5288(18)30568-X","article-title":"Response of young pigs to foot-and-mouth disease oil emulsion vaccination in the presence and absence of maternally derived neutralising antibodies","volume":"41","author":"Francis","year":"1986","journal-title":"Res. Vet. Sci."},{"issue":"1","key":"10.1016\/j.antiviral.2016.03.005_bib16","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1586\/14760584.3.1.23","article-title":"Antibody regulation of Tcell immunity: implications for vaccine strategies against intracellular pathogens","volume":"3","author":"Igietseme","year":"2004","journal-title":"Expert Rev. Vaccines"},{"issue":"3","key":"10.1016\/j.antiviral.2016.03.005_bib17","doi-asserted-by":"crossref","first-page":"637","DOI":"10.20506\/rst.21.3.1356","article-title":"The economics of foot and mouth disease","volume":"21","author":"James","year":"2002","journal-title":"Rev. Sci. Tech."},{"issue":"30","key":"10.1016\/j.antiviral.2016.03.005_bib18","doi-asserted-by":"crossref","first-page":"5660","DOI":"10.1016\/j.vaccine.2006.10.052","article-title":"Global FMD control\u2013is it an option?","volume":"25","author":"Kitching","year":"2007","journal-title":"Vaccine"},{"issue":"9","key":"10.1016\/j.antiviral.2016.03.005_bib19","first-page":"258","article-title":"Outbreak of foot-and-mouth disease virus serotype O in the UK caused by a pandemic strain","volume":"148","author":"Knowles","year":"2001","journal-title":"Vet. Rec."},{"key":"10.1016\/j.antiviral.2016.03.005_bib20","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1297-9716-43-64","article-title":"Interplay of foot-and-mouth disease virus, antibodies and plasmacytoid dendritic cells: virus opsonization under non-neutralizing conditions results in enhanced interferon-alpha responses","volume":"43","author":"Lannes","year":"2012","journal-title":"Vet. Res."},{"key":"10.1016\/j.antiviral.2016.03.005_bib21","series-title":"Foot-and-Mouth Disease: Current Perspective","article-title":"Functional and structural aspects of the interaction of foot-and-mouth disease virus with antibodies","author":"Mateu","year":"2004"},{"key":"10.1016\/j.antiviral.2016.03.005_bib22","series-title":"Foot-and-Mouth Disease: Current Perspectives","article-title":"Immunology of foot-andmouth disease","author":"McCullough","year":"2004"},{"issue":"4","key":"10.1016\/j.antiviral.2016.03.005_bib23","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1128\/JVI.66.4.1835-1840.1992","article-title":"Protective immune response against foot-and-mouth disease","volume":"66","author":"McCullough","year":"1992","journal-title":"J.\u00a0Virol."},{"issue":"2","key":"10.1016\/j.antiviral.2016.03.005_bib24","first-page":"187","article-title":"Opsonization-enhanced phagocytosis of foot-and-mouth disease virus","volume":"65","author":"McCullough","year":"1988","journal-title":"Immunology"},{"issue":"4","key":"10.1016\/j.antiviral.2016.03.005_bib25","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1021\/bc300515t","article-title":"Influence of conjugation chemistry and B epitope orientation on the immune response of branched peptide antigens","volume":"24","author":"Monso","year":"2013","journal-title":"Bioconjug Chem."},{"issue":"3","key":"10.1016\/j.antiviral.2016.03.005_bib26","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0264-410X(90)90054-P","article-title":"Isotype responses of infected, virus-vaccinated and peptide-vaccinated cattle to foot-and-mouth disease virus","volume":"8","author":"Mulcahy","year":"1990","journal-title":"Vaccine"},{"issue":"16","key":"10.1016\/j.antiviral.2016.03.005_bib27","doi-asserted-by":"crossref","first-page":"8497","DOI":"10.1128\/JVI.00340-07","article-title":"Guinea pig-adapted foot-and-mouth disease virus with altered receptor recognition can productively infect a natural host","volume":"81","author":"Nu\u00f1ez","year":"2007","journal-title":"J.\u00a0Virol."},{"issue":"5","key":"10.1016\/j.antiviral.2016.03.005_bib28","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/nrd2224","article-title":"More than one reason to rethink the use of peptides in vaccine design","volume":"6","author":"Purcell","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"issue":"3","key":"10.1016\/j.antiviral.2016.03.005_bib29","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1586\/erv.11.4","article-title":"Development of vaccines toward the global control and eradication of foot-and-mouth disease","volume":"10","author":"Rodriguez","year":"2011","journal-title":"Expert Rev. Vaccines"},{"issue":"11","key":"10.1016\/j.antiviral.2016.03.005_bib30","doi-asserted-by":"crossref","first-page":"e1003001","DOI":"10.1371\/journal.ppat.1003001","article-title":"Vaccines: from empirical development to rational design","volume":"8","author":"Rueckert","year":"2012","journal-title":"PLoS Pathog."},{"issue":"1","key":"10.1016\/j.antiviral.2016.03.005_bib31","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1865-1682.2007.01016.x","article-title":"Planning for the progressive control of foot-and-mouth disease worldwide","volume":"55","author":"Rweyemamu","year":"2008","journal-title":"Transbound. Emerg. Dis."},{"issue":"Pt 10","key":"10.1016\/j.antiviral.2016.03.005_bib32","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1099\/0022-1317-73-10-2601","article-title":"Heterotypic lymphoproliferative response in pigs vaccinated with foot-and-mouth disease virus. Involvement of isolated capsid proteins","volume":"73","author":"Saiz","year":"1992","journal-title":"J.\u00a0Gen. Virol."},{"issue":"6","key":"10.1016\/j.antiviral.2016.03.005_bib33","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1093\/embo-reports\/kve122","article-title":"Foot-and-mouth disease in Europe","volume":"2","author":"Sobrino","year":"2001","journal-title":"EMBO Rep."},{"issue":"1","key":"10.1016\/j.antiviral.2016.03.005_bib34","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1865-1682.2007.01017.x","article-title":"Incidence and distribution of foot-and-mouth disease in Asia, Africa and South America; combining expert opinion, official disease information and livestock populations to assist risk assessment","volume":"55","author":"Sumption","year":"2008","journal-title":"Transbound. Emerg. Dis."},{"issue":"4","key":"10.1016\/j.antiviral.2016.03.005_bib35","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1128\/JVI.71.4.2606-2614.1997","article-title":"A\u00a0large-scale evaluation of peptide vaccines against foot-and-mouth disease: lack of solid protection in cattle and isolation of escape mutants","volume":"71","author":"Taboga","year":"1997","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.antiviral.2016.03.005_bib36","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1186\/1743-422X-8-268","article-title":"Research in advance for FMD novel vaccines","volume":"8","author":"Zhang","year":"2011","journal-title":"Virol. J."},{"key":"10.1016\/j.antiviral.2016.03.005_bib37","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1146\/annurev.immunol.21.120601.141045","article-title":"On natural and artificial vaccinations","volume":"21","author":"Zinkernagel","year":"2003","journal-title":"Annu. Rev. Immunol."}],"container-title":["Antiviral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166354216301322?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166354216301322?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T18:26:34Z","timestamp":1600280794000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166354216301322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":37,"alternative-id":["S0166354216301322"],"URL":"https:\/\/doi.org\/10.1016\/j.antiviral.2016.03.005","relation":{},"ISSN":["0166-3542"],"issn-type":[{"value":"0166-3542","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Full protection of swine against foot-and-mouth disease by a bivalent B-cell epitope dendrimer peptide","name":"articletitle","label":"Article Title"},{"value":"Antiviral Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.antiviral.2016.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}