{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:59:45Z","timestamp":1792760385967,"version":"4.5.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004700","name":"Taipei Medical University","doi-asserted-by":"publisher","award":["LTL: TMU101-AE3-Y19"],"award-info":[{"award-number":["LTL: TMU101-AE3-Y19"]}],"id":[{"id":"10.13039\/501100004700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["LTL: MOST103-2320-B-038-031-MY3"],"award-info":[{"award-number":["LTL: MOST103-2320-B-038-031-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["CCL: NSC98-2313-B-037-003-MY3"],"award-info":[{"award-number":["CCL: NSC98-2313-B-037-003-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Research"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.antiviral.2016.03.012","type":"journal-article","created":{"date-parts":[[2016,3,21]],"date-time":"2016-03-21T08:01:25Z","timestamp":1458547285000},"page":"58-68","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"special_numbering":"C","title":["Activity-based and fraction-guided analysis of Phyllanthus urinaria identifies loliolide as a potent inhibitor of hepatitis C virus entry"],"prefix":"10.1016","volume":"130","author":[{"given":"Chueh-Yao","family":"Chung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Hsuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Burnouf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guey-Horng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun-Pang","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alagie","family":"Jassey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Jei","family":"Tai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Jeng","family":"Tai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Jang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Hong","family":"Yen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Ching","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7374-7234","authenticated-orcid":false,"given":"Liang-Tzung","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.antiviral.2016.03.012_bib1","doi-asserted-by":"crossref","first-page":"12766","DOI":"10.1073\/pnas.96.22.12766","article-title":"Hepatitis C virus and other flaviviridae viruses enter cells via low density lipoprotein receptor","volume":"96","author":"Agnello","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.antiviral.2016.03.012_bib2","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1002\/ptr.4608","article-title":"Bioactivity-guided fractionation of Phyllanthus orbicularis and identification of the principal anti HSV-2 compounds","volume":"26","author":"Alvarez","year":"2012","journal-title":"Phytother. Res."},{"key":"10.1016\/j.antiviral.2016.03.012_bib3","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1136\/gutjnl-2012-304299","article-title":"Turmeric curcumin inhibits entry of all hepatitis C virus genotypes into human liver cells","volume":"63","author":"Anggakusuma","year":"2014","journal-title":"Gut"},{"issue":"32 Suppl","key":"10.1016\/j.antiviral.2016.03.012_bib4","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1478-3231.2011.02699.x","article-title":"Direct acting antivirals for the treatment of chronic hepatitis C: one pill a day for tomorrow","volume":"1","author":"Asselah","year":"2012","journal-title":"Liver Int."},{"key":"10.1016\/j.antiviral.2016.03.012_bib5","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1002\/hep.22465","article-title":"Hepatitis C virus envelope components alter localization of hepatocyte tight junction-associated proteins and promote occludin retention in the endoplasmic reticulum","volume":"48","author":"Benedicto","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.antiviral.2016.03.012_bib6","first-page":"1866","article-title":"Silibinin inhibits hepatitis C virus entry into hepatocytes by hindering clathrin-dependent trafficking","volume":"15","author":"Blaising","year":"2013","journal-title":"Cell Microbiol."},{"issue":"8 Suppl","key":"10.1016\/j.antiviral.2016.03.012_bib7","doi-asserted-by":"crossref","first-page":"S86","DOI":"10.1016\/0264-410X(90)90225-B","article-title":"Hepatitis B virus and primary hepatocellular carcinoma: treatment of HBV carriers with Phyllanthus amarus","author":"Blumberg","year":"1990","journal-title":"Vaccine"},{"key":"10.1016\/j.antiviral.2016.03.012_bib8","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1002\/hep.24803","article-title":"(-)-Epigallocatechin-3-gallate is a new inhibitor of hepatitis C virus entry","volume":"55","author":"Calland","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.antiviral.2016.03.012_bib9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/hep.24470","article-title":"Telaprevir, boceprevir, cytochrome P450 and immunosuppressive agents\u2013a potentially lethal cocktail","volume":"54","author":"Charlton","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.antiviral.2016.03.012_bib10","doi-asserted-by":"crossref","first-page":"487380","DOI":"10.1155\/2012\/487380","article-title":"Gallic Acid Enriched Fraction of Phyllanthus emblica Potentiates Indomethacin-Induced Gastric Ulcer Healing via e-NOS-Dependent Pathway","volume":"2012","author":"Chatterjee","year":"2012","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"10.1016\/j.antiviral.2016.03.012_bib11","doi-asserted-by":"crossref","first-page":"259103","DOI":"10.1093\/ecam\/nep157","article-title":"Excoecarianin, isolated from Phyllanthus urinaria linnea, inhibits herpes simplex virus type 2 infection through inactivation of viral particles","volume":"2011","author":"Cheng","year":"2011","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"10.1016\/j.antiviral.2016.03.012_bib12","doi-asserted-by":"crossref","first-page":"e0117800","DOI":"10.1371\/journal.pone.0117800","article-title":"TnBPTriton X-45 treatment of plasma for transfusion efficiently inactivates hepatitis C virus","volume":"10","author":"Chou","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.antiviral.2016.03.012_bib13","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1002\/hep.24610","article-title":"The green tea polyphenol, epigallocatechin-3-gallate, inhibits hepatitis C virus entry","volume":"54","author":"Ciesek","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.antiviral.2016.03.012_bib14","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1111\/j.1462-5822.2007.01107.x","article-title":"Early steps of the hepatitis C virus life cycle","volume":"10","author":"Dubuisson","year":"2008","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.antiviral.2016.03.012_bib15","doi-asserted-by":"crossref","first-page":"g3308","DOI":"10.1136\/bmj.g3308","article-title":"Antiviral treatment of hepatitis C","volume":"348","author":"Feeney","year":"2014","journal-title":"BMJ"},{"key":"10.1016\/j.antiviral.2016.03.012_bib16","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/jmv.10196","article-title":"Cellular glycosaminoglycans and low density lipoprotein receptor are involved in hepatitis C virus adsorption","volume":"68","author":"Germi","year":"2002","journal-title":"J.\u00a0Med. Virol."},{"key":"10.1016\/j.antiviral.2016.03.012_bib17","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1002\/jps.2600651038","article-title":"Chemical constituents of genianaceae XX: natural occurrence of (-)-loliolide in Canscora decussata","volume":"65","author":"Ghosal","year":"1976","journal-title":"J.\u00a0Pharm. Sci."},{"key":"10.1016\/j.antiviral.2016.03.012_bib18","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1053\/j.gastro.2007.08.005","article-title":"Robust hepatitis C genotype 3a cell culture releasing adapted intergenotypic 3a\/2a (S52\/JFH1) viruses","volume":"133","author":"Gottwein","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.antiviral.2016.03.012_bib19","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/hep.22673","article-title":"Development and characterization of hepatitis C virus genotype 1-7 cell culture systems: role of CD81 and scavenger receptor class B type I and effect of antiviral drugs","volume":"49","author":"Gottwein","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.antiviral.2016.03.012_bib20","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.antiviral.2015.04.003","article-title":"Limonium sinense and gallic acid suppress hepatitis C virus infection by blocking early viral entry","volume":"118","author":"Hsu","year":"2015","journal-title":"Antivir. Res."},{"key":"10.1016\/j.antiviral.2016.03.012_bib21","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.mito.2014.05.002","article-title":"Phyllanthus urinaria induces mitochondrial dysfunction in human osteosarcoma 143B cells associated with modulation of mitochondrial fission\/fusion proteins","volume":"17","author":"Huang","year":"2014","journal-title":"Mitochondrion"},{"key":"10.1016\/j.antiviral.2016.03.012_bib22","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1056\/NEJMoa1012912","article-title":"Telaprevir for previously untreated chronic hepatitis C virus infection","volume":"364","author":"Jacobson","year":"2011","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.antiviral.2016.03.012_bib23","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1038\/nprot.2006.395","article-title":"Cell culture and infection system for hepatitis C virus","volume":"1","author":"Kato","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.antiviral.2016.03.012_bib24","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1590\/S1517-83822014005000030","article-title":"In\u00a0vitro inhibition of the bovine viral diarrhoea virus by the essential oil of Ocimum basilicum (basil) and monoterpenes","volume":"45","author":"Kubica","year":"2014","journal-title":"Braz J. Microbiol."},{"key":"10.1016\/j.antiviral.2016.03.012_bib25","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.jep.2008.05.022","article-title":"Inhibition of Helicobacter pylori-induced inflammation in human gastric epithelial AGS cells by Phyllanthus urinaria extracts","volume":"118","author":"Lai","year":"2008","journal-title":"J.\u00a0Ethnopharmacol."},{"key":"10.1016\/j.antiviral.2016.03.012_bib26","doi-asserted-by":"crossref","first-page":"498","DOI":"10.3109\/15376516.2010.511301","article-title":"Protective effect of Phyllanthus niruri on alcohol and heated sunflower oil induced hyperlipidemia in Wistar rats","volume":"20","author":"Latha","year":"2010","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.antiviral.2016.03.012_bib27","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1056\/NEJM200107053450107","article-title":"Hepatitis C virus infection","volume":"345","author":"Lauer","year":"2001","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.antiviral.2016.03.012_bib28","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1046\/j.1365-2362.1996.410595.x","article-title":"Phyllanthus amarus down-regulates hepatitis B virus mRNA transcription and replication","volume":"26","author":"Lee","year":"1996","journal-title":"Eur. J. Clin. Invest"},{"key":"10.1016\/j.antiviral.2016.03.012_bib29","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1186\/1472-6882-13-192","article-title":"Effects of cocktail of four local Malaysian medicinal plants (Phyllanthus spp.) against dengue virus 2","volume":"13","author":"Lee","year":"2013","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.antiviral.2016.03.012_bib30","doi-asserted-by":"crossref","first-page":"371","DOI":"10.2217\/fvl.13.11","article-title":"Viral hepatitis in resource-limited countries and access to antiviral therapies: current and future challenges","volume":"8","author":"Lemoine","year":"2013","journal-title":"Future Virol."},{"key":"10.1016\/j.antiviral.2016.03.012_bib31","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1056\/NEJMra1213651","article-title":"Current and future therapies for hepatitis C virus infection","volume":"368","author":"Liang","year":"2013","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.antiviral.2016.03.012_bib32","doi-asserted-by":"crossref","first-page":"4386","DOI":"10.1128\/JVI.01492-10","article-title":"Hydrolyzable tannins (chebulagic acid and punicalagin) target viral glycoprotein-glycosaminoglycan interactions to inhibit herpes simplex virus 1 entry and cell-to-cell spread","volume":"85","author":"Lin","year":"2011","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.antiviral.2016.03.012_bib33","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/1471-2180-13-187","article-title":"Broad-spectrum antiviral activity of chebulagic acid and punicalagin against viruses that use glycosaminoglycans for entry","volume":"13","author":"Lin","year":"2013","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.antiviral.2016.03.012_bib34","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.jhep.2014.10.040","article-title":"Saikosaponin b2 is a naturally occurring terpenoid that efficiently inhibits hepatitis C virus entry","volume":"62","author":"Lin","year":"2015","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.antiviral.2016.03.012_bib35","doi-asserted-by":"crossref","first-page":"9170","DOI":"10.1128\/JVI.00559-10","article-title":"Replication of subgenomic hepatitis C virus replicons in mouse fibroblasts is facilitated by deletion of interferon regulatory factor 3 and expression of liver-specific microRNA 122","volume":"84","author":"Lin","year":"2010","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.antiviral.2016.03.012_bib36","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1021\/np800792d","article-title":"Anti-coxsackie virus B3 norsesquiterpenoids from the roots of Phyllanthus emblica","volume":"72","author":"Liu","year":"2009","journal-title":"J.\u00a0Nat. Prod."},{"key":"10.1016\/j.antiviral.2016.03.012_bib37","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1128\/JVI.01888-08","article-title":"Tight junction proteins claudin-1 and occludin control hepatitis C virus entry and are downregulated during infection to prevent superinfection","volume":"83","author":"Liu","year":"2009","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.antiviral.2016.03.012_bib38","doi-asserted-by":"crossref","first-page":"8764","DOI":"10.1039\/C4OB01196A","article-title":"Anti-hepatitis B virus activities and absolute configurations of sesquiterpenoid glycosides from Phyllanthus emblica","volume":"12","author":"Lv","year":"2014","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.antiviral.2016.03.012_bib39","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1136\/gut.2005.076646","article-title":"Treating viral hepatitis C: efficacy, side effects, and complications","volume":"55","author":"Manns","year":"2006","journal-title":"Gut"},{"key":"10.1016\/j.antiviral.2016.03.012_bib40","doi-asserted-by":"crossref","first-page":"10777","DOI":"10.1073\/pnas.1301764110","article-title":"Identification of transferrin receptor 1 as a hepatitis C virus entry factor","volume":"110","author":"Martin","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.antiviral.2016.03.012_bib41","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/(SICI)1096-9071(199903)57:3<223::AID-JMV2>3.0.CO;2-4","article-title":"Low density lipoprotein receptor as a candidate receptor for hepatitis C virus","volume":"57","author":"Monazahian","year":"1999","journal-title":"J.\u00a0Med. Virol."},{"key":"10.1016\/j.antiviral.2016.03.012_bib42","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.bbrc.2013.09.100","article-title":"Specific inhibition of hepatitis C virus entry into host hepatocytes by fungi-derived sulochrin and its derivatives","volume":"440","author":"Nakajima","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.antiviral.2016.03.012_bib43","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1126\/science.282.5390.938","article-title":"Binding of hepatitis C virus to CD81","volume":"282","author":"Pileri","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.antiviral.2016.03.012_bib44","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1038\/nature07684","article-title":"Human occludin is a hepatitis C virus entry factor required for infection of mouse cells","volume":"457","author":"Ploss","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.antiviral.2016.03.012_bib45","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1021\/np9600560","article-title":"Niruriside, a new HIV REV\/RRE binding inhibitor from Phyllanthus niruri","volume":"59","author":"Qian-Cutrone","year":"1996","journal-title":"J.\u00a0Nat. Prod."},{"key":"10.1016\/j.antiviral.2016.03.012_bib46","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.virusres.2011.03.014","article-title":"Inhibition of hepatitis C virus replication by herbal extract: Phyllanthus amarus as potent natural source","volume":"158","author":"Ravikumar","year":"2011","journal-title":"Virus Res."},{"key":"10.1016\/j.antiviral.2016.03.012_bib47","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/nm.2581","article-title":"Identification of the Niemann-Pick C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor","volume":"18","author":"Sainz","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.antiviral.2016.03.012_bib48","doi-asserted-by":"crossref","first-page":"12407","DOI":"10.1128\/JVI.01552-09","article-title":"Hepatoma cell density promotes claudin-1 and scavenger receptor BI expression and hepatitis C virus internalization","volume":"83","author":"Schwarz","year":"2009","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.antiviral.2016.03.012_bib49","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/hep.22039","article-title":"Phyllanthus urinaria ameliorates the severity of nutritional steatohepatitis both in\u00a0vitro and in\u00a0vivo","volume":"47","author":"Shen","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.antiviral.2016.03.012_bib50","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/S1473-3099(05)70216-4","article-title":"Global epidemiology of hepatitis C virus infection","volume":"5","author":"Shepard","year":"2005","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.antiviral.2016.03.012_bib51","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3109\/15376516.2010.529189","article-title":"Protective effects of Phyllanthus amarus on fibrotic markers during alcohol and polyunsaturated fatty acid-induced toxicity","volume":"21","author":"Surya Narayanan","year":"2011","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.antiviral.2016.03.012_bib52","doi-asserted-by":"crossref","first-page":"564","DOI":"10.7150\/ijms.7704","article-title":"Inhibition of MAPKs, myc\/max, NFkappaB, and hypoxia pathways by Phyllanthus prevents proliferation, metastasis and angiogenesis in human melanoma (MeWo) Cancer cell line","volume":"11","author":"Tang","year":"2014","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.antiviral.2016.03.012_bib53","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.cld.2008.03.010","article-title":"Hepatitis C and liver transplantation: enhancing outcomes and should patients be retransplanted","volume":"12","author":"Verna","year":"2008","journal-title":"Clin. Liver Dis."},{"key":"10.1016\/j.antiviral.2016.03.012_bib54","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1440-1746.2012.07286.x","article-title":"Treatment of non-alcoholic steatohepatitis with Phyllanthus urinaria: a randomized trial","volume":"28","author":"Wong","year":"2013","journal-title":"J.\u00a0Gastroenterol. Hepatol."},{"key":"10.1016\/j.antiviral.2016.03.012_bib55","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1136\/gutjnl-2013-306155","article-title":"Synergy of entry inhibitors with direct-acting antivirals uncovers novel combinations for prevention and treatment of hepatitis C","volume":"64","author":"Xiao","year":"2015","journal-title":"Gut"},{"key":"10.1016\/j.antiviral.2016.03.012_bib56","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.antiviral.2005.02.008","article-title":"Acetone, ethanol and methanol extracts of Phyllanthus urinaria inhibit HSV-2 infection in\u00a0vitro","volume":"67","author":"Yang","year":"2005","journal-title":"Antivir. Res."},{"key":"10.1016\/j.antiviral.2016.03.012_bib57","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1002\/ptr.2232","article-title":"Hippomanin A from acetone extract of Phyllanthus urinaria inhibited HSV-2 but not HSV-1 infection in\u00a0vitro","volume":"21","author":"Yang","year":"2007","journal-title":"Phytother. Res."},{"key":"10.1016\/j.antiviral.2016.03.012_bib58","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.jep.2006.09.039","article-title":"The in\u00a0vitro activity of geraniin and 1,3,4,6-tetra-O-galloyl-beta-D-glucose isolated from Phyllanthus urinaria against herpes simplex virus type 1 and type 2 infection","volume":"110","author":"Yang","year":"2007","journal-title":"J.\u00a0Ethnopharmacol."},{"key":"10.1016\/j.antiviral.2016.03.012_bib59","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s12272-014-0390-9","article-title":"Antiviral effects of Phyllanthus urinaria containing corilagin against human enterovirus 71 and Coxsackievirus A16 in\u00a0vitro","volume":"38","author":"Yeo","year":"2015","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.antiviral.2016.03.012_bib60","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.ejmech.2014.03.017","article-title":"Development of bivalent oleanane-type triterpenes as potent HCV entry inhibitors","volume":"77","author":"Yu","year":"2014","journal-title":"Eur. J. Med. Chem."}],"container-title":["Antiviral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166354216301577?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166354216301577?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T04:46:12Z","timestamp":1718426772000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166354216301577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":60,"alternative-id":["S0166354216301577"],"URL":"https:\/\/doi.org\/10.1016\/j.antiviral.2016.03.012","relation":{},"ISSN":["0166-3542"],"issn-type":[{"value":"0166-3542","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activity-based and fraction-guided analysis of Phyllanthus urinaria identifies loliolide as a potent inhibitor of hepatitis C virus entry","name":"articletitle","label":"Article Title"},{"value":"Antiviral Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.antiviral.2016.03.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}