{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:03:01Z","timestamp":1791306181189,"version":"4.3.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002661","name":"Fonds National de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"publisher"}]},{"name":"T\u00e9l\u00e9vie"},{"DOI":"10.13039\/501100002749","name":"Belgian Science Policy Office","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002749","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005026","name":"Belgian Foundation against Cancer (FBC),","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005026","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Centre anticanc\u00e9reux pr\u00e8s ULg"},{"DOI":"10.13039\/501100006673","name":"Fonds L\u00e9on Fredericq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006673","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Gembloux Agrobiotech (GxABT)"},{"name":"ULg Fonds Sp\u00e9ciaux pour la Recherche"},{"name":"Service Public F\u00e9d\u00e9ral"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Research"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.antiviral.2016.10.015","type":"journal-article","created":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T22:01:00Z","timestamp":1478815260000},"page":"41-48","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":133,"special_numbering":"C","title":["Reducing the global burden of HTLV-1 infection: An agenda for research and action"],"prefix":"10.1016","volume":"137","author":[{"given":"Luc","family":"Willems","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Accolla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Bangham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Bazarbachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2445-4213","authenticated-orcid":false,"given":"Umberto","family":"Bertazzoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Barbara de Freitas","family":"Carneiro-Proietti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Chieco-Bianchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Ciminale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordana","family":"Coelho-dos-Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Esparza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Gallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Gessain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Gotuzzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Harford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Hermine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Jacobson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Macchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calum","family":"Macpherson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud","family":"Mahieux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Matsuoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9677-9703","authenticated-orcid":false,"given":"Jean-Marie","family":"Peloponese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6416-5096","authenticated-orcid":false,"given":"Viviana","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Tagaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3773-2390","authenticated-orcid":false,"given":"Graham P.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiki","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihisa","family":"Yamano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.antiviral.2016.10.015_bib1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.it.2007.09.006","article-title":"How does HTLV-I persist despite a strong cell-mediated immune response?","volume":"29","author":"Asquith","year":"2008","journal-title":"Trends Immunol."},{"key":"10.1016\/j.antiviral.2016.10.015_bib2","doi-asserted-by":"crossref","first-page":"15012","DOI":"10.1038\/nrdp.2015.12","article-title":"HTLV-1-associated myelopathy\/tropical spastic paraparesis","volume":"1","author":"Bangham","year":"2015","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.antiviral.2016.10.015_bib3","doi-asserted-by":"crossref","first-page":"4177","DOI":"10.1200\/JCO.2010.28.0669","article-title":"Meta-analysis on the use of zidovudine and interferon-alfa in adult T-cell leukemia\/lymphoma showing improved survival in the leukemic subtypes","volume":"28","author":"Bazarbachi","year":"2010","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.antiviral.2016.10.015_bib4","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1182\/blood-2011-05-356790","article-title":"Interaction of HTLV-1 Tax with minichromosome maintenance proteins accelerates the replication timing program","volume":"119","author":"Boxus","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.antiviral.2016.10.015_bib5","doi-asserted-by":"crossref","first-page":"9876","DOI":"10.1128\/JVI.00799-06","article-title":"Human T-cell lymphotropic virus type 3: complete nucleotide sequence and characterization of the human tax3 protein","volume":"80","author":"Calattini","year":"2006","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.antiviral.2016.10.015_bib6","doi-asserted-by":"crossref","first-page":"8945","DOI":"10.1128\/JVI.00261-15","article-title":"Mutation of a single envelope N-Linked glycosylation site enhances the pathogenicity of bovine leukemia virus","volume":"89","author":"de Brogniez","year":"2015","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.antiviral.2016.10.015_bib7","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12977-016-0290-9","article-title":"Development of neurologic diseases in a patient with primate T lymphotropic virus type 1 (PTLV-1)","volume":"13","author":"Enose-Akahata","year":"2016","journal-title":"Retrovirology"},{"key":"10.1016\/j.antiviral.2016.10.015_bib8","first-page":"1","article-title":"A\u00a0severe bite from a nonhuman primate is a major risk factor for HTLV-1 infection in hunters from central Africa","author":"Filippone","year":"2015","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.antiviral.2016.10.015_bib9","doi-asserted-by":"crossref","first-page":"4954","DOI":"10.1038\/sj.onc.1203870","article-title":"High circulating proviral load with oligoclonal expansion of HTLV-1 bearing T cells in HTLV-1 carriers with strongyloidiasis","volume":"19","author":"Gabet","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/j.antiviral.2016.10.015_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2012.00388","article-title":"Epidemiological aspects and world distribution of HTLV-1 infection","volume":"3","author":"Gessain","year":"2012","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.antiviral.2016.10.015_bib11","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/1742-4690-7-99","article-title":"Current concepts regarding the HTLV-1 receptor complex","volume":"7","author":"Ghez","year":"2010","journal-title":"Retrovirology"},{"key":"10.1016\/j.antiviral.2016.10.015_bib12","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1182\/blood-2010-10-312926","article-title":"The host genomic environment of the provirus determines the abundance of HTLV-1\u00a0\u2212 infected T-cell clones","volume":"117","author":"Gillet","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.antiviral.2016.10.015_bib13","doi-asserted-by":"crossref","first-page":"e1003687","DOI":"10.1371\/journal.ppat.1003687","article-title":"Massive depletion of bovine leukemia virus proviral clones located in genomic transcriptionally active sites during primary infection","volume":"9","author":"Gillet","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.antiviral.2016.10.015_bib14","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1128\/CMR.00063-09","article-title":"Epidemiology, treatment, and prevention of human T-cell leukemia virus type 1-associated diseases","volume":"23","author":"Gon\u00e7alves","year":"2010","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.antiviral.2016.10.015_bib15","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.3390\/v6062416","article-title":"Vaccination against \u03b4-retroviruses: the bovine leukemia virus paradigm","volume":"6","author":"Guti\u00e9rrez","year":"2014","journal-title":"Viruses"},{"key":"10.1016\/j.antiviral.2016.10.015_bib16","doi-asserted-by":"crossref","DOI":"10.1038\/ng.3415","article-title":"Integrated molecular analysis of adult T cell leukemia\/lymphoma","author":"Kataoka","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.antiviral.2016.10.015_bib17","doi-asserted-by":"crossref","first-page":"6604","DOI":"10.3390\/v7122960","article-title":"Recent advances in therapeutic approaches for adult T-cell leukemia\/lymphoma","volume":"7","author":"Kato","year":"2015","journal-title":"Viruses"},{"key":"10.1016\/j.antiviral.2016.10.015_bib18","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1742-4690-10-91","article-title":"The combination of arsenic, interferon-alpha, and zidovudine restores an \u201cimmunocompetent-like\u201d cytokine expression profile in patients with adult T-cell leukemia lymphoma","volume":"10","author":"Kchour","year":"2013","journal-title":"Retrovirology"},{"key":"10.1016\/j.antiviral.2016.10.015_bib19","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1586\/1744666X.2014.966690","article-title":"Inflammatory manifestations of HTLV-1 and their therapeutic options","volume":"10","author":"Martin","year":"2014","journal-title":"Expert Rev. Clin. Immunol."},{"key":"10.1016\/j.antiviral.2016.10.015_bib20","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nrc2111","article-title":"Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation","volume":"7","author":"Matsuoka","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.antiviral.2016.10.015_bib21","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.antiviral.2015.06.003","article-title":"The global virus Network: challenging chikungunya","volume":"120","author":"McSweegan","year":"2015","journal-title":"Antivir. Res."},{"key":"10.1016\/j.antiviral.2016.10.015_bib22","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.tracli.2015.12.001","article-title":"Infection with human T-lymphotropic virus types-1 and -2 (HTLV-1 and -2): implications for blood transfusion safety","volume":"23","author":"Murphy","year":"2016","journal-title":"Transfus. Clin. Biol. J. Soci\u00e9t\u00e9 Fr. Transfus. Sang."},{"key":"10.1016\/j.antiviral.2016.10.015_bib23","doi-asserted-by":"crossref","first-page":"6306","DOI":"10.1182\/blood-2011-04-349910","article-title":"Brief report Safety of long-term treatment of HAM\/TSP patients with valproic acid","volume":"118","author":"Olindo","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.antiviral.2016.10.015_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2012.00378","article-title":"Pathways of cell-cell transmission of HTLV-1","volume":"3","author":"Pique","year":"2012","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.antiviral.2016.10.015_bib25","first-page":"1","article-title":"Zoonotic transmission of two new strains of human T-lymphotropic virus type 4 in hunters bitten by a Gorilla in central Africa","author":"Richard","year":"2016","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.antiviral.2016.10.015_bib26","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1172\/JCI27198","article-title":"HTLV-1 propels untransformed CD4+ lymphocytes into the cell cycle while protecting CD8+ cells from death","volume":"116","author":"Sibon","year":"2006","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.antiviral.2016.10.015_bib27","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/bjh.13302","article-title":"Clinical outcomes of a novel therapeutic vaccine with Tax peptide-pulsed dendritic cells for adult T cell leukaemia\/lymphoma in a pilot study","volume":"169","author":"Suehiro","year":"2015","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.antiviral.2016.10.015_bib28","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1200\/JCO.2008.18.2428","article-title":"Definition, prognostic factors, treatment, and response criteria of adult T-cell leukemia-lymphoma: a proposal from an international consensus meeting","volume":"27","author":"Tsukasaki","year":"2009","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.antiviral.2016.10.015_bib29","doi-asserted-by":"crossref","first-page":"5217","DOI":"10.1158\/1078-0432.CCR-14-0572","article-title":"Human T-cell lymphotropic virus type I-associated adult T-cell leukemia-lymphoma: new directions in clinical research","volume":"20","author":"Tsukasaki","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.antiviral.2016.10.015_bib30","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ccr.2011.12.015","article-title":"Polycomb-mediated loss of miR-31 activates nik-dependent NF-\u03baB pathway in adult T cell leukemia and other cancers","volume":"21","author":"Yamagishi","year":"2012","journal-title":"Cancer Cell"}],"container-title":["Antiviral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166354216306258?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166354216306258?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T16:54:06Z","timestamp":1536252846000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166354216306258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":30,"alternative-id":["S0166354216306258"],"URL":"https:\/\/doi.org\/10.1016\/j.antiviral.2016.10.015","relation":{},"ISSN":["0166-3542"],"issn-type":[{"value":"0166-3542","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reducing the global burden of HTLV-1 infection: An agenda for research and action","name":"articletitle","label":"Article Title"},{"value":"Antiviral Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.antiviral.2016.10.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}