{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:07:19Z","timestamp":1792076839258,"version":"4.4.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"NIAID, NIH","award":["HHSN272201000039I"],"award-info":[{"award-number":["HHSN272201000039I"]}]},{"name":"NIAID, NIH","award":["HHSN272201100019I\/HHSN27200016"],"award-info":[{"award-number":["HHSN272201100019I\/HHSN27200016"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Research"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.antiviral.2016.11.003","type":"journal-article","created":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T05:30:57Z","timestamp":1478755857000},"page":"14-22","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":157,"special_numbering":"C","title":["Efficacy of the broad-spectrum antiviral compound BCX4430 against Zika virus in cell culture and in a mouse model"],"prefix":"10.1016","volume":"137","author":[{"given":"Justin G.","family":"Julander","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkatraman","family":"Siddharthan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ray","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsey","family":"Tolbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad","family":"Apuli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preston","family":"Collins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makda","family":"Gebre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Skot","family":"Neilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Van Wettere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3974-3405","authenticated-orcid":false,"given":"Young-Min","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8320-1323","authenticated-orcid":false,"given":"William P.","family":"Sheridan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Morrey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.S.","family":"Babu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.antiviral.2016.11.003_bib1","doi-asserted-by":"crossref","first-page":"e0004682","DOI":"10.1371\/journal.pntd.0004682","article-title":"Characterization of Lethal Zika virus infection in AG129 mice","volume":"10","author":"Aliota","year":"2016","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.antiviral.2016.11.003_bib2","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1590\/0004-282X20160035","article-title":"Guillain-Barre syndrome associated with the Zika virus outbreak in Brazil","volume":"74","author":"Araujo","year":"2016","journal-title":"Arq. Neuropsiquiatr."},{"key":"10.1016\/j.antiviral.2016.11.003_bib3","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD003510","article-title":"Antiretrovirals for reducing the risk of mother-to-child transmission of HIV infection","author":"Brocklehurst","year":"2002","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.antiviral.2016.11.003_bib4","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1097\/00042560-200204150-00009","article-title":"Combination antiretroviral strategies for the treatment of pregnant HIV-1-infected women and prevention of perinatal HIV-1 transmission","volume":"29","author":"Cooper","year":"2002","journal-title":"J.\u00a0Acquir Immune Defic. Syndr."},{"key":"10.1016\/j.antiviral.2016.11.003_bib5","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1016\/S0140-6736(16)30253-7","article-title":"Positive IgM for Zika virus in the cerebrospinal fluid of 30 neonates with microcephaly in Brazil","volume":"387","author":"Cordeiro","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.antiviral.2016.11.003_bib6","doi-asserted-by":"crossref","DOI":"10.7326\/M16-0332","article-title":"Emergence of congenital Zika syndrome: viewpoint from the front Lines","author":"Costa","year":"2016","journal-title":"Ann. Intern Med."},{"key":"10.1016\/j.antiviral.2016.11.003_bib7","doi-asserted-by":"crossref","first-page":"i1901","DOI":"10.1136\/bmj.i1901","article-title":"Clinical features and neuroimaging (CT and MRI) findings in presumed Zika virus related congenital infection and microcephaly: retrospective case series study","volume":"353","author":"de Fatima Vasco Aragao","year":"2016","journal-title":"BMJ"},{"key":"10.1016\/j.antiviral.2016.11.003_bib8","series-title":"Guillain-Barre Syndrome during Ongoing Zika Virus Transmission - Puerto Rico","first-page":"910","author":"Dirlikov","year":"2016"},{"key":"10.1016\/j.antiviral.2016.11.003_bib9","doi-asserted-by":"crossref","first-page":"e0004658","DOI":"10.1371\/journal.pntd.0004658","article-title":"A\u00a0susceptible mouse model for Zika virus infection","volume":"10","author":"Dowall","year":"2016","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.antiviral.2016.11.003_bib10","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1056\/NEJMoa1601824","article-title":"Zika virus infection with prolonged maternal viremia and fetal brain abnormalities","volume":"374","author":"Driggers","year":"2016","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.antiviral.2016.11.003_bib11","article-title":"Zika virus: a previously slow pandemic spreads rapidly through the Americas","author":"Gatherer","year":"2015","journal-title":"J.\u00a0Gen. Virol."},{"key":"10.1016\/j.antiviral.2016.11.003_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0012760","article-title":"Development of a new tacaribe arenavirus infection model and its use to explore antiviral activity of a novel aristeromycin analog","volume":"5","author":"Gowen","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.antiviral.2016.11.003_bib13","doi-asserted-by":"crossref","first-page":"12102","DOI":"10.1073\/pnas.96.21.12102","article-title":"An infection-based model of neurodevelopmental damage","volume":"96","author":"Hornig","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.antiviral.2016.11.003_bib14","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1097\/QAD.0000000000000620","article-title":"Pregnancy is associated with elevation of liver enzymes in HIV-positive women on antiretroviral therapy","volume":"29","author":"Huntington","year":"2015","journal-title":"AIDS"},{"key":"10.1016\/j.antiviral.2016.11.003_bib15","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1128\/JVI.73.1.783-786.1999","article-title":"New mouse model for dengue virus vaccine testing","volume":"73","author":"Johnson","year":"1999","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.antiviral.2016.11.003_bib16","doi-asserted-by":"crossref","first-page":"6607","DOI":"10.1128\/AAC.03368-14","article-title":"BCX4430, a novel nucleoside analog, effectively treats yellow fever in a Hamster model","volume":"58","author":"Julander","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.antiviral.2016.11.003_bib17","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1128\/AAC.01074-08","article-title":"Activity of T-705 in a hamster model of yellow fever virus infection in comparison with that of a chemically related compound, T-1106","volume":"53","author":"Julander","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.antiviral.2016.11.003_bib18","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.antiviral.2008.01.007","article-title":"C3H\/HeN mouse model for the evaluation of antiviral agents for the treatment of Venezuelan equine encephalitis virus infection","volume":"78","author":"Julander","year":"2008","journal-title":"Antivir. Res."},{"key":"10.1016\/j.antiviral.2016.11.003_bib19","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00252-16","article-title":"Zika virus: new clinical syndromes and its emergence in the Western hemisphere","author":"Lazear","year":"2016","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.antiviral.2016.11.003_bib20","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.chom.2016.03.010","article-title":"A\u00a0mouse model of Zika virus pathogenesis","volume":"19","author":"Lazear","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.antiviral.2016.11.003_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.stem.2016.10.017","article-title":"Zika virus disrupts neural progenitor development and leads to microcephaly in mice","author":"Li","year":"2016","journal-title":"Cell Stem Cell."},{"key":"10.1016\/j.antiviral.2016.11.003_bib22","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.cell.2016.05.008","article-title":"Zika virus infection during pregnancy in mice causes placental damage and fetal demise","volume":"165","author":"Miner","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.antiviral.2016.11.003_bib23","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1056\/NEJMoa1600651","article-title":"Zika virus associated with microcephaly","volume":"374","author":"Mlakar","year":"2016","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.antiviral.2016.11.003_bib24","doi-asserted-by":"crossref","first-page":"318","DOI":"10.3109\/13550284.2010.501847","article-title":"Neurological suppression of diaphragm electromyographs in hamsters infected with West Nile virus","volume":"16","author":"Morrey","year":"2010","journal-title":"J.\u00a0Neurovirol."},{"key":"10.1016\/j.antiviral.2016.11.003_bib25","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0166-3542(02)00013-X","article-title":"Identification of active antiviral compounds against a New York isolate of West Nile virus","volume":"55","author":"Morrey","year":"2002","journal-title":"Antivir. Res."},{"key":"10.1016\/j.antiviral.2016.11.003_bib26","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1590\/0074-02760160085","article-title":"Zika virus damages the human placental barrier and presents marked fetal neurotropism","volume":"111","author":"Noronha","year":"2016","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.antiviral.2016.11.003_bib27","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/(SICI)1096-9071(199802)54:2<113::AID-JMV8>3.0.CO;2-9","article-title":"Maternal viral load, CD4 cell count and vertical transmission of HIV-1","volume":"54","author":"O'Shea","year":"1998","journal-title":"J.\u00a0Med. Virol."},{"key":"10.1016\/j.antiviral.2016.11.003_bib28","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1093\/infdis\/jiu393","article-title":"HIV protease inhibitor use during pregnancy is associated with decreased progesterone levels, suggesting a potential mechanism contributing to fetal growth restriction","volume":"211","author":"Papp","year":"2015","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.antiviral.2016.11.003_bib29","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1016\/j.vaccine.2011.01.076","article-title":"Probing the attenuation and protective efficacy of a candidate chikungunya virus vaccine in mice with compromised interferon (IFN) signaling","volume":"29","author":"Partidos","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.antiviral.2016.11.003_bib30","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1002\/jmv.24563","article-title":"Zika virus: an update on epidemiology, pathology, molecular biology, and animal model","volume":"88","author":"Ramos da Silva","year":"2016","journal-title":"J.\u00a0Med. Virol."},{"key":"10.1016\/j.antiviral.2016.11.003_bib31","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1056\/NEJMsr1604338","article-title":"Zika virus and birth defects\u2013reviewing the evidence for causality","volume":"374","author":"Rasmussen","year":"2016","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.antiviral.2016.11.003_bib32","doi-asserted-by":"crossref","DOI":"10.4269\/ajtmh.16-0111","article-title":"Characterization of a novel murine model to study Zika virus","author":"Rossi","year":"2016","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.antiviral.2016.11.003_bib33","doi-asserted-by":"crossref","first-page":"4251","DOI":"10.1128\/JVI.00017-09","article-title":"Persistent West Nile virus associated with a neurological sequela in hamsters identified by motor unit number estimation","volume":"83","author":"Siddharthan","year":"2009","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.antiviral.2016.11.003_bib34","doi-asserted-by":"crossref","first-page":"3180","DOI":"10.1016\/j.vaccine.2012.03.003","article-title":"A\u00a0small animal peripheral challenge model of yellow fever using interferon-receptor deficient mice and the 17D-204 vaccine strain","volume":"30","author":"Thibodeaux","year":"2012","journal-title":"Vaccine"},{"key":"10.1016\/j.antiviral.2016.11.003_bib35","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/nature13027","article-title":"Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430","volume":"508","author":"Warren","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.antiviral.2016.11.003_bib36","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/cr.2016.58","article-title":"Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice","volume":"26","author":"Wu","year":"2016","journal-title":"Cell Res."},{"key":"10.1016\/j.antiviral.2016.11.003_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2016.08.004","article-title":"Vaginal exposure to Zika virus during pregnancy leads to fetal brain infection","volume":"166","author":"Yockey","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.antiviral.2016.11.003_bib38","doi-asserted-by":"crossref","first-page":"e0004695","DOI":"10.1371\/journal.pntd.0004695","article-title":"The viral polymerase inhibitor 7-Deaza-2'-C-Methyladenosine is a potent inhibitor of in\u00a0vitro Zika virus replication and delays disease progression in a robust mouse infection model","volume":"10","author":"Zmurko","year":"2016","journal-title":"PLoS Negl. Trop. Dis."}],"container-title":["Antiviral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166354216306659?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166354216306659?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T06:30:19Z","timestamp":1601188219000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166354216306659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":38,"alternative-id":["S0166354216306659"],"URL":"https:\/\/doi.org\/10.1016\/j.antiviral.2016.11.003","relation":{},"ISSN":["0166-3542"],"issn-type":[{"value":"0166-3542","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy of the broad-spectrum antiviral compound BCX4430 against Zika virus in cell culture and in a mouse model","name":"articletitle","label":"Article Title"},{"value":"Antiviral Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.antiviral.2016.11.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}