{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T07:22:03Z","timestamp":1794036123940,"version":"4.8.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"ZIKAlliance","award":["734548"],"award-info":[{"award-number":["734548"]}]},{"name":"Marie Sk\u0142odowska-Curie ETN \u2018ANTIVIRALS\u2019","award":["642434"],"award-info":[{"award-number":["642434"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Research"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.antiviral.2017.04.016","type":"journal-article","created":{"date-parts":[[2017,4,28]],"date-time":"2017-04-28T18:46:19Z","timestamp":1493405179000},"page":"230-236","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":92,"special_numbering":"C","title":["Suramin inhibits Zika virus replication by interfering with virus attachment and release of infectious particles"],"prefix":"10.1016","volume":"143","author":[{"given":"Irina C.","family":"Albulescu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Kovacikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Tas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3297-2309","authenticated-orcid":false,"given":"Eric J.","family":"Snijder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn J.","family":"van Hemert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.antiviral.2017.04.016_bib1","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.antiviral.2016.11.018","article-title":"Evaluation of anti-Zika virus activities of broad-spectrum antivirals and NIH clinical collection compounds using a cell-based, high-throughput screen assay","volume":"138","author":"Adcock","year":"2017","journal-title":"Antivir. Res."},{"key":"10.1016\/j.antiviral.2017.04.016_bib2","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.antiviral.2015.06.013","article-title":"Suramin inhibits chikungunya virus replication through multiple mechanisms","volume":"121","author":"Albulescu","year":"2015","journal-title":"Antivir. Res."},{"key":"10.1016\/j.antiviral.2017.04.016_bib3","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/0959-8049(95)00588-9","article-title":"Intracellular localisation of suramin, an anticancer drug, in human colon adenocarcinoma cells: a study by quantitative autoradiography","volume":"32A","author":"Baghdiguian","year":"1996","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.antiviral.2017.04.016_bib4","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.chom.2016.07.004","article-title":"A\u00a0screen of FDA-approved drugs for inhibitors of Zika virus infection","volume":"20","author":"Barrows","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.antiviral.2017.04.016_bib5","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.bbrc.2014.09.113","article-title":"Suramin inhibits helicase activity of NS3 protein of dengue virus in a fluorescence-based high throughput assay format","volume":"453","author":"Basavannacharya","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.antiviral.2017.04.016_bib6","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1089\/vbz.2014.1607","article-title":"Molecular characterization of three Zika flaviviruses obtained from sylvatic mosquitoes in the Central African Republic","volume":"14","author":"Berthet","year":"2014","journal-title":"Vector Borne Zoonotic Dis."},{"key":"10.1016\/j.antiviral.2017.04.016_bib7","first-page":"4677s","article-title":"Inhibitors of retroviral DNA polymerase: their implication in the treatment of AIDS","volume":"45","author":"Chandra","year":"1985","journal-title":"Cancer Res."},{"key":"10.1016\/j.antiviral.2017.04.016_bib8","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1038\/nm0897-866","article-title":"Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfate","volume":"3","author":"Chen","year":"1997","journal-title":"Nat. Med."},{"key":"10.1016\/j.antiviral.2017.04.016_bib9","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1016\/j.molmed.2016.09.006","article-title":"Drug repurposing: new treatments for Zika virus infection?","volume":"22","author":"Cheng","year":"2016","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.antiviral.2017.04.016_bib10","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1002\/jcp.1041320120","article-title":"Suramin inhibition of growth factor receptor binding and mitogenicity in AKR-2B cells","volume":"132","author":"Coffey","year":"1987","journal-title":"J.\u00a0Cell Physiol."},{"key":"10.1016\/j.antiviral.2017.04.016_bib11","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.chom.2016.09.011","article-title":"Zika and other emerging viruses: aiming at the right target","volume":"20","author":"Dallmeier","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.antiviral.2017.04.016_bib12","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/0304-3835(79)90017-X","article-title":"Suramin: a potent inhibitor of the reverse transcriptase of RNA tumor viruses","volume":"8","author":"De Clercq","year":"1979","journal-title":"Cancer Lett."},{"key":"10.1016\/j.antiviral.2017.04.016_bib13","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/0035-9203(52)90042-4","article-title":"Zika virus. I. Isolations and serological specificity","volume":"46","author":"Dick","year":"1952","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.antiviral.2017.04.016_bib14","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.antiviral.2016.09.010","article-title":"Flavivirus RNA transactions from viral entry to genome replication","volume":"134","author":"Garcia-Blanco","year":"2016","journal-title":"Antivir. Res."},{"key":"10.1016\/j.antiviral.2017.04.016_bib15","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1186\/s12985-016-0607-2","article-title":"Suramin is a potent inhibitor of Chikungunya and Ebola virus cell entry","volume":"13","author":"Henss","year":"2016","journal-title":"Virol. J."},{"key":"10.1016\/j.antiviral.2017.04.016_bib16","doi-asserted-by":"publisher","first-page":"e0133511","DOI":"10.1371\/journal.pone.0133511","article-title":"Suramin inhibits chikungunya virus entry and transmission","volume":"10","author":"Ho","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.antiviral.2017.04.016_bib17","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1021\/acs.biochem.6b01056","article-title":"Interaction of Zika virus envelope protein with glycosaminoglycans","volume":"56","author":"Kim","year":"2017","journal-title":"Biochemistry"},{"key":"10.1016\/j.antiviral.2017.04.016_bib18","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1007\/s00705-006-0903-z","article-title":"Full-length sequencing and genomic characterization of Bagaza, Kedougou, and Zika viruses","volume":"152","author":"Kuno","year":"2007","journal-title":"Arch. Virol."},{"key":"10.1016\/j.antiviral.2017.04.016_bib19","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.antiviral.2016.07.025","article-title":"Suramin treatment reduces chikungunya pathogenesis in mice","volume":"134","author":"Kuo","year":"2016","journal-title":"Antivir. Res."},{"key":"10.1016\/j.antiviral.2017.04.016_bib20","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1099\/vir.0.81320-0","article-title":"The glycosylation site in the envelope protein of West Nile virus (Sarafend) plays an important role in replication and maturation processes","volume":"87","author":"Li","year":"2006","journal-title":"J.\u00a0Gen. Virol."},{"key":"10.1016\/j.antiviral.2017.04.016_bib21","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1161\/CIRCRESAHA.116.309866","article-title":"AXL-mediated productive infection of human endothelial cells by Zika virus","volume":"119","author":"Liu","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.antiviral.2017.04.016_bib22","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.jmb.2012.03.008","article-title":"Structure-based inhibition of Norovirus RNA-dependent RNA polymerases","volume":"419","author":"Mastrangelo","year":"2012","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.antiviral.2017.04.016_bib23","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.celrep.2016.12.045","article-title":"Axl mediates ZIKA virus entry in human glial cells and modulates innate immune responses","volume":"18","author":"Meertens","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.antiviral.2017.04.016_bib24","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.chom.2017.01.004","article-title":"Zika virus pathogenesis and tissue tropism","volume":"21","author":"Miner","year":"2017","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.antiviral.2017.04.016_bib25","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.01.022","article-title":"Role of N-glycosylation on Zika virus E protein secretion, viral assembly and infectivity","author":"Mossenta","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.antiviral.2017.04.016_bib26","doi-asserted-by":"publisher","first-page":"8607","DOI":"10.1093\/nar\/gks623","article-title":"Identification and analysis of hepatitis C virus NS3 helicase inhibitors using nucleic acid binding assays","volume":"40","author":"Mukherjee","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.antiviral.2017.04.016_bib27","doi-asserted-by":"publisher","first-page":"e1005184","DOI":"10.1371\/journal.ppat.1005184","article-title":"The suramin derivative NF449 interacts with the 5-fold vertex of the enterovirus A71 capsid to prevent virus attachment to PSGL-1 and heparan sulfate","volume":"11","author":"Nishimura","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.antiviral.2017.04.016_bib28","doi-asserted-by":"publisher","first-page":"e62","DOI":"10.1038\/emi.2014.60","article-title":"The approved pediatric drug suramin identified as a clinical candidate for the treatment of EV71 infection-suramin inhibits EV71 infection in\u00a0vitro and in\u00a0vivo","volume":"3","author":"Ren","year":"2014","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.antiviral.2017.04.016_bib29","doi-asserted-by":"publisher","first-page":"2024","DOI":"10.1073\/pnas.1620558114","article-title":"AXL-dependent infection of human fetal endothelial cells distinguishes Zika virus from other pathogenic flaviviruses","volume":"114","author":"Richard","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.antiviral.2017.04.016_bib30","doi-asserted-by":"publisher","first-page":"e71047","DOI":"10.1371\/journal.pone.0071047","article-title":"Characterization of synthetic Chikungunya viruses based on the consensus sequence of recent E1-226V isolates","volume":"8","author":"Scholte","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.antiviral.2017.04.016_bib36","doi-asserted-by":"publisher","first-page":"4457","DOI":"10.1128\/JVI.03612-14","article-title":"Stress granule components G3BP1 and G3BP2 play a proviral role early in Chikungunya virus replication","volume":"89","author":"Scholte","year":"2015","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.antiviral.2017.04.016_bib31","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.chom.2016.07.002","article-title":"Zika virus targets different primary human placental cells, suggesting two routes for vertical transmission","volume":"20","author":"Tabata","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.antiviral.2017.04.016_bib32","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.antiviral.2013.11.016","article-title":"Naphthalene-sulfonate inhibitors of human norovirus RNA-dependent RNA-polymerase","volume":"102","author":"Tarantino","year":"2014","journal-title":"Antivir. Res."},{"key":"10.1016\/j.antiviral.2017.04.016_bib37","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-02652-w","article-title":"Quasispecies composition and evolution of a typical Zika virus clinical isolate from Suriname","author":"Van Boheemen","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.antiviral.2017.04.016_bib33","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1006\/jmcc.1996.0142","article-title":"Suramin is a potent inhibitor of vascular endothelial growth factor. A contribution to the molecular basis of its antiangiogenic action","volume":"28","author":"Waltenberger","year":"1996","journal-title":"J.\u00a0Mol. Cell Cardiol."},{"key":"10.1016\/j.antiviral.2017.04.016_bib34","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/j.bbrc.2016.06.149","article-title":"Suramin blocks interaction between human FGF1 and FGFR2 D2 domain and reduces downstream signaling activity","volume":"477","author":"Wu","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.antiviral.2017.04.016_bib35","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1038\/nm.4184","article-title":"Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen","volume":"22","author":"Xu","year":"2016","journal-title":"Nat. Med."}],"container-title":["Antiviral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166354217300931?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166354217300931?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,22]],"date-time":"2019-09-22T07:54:37Z","timestamp":1569138877000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166354217300931"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":37,"alternative-id":["S0166354217300931"],"URL":"https:\/\/doi.org\/10.1016\/j.antiviral.2017.04.016","relation":{},"ISSN":["0166-3542"],"issn-type":[{"value":"0166-3542","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Suramin inhibits Zika virus replication by interfering with virus attachment and release of infectious particles","name":"articletitle","label":"Article Title"},{"value":"Antiviral Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.antiviral.2017.04.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}