{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T07:56:44Z","timestamp":1773388604580,"version":"3.50.1"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31370873"],"award-info":[{"award-number":["31370873"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31570865"],"award-info":[{"award-number":["31570865"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Program of 1000 Young Talents","award":["31501139"],"award-info":[{"award-number":["31501139"]}]},{"name":"Jiangsu Provincial Distinguished Young Scholars","award":["BK20130004"],"award-info":[{"award-number":["BK20130004"]}]},{"DOI":"10.13039\/501100005240","name":"Ministry of Education of China","doi-asserted-by":"publisher","award":["PCSIRT-IRT1075"],"award-info":[{"award-number":["PCSIRT-IRT1075"]}],"id":[{"id":"10.13039\/501100005240","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Research"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1016\/j.antiviral.2017.06.002","type":"journal-article","created":{"date-parts":[[2017,6,3]],"date-time":"2017-06-03T06:15:18Z","timestamp":1496470518000},"page":"120-129","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Ubiquitin C-terminal hydrolase-L3 promotes interferon antiviral activity by stabilizing type I-interferon receptor"],"prefix":"10.1016","volume":"144","author":[{"given":"Peng","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiao","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yibo","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Miao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhua","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.antiviral.2017.06.002_bib1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/nrd3321","article-title":"Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets. Nature reviews","volume":"10","author":"Bedford","year":"2011","journal-title":"Drug Discov."},{"key":"10.1016\/j.antiviral.2017.06.002_bib2","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nrd2422","article-title":"Interferons at age 50: past, current and future impact on biomedicine. Nature reviews","volume":"6","author":"Borden","year":"2007","journal-title":"Drug Discov."},{"key":"10.1016\/j.antiviral.2017.06.002_bib3","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1126\/science.1075901","article-title":"Role of predicted metalloprotease motif of Jab1\/Csn5 in cleavage of Nedd8 from Cul1","volume":"298","author":"Cope","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.antiviral.2017.06.002_bib4","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1111\/j.1462-5822.2007.00896.x","article-title":"Apicomplexan UCHL3 retains dual specificity for ubiquitin and Nedd8 throughout evolution","volume":"9","author":"Frickel","year":"2007","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.antiviral.2017.06.002_bib5","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.virol.2005.09.024","article-title":"The interferon response circuit: induction and suppression by pathogenic viruses","volume":"344","author":"Haller","year":"2006","journal-title":"Virology"},{"key":"10.1016\/j.antiviral.2017.06.002_bib6","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1600-065X.2012.01098.x","article-title":"Regulation of NF-kappaB by ubiquitination and degradation of the IkappaBs","volume":"246","author":"Kanarek","year":"2012","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.antiviral.2017.06.002_bib7","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev.immunol.18.1.621","article-title":"Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity","volume":"18","author":"Karin","year":"2000","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.antiviral.2017.06.002_bib8","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.febslet.2011.03.053","article-title":"Ubiquitin C-terminal hydrolase-L3 regulates Smad1 ubiquitination and osteoblast differentiation","volume":"585","author":"Kim","year":"2011","journal-title":"FEBS Lett."},{"key":"10.1016\/j.antiviral.2017.06.002_bib9","doi-asserted-by":"crossref","first-page":"46614","DOI":"10.1074\/jbc.M407082200","article-title":"Phosphorylation and specific ubiquitin acceptor sites are required for ubiquitination and degradation of the IFNAR1 subunit of type I interferon receptor","volume":"279","author":"Kumar","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.antiviral.2017.06.002_bib10","doi-asserted-by":"crossref","first-page":"24974","DOI":"10.1074\/jbc.M116.737098","article-title":"Ubiquitin-dependent turnover of adenosine deaminase acting on RNA 1 (ADAR1) is required for efficient antiviral activity of type I interferon","volume":"291","author":"Li","year":"2016","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.antiviral.2017.06.002_bib11","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1002\/jcp.22876","article-title":"Essential role of maternal UCHL1 and UCHL3 in fertilization and preimplantation embryo development","volume":"227","author":"Mtango","year":"2012","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.antiviral.2017.06.002_bib12","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1002\/jcp.22931","article-title":"Essential role of ubiquitin C-terminal hydrolases UCHL1 and UCHL3 in mammalian oocyte maturation","volume":"227","author":"Mtango","year":"2012","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.antiviral.2017.06.002_bib13","doi-asserted-by":"crossref","first-page":"30969","DOI":"10.1074\/jbc.M113.485847","article-title":"Jun activation domain-binding protein 1 (JAB1) is required for the optimal response to interferons","volume":"288","author":"Muromoto","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.antiviral.2017.06.002_bib14","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1038\/nature04839","article-title":"CRD-BP mediates stabilization of betaTrCP1 and c-myc mRNA in response to beta-catenin signalling","volume":"441","author":"Noubissi","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.antiviral.2017.06.002_bib15","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1146\/annurev.bi.56.070187.003455","article-title":"Interferons and their actions","volume":"56","author":"Pestka","year":"1987","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.antiviral.2017.06.002_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1099\/vir.0.83391-0","article-title":"Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures","volume":"89","author":"Randall","year":"2008","journal-title":"J.\u00a0General Virol."},{"key":"10.1016\/j.antiviral.2017.06.002_bib17","doi-asserted-by":"crossref","first-page":"e1005764","DOI":"10.1371\/journal.ppat.1005764","article-title":"Deubiquitinase USP2a sustains interferons antiviral activity by restricting ubiquitination of activated STAT1 in the nucleus","volume":"12","author":"Ren","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.antiviral.2017.06.002_bib18","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1146\/annurev.biochem.78.082307.091526","article-title":"Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes","volume":"78","author":"Reyes-Turcu","year":"2009","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.antiviral.2017.06.002_bib19","first-page":"559","article-title":"Interferon-inducible antiviral effectors. Nature reviews","volume":"8","author":"Sadler","year":"2008","journal-title":"Immunology"},{"key":"10.1016\/j.antiviral.2017.06.002_bib20","doi-asserted-by":"crossref","first-page":"132","DOI":"10.2353\/ajpath.2006.060085","article-title":"Photoreceptor cell apoptosis in the retinal degeneration of Uchl3-deficient mice","volume":"169","author":"Sano","year":"2006","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.antiviral.2017.06.002_bib21","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.neuint.2010.03.021","article-title":"Skeletal muscles of Uchl3 knockout mice show polyubiquitinated protein accumulation and stress responses","volume":"56","author":"Setsuie","year":"2010","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.antiviral.2017.06.002_bib22","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.bbrc.2014.08.144","article-title":"Ubiquitin C-terminal hydrolase-L3 regulates EMT process and cancer metastasis in prostate cell lines","volume":"452","author":"Song","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.antiviral.2017.06.002_bib23","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.cell.2009.04.042","article-title":"Defining the human deubiquitinating enzyme interaction landscape","volume":"138","author":"Sowa","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.antiviral.2017.06.002_bib24","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1006\/bbrc.1998.9532","article-title":"Cleavage of the C-terminus of NEDD8 by UCH-L3","volume":"251","author":"Wada","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.antiviral.2017.06.002_bib25","doi-asserted-by":"crossref","first-page":"e0165198","DOI":"10.1371\/journal.pone.0165198","article-title":"Ubiquitin carboxy-terminal HydrolaseL3 correlates with human sperm count, motility and fertilization","volume":"11","author":"Wang","year":"2016","journal-title":"PloS One"},{"key":"10.1016\/j.antiviral.2017.06.002_bib26","first-page":"233","article-title":"Roles of F-box proteins in cancer. Nature reviews","volume":"14","author":"Wang","year":"2014","journal-title":"Cancer"},{"key":"10.1016\/j.antiviral.2017.06.002_bib27","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jgg.2013.02.001","article-title":"Role of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases in skin cancer","volume":"40","author":"Xie","year":"2013","journal-title":"J.\u00a0Genet. Genomics\u00a0= Yi chuan xue bao"}],"container-title":["Antiviral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166354217300086?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166354217300086?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,26]],"date-time":"2022-06-26T05:51:04Z","timestamp":1656222664000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166354217300086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":27,"alternative-id":["S0166354217300086"],"URL":"https:\/\/doi.org\/10.1016\/j.antiviral.2017.06.002","relation":{},"ISSN":["0166-3542"],"issn-type":[{"value":"0166-3542","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ubiquitin C-terminal hydrolase-L3 promotes interferon antiviral activity by stabilizing type I-interferon receptor","name":"articletitle","label":"Article Title"},{"value":"Antiviral Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.antiviral.2017.06.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}