{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T19:23:03Z","timestamp":1777576983164,"version":"3.51.4"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST105-2321-B-007-006"],"award-info":[{"award-number":["MOST105-2321-B-007-006"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST104-2321-B-007-006"],"award-info":[{"award-number":["MOST104-2321-B-007-006"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Research"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.antiviral.2017.09.014","type":"journal-article","created":{"date-parts":[[2017,9,22]],"date-time":"2017-09-22T18:15:39Z","timestamp":1506104139000},"page":"213-220","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Recombinant hemagglutinin proteins formulated in a novel PELC\/CpG adjuvant for H7N9 subunit vaccine development"],"prefix":"10.1016","volume":"146","author":[{"given":"Ting-Hsuan","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5373-867X","authenticated-orcid":false,"given":"Ying-Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9721-0017","authenticated-orcid":false,"given":"Jia-Tsrong","family":"Jan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Hsi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maureen","family":"Spearman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Butler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suh-Chin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.antiviral.2017.09.014_bib1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0168-1702(01)00272-6","article-title":"Glycosylation of haemagglutinin and stalk-length of neuraminidase combine to regulate the growth of avian influenza viruses in tissue culture","volume":"79","author":"Baigent","year":"2001","journal-title":"Virus Res."},{"key":"10.1016\/j.antiviral.2017.09.014_bib2","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3008761","article-title":"A cell culture-derived MF59-adjuvanted pandemic A\/H7N9 vaccine is immunogenic in adults","volume":"6","author":"Bart","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.antiviral.2017.09.014_bib3","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1128\/JVI.02553-15","article-title":"Changes in the length of the neuraminidase stalk region impact H7N9 virulence in mice","volume":"90","author":"Bi","year":"2016","journal-title":"J. Virol."},{"key":"10.1016\/j.antiviral.2017.09.014_bib4","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.vaccine.2015.12.062","article-title":"A highly immunogenic vaccine against A\/H7N9 influenza virus","volume":"34","author":"Cao","year":"2016","journal-title":"Vaccine"},{"key":"10.1016\/j.antiviral.2017.09.014_bib5","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.cellimm.2016.04.004","article-title":"RIG-I ligand enhances the immunogenicity of recombinant H7HA protein","volume":"304\u2013305","author":"Cao","year":"2016","journal-title":"Cell Immunol."},{"key":"10.1016\/j.antiviral.2017.09.014_bib6","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1016\/S0140-6736(13)60903-4","article-title":"Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome","volume":"381","author":"Chen","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.antiviral.2017.09.014_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0120793","article-title":"Evaluation of MDCK cell-derived influenza H7N9 vaccine candidates in ferrets","volume":"10","author":"Chia","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.antiviral.2017.09.014_bib8","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.1038\/srep03058","article-title":"Adaptation of novel H7N9 influenza A virus to human receptors","volume":"3","author":"Dortmans","year":"2013","journal-title":"Sci. Rep."},{"key":"10.1016\/j.antiviral.2017.09.014_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0099322","article-title":"Response of mice and ferrets to a monovalent influenza A (H7N9) split vaccine","volume":"9","author":"Duan","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.antiviral.2017.09.014_bib10","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1056\/NEJMoa1305584","article-title":"Clinical findings in 111 cases of influenza A (H7N9) virus infection","volume":"368","author":"Gao","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.antiviral.2017.09.014_bib11","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1056\/NEJMoa1304459","article-title":"Human infection with a novel avian-origin influenza A (H7N9) virus","volume":"368","author":"Gao","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.antiviral.2017.09.014_bib12","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/nrmicro1208","article-title":"Influenza: lessons from past pandemics, warnings from current incidents","volume":"3","author":"Horimoto","year":"2005","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.antiviral.2017.09.014_bib13","doi-asserted-by":"crossref","first-page":"36732","DOI":"10.1038\/srep36732","article-title":"Degradable emulsion as vaccine adjuvant reshapes antigen-specific immunity and thereby ameliorates vaccine efficacy","volume":"6","author":"Huang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.antiviral.2017.09.014_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0012279","article-title":"Emulsified nanoparticles containing inactivated influenza virus and CpG oligodeoxynucleotides critically influences the host immune responses in mice","volume":"5","author":"Huang","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.antiviral.2017.09.014_bib15","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2017.22.13.30496","article-title":"Significantly elevated number of human infections with H7N9 virus in Jiangsu in eastern China, October 2016 to January 2017","volume":"22","author":"Huo","year":"2017","journal-title":"Euro Surveill."},{"key":"10.1016\/j.antiviral.2017.09.014_bib16","doi-asserted-by":"crossref","first-page":"254","DOI":"10.15585\/mmwr.mm6609e2","article-title":"Increase in human infections with avian influenza A(H7N9) virus during the fifth epidemic - China, October 2016-February 2017","volume":"66","author":"Iuliano","year":"2017","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"10.1016\/j.antiviral.2017.09.014_bib17","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1001\/jama.2015.7916","article-title":"Effect of varying doses of a monovalent H7N9 influenza vaccine with and without AS03 and MF59 adjuvants on immune response: a randomized clinical trial","volume":"314","author":"Jackson","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.antiviral.2017.09.014_bib18","doi-asserted-by":"crossref","first-page":"6421","DOI":"10.1016\/j.vaccine.2014.09.049","article-title":"H5 N-terminal beta sheet promotes oligomerization of H7-HA1 that induces better antibody affinity maturation and enhanced protection against H7N7 and H7N9 viruses compared to inactivated influenza vaccine","volume":"32","author":"Khurana","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.antiviral.2017.09.014_bib19","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.vaccine.2013.11.036","article-title":"One-shot vaccination with an insect cell-derived low-dose influenza A H7 virus-like particle preparation protects mice against H7N9 challenge","volume":"32","author":"Klausberger","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.antiviral.2017.09.014_bib20","doi-asserted-by":"crossref","first-page":"3976","DOI":"10.1128\/JVI.03095-13","article-title":"Divergent H7 immunogens offer protection from H7N9 virus challenge","volume":"88","author":"Krammer","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.antiviral.2017.09.014_bib21","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1093\/infdis\/jiu528","article-title":"A single immunization with modified vaccinia virus Ankara-based influenza virus H7 vaccine affords protection in the influenza A(H7N9) pneumonia ferret model","volume":"211","author":"Kreijtz","year":"2015","journal-title":"J. Infect. Dis."},{"issue":"11","key":"10.1016\/j.antiviral.2017.09.014_bib22","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.02259-16","article-title":"Evaluation of the immune responses to and cross-protective efficacy of Eurasian H7 avian influenza viruses","volume":"91","author":"Kwon","year":"2017","journal-title":"J. Virol."},{"key":"10.1016\/j.antiviral.2017.09.014_bib23","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/nature12515","article-title":"The genesis and source of the H7N9 influenza viruses causing human infections in China","volume":"502","author":"Lam","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.antiviral.2017.09.014_bib24","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s11427-013-4491-3","article-title":"Environmental connections of novel avian-origin H7N9 influenza virus infection and virus adaptation to the human","volume":"56","author":"Li","year":"2013","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.antiviral.2017.09.014_bib25","article-title":"Recombinant trimeric HA protein immunogenicity of H5N1 avian influenza viruses and their combined use with inactivated or adenovirus vaccines","volume":"6","author":"Lin","year":"2011","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.antiviral.2017.09.014_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0066719","article-title":"Different immunity elicited by recombinant H5N1 hemagglutinin proteins containing pauci-mannose, high-mannose, or complex type N-glycans","volume":"8","author":"Lin","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.antiviral.2017.09.014_bib27","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1016\/S0140-6736(13)60938-1","article-title":"Origin and diversity of novel avian influenza A H7N9 viruses causing human infection: phylogenetic, structural, and coalescent analyses","volume":"381","author":"Liu","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.antiviral.2017.09.014_bib28","doi-asserted-by":"crossref","first-page":"8153","DOI":"10.1128\/JVI.00894-14","article-title":"Analysis of recombinant H7N9 wild-type and mutant viruses in pigs shows that the Q226L mutation in HA is important for transmission","volume":"88","author":"Liu","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.antiviral.2017.09.014_bib29","doi-asserted-by":"crossref","first-page":"7224","DOI":"10.1128\/JVI.00585-15","article-title":"Cross-reactive neuraminidase-inhibiting antibodies elicited by immunization with recombinant neuraminidase proteins of H5N1 and pandemic H1N1 influenza a viruses","volume":"89","author":"Liu","year":"2015","journal-title":"J. Virol."},{"key":"10.1016\/j.antiviral.2017.09.014_bib30","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1016\/j.vaccine.2015.03.009","article-title":"Recombinant virus-like particles elicit protective immunity against avian influenza A(H7N9) virus infection in ferrets","volume":"33","author":"Liu","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.antiviral.2017.09.014_bib31","doi-asserted-by":"crossref","first-page":"8496","DOI":"10.1128\/JVI.00880-16","article-title":"Unmasking stem-specific neutralizing epitopes by abolishing N-Linked glycosylation sites of influenza virus hemagglutinin proteins for vaccine design","volume":"90","author":"Liu","year":"2016","journal-title":"J. Virol."},{"key":"10.1016\/j.antiviral.2017.09.014_bib32","doi-asserted-by":"crossref","first-page":"6085","DOI":"10.1128\/JVI.00452-16","article-title":"Influenza virus hemagglutinin glycoproteins with different N-Glycan patterns activate dendritic cells in vitro","volume":"90","author":"Liu","year":"2016","journal-title":"J. Virol."},{"key":"10.1016\/j.antiviral.2017.09.014_bib33","doi-asserted-by":"crossref","first-page":"12011","DOI":"10.1128\/JVI.01316-10","article-title":"Dendritic cell activation by recombinant hemagglutinin proteins of H1N1 and H5N1 influenza A viruses","volume":"84","author":"Liu","year":"2010","journal-title":"J. Virol."},{"issue":"11","key":"10.1016\/j.antiviral.2017.09.014_bib34","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1093\/infdis\/jiw414","article-title":"Immunogenicity and safety of an AS03-adjuvanted H7N9 pandemic influenza vaccine in a randomized trial in healthy adults","volume":"214","author":"Madan","year":"2016","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.antiviral.2017.09.014_bib35","doi-asserted-by":"crossref","first-page":"5928","DOI":"10.1128\/JVI.00130-16","article-title":"Multiple natural substitutions in avian influenza a virus PB2 facilitate efficient replication in human cells","volume":"90","author":"Manz","year":"2016","journal-title":"J. Virol."},{"key":"10.1016\/j.antiviral.2017.09.014_bib36","doi-asserted-by":"crossref","first-page":"3568","DOI":"10.1128\/JVI.02740-13","article-title":"Amino acid substitutions in polymerase basic protein 2 gene contribute to the pathogenicity of the novel A\/H7N9 influenza virus in mammalian hosts","volume":"88","author":"Mok","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.antiviral.2017.09.014_bib37","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1001\/jama.2014.12854","article-title":"Serological responses to an avian influenza A\/H7N9 vaccine mixed at the point-of-use with MF59 adjuvant: a randomized clinical trial","volume":"312","author":"Mulligan","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.antiviral.2017.09.014_bib38","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1016\/j.vaccine.2016.03.037","article-title":"Analysis of the immunogenicity and bioactivities of a split influenza A\/H7N9 vaccine mixed with MF59 adjuvant in BALB\/c mice","volume":"34","author":"Ou","year":"2016","journal-title":"Vaccine"},{"key":"10.1016\/j.antiviral.2017.09.014_bib39","doi-asserted-by":"crossref","first-page":"6282","DOI":"10.1016\/j.vaccine.2015.09.065","article-title":"Plant-derived H7 VLP vaccine elicits protective immune response against H7N9 influenza virus in mice and ferrets","volume":"33","author":"Pillet","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.antiviral.2017.09.014_bib40","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.antiviral.2014.06.017","article-title":"Cross-protective efficacy of baculovirus displayed hemagglutinin against highly pathogenic influenza H7 subtypes","volume":"109","author":"Prabakaran","year":"2014","journal-title":"Antivir. Res."},{"key":"10.1016\/j.antiviral.2017.09.014_bib41","first-page":"125","article-title":"Detailed structural analysis of N-glycans released from glycoproteins in SDS-PAGE gel bands using HPLC combined with exoglycosidase array digestions","volume":"347","author":"Royle","year":"2006","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.antiviral.2017.09.014_bib42","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1016\/j.vaccine.2016.04.081","article-title":"Toward understanding the mechanism underlying the strong adjuvant activity of aluminum salt nanoparticles","volume":"34","author":"Ruwona","year":"2016","journal-title":"Vaccine"},{"key":"10.1016\/j.antiviral.2017.09.014_bib43","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1126\/science.1242917","article-title":"Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses","volume":"342","author":"Shi","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.antiviral.2017.09.014_bib44","doi-asserted-by":"crossref","first-page":"4305","DOI":"10.1016\/j.vaccine.2013.07.043","article-title":"Development of influenza H7N9 virus like particle (VLP) vaccine: homologous A\/Anhui\/1\/2013 (H7N9) protection and heterologous A\/chicken\/Jalisco\/CPA1\/2012 (H7N3) cross-protection in vaccinated mice challenged with H7N9 virus","volume":"31","author":"Smith","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.antiviral.2017.09.014_bib45","article-title":"Immunopotentiation of different adjuvants on humoral and cellular immune responses induced by HA1-2 subunit vaccines of H7N9 influenza in mice","volume":"11","author":"Song","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.antiviral.2017.09.014_bib46","doi-asserted-by":"crossref","first-page":"5509","DOI":"10.1038\/ncomms6509","article-title":"The K526R substitution in viral protein PB2 enhances the effects of E627K on influenza virus replication","volume":"5","author":"Song","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.antiviral.2017.09.014_bib47","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jconrel.2013.10.027","article-title":"A novel emulsion-type adjuvant containing CpG oligodeoxynucleotides enhances CD8+ T-cell-mediated anti-tumor immunity","volume":"173","author":"Song","year":"2014","journal-title":"J. Control Release"},{"key":"10.1016\/j.antiviral.2017.09.014_bib48","doi-asserted-by":"crossref","first-page":"4269","DOI":"10.1073\/pnas.1116200109","article-title":"A distinct lineage of influenza A virus from bats","volume":"109","author":"Tong","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.antiviral.2017.09.014_bib49","doi-asserted-by":"crossref","first-page":"5561","DOI":"10.1128\/JVI.03173-15","article-title":"Two outbreak sources of influenza a (H7N9) viruses have been established in China","volume":"90","author":"Wang","year":"2016","journal-title":"J. Virol."},{"key":"10.1016\/j.antiviral.2017.09.014_bib50","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1038\/srep02318","article-title":"Towards a better understanding of the novel avian-origin H7N9 influenza A virus in China","volume":"3","author":"Wang","year":"2013","journal-title":"Sci. Rep."},{"key":"10.1016\/j.antiviral.2017.09.014_bib51","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nature12392","article-title":"Characterization of H7N9 influenza A viruses isolated from humans","volume":"501","author":"Watanabe","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.antiviral.2017.09.014_bib52","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0113963","article-title":"Immunogenicity and protective efficacy of a Vero cell culture-derived whole-virus H7N9 vaccine in mice and guinea pigs","volume":"10","author":"Wodal","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.antiviral.2017.09.014_bib53","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1093\/infdis\/jiv099","article-title":"Impact of adjuvants on the immunogenicity and efficacy of split-virion H7N9 vaccine in ferrets","volume":"212","author":"Wong","year":"2015","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.antiviral.2017.09.014_bib54","doi-asserted-by":"crossref","first-page":"4485","DOI":"10.1016\/j.vaccine.2014.06.043","article-title":"Squalene-adjuvanted H7N9 virus vaccine induces robust humoral immune response against H7N9 and H7N7 viruses","volume":"32","author":"Wu","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.antiviral.2017.09.014_bib55","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/nature12372","article-title":"Receptor binding by an H7N9 influenza virus from humans","volume":"499","author":"Xiong","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.antiviral.2017.09.014_bib56","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.virol.2014.01.016","article-title":"Rapid adaptation of avian H7N9 virus in pigs","volume":"452\u2013453","author":"Xu","year":"2014","journal-title":"Virology"},{"key":"10.1016\/j.antiviral.2017.09.014_bib57","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1099\/vir.0.061721-0","article-title":"The PB2 E627K mutation contributes to the high polymerase activity and enhanced replication of H7N9 influenza virus","volume":"95","author":"Zhang","year":"2014","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.antiviral.2017.09.014_bib58","doi-asserted-by":"crossref","first-page":"6","DOI":"10.5365\/wpsar.2017.8.1.001","article-title":"Sudden increase in human infection with avian influenza A(H7N9) virus in China, September-December 2016","volume":"8","author":"Zhou","year":"2017","journal-title":"West. Pac Surveill. Response J."},{"key":"10.1016\/j.antiviral.2017.09.014_bib59","doi-asserted-by":"crossref","first-page":"14170","DOI":"10.1038\/srep14170","article-title":"Dual E627K and D701N mutations in the PB2 protein of A(H7N9) influenza virus increased its virulence in mammalian models","volume":"5","author":"Zhu","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.antiviral.2017.09.014_bib60","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1073\/pnas.1218509110","article-title":"Hemagglutinin homologue from H17N10 bat influenza virus exhibits divergent receptor-binding and pH-dependent fusion activities","volume":"110","author":"Zhu","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Antiviral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166354217304187?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166354217304187?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T14:53:07Z","timestamp":1575384787000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166354217304187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":60,"alternative-id":["S0166354217304187"],"URL":"https:\/\/doi.org\/10.1016\/j.antiviral.2017.09.014","relation":{},"ISSN":["0166-3542"],"issn-type":[{"value":"0166-3542","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Recombinant hemagglutinin proteins formulated in a novel PELC\/CpG adjuvant for H7N9 subunit vaccine development","name":"articletitle","label":"Article Title"},{"value":"Antiviral Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.antiviral.2017.09.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}