{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T14:23:14Z","timestamp":1789741394358,"version":"4.0.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01AI095499"],"award-info":[{"award-number":["R01AI095499"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["U19AI109740"],"award-info":[{"award-number":["U19AI109740"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["3T32AI007245-33S1"],"award-info":[{"award-number":["3T32AI007245-33S1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Research"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.antiviral.2017.10.014","type":"journal-article","created":{"date-parts":[[2017,10,17]],"date-time":"2017-10-17T02:00:16Z","timestamp":1508205616000},"page":"124-130","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Antiviral activity of N-(4-hydroxyphenyl) retinamide (4-HPR) against Zika virus"],"prefix":"10.1016","volume":"147","author":[{"given":"Jared D.","family":"Pitts","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pi-Chun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0682-3054","authenticated-orcid":false,"given":"Melissanne","family":"de Wispelaere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7456-2557","authenticated-orcid":false,"given":"Priscilla L.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.antiviral.2017.10.014_bib1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1128\/AAC.04177-14","article-title":"The bioactive lipid 4-hydroxyphenyl retinamide inhibits flavivirus replication","volume":"59","author":"Carocci","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.antiviral.2017.10.014_bib2","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1021\/acsinfecdis.6b00086","article-title":"Desmosterol increases lipid bilayer fluidity during hepatitis C virus infection","volume":"2","author":"Costello","year":"2016","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.antiviral.2017.10.014_bib3","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.molcel.2015.07.023","article-title":"Tracking distinct RNA populations using efficient and reversible covalent chemistry","volume":"59","author":"Duffy","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.antiviral.2017.10.014_bib4","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/cpch.12","article-title":"Enriching s(4) U-RNA using methane thiosulfonate (MTS) chemistry","volume":"8","author":"Duffy","year":"2016","journal-title":"Curr. Protoc. Chem. Biol."},{"key":"10.1016\/j.antiviral.2017.10.014_bib5","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1016\/j.celrep.2017.01.056","article-title":"Frequent Zika virus sexual transmission and prolonged viral RNA shedding in an immunodeficient mouse model","volume":"18","author":"Duggal","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.antiviral.2017.10.014_bib6","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/978-1-62703-601-6_6","article-title":"High resolution gene expression profiling of RNA synthesis, processing, and decay by metabolic labeling of newly transcribed RNA using 4-thiouridine","volume":"1064","author":"D\u00f6lken","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.antiviral.2017.10.014_bib7","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1261\/rna.1136108","article-title":"High-resolution gene expression profiling for simultaneous kinetic parameter analysis of RNA synthesis and decay","volume":"14","author":"D\u00f6lken","year":"2008","journal-title":"RNA"},{"key":"10.1016\/j.antiviral.2017.10.014_bib8","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1056\/NEJMc1604449","article-title":"Evidence of sexual transmission of Zika virus","volume":"374","author":"D'Ortenzio","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.antiviral.2017.10.014_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.antiviral.2016.03.006","article-title":"Novel dengue virus inhibitor 4-HPR activates ATF4 independent of protein kinase R-like Endoplasmic Reticulum Kinase and elevates levels of eIF2\u03b1 phosphorylation in virus infected cells","volume":"130","author":"Fraser","year":"2016","journal-title":"Antivir. Res."},{"key":"10.1016\/j.antiviral.2017.10.014_bib10","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1093\/infdis\/jiu319","article-title":"A nuclear transport inhibitor that modulates the unfolded protein response and provides in vivo protection against lethal dengue virus infection","volume":"210","author":"Fraser","year":"2014","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.antiviral.2017.10.014_bib11","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/nature20556","article-title":"Zika virus infection damages the testes in mice","volume":"540","author":"Govero","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.antiviral.2017.10.014_bib12","doi-asserted-by":"crossref","first-page":"17345","DOI":"10.1073\/pnas.1010811107","article-title":"Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis","volume":"107","author":"Heaton","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.antiviral.2017.10.014_bib13","doi-asserted-by":"crossref","first-page":"4611","DOI":"10.1128\/JVI.73.6.4611-4621.1999","article-title":"Genetic interaction of flavivirus nonstructural proteins NS1 and NS4A as a determinant of replicase function","volume":"73","author":"Lindenbach","year":"1999","journal-title":"J. Virol."},{"key":"10.1016\/j.antiviral.2017.10.014_bib14","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/j.cell.2016.11.016","article-title":"Zika virus causes testis damage and leads to male infertility in mice","volume":"167","author":"Ma","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.antiviral.2017.10.014_bib15","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s10633-008-9132-y","article-title":"Total rod ERG suppression with high dose compassionate Fenretinide usage","volume":"117","author":"Marmor","year":"2008","journal-title":"Doc. Ophthalmol."},{"key":"10.1016\/j.antiviral.2017.10.014_bib16","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1097\/IAE.0b013e318265801d","article-title":"Investigation of oral fenretinide for treatment of geographic atrophy in age-related macular degeneration","volume":"33","author":"Mata","year":"2013","journal-title":"Retina (Philadelphia, Pa.)"},{"key":"10.1016\/j.antiviral.2017.10.014_bib17","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1007\/s00280-009-1228-x","article-title":"A phase II study of fenretinide in patients with hormone refractory prostate cancer: a trial of the cancer Therapeutics research group","volume":"66","author":"Moore","year":"2010","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.antiviral.2017.10.014_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmi.2017.07.006","article-title":"Detection of Zika virus RNA in semen of asymptomatic blood donors","author":"Musso","year":"2017","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.antiviral.2017.10.014_bib19","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3201\/eid2102.141363","article-title":"Potential sexual transmission of Zika virus","volume":"21","author":"Musso","year":"2015","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.antiviral.2017.10.014_bib20","article-title":"Persistence of Zika virus in semen 93 days after the onset of symptoms","author":"Oliveira Souto","year":"2016","journal-title":"Enferm. Infecc. Microbiol. Clin."},{"key":"10.1016\/j.antiviral.2017.10.014_bib21","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMoa1613108","article-title":"Persistence of Zika virus in body fluids - preliminary report","author":"Paz-Bailey","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.antiviral.2017.10.014_bib22","doi-asserted-by":"crossref","first-page":"14226","DOI":"10.1074\/jbc.M111.222703","article-title":"Dengue virus modulates the unfolded protein response in a time-dependent manner","volume":"286","author":"Pe\u00f1a","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"Suppl 1","key":"10.1016\/j.antiviral.2017.10.014_bib23","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1007\/s12032-010-9682-1","article-title":"Phase III double-blind, placebo-controlled, prospective randomized trial of adjuvant tamoxifen vs. tamoxifen and fenretinide in postmenopausal women with positive receptors (EB193): an intergroup trial coordinated by the eastern cooperative oncology group","volume":"28","author":"Rao","year":"2011","journal-title":"Med. Oncol."},{"key":"10.1016\/j.antiviral.2017.10.014_bib24","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s10637-009-9228-6","article-title":"Phase II trial of fenretinide (NSC 374551) in patients with recurrent small cell lung cancer","volume":"27","author":"Schneider","year":"2009","journal-title":"Invest New Drugs"},{"key":"10.1016\/j.antiviral.2017.10.014_bib33","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"7","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.antiviral.2017.10.014_bib25","doi-asserted-by":"crossref","first-page":"856","DOI":"10.3201\/eid2305.161538","article-title":"Persistence of Zika virus in breast milk after infection in late stage of pregnancy","volume":"23","author":"Sotelo","year":"2017","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.antiviral.2017.10.014_bib26","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.cell.2015.10.046","article-title":"Defining Hsp70 subnetworks in dengue virus replication reveals key vulnerability in flavivirus infection","volume":"163","author":"Taguwa","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.antiviral.2017.10.014_bib27","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1126\/science.1201396","article-title":"Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis","volume":"332","author":"Tsaytler","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.antiviral.2017.10.014_bib28","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1743-422X-4-91","article-title":"Dengue virus serotype infection specifies the activation of the unfolded protein response","volume":"4","author":"Umareddy","year":"2007","journal-title":"Virol. J."},{"key":"10.1016\/j.antiviral.2017.10.014_bib29","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1093\/jnci\/91.21.1847","article-title":"Randomized trial of fenretinide to prevent second breast malignancy in women with early breast cancer","volume":"91","author":"Veronesi","year":"1999","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.antiviral.2017.10.014_bib30","doi-asserted-by":"crossref","first-page":"6858","DOI":"10.1158\/1078-0432.CCR-11-0995","article-title":"Phase II study of oral capsular 4-hydroxyphenylretinamide (4-HPR\/fenretinide) in pediatric patients with refractory or recurrent neuroblastoma: a report from the children's oncology group","volume":"17","author":"Villablanca","year":"2011","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.antiviral.2017.10.014_bib31","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jchromb.2004.02.031","article-title":"Liquid chromatography method for quantifying N-(4-hydroxyphenyl)retinamide and N-(4-methoxyphenyl) retinamide in tissues","volume":"808","author":"Vratilova","year":"2004","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.antiviral.2017.10.014_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2017.10.016","article-title":"Nuclear import inhibitor N-(4-hydroxyphenyl) retinamide targets Zika virus (ZIKV) nonstructural protein 5 to inhibit ZIKV infection","author":"Wang","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Antiviral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166354217306137?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166354217306137?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T00:50:41Z","timestamp":1603155041000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166354217306137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":33,"alternative-id":["S0166354217306137"],"URL":"https:\/\/doi.org\/10.1016\/j.antiviral.2017.10.014","relation":{},"ISSN":["0166-3542"],"issn-type":[{"value":"0166-3542","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antiviral activity of N-(4-hydroxyphenyl) retinamide (4-HPR) against Zika virus","name":"articletitle","label":"Article Title"},{"value":"Antiviral Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.antiviral.2017.10.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}