{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T12:11:39Z","timestamp":1778674299225,"version":"3.51.4"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CPII014\/00025"],"award-info":[{"award-number":["CPII014\/00025"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["RETIC RD12\/0017\/0029"],"award-info":[{"award-number":["RETIC RD12\/0017\/0029"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["RD12\/0025\/0020"],"award-info":[{"award-number":["RD12\/0025\/0020"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PT13\/0010\/0028"],"award-info":[{"award-number":["PT13\/0010\/0028"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["RD12\/0017\/0037"],"award-info":[{"award-number":["RD12\/0017\/0037"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Research"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.antiviral.2017.12.002","type":"journal-article","created":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T03:14:49Z","timestamp":1512530089000},"page":"15-19","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Association of heterozygous CCR5\u039432 deletion with survival in HIV-infection: A cohort study"],"prefix":"10.1016","volume":"150","author":[{"given":"Ezequiel","family":"Ruiz-Mateos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Tarancon-Diez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana I.","family":"Alvarez-Rios","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Dominguez-Molina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Genebat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ildefonso","family":"Pulido","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Antonia","family":"Abad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0813-4500","authenticated-orcid":false,"given":"Maria Angeles","family":"Mu\u00f1oz-Fernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Leal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.antiviral.2017.12.002_bib1","doi-asserted-by":"crossref","first-page":"e4727","DOI":"10.1097\/MD.0000000000004727","article-title":"Overall and cause-specific excess mortality in HIV-positive persons compared with the general population: role of HCV coinfection","volume":"95","author":"Alejos","year":"2016","journal-title":"Medicine"},{"key":"10.1016\/j.antiviral.2017.12.002_bib2","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1086\/315704","article-title":"The CCR5Delta32 allele slows disease progression of human immunodeficiency virus-1-infected children receiving antiretroviral treatment","volume":"182","author":"Barroga","year":"2000","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.antiviral.2017.12.002_bib3","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1177\/135965350501000711","article-title":"Association of the CCR5delta32 mutation with clinical response and >5-year survival following initiation of first triple antiretroviral regimen","volume":"10","author":"Brumme","year":"2005","journal-title":"Antivir. Ther."},{"key":"10.1016\/j.antiviral.2017.12.002_bib4","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/infdis\/jiq023","article-title":"Concordance of CCR5 genotypes that influence cell-mediated immunity and HIV-1 disease progression rates","volume":"203","author":"Catano","year":"2011","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.antiviral.2017.12.002_bib5","doi-asserted-by":"crossref","first-page":"882","DOI":"10.7326\/0003-4819-127-10-199711150-00004","article-title":"Association between CCR5 genotype and the clinical course of HIV-1 infection","volume":"127","author":"de Roda Husman","year":"1997","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.antiviral.2017.12.002_bib6","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1126\/science.273.5283.1856","volume":"273","author":"Dean","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.antiviral.2017.12.002_bib7","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1093\/cid\/ciw120","article-title":"Analysis of non-AIDS-defining events in HIV Controllers","volume":"62","author":"Dominguez-Molina","year":"2016","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.antiviral.2017.12.002_bib8","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1093\/cid\/civ463","article-title":"Age at entry into Care, timing of antiretroviral therapy initiation, and 10-year mortality among HIV-seropositive adults in the United States","volume":"61","author":"Edwards","year":"2015","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.antiviral.2017.12.002_bib9","doi-asserted-by":"crossref","first-page":"15276","DOI":"10.1073\/pnas.2435085100","article-title":"Evaluating plague and smallpox as historical selective pressures for the CCR5-Delta 32 HIV-resistance allele","volume":"100","author":"Galvani","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.antiviral.2017.12.002_bib10","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1097\/QAD.0000000000000629","article-title":"Viremic control and viral coreceptor usage in two HIV-1-infected persons homozygous for CCR5 \u039432","volume":"29","author":"Henrich","year":"2015","journal-title":"AIDS"},{"key":"10.1016\/j.antiviral.2017.12.002_bib11","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1093\/infdis\/jiv504","article-title":"CCR5-\u039432 heterozygosity, HIV-1 reservoir size, and lymphocyte activation in individuals receiving long-term suppressive antiretroviral therapy","volume":"213","author":"Henrich","year":"2016","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.antiviral.2017.12.002_bib12","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1038\/nm1196-1240","article-title":"The role of a mutant CCR5 allele in HIV-1 transmission and disease progression","volume":"2","author":"Huang","year":"1996","journal-title":"Nat. Med."},{"key":"10.1016\/j.antiviral.2017.12.002_bib13","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1097\/COH.0000000000000292","article-title":"Effect of coinfection with hepatitis C virus on survival of individuals with HIV-1 infection","volume":"11","author":"Klein","year":"2016","journal-title":"Curr. Opin. HIV AIDS"},{"key":"10.1016\/j.antiviral.2017.12.002_bib14","doi-asserted-by":"crossref","first-page":"14658","DOI":"10.1073\/pnas.1514867112","article-title":"Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load","volume":"112","author":"McLaren","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.antiviral.2017.12.002_bib15","doi-asserted-by":"crossref","first-page":"570","DOI":"10.7326\/0003-4819-130-7-199904060-00005","article-title":"Relations among CD4 lymphocyte count nadir, antiretroviral therapy, and HIV-1 disease progression: results from the EuroSIDA study","volume":"130","author":"Miller","year":"1999","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.antiviral.2017.12.002_bib16","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.antiviral.2015.03.002","article-title":"Increased risk of non-AIDS-related events in HIV subjects with persistent low CD4 counts despite cART in the CoRIS cohort","volume":"117","author":"Pacheco","year":"2015","journal-title":"Antivir. Res."},{"key":"10.1016\/j.antiviral.2017.12.002_bib17","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1056\/NEJM199803263381301","article-title":"Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators","volume":"338","author":"Palella","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.antiviral.2017.12.002_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0022215","article-title":"Risk of all-cause mortality in HIV infected patients is associated with clinical, immunologic predictors and the CCR5 \u039432 deletion","volume":"6","author":"Parczewski","year":"2011","journal-title":"PLos One"},{"key":"10.1016\/j.antiviral.2017.12.002_bib19","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1001\/jama.282.8.734","article-title":"Association of the CCR5delta32 mutation with improved response to antiretroviral therapy","volume":"282","author":"Valdez","year":"1999","journal-title":"JAMA"},{"key":"10.1016\/j.antiviral.2017.12.002_bib20","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1089\/vim.2006.19.759","article-title":"Immunovirologic characteristics of human immunodeficiency virus-infected patients consisting mainly of injecting drug users on highly active antiretroviral treatment with prolonged virologic failure","volume":"19","author":"Vallejo","year":"2006","journal-title":"Viral Immunol."},{"key":"10.1016\/j.antiviral.2017.12.002_bib21","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1093\/infdis\/jiu338","article-title":"Decreased HIV type 1 transcription in CCR5-\u039432 heterozygotes during suppressive antiretroviral therapy","volume":"210","author":"Wang","year":"2014","journal-title":"J. Infect. Dis."}],"container-title":["Antiviral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166354217306472?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166354217306472?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T11:21:11Z","timestamp":1778671271000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166354217306472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":21,"alternative-id":["S0166354217306472"],"URL":"https:\/\/doi.org\/10.1016\/j.antiviral.2017.12.002","relation":{},"ISSN":["0166-3542"],"issn-type":[{"value":"0166-3542","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of heterozygous CCR5\u039432 deletion with survival in HIV-infection: A cohort study","name":"articletitle","label":"Article Title"},{"value":"Antiviral Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.antiviral.2017.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}