{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:42:46Z","timestamp":1790289766616,"version":"4.1.0"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Research"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.antiviral.2018.02.018","type":"journal-article","created":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T14:18:25Z","timestamp":1519913905000},"page":"78-84","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Bivalent vaccine platform based on ca influenza virus vaccine elicits protective immunity against human adenoviruses"],"prefix":"10.1016","volume":"153","author":[{"given":"Hongjing","family":"Gu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqian","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongpeng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingna","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peirui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaogeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiliang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penghui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.antiviral.2018.02.018_bib1","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1080\/21645515.2016.1210729","article-title":"Viral vector-based influenza vaccines","volume":"12","author":"de Vries","year":"2016","journal-title":"Hum. Vaccines Immunother."},{"key":"10.1016\/j.antiviral.2018.02.018_bib2","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1073\/pnas.88.5.1651","article-title":"A mouse model for investigating the molecular pathogenesis of adenovirus pneumonia","volume":"88","author":"Ginsberg","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.antiviral.2018.02.018_bib3","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1086\/313999","article-title":"Adult adenovirus infections: loss of orphaned vaccines precipitates military respiratory disease epidemics. For the Adenovirus Surveillance Group","volume":"31","author":"Gray","year":"2000","journal-title":"Clin. Infect. Dis. Offic. Publ. Infect. Dis. Soc. Am."},{"key":"10.1016\/j.antiviral.2018.02.018_bib4","first-page":"1","volume":"vol. 52","author":"Harper","year":"2003"},{"key":"10.1016\/j.antiviral.2018.02.018_bib5","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1016\/j.vaccine.2012.12.029","article-title":"History of the restoration of adenovirus type 4 and type 7 vaccine, live oral (Adenovirus Vaccine) in the context of the Department of Defense acquisition system","volume":"31","author":"Hoke","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.antiviral.2018.02.018_bib6","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1080\/14760584.2016.1208088","article-title":"Cold-adapted influenza viruses as a promising platform for viral-vector vaccines","volume":"15","author":"Isakova-Sivak","year":"2016","journal-title":"Expet Rev. Vaccine"},{"key":"10.1016\/j.antiviral.2018.02.018_bib7","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1186\/1743-422X-10-271","article-title":"Prevalence of adenovirus in children with acute respiratory tract infection in Lanzhou, China","volume":"10","author":"Jin","year":"2013","journal-title":"Virol. J."},{"key":"10.1016\/j.antiviral.2018.02.018_bib8","article-title":"Computational and serologic analysis of novel and known viruses in species human adenovirus D in which serology and genomics do not correlate","volume":"7","author":"Liu","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.antiviral.2018.02.018_bib9","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1128\/JVI.67.1.101-111.1993","article-title":"Pathogenesis of adenovirus type 5 pneumonia in cotton rats (Sigmodon hispidus)","volume":"67","author":"Prince","year":"1993","journal-title":"J. Virol."},{"key":"10.1016\/j.antiviral.2018.02.018_bib10","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.1128\/JCM.43.7.3083-3094.2005","article-title":"Genomic and bioinformatics analyses of HAdV-4vac and HAdV-7vac, two human adenovirus (HAdV) strains that constituted original prophylaxis against HAdV-related acute respiratory disease, a reemerging epidemic disease","volume":"43","author":"Purkayastha","year":"2005","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.antiviral.2018.02.018_bib11","doi-asserted-by":"crossref","first-page":"7964","DOI":"10.1128\/JVI.07076-11","article-title":"Serotype-specific neutralizing antibody epitopes of human adenovirus type 3 (HAdV-3) and HAdV-7 reside in multiple hexon hypervariable regions","volume":"86","author":"Qiu","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.antiviral.2018.02.018_bib12","doi-asserted-by":"crossref","first-page":"570","DOI":"10.3181\/00379727-84-20714","article-title":"Isolation of a cytopathogenic agent from human adenoids undergoing spontaneous degeneration in tissue culture","volume":"84","author":"Rowe","year":"1953","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.antiviral.2018.02.018_bib13","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1590\/S0100-879X2005000400004","article-title":"Recombinant viruses as vaccines against viral diseases","volume":"38","author":"Souza","year":"2005","journal-title":"Braz. J. Med. Biol. Res.= Rev. Bras. Pesqui. Med. Biol."},{"key":"10.1016\/j.antiviral.2018.02.018_bib14","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.virusres.2011.06.017","article-title":"Construction and characterization of human adenovirus serotype 3 packaged by serotype 7 hexon","volume":"160","author":"Tian","year":"2011","journal-title":"Virus Res."},{"key":"10.1016\/j.antiviral.2018.02.018_bib15","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1093\/infdis\/124.2.148","article-title":"Immunization with live types 7 and 4 adenovirus vaccines. I. Safety, infectivity, antigenicity, and potency of adenovirus type 7 vaccine in humans","volume":"124","author":"Top","year":"1971","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.antiviral.2018.02.018_bib16","first-page":"15011","article-title":"Molecular epidemiology of respiratory adenovirus detection in hospitalized children in Shenzhen, China","volume":"8","author":"Wang","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.antiviral.2018.02.018_bib17","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.vaccine.2010.11.026","article-title":"Immunogenicity and protective efficacy of a live attenuated vaccine against the 2009 pandemic A H1N1 in mice and ferrets","volume":"29","author":"Yang","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.antiviral.2018.02.018_bib18","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.antiviral.2015.06.015","article-title":"Recombinant influenza virus carrying human adenovirus epitopes elicits protective immunity in mice","volume":"121","author":"Yang","year":"2015","journal-title":"Antivir. Res."},{"key":"10.1016\/j.antiviral.2018.02.018_bib19","article-title":"Structure-based high-throughput epitope analysis of hexon proteins in B and C species human adenoviruses (HAdVs)","volume":"7","author":"Yuan","year":"2012","journal-title":"PLoS One"}],"container-title":["Antiviral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166354217303054?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166354217303054?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T18:04:48Z","timestamp":1603908288000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166354217303054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":19,"alternative-id":["S0166354217303054"],"URL":"https:\/\/doi.org\/10.1016\/j.antiviral.2018.02.018","relation":{},"ISSN":["0166-3542"],"issn-type":[{"value":"0166-3542","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bivalent vaccine platform based on ca influenza virus vaccine elicits protective immunity against human adenoviruses","name":"articletitle","label":"Article Title"},{"value":"Antiviral Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.antiviral.2018.02.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}