{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:13:34Z","timestamp":1790615614609,"version":"4.1.0"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T00:00:00Z","timestamp":1530662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Indonesia Endowment Fund"},{"DOI":"10.13039\/501100003246","name":"Netherlands Organisation for Scientific Research","doi-asserted-by":"publisher","award":["NWO-VICI-91812628"],"award-info":[{"award-number":["NWO-VICI-91812628"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Netherlands Organisation for Scientific Research","doi-asserted-by":"publisher","award":["NWO-ECHO-711.017.002"],"award-info":[{"award-number":["NWO-ECHO-711.017.002"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Horizon Breakthrough fellowship from the Netherlands Genomics Initiative","award":["93518028"],"award-info":[{"award-number":["93518028"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Research"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.antiviral.2018.06.017","type":"journal-article","created":{"date-parts":[[2018,7,3]],"date-time":"2018-07-03T01:13:49Z","timestamp":1530580429000},"page":"68-79","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"special_numbering":"C","title":["Posaconazole inhibits dengue virus replication by targeting oxysterol-binding protein"],"prefix":"10.1016","volume":"157","author":[{"given":"Febrina","family":"Meutiawati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bodine","family":"Bezemer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2509-5213","authenticated-orcid":false,"given":"Jeroen R.P.M.","family":"Strating","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gijs J.","family":"Overheul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"\u017dusinaite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank J.M.","family":"van Kuppeveld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen W.R.","family":"van Cleef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0221-4689","authenticated-orcid":false,"given":"Ronald P.","family":"van Rij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.antiviral.2018.06.017_bib1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.antiviral.2017.01.008","article-title":"Uncovering oxysterol-binding protein (OSBP) as a target of the anti-enteroviral compound TTP-8307","volume":"140","author":"Albulescu","year":"2017","journal-title":"Antivir. Res."},{"key":"10.1016\/j.antiviral.2018.06.017_bib2","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.antiviral.2015.02.013","article-title":"Broad-range inhibition of enterovirus replication by OSW-1, a natural compound targeting OSBP","volume":"117","author":"Albulescu","year":"2015","journal-title":"Antivir. Res."},{"key":"10.1016\/j.antiviral.2018.06.017_bib3","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.virol.2005.06.009","article-title":"Role of RNA structures present at the 3'UTR of dengue virus on translation, RNA synthesis, and viral replication","volume":"339","author":"Alvarez","year":"2005","journal-title":"Virology"},{"key":"10.1016\/j.antiviral.2018.06.017_bib4","doi-asserted-by":"crossref","first-page":"9237","DOI":"10.1128\/JVI.00958-09","article-title":"Role of oxysterol binding protein in hepatitis C virus infection","volume":"83","author":"Amako","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.antiviral.2018.06.017_bib5","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1128\/JVI.02249-10","article-title":"Phosphatidylinositol 4-kinase III beta is a target of enviroxime-like compounds for antipoliovirus activity","volume":"85","author":"Arita","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.antiviral.2018.06.017_bib6","doi-asserted-by":"crossref","first-page":"4252","DOI":"10.1128\/JVI.03546-12","article-title":"Oxysterol-binding protein family I is the target of minor enviroxime-like compounds","volume":"87","author":"Arita","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.antiviral.2018.06.017_bib7","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/1348-0421.12261","article-title":"Phosphatidylinositol 4-kinase III beta is the target of oxoglaucine and pachypodol (Ro 09-0179) for their anti-poliovirus activities, and is located at upstream of the target step of brefeldin A","volume":"59","author":"Arita","year":"2015","journal-title":"Microbiol. Immunol."},{"key":"10.1016\/j.antiviral.2018.06.017_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004388","article-title":"Co-opted oxysterol-binding ORP and VAP proteins channel sterols to RNA virus replication sites via membrane contact sites","volume":"10","author":"Barajas","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.antiviral.2018.06.017_bib9","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"Bhatt","year":"2013","journal-title":"Nat. New Biol."},{"key":"10.1016\/j.antiviral.2018.06.017_bib10","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/369756a0","article-title":"A mammalian protein targeted by G1-arresting rapamycin-receptor complex","volume":"369","author":"Brown","year":"1994","journal-title":"Nat. New Biol."},{"key":"10.1016\/j.antiviral.2018.06.017_bib11","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nchembio.625","article-title":"Natural products reveal cancer cell dependence on oxysterol-binding proteins","volume":"7","author":"Burgett","year":"2011","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.antiviral.2018.06.017_bib12","doi-asserted-by":"crossref","first-page":"15705","DOI":"10.1074\/jbc.M114.571216","article-title":"Oxysterol-binding protein (OSBP)-related protein 4 (ORP4) is essential for cell proliferation and survival","volume":"289","author":"Charman","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.antiviral.2018.06.017_bib13","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1158\/1535-7163.MCT-15-0729-T","article-title":"Posaconazole, a second-generation triazole antifungal drug, inhibits the hedgehog signaling pathway and progression of basal cell Carcinoma","volume":"15","author":"Chen","year":"2016","journal-title":"Mol. Canc. Therapeut."},{"key":"10.1016\/j.antiviral.2018.06.017_bib14","doi-asserted-by":"crossref","first-page":"14071","DOI":"10.1073\/pnas.182542899","article-title":"Small molecule modulation of Smoothened activity","volume":"99","author":"Chen","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.antiviral.2018.06.017_bib15","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1021\/cb600362d","article-title":"Inhibition of angiogenesis by the antifungal drug itraconazole","volume":"2","author":"Chong","year":"2007","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.antiviral.2018.06.017_bib16","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.mib.2012.05.013","article-title":"Lipids at the interface of virus-host interactions","volume":"15","author":"Chukkapalli","year":"2012","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.antiviral.2018.06.017_bib17","doi-asserted-by":"crossref","first-page":"e02882","DOI":"10.7554\/eLife.02882","article-title":"Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis","volume":"3","author":"Das","year":"2014","journal-title":"eLife"},{"key":"10.1016\/j.antiviral.2018.06.017_bib18","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1242\/jcs.181586","article-title":"Three-dimensional imaging of the intracellular assembly of a functional viral RNA replicase complex","volume":"130","author":"Fernandez de Castro","year":"2017","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.antiviral.2018.06.017_bib19","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/0470058005.ch2","article-title":"Dengue\/dengue haemorrhagic fever: history and current status","volume":"277","author":"Gubler","year":"2006","journal-title":"Novartis Found. Symp."},{"key":"10.1016\/j.antiviral.2018.06.017_bib20","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1056\/NEJMoa1506223","article-title":"Efficacy and long-Term safety of a dengue vaccine in regions of endemic disease","volume":"373","author":"Hadinegoro","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.antiviral.2018.06.017_bib21","doi-asserted-by":"crossref","first-page":"E7276","DOI":"10.1073\/pnas.1512867112","article-title":"Antifungal drug itraconazole targets VDAC1 to modulate the AMPK\/mTOR signaling axis in endothelial cells","volume":"112","author":"Head","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.antiviral.2018.06.017_bib22","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1021\/acschembio.6b00849","article-title":"Simultaneous targeting of NPC1 and VDAC1 by itraconazole leads to synergistic inhibition of mTOR signaling and angiogenesis","volume":"12","author":"Head","year":"2017","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.antiviral.2018.06.017_bib23","doi-asserted-by":"crossref","first-page":"17345","DOI":"10.1073\/pnas.1010811107","article-title":"Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis","volume":"107","author":"Heaton","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.antiviral.2018.06.017_bib24","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.virol.2005.08.034","article-title":"Inhibition of dengue virus translation and RNA synthesis by a morpholino oligomer targeted to the top of the terminal 3' stem-loop structure","volume":"344","author":"Holden","year":"2006","journal-title":"Virology"},{"key":"10.1016\/j.antiviral.2018.06.017_bib25","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.cell.2010.03.050","article-title":"Viral reorganization of the secretory pathway generates distinct organelles for RNA replication","volume":"141","author":"Hsu","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.antiviral.2018.06.017_bib26","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1042\/BJ20042082","article-title":"Overexpression of OSBP-related protein 2 (ORP2) induces changes in cellular cholesterol metabolism and enhances endocytosis","volume":"390","author":"Hynynen","year":"2005","journal-title":"Biochem. J."},{"key":"10.1016\/j.antiviral.2018.06.017_bib27","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1194\/jlr.M800661-JLR200","article-title":"OSBP-related protein 2 is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids","volume":"50","author":"Hynynen","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.antiviral.2018.06.017_bib28","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1042\/bse0570043","article-title":"Cholesterol trafficking and distribution","volume":"57","author":"Iaea","year":"2015","journal-title":"Essays Biochem."},{"key":"10.1016\/j.antiviral.2018.06.017_bib29","doi-asserted-by":"crossref","first-page":"e01952","DOI":"10.1128\/JVI.01952-17","article-title":"A model of OSBP-mediated cholesterol supply to Aichi virus RNA replication sites involving protein-protein interactions among viral proteins, ACBD3, OSBP, VAP-A\/B, and SAC1","volume":"92","author":"Ishikawa-Sasaki","year":"2018","journal-title":"J. Virol."},{"key":"10.1016\/j.antiviral.2018.06.017_bib30","doi-asserted-by":"crossref","first-page":"5269","DOI":"10.1128\/AAC.00686-10","article-title":"A derivate of the antibiotic doxorubicin is a selective inhibitor of dengue and yellow fever virus replication in vitro","volume":"54","author":"Kaptein","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.antiviral.2018.06.017_bib31","doi-asserted-by":"crossref","first-page":"E122","DOI":"10.3390\/v8050122","article-title":"Dengue virus reporter replicon is a valuable tool for antiviral drug discovery and analysis of virus replication mechanisms","volume":"8","author":"Kato","year":"2016","journal-title":"Viruses"},{"key":"10.1016\/j.antiviral.2018.06.017_bib32","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.ccr.2010.02.027","article-title":"Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth","volume":"17","author":"Kim","year":"2010","journal-title":"Canc. Cell"},{"key":"10.1016\/j.antiviral.2018.06.017_bib33","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s11046-014-9792-y","article-title":"Posaconazole salvage treatment for invasive fungal infection","volume":"178","author":"Kim","year":"2014","journal-title":"Mycopathologia"},{"key":"10.1016\/j.antiviral.2018.06.017_bib34","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0022-2275(20)30166-8","article-title":"ORP2, a homolog of oxysterol binding protein, regulates cellular cholesterol metabolism","volume":"43","author":"Laitinen","year":"2002","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.antiviral.2018.06.017_bib35","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1002\/(SICI)1097-0061(19990630)15:9<755::AID-YEA417>3.0.CO;2-8","article-title":"Characteristics of the heterologously expressed human lanosterol 14alpha-demethylase (other names: P45014DM, CYP51, P45051) and inhibition of the purified human and Candida albicans CYP51 with azole antifungal agents","volume":"15","author":"Lamb","year":"1999","journal-title":"Yeast"},{"key":"10.1016\/j.antiviral.2018.06.017_bib36","doi-asserted-by":"crossref","first-page":"8455","DOI":"10.1073\/pnas.0609699104","article-title":"Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists","volume":"104","author":"Lauth","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.antiviral.2018.06.017_bib37","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1002\/cbic.200700403","article-title":"A small-molecule antagonist of the hedgehog signaling pathway","volume":"8","author":"Lee","year":"2007","journal-title":"Chembiochem Eur. J. Chem. Biol."},{"key":"10.1016\/j.antiviral.2018.06.017_bib38","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/S0022-2275(20)31570-4","article-title":"The OSBP-related protein family in humans","volume":"42","author":"Lehto","year":"2001","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.antiviral.2018.06.017_bib39","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1743-422X-10-64","article-title":"Development and characterization of the replicon system of Japanese encephalitis live vaccine virus SA14-14-2","volume":"10","author":"Li","year":"2013","journal-title":"Virol. J."},{"key":"10.1016\/j.antiviral.2018.06.017_bib40","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.antiviral.2013.09.013","article-title":"Ten years of dengue drug discovery: progress and prospects","volume":"100","author":"Lim","year":"2013","journal-title":"Antivir. Res."},{"key":"10.1016\/j.antiviral.2018.06.017_bib41","doi-asserted-by":"crossref","first-page":"12901","DOI":"10.1128\/JVI.77.23.12901-12906.2003","article-title":"Potential high-throughput assay for screening inhibitors of West Nile virus replication","volume":"77","author":"Lo","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.antiviral.2018.06.017_bib42","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.chom.2007.09.003","article-title":"Cholesterol manipulation by West Nile virus perturbs the cellular immune response","volume":"2","author":"Mackenzie","year":"2007","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.antiviral.2018.06.017_bib43","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.cell.2013.09.056","article-title":"A four-step cycle driven by PI(4)P hydrolysis directs sterol\/PI(4)P exchange by the ER-Golgi tether OSBP","volume":"155","author":"Mesmin","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.antiviral.2018.06.017_bib44","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1099\/jgv.0.000938","article-title":"Reverse genetic system, genetically stable reporter viruses and packaged subgenomic replicon based on a Brazilian Zika virus isolate","volume":"98","author":"Mutso","year":"2017","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.antiviral.2018.06.017_bib45","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.antiviral.2007.06.007","article-title":"Construction and characterization of a stable subgenomic dengue virus type 2 replicon system for antiviral compound and siRNA testing","volume":"76","author":"Ng","year":"2007","journal-title":"Antivir. Res."},{"key":"10.1016\/j.antiviral.2018.06.017_bib46","article-title":"Inhibition of HCV replication by oxysterol-binding protein-related protein 4 (ORP4) through interaction with HCV NS5B and alteration of lipid droplet formation","volume":"8","author":"Park","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.antiviral.2018.06.017_bib47","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1358\/dot.2015.51.12.2421058","article-title":"Triazole antifungals: a review","volume":"51","author":"Peyton","year":"2015","journal-title":"Drugs Today (Barc)"},{"key":"10.1016\/j.antiviral.2018.06.017_bib48","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.antiviral.2011.11.014","article-title":"U18666A, an intra-cellular cholesterol transport inhibitor, inhibits dengue virus entry and replication","volume":"93","author":"Poh","year":"2012","journal-title":"Antivir. Res."},{"key":"10.1016\/j.antiviral.2018.06.017_bib49","doi-asserted-by":"crossref","first-page":"4980","DOI":"10.1128\/AAC.49.12.4980-4988.2005","article-title":"High-throughput assays using a luciferase-expressing replicon, virus-like particles, and full-length virus for West Nile virus drug discovery","volume":"49","author":"Puig-Basagoiti","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.antiviral.2018.06.017_bib50","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.antiviral.2017.11.011","article-title":"Antifungal azoles itraconazole and posaconazole exhibit potent in vitro antiviral activity against clinical isolates of parechovirus A3 (Picornaviridae)","volume":"149","author":"Rhoden","year":"2018","journal-title":"Antivir. Res."},{"key":"10.1016\/j.antiviral.2018.06.017_bib51","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.virol.2009.03.025","article-title":"Cholesterol biosynthesis modulation regulates dengue viral replication","volume":"389","author":"Rothwell","year":"2009","journal-title":"Virology"},{"key":"10.1016\/j.antiviral.2018.06.017_bib52","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.chom.2014.10.003","article-title":"Rhinovirus uses a phosphatidylinositol 4-phosphate\/cholesterol counter-current for the formation of replication compartments at the ER-Golgi interface","volume":"16","author":"Roulin","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.antiviral.2018.06.017_bib53","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1128\/AAC.00163-06","article-title":"In vitro activities of posaconazole, fluconazole, itraconazole, voriconazole, and amphotericin B against a large collection of clinically important molds and yeasts","volume":"50","author":"Sabatelli","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.antiviral.2018.06.017_bib54","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.antiviral.2018.06.017_bib55","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1128\/CMR.12.1.40","article-title":"Current and emerging azole antifungal agents","volume":"12","author":"Sheehan","year":"1999","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.antiviral.2018.06.017_bib56","doi-asserted-by":"crossref","first-page":"e1752","DOI":"10.1371\/journal.pntd.0001752","article-title":"Therapeutics for dengue: recommendations for design and conduct of early-phase clinical trials","volume":"6","author":"Simmons","year":"2012","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.antiviral.2018.06.017_bib57","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.celrep.2014.12.054","article-title":"Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein","volume":"10","author":"Strating","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.antiviral.2018.06.017_bib58","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ceb.2017.02.005","article-title":"Viral rewiring of cellular lipid metabolism to create membranous replication compartments","volume":"47","author":"Strating","year":"2017","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.antiviral.2018.06.017_bib59","first-page":"218","article-title":"Mechanism of action of ribavirin in the treatment of chronic hepatitis C","volume":"3","author":"Te","year":"2007","journal-title":"Gastroenterol. Hepatol. (N Y)"},{"key":"10.1016\/j.antiviral.2018.06.017_bib60","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1073\/pnas.1619571114","article-title":"Triazoles inhibit cholesterol export from lysosomes by binding to NPC1","volume":"114","author":"Trinh","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.antiviral.2018.06.017_bib61","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.antiviral.2013.05.011","article-title":"Identification of a new dengue virus inhibitor that targets the viral NS4B protein and restricts genomic RNA replication","volume":"99","author":"van Cleef","year":"2013","journal-title":"Antivir. Res."},{"key":"10.1016\/j.antiviral.2018.06.017_bib62","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1128\/AAC.02462-15","article-title":"Escape mutations in NS4B render dengue virus insensitive to the antiviral activity of the paracetamol metabolite AM404","volume":"60","author":"van Cleef","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.antiviral.2018.06.017_bib63","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1128\/AAC.37.10.2101","article-title":"Effects of itraconazole on cytochrome P-450-dependent sterol 14 alpha-demethylation and reduction of 3-ketosteroids in Cryptococcus neoformans","volume":"37","author":"Vanden Bossche","year":"1993","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.antiviral.2018.06.017_bib64","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1053\/j.gastro.2014.02.002","article-title":"Oxysterol-binding protein is a phosphatidylinositol 4-kinase effector required for HCV replication membrane integrity and cholesterol trafficking","volume":"146","author":"Wang","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.antiviral.2018.06.017_bib65","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/S0953-7562(96)80175-4","article-title":"Medical mycology","volume":"100","author":"Warnock","year":"1996","journal-title":"Mycol. Res."},{"key":"10.1016\/j.antiviral.2018.06.017_bib66","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1128\/AAC.02067-12","article-title":"Azole affinity of sterol 14alpha-demethylase (CYP51) enzymes from Candida albicans and Homo sapiens","volume":"57","author":"Warrilow","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.antiviral.2018.06.017_bib67","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.chom.2009.03.007","article-title":"Composition and three-dimensional architecture of the dengue virus replication and assembly sites","volume":"5","author":"Welsch","year":"2009","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.antiviral.2018.06.017_bib68","doi-asserted-by":"crossref","first-page":"11183","DOI":"10.1128\/JVI.05468-11","article-title":"Inhibition of dengue virus by targeting viral NS4B protein","volume":"85","author":"Xie","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.antiviral.2018.06.017_bib69","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ebiom.2016.09.013","article-title":"Zika virus replicons for drug discovery","volume":"12","author":"Xie","year":"2016","journal-title":"EBioMedicine"},{"key":"10.1016\/j.antiviral.2018.06.017_bib70","doi-asserted-by":"crossref","first-page":"4764","DOI":"10.1073\/pnas.0910872107","article-title":"Cholesterol trafficking is required for mTOR activation in endothelial cells","volume":"107","author":"Xu","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.antiviral.2018.06.017_bib71","doi-asserted-by":"crossref","first-page":"3304","DOI":"10.1016\/j.yexcr.2010.06.008","article-title":"OSBP-related protein 11 (ORP11) dimerizes with ORP9 and localizes at the Golgi-late endosome interface","volume":"316","author":"Zhou","year":"2010","journal-title":"Exp. Cell Res."}],"container-title":["Antiviral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166354218301128?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166354218301128?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,7]],"date-time":"2024-07-07T22:10:34Z","timestamp":1720390234000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166354218301128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":71,"alternative-id":["S0166354218301128"],"URL":"https:\/\/doi.org\/10.1016\/j.antiviral.2018.06.017","relation":{},"ISSN":["0166-3542"],"issn-type":[{"value":"0166-3542","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Posaconazole inhibits dengue virus replication by targeting oxysterol-binding protein","name":"articletitle","label":"Article Title"},{"value":"Antiviral Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.antiviral.2018.06.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}