{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:13:16Z","timestamp":1789693996358,"version":"4.0.1"},"reference-count":46,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T00:00:00Z","timestamp":1554854400000},"content-version":"vor","delay-in-days":40,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Hepatology"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.aohep.2018.12.002","type":"journal-article","created":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T01:28:13Z","timestamp":1556587693000},"page":"287-290","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Vasoconstrictors in hepatorenal syndrome \u2013 A critical review"],"prefix":"10.1016","volume":"18","author":[{"given":"\u00c2ngelo Z.","family":"Mattos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando C.","family":"Schacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo A.","family":"Mattos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.aohep.2018.12.002_bib0235","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.jhep.2014.12.029","article-title":"Diagnosis and management of acute kidney injury in patients with cirrhosis: revised consensus recommendations of the International Club of Ascites","volume":"62","author":"Angeli","year":"2015","journal-title":"J Hepatol"},{"key":"10.1016\/j.aohep.2018.12.002_bib0240","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1155\/2015\/967683","article-title":"Renal impairment in cirrhosis unrelated to hepatorenal syndrome","volume":"29","author":"Low","year":"2015","journal-title":"Can J Gastroenterol Hepatol"},{"key":"10.1016\/j.aohep.2018.12.002_bib0245","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1053\/j.gastro.2010.07.043","article-title":"Prognostic importance of the cause of renal failure in patients with cirrhosis","volume":"140","author":"Mart\u00edn-Llah\u00ed","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.aohep.2018.12.002_bib0250","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/hep.510230122","article-title":"Definition and diagnostic criteria of refractory ascites and hepatorenal syndrome in cirrhosis. International Ascites Club","volume":"23","author":"Arroyo","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/j.aohep.2018.12.002_bib0255","first-page":"1310","article-title":"Diagnosis, prevention and treatment of hepatorenal syndrome in cirrhosis","volume":"56","author":"Salerno","year":"2007","journal-title":"Gut"},{"key":"10.1016\/j.aohep.2018.12.002_bib0260","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.jhep.2018.03.024","article-title":"EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis","volume":"69","author":"The European Association for the Study of the Liver","year":"2018","journal-title":"J Hepatol"},{"key":"10.1016\/j.aohep.2018.12.002_bib0265","first-page":"474","article-title":"Hepatorenal syndrome: current concepts related to diagnosis and management","volume":"15","author":"Mattos","year":"2016","journal-title":"Ann Hepatol"},{"key":"10.1016\/j.aohep.2018.12.002_bib0270","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1590\/s0004-2803.201800000-71","article-title":"Recommendations of the Brazilian Society of Hepatology for the management of acute kidney injury in patients with cirrhosis","volume":"55","author":"Terra","year":"2018","journal-title":"Arq Gastroenterol"},{"key":"10.1016\/j.aohep.2018.12.002_bib0275","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1002\/lt.22395","article-title":"Impact of liver transplantation on the survival of patients treated for hepatorenal syndrome type 1","volume":"17","author":"Boyer","year":"2011","journal-title":"Liver Transpl"},{"key":"10.1016\/j.aohep.2018.12.002_bib0280","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1002\/lt.22433","article-title":"Hepatorenal syndrome, pharmacological therapy, and liver transplantation","volume":"17","author":"Gin\u00e8s","year":"2011","journal-title":"Liver Transpl"},{"key":"10.1016\/j.aohep.2018.12.002_bib0285","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1002\/hep.23286","article-title":"Systematic review of randomized trials on vasoconstrictor drugs for hepatorenal syndrome","volume":"51","author":"Gluud","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.aohep.2018.12.002_bib0290","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1053\/j.ajkd.2011.07.017","article-title":"Therapeutic response to vasoconstrictors in hepatorenal syndrome parallels increase in mean arterial pressure: a pooled analysis of clinical trials","volume":"58","author":"Velez","year":"2011","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.aohep.2018.12.002_bib0295","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1053\/jhep.2002.35819","article-title":"Terlipressin therapy with and without albumin for patients with hepatorenal syndrome: results of a prospective, nonrandomized study","volume":"36","author":"Ortega","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.aohep.2018.12.002_bib0300","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/s12876-015-0389-9","article-title":"Albumin treatment regimen for type 1 hepatorenal syndrome: a dose-response meta-analysis","volume":"15","author":"Salerno","year":"2015","journal-title":"BMC Gastroenterol"},{"key":"10.1016\/j.aohep.2018.12.002_bib0305","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1053\/j.gastro.2008.02.014","article-title":"A randomized, prospective, double-blind, placebo-controlled trial of terlipressin for type 1 hepatorenal syndrome","volume":"134","author":"Sanyal","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.aohep.2018.12.002_bib0310","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1053\/j.gastro.2008.02.024","article-title":"Terlipressin and albumin vs albumin in patients with cirrhosis and hepatorenal syndrome: a randomized study","volume":"134","author":"Mart\u00edn-Llah\u00ed","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.aohep.2018.12.002_bib0315","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1111\/j.1365-2036.2006.03086.x","article-title":"Meta-analysis: terlipressin therapy for the hepatorenal syndrome","volume":"24","author":"Fabrizi","year":"2006","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.aohep.2018.12.002_bib0320","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0168-8278(98)80151-7","article-title":"Beneficial effects of the 2-day administration of terlipressin in patients with cirrhosis and hepatorenal syndrome","volume":"29","author":"Hadengue","year":"1998","journal-title":"J Hepatol"},{"key":"10.1016\/j.aohep.2018.12.002_bib0325","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0168-8278(00)80158-0","article-title":"Terlipressin plus albumin infusion: an effective and safe therapy of hepatorenal syndrome","volume":"33","author":"Uriz","year":"2000","journal-title":"J Hepatol"},{"key":"10.1016\/j.aohep.2018.12.002_bib0330","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1097\/00042737-200212000-00013","article-title":"Renal failure in cirrhotic patients: role of terlipressin in clinical approach to hepatorenal syndrome type 2","volume":"14","author":"Alessandria","year":"2002","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.aohep.2018.12.002_bib0335","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1046\/j.1440-1746.2003.02934.x","article-title":"Beneficial effects of terlipressin in hepatorenal syndrome: a prospective, randomized placebo-controlled clinical trial","volume":"18","author":"Solanki","year":"2003","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.aohep.2018.12.002_bib0340","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1007\/s10620-007-9919-9","article-title":"Terlipressin and albumin in patients with cirrhosis and type I hepatorenal syndrome","volume":"53","author":"Neri","year":"2008","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.aohep.2018.12.002_bib0345","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1053\/j.gastro.2016.02.026","article-title":"Terlipressin plus albumin is more effective than albumin alone in improving renal function in patients with cirrhosis and hepatorenal syndrome type 1","volume":"150","author":"Boyer","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.aohep.2018.12.002_bib0350","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1177\/039139880903200303","article-title":"Terlipressin for hepatorenal syndrome: a meta-analysis of randomized trials","volume":"32","author":"Fabrizi","year":"2009","journal-title":"Int J Artif Organs"},{"key":"10.1016\/j.aohep.2018.12.002_bib0355","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1111\/j.1440-1746.2009.06132.x","article-title":"Terlipressin therapy for reversal of type 1 hepatorenal syndrome: a meta-analysis of randomized controlled trials","volume":"25","author":"Sagi","year":"2010","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.aohep.2018.12.002_bib0360","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s11255-010-9725-8","article-title":"Terlipressin in hepatorenal syndrome: a systematic review and meta-analysis","volume":"43","author":"Dobre","year":"2011","journal-title":"Int Urol Nephrol"},{"key":"10.1016\/j.aohep.2018.12.002_bib0365","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/apt.13912","article-title":"Systematic review with meta-analysis: vasoactive drugs for the treatment of hepatorenal syndrome type 1","volume":"45","author":"Gifford","year":"2017","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.aohep.2018.12.002_bib0370","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD005162.pub3","article-title":"Terlipressin for hepatorenal syndrome","volume":"9","author":"Gluud","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.aohep.2018.12.002_bib0375","doi-asserted-by":"crossref","first-page":"54","DOI":"10.4103\/0253-7613.106436","article-title":"Survival benefits of terlipressin and non-responder state in hepatorenal syndrome: a meta-analysis","volume":"45","author":"Hiremath","year":"2013","journal-title":"Indian J Pharmacol"},{"key":"10.1016\/j.aohep.2018.12.002_bib0380","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.jhep.2013.12.032","article-title":"Terlipressin and albumin for type-1 hepatorenal syndrome associated with sepsis","volume":"60","author":"Rodr\u00edguez","year":"2014","journal-title":"J Hepatol"},{"key":"10.1016\/j.aohep.2018.12.002_bib0385","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.cgh.2016.07.016","article-title":"Terlipressin improves renal function and reverses hepatorenal syndrome in patients with systemic inflammatory response syndrome","volume":"15","author":"Wong","year":"2017","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.aohep.2018.12.002_bib0390","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1002\/hep.28396","article-title":"Terlipressin given by continuous intravenous infusion versus intravenous boluses in the treatment of hepatorenal syndrome: a randomized controlled study","volume":"63","author":"Cavallin","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.aohep.2018.12.002_bib0395","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1002\/hep.28647","article-title":"Terlipressin given by continuous intravenous infusion or by intravenous boluses: is there already an answer?","volume":"64","author":"Mattos","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.aohep.2018.12.002_bib0400","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s11606-017-4178-8","article-title":"Vasoactive agents for hepatorenal syndrome: a mixed treatment comparison network meta-analysis and trial sequential analysis of randomized clinical trials","volume":"33","author":"Sridharan","year":"2018","journal-title":"Gen Intern Med"},{"key":"10.1016\/j.aohep.2018.12.002_bib0405","doi-asserted-by":"crossref","first-page":"R23","DOI":"10.1186\/cc11188","article-title":"Hepatorenal syndrome: the 8th International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group","volume":"16","author":"Nadim","year":"2012","journal-title":"Crit Care"},{"key":"10.1016\/j.aohep.2018.12.002_bib0410","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1053\/jhep.2002.34343","article-title":"Effects of noradrenalin and albumin in patients with type I hepatorenal syndrome: a pilot study","volume":"36","author":"Duvoux","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.aohep.2018.12.002_bib0415","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.jhep.2007.04.010","article-title":"Noradrenalin vs terlipressin in patients with hepatorenal syndrome: a prospective, randomized, unblinded, pilot study","volume":"47","author":"Alessandria","year":"2007","journal-title":"J Hepatol"},{"key":"10.1016\/j.aohep.2018.12.002_bib0420","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1111\/liv.12179","article-title":"Noradrenaline vs terlipressin in the treatment of type 2 hepatorenal syndrome: a randomized pilot study","volume":"33","author":"Ghosh","year":"2013","journal-title":"Liver Int"},{"key":"10.1016\/j.aohep.2018.12.002_bib0425","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.jhep.2012.01.012","article-title":"Noradrenaline vs. terlipressin in the treatment of hepatorenal syndrome: a randomized study","volume":"56","author":"Singh","year":"2012","journal-title":"J Hepatol"},{"key":"10.1016\/j.aohep.2018.12.002_bib0430","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1111\/j.1572-0241.2008.01828.x","article-title":"An open label, pilot, randomized controlled trial of noradrenaline versus terlipressin in the treatment of type 1 hepatorenal syndrome and predictors of response","volume":"103","author":"Sharma","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.aohep.2018.12.002_bib0435","first-page":"30","article-title":"Noradrenaline is as effective as terlipressin in hepatorenal syndrome type 1: a prospective, randomized trial","volume":"64","author":"Goyal","year":"2016","journal-title":"J Assoc Physicians India"},{"key":"10.1016\/j.aohep.2018.12.002_bib0440","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/MEG.0000000000000537","article-title":"Terlipressin versus noradrenaline in the treatment of hepatorenal syndrome: systematic review with meta-analysis and full economic evaluation","volume":"28","author":"Mattos","year":"2016","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.aohep.2018.12.002_bib0445","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1590\/S0004-28032016000200014","article-title":"Terlipressin versus noradrenaline for hepatorenal syndrome. Economic evaluation under the perspective of the Brazilian Public Health System","volume":"53","author":"Mattos","year":"2016","journal-title":"Arq Gastroenterol"},{"key":"10.1016\/j.aohep.2018.12.002_bib0450","article-title":"Terlipressin is superior to noradrenaline in the management of acute kidney injury in acute on chronic liver failure","author":"Arora","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.aohep.2018.12.002_bib0455","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1016\/j.cgh.2018.01.035","article-title":"Association between grade of acute on chronic liver failure and response to terlipressin and albumin in patients with hepatorenal syndrome","volume":"16","author":"Piano","year":"2018","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.aohep.2018.12.002_bib0460","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/hep.27709","article-title":"Terlipressin plus albumin versus midodrine and octreotide plus albumin in the treatment of hepatorenal syndrome: a randomized trial","volume":"62","author":"Cavallin","year":"2015","journal-title":"Hepatology"}],"container-title":["Annals of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1665268119300511?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1665268119300511?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T11:04:57Z","timestamp":1561028697000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1665268119300511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["S1665268119300511"],"URL":"https:\/\/doi.org\/10.1016\/j.aohep.2018.12.002","relation":{},"ISSN":["1665-2681"],"issn-type":[{"value":"1665-2681","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vasoconstrictors in hepatorenal syndrome \u2013 A critical review","name":"articletitle","label":"Article Title"},{"value":"Annals of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aohep.2018.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Fundaci\u00f3n Cl\u00ednica M\u00e9dica Sur, A.C. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}]}}