{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T18:29:08Z","timestamp":1787596148870,"version":"build-2736575974"},"reference-count":37,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T00:00:00Z","timestamp":1556150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Taipei Veterans General Hospital, Taipei, Taiwan","award":["VGHUST103-G1-2-3"],"award-info":[{"award-number":["VGHUST103-G1-2-3"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Hepatology"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.aohep.2018.12.008","type":"journal-article","created":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T00:11:26Z","timestamp":1557360686000},"page":"633-639","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Folic acid ameliorates homocysteine-induced angiogenesis and portosystemic collaterals in cirrhotic rats"],"prefix":"10.1016","volume":"18","author":[{"given":"Hsin-Ling","family":"Ho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Hung","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Hsin","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teh-Ia","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Chih","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fa-Yauh","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Chun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Chih","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shou-Dong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.aohep.2018.12.008_bib0190","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.jhep.2014.05.047","article-title":"Vascular pathobiology in chronic liver disease and cirrhosis \u2013 current status and future directions","volume":"61","author":"Iwakiri","year":"2014","journal-title":"J Hepatol"},{"key":"10.1016\/j.aohep.2018.12.008_bib0195","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1089\/jir.2016.0111","article-title":"Prediction of fibrosis progression rate in patients with chronic hepatitis C genotype 4: role of cirrhosis risk score and host factors","volume":"37","author":"Besheer","year":"2017","journal-title":"J Interferon Cytokine Res"},{"key":"10.1016\/j.aohep.2018.12.008_bib0200","doi-asserted-by":"crossref","first-page":"299","DOI":"10.5152\/tjg.2018.17570","article-title":"Diagnosis of cirrhosis in patients with chronic hepatitis C genotype 4: role of ABCB11 genotype polymorphism and plasma bile acid levels","volume":"29","author":"Besheer","year":"2018","journal-title":"Turk J Gastroenterol"},{"key":"10.1016\/j.aohep.2018.12.008_bib0205","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.jhep.2008.12.011","article-title":"Angiogenesis in liver disease","volume":"50","author":"Fern\u00e1ndez","year":"2009","journal-title":"J Hepatol"},{"key":"10.1016\/j.aohep.2018.12.008_bib0210","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s11010-013-1869-2","article-title":"Nutriepigenetic regulation by folate\u2013homocysteine\u2013methionine axis: a review","volume":"387","author":"Bhargava","year":"2014","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.aohep.2018.12.008_bib0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000437098","article-title":"Homocysteine-induced endothelial dysfunction","volume":"67","author":"Lai","year":"2015","journal-title":"Ann Nutr Metab"},{"key":"10.1016\/j.aohep.2018.12.008_bib0220","doi-asserted-by":"crossref","DOI":"10.1007\/s00380-018-1210-9","article-title":"Age-dependent effects of homocysteine and dimethylarginines on cardiovascular mortality in claudicant patients with lower extremity arterial disease","author":"Jud","year":"2018","journal-title":"Heart Vessels"},{"key":"10.1016\/j.aohep.2018.12.008_bib0225","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2298\/VSP110823032C","article-title":"Plasma homocysteine levels in patients with liver cirrhosis","volume":"70","author":"Culafi\u0107","year":"2013","journal-title":"Vojnosanit Pregl"},{"key":"10.1016\/j.aohep.2018.12.008_bib0230","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.ejim.2009.03.002","article-title":"Homocysteine and endothelial markers are increased in patients with chronic liver diseases","volume":"20","author":"Remkov\u00e1","year":"2009","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.aohep.2018.12.008_bib0235","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1111\/liv.12979","article-title":"Hyperhomocysteinemia is associated with severity of cirrhosis and negative impact after liver transplantation","volume":"36","author":"Bhanji","year":"2016","journal-title":"Liver Int"},{"key":"10.1016\/j.aohep.2018.12.008_bib0240","doi-asserted-by":"crossref","first-page":"14844","DOI":"10.1074\/jbc.M312948200","article-title":"Homocysteine increases the expression of vascular endothelial growth factor by a mechanism involving endoplasmic reticulum stress and transcription factor ATF4","volume":"279","author":"Roybal","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.aohep.2018.12.008_bib0245","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0304-4165(03)00161-2","article-title":"Homocysteine induces vascular endothelial growth factor expression in differentiated THP-1 macrophages","volume":"1623","author":"Maeda","year":"2003","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.aohep.2018.12.008_bib0250","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1271\/bbb.60657","article-title":"Short-term hyperhomocysteinemia-induced oxidative stress activates retinal glial cells and increases vascular endothelial growth factor expression in rat retina","volume":"71","author":"Lee","year":"2007","journal-title":"Biosci Biotechnol Biochem"},{"key":"10.1016\/j.aohep.2018.12.008_bib0255","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1253\/circj.66.158","article-title":"Plasma level of homocysteine is inversely-associated with the development of collateral circulation in patients with single-vessel coronary artery disease","volume":"66","author":"Nagai","year":"2002","journal-title":"Circ J"},{"key":"10.1016\/j.aohep.2018.12.008_bib0260","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1161\/01.ATV.20.12.2579","article-title":"Hyperhomocysteinemia impairs angiogenesis in response to hindlimb ischemia","volume":"20","author":"Duan","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.aohep.2018.12.008_bib0265","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1182\/blood.V94.3.959.415k20_959_967","article-title":"Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells","volume":"94","author":"Outinen","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.aohep.2018.12.008_bib0270","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1080\/07315724.2017.1330162","article-title":"Efficacy of folic acid therapy in patients with hyperhomocysteinemia","volume":"36","author":"Tian","year":"2017","journal-title":"J Am Coll Nutr"},{"key":"10.1016\/j.aohep.2018.12.008_bib0275","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.atherosclerosis.2014.03.032","article-title":"The effect of homocysteine-lowering therapy with folic acid on flow-mediated vasodilation in patients with coronary artery disease: a meta-analysis of randomized controlled trials","volume":"235","author":"Liu","year":"2014","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.aohep.2018.12.008_bib0280","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jss.2007.04.038","article-title":"Lowering homocysteine decreases levels and expression of VEGF165 and endostatin","volume":"146","author":"Atta","year":"2008","journal-title":"J Surg Res"},{"key":"10.1016\/j.aohep.2018.12.008_bib0285","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1079\/BJN2002779","article-title":"Folic acid treatment reduces elevated plasma levels of symmetric dimethylarginine in hypermocysteinaemic subjects","volume":"89","author":"Holven","year":"2003","journal-title":"Br J Nutr"},{"key":"10.1016\/j.aohep.2018.12.008_bib0290","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1023\/B:BIRY.0000033744.32059.bd","article-title":"Plasma trace elements, vitamin B12, folate, and homocysteine levels in cirrhotic patients compared to healthy controls","volume":"69","author":"Halifeoglu","year":"2004","journal-title":"Biochemistry (Mosc)"},{"key":"10.1016\/j.aohep.2018.12.008_bib0295","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1136\/bmj.2.5650.150","article-title":"Serum and urinary folate in liver disease","volume":"2","author":"Retief","year":"1969","journal-title":"Br Med J"},{"key":"10.1016\/j.aohep.2018.12.008_bib0300","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/path.1700750212","article-title":"Disturbances of structure and function in the liver as the result of biliary obstruction","volume":"75","author":"Cameron","year":"1958","journal-title":"J Pathol Bacteriol"},{"key":"10.1016\/j.aohep.2018.12.008_bib0305","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1002\/hep.27679","article-title":"Caffeine ameliorates hemodynamic derangements and portosystemic collaterals in cirrhotic rats","volume":"61","author":"Hsu","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.aohep.2018.12.008_bib0310","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/hep.25625","article-title":"Cannabinoid receptor 2 agonist ameliorates mesenteric angiogenesis and portosystemic collaterals in cirrhotic rats","volume":"56","author":"Huang","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.aohep.2018.12.008_bib0315","first-page":"H1150","article-title":"On the validity of blood flow measurement using colored microspheres","volume":"276","author":"Hodeige","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/j.aohep.2018.12.008_bib0320","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1369\/jhc.4A6250.2004","article-title":"Immunohistochemical identification of an extracellular matrix scaffold that microguides capillary sprouting in vivo","volume":"52","author":"Anderson","year":"2004","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.aohep.2018.12.008_bib0325","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"10.1016\/j.aohep.2018.12.008_bib0330","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.mvr.2013.07.002","article-title":"Folic acid attenuates hyperhomocysteinemia-induced glomerular damage in rats","volume":"89","author":"Cao","year":"2013","journal-title":"Microvasc Res"},{"key":"10.1016\/j.aohep.2018.12.008_bib0335","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1042\/CS20160470","article-title":"Homocysteine deteriorates intrahepatic derangement and portal-systemic collaterals in cirrhotic rats","volume":"131","author":"Tung","year":"2017","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.aohep.2018.12.008_bib0340","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/sj.ejcn.1602912","article-title":"Acute autonomic effects of vitamins and fats in male smokers","volume":"63","author":"Wright","year":"2009","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.aohep.2018.12.008_bib0345","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ejphar.2013.05.026","article-title":"Folic acid modulates eNOS activity via effects on posttranslational modifications and protein\u2013protein interactions","volume":"714","author":"Taylor","year":"2013","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.aohep.2018.12.008_bib0350","doi-asserted-by":"crossref","first-page":"15380","DOI":"10.1074\/jbc.M112.427765","article-title":"Endomembrane H-Ras controls vascular endothelial growth factor-induced nitric-oxide synthase-mediated endothelial cell migration","volume":"288","author":"Haeussler","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1016\/j.aohep.2018.12.008_bib0355","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1007\/s00261-015-0391-2","article-title":"Prediction of esophageal varices in cirrhotic patients with apparent diffusion coefficient of the spleen","volume":"40","author":"Razek","year":"2015","journal-title":"Abdom Imaging"},{"key":"10.1016\/j.aohep.2018.12.008_bib0360","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1007\/s11547-014-0408-x","article-title":"Apparent diffusion coefficient value of hepatic fibrosis and inflammation in children with chronic hepatitis","volume":"119","author":"Razek","year":"2014","journal-title":"Radiol Med"},{"key":"10.1016\/j.aohep.2018.12.008_bib0365","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ejrad.2009.10.012","article-title":"Diagnosis and quantification of hepatic fibrosis in children with diffusion weighted MR imaging","volume":"78","author":"Razek","year":"2011","journal-title":"Eur J Radiol"},{"key":"10.1016\/j.aohep.2018.12.008_bib0370","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1007\/s00234-014-1409-0","article-title":"Minimal hepatic encephalopathy in children with liver cirrhosis: diffusion-weighted MR imaging and proton MR spectroscopy of the brain","volume":"56","author":"Razek","year":"2014","journal-title":"Neuroradiology"}],"container-title":["Annals of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1665268119300729?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1665268119300729?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,11,24]],"date-time":"2019-11-24T21:26:58Z","timestamp":1574630818000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1665268119300729"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S1665268119300729"],"URL":"https:\/\/doi.org\/10.1016\/j.aohep.2018.12.008","relation":{},"ISSN":["1665-2681"],"issn-type":[{"value":"1665-2681","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Folic acid ameliorates homocysteine-induced angiogenesis and portosystemic collaterals in cirrhotic rats","name":"articletitle","label":"Article Title"},{"value":"Annals of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aohep.2018.12.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Fundaci\u00f3n Cl\u00ednica M\u00e9dica Sur, A.C. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}]}}